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The map label for this gene is accC [H]

Identifier: 220915803

GI number: 220915803

Start: 762410

End: 763792

Strand: Direct

Name: accC [H]

Synonym: A2cp1_0684

Alternate gene names: 220915803

Gene position: 762410-763792 (Clockwise)

Preceding gene: 220915802

Following gene: 220915804

Centisome position: 15.16

GC content: 70.07

Gene sequence:

>1383_bases
ATGTTCAAGAAGGTCCTCATCGCCAACCGCGGCGAGATCGCGCTCCGTGTGCTCCGAGCCTGCAAGGAGCTCGGCGTCGC
CACGGTCGCGGTCCACTCCACCGCCGACGCCGAGTCGCTCCACGTGCGCTTCGCCGACGAGGCGATCTGCATCGGGCCGC
CGCAGTCGCGCGACAGCTACCTGAACCCGCGCGCGCTGCTCGCCGCCGCCGACGTCACCGGCGCCGACGCCCTCCACCCC
GGCTACGGCTTCCTCTCGGAGAACGCCGAGTTCGCGGCGATGGTCGAGAAGATGGGGCTGAAGTTCATCGGGCCGCGGCC
GGAGATGATCCGCCTCATGGGCAACAAGGTGGCGGCCCGCGAGGCGGCGGAGCAGGCCGGCCTGCCCCTGCTGCCCGGCG
CCCGGGGCAAGCTCGCCGACGCCGAGGAGGCGGAGCGCATCGCCGAGCAGGTGGGCTACCCGGTGATCCTGAAGGCGGCC
GCGGGCGGCGGCGGGCGCGGCATGAAGATCTGCCGCGACCGGAGCCAGATCCGCCAGCTGTTCGAGACCGCGTCCACCGA
GGCGCTCGCCGCGTTCGGCGACGGCTCGATGTACCTCGAGCGCTACGTCGAGATGCCGCGCCACATCGAGCTGCAGATCG
TGGCCGACGAGCACGGCAACATCATCCACCTCGGCGAGCGCGAGTGCTCGGTCCAGCGCCGCCACCAGAAGCTCATCGAG
GAGTCGCCGTCGCCCGCCGTCACCCCGGAGCTGCGCCGGGAGATGGGCGAGGTGGCCCTCAAGGCCATGAGAAAGATCGG
CTACAACAACGTGGGGACCATCGAGTTCCTCATGGACGAGAAGGGCCGCTACTACTTCATGGAGATGAACACCCGCATCC
AGGTGGAGCACCCGGTGACCGAGCAGGTCTACGGGCTCGACCTGCTGCGGGAGCAGATCCGGCTCGCGGCGGGCGAGAAG
CTGGAGCGCTCGCAGGCCTCGGTGGTCCCGCAGGCGCACTCCATCGAGTGCCGCGTGAACGCGGAGGACCCGGTCACGTT
CGCGCCGTCGCCGGGGCGGATCACCGGCTACCACCAGCCGGGCGGGTACGGCGTCCGCGTCGACACCATGGCGTACGAGC
AGTACAAGGTGCAGCCGTACTACGACTCGCTGGTGGCGAAGCTGATCGTCACCGGGGCGAACCGGGAGATCGCGCTGCGC
CGGGCCATGCGCGCGCTCAACGAGTACGTGATCGAGGGGATCAAGACCAACATCCCCTTCCACAAGCGCGTGCTCACCTT
CCCGGCCTTCACGGCGGGGCAGTACGACACCCGCATCGTCGAGCAGATCCTGAACCCGCCCGCGCCGGAGGAGACCCCCG
CCTCCAAGGTGGCGGGCGCGTAG

Upstream 100 bases:

>100_bases
GACGGCACCGTCGCCGAGATCTACGTCCAGAACGCCACCCCGGTGGAGTTCGGCGAGCCGCTGTTCCGCATCGTCGCGGG
CTAGGCCCGGAGAGGCCGGC

Downstream 100 bases:

>100_bases
GCCTCGCCGCCGCCGCGGGGGCCGCCGGGCCCCGCGCGACGGCCGGTCCGGAGGGGCAGAGACGGGAAAATTCCCGCGTC
ACTTCGCGGGATTCGCGTCT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MFKKVLIANRGEIALRVLRACKELGVATVAVHSTADAESLHVRFADEAICIGPPQSRDSYLNPRALLAAADVTGADALHP
GYGFLSENAEFAAMVEKMGLKFIGPRPEMIRLMGNKVAAREAAEQAGLPLLPGARGKLADAEEAERIAEQVGYPVILKAA
AGGGGRGMKICRDRSQIRQLFETASTEALAAFGDGSMYLERYVEMPRHIELQIVADEHGNIIHLGERECSVQRRHQKLIE
ESPSPAVTPELRREMGEVALKAMRKIGYNNVGTIEFLMDEKGRYYFMEMNTRIQVEHPVTEQVYGLDLLREQIRLAAGEK
LERSQASVVPQAHSIECRVNAEDPVTFAPSPGRITGYHQPGGYGVRVDTMAYEQYKVQPYYDSLVAKLIVTGANREIALR
RAMRALNEYVIEGIKTNIPFHKRVLTFPAFTAGQYDTRIVEQILNPPAPEETPASKVAGA

Sequences:

>Translated_460_residues
MFKKVLIANRGEIALRVLRACKELGVATVAVHSTADAESLHVRFADEAICIGPPQSRDSYLNPRALLAAADVTGADALHP
GYGFLSENAEFAAMVEKMGLKFIGPRPEMIRLMGNKVAAREAAEQAGLPLLPGARGKLADAEEAERIAEQVGYPVILKAA
AGGGGRGMKICRDRSQIRQLFETASTEALAAFGDGSMYLERYVEMPRHIELQIVADEHGNIIHLGERECSVQRRHQKLIE
ESPSPAVTPELRREMGEVALKAMRKIGYNNVGTIEFLMDEKGRYYFMEMNTRIQVEHPVTEQVYGLDLLREQIRLAAGEK
LERSQASVVPQAHSIECRVNAEDPVTFAPSPGRITGYHQPGGYGVRVDTMAYEQYKVQPYYDSLVAKLIVTGANREIALR
RAMRALNEYVIEGIKTNIPFHKRVLTFPAFTAGQYDTRIVEQILNPPAPEETPASKVAGA
>Mature_460_residues
MFKKVLIANRGEIALRVLRACKELGVATVAVHSTADAESLHVRFADEAICIGPPQSRDSYLNPRALLAAADVTGADALHP
GYGFLSENAEFAAMVEKMGLKFIGPRPEMIRLMGNKVAAREAAEQAGLPLLPGARGKLADAEEAERIAEQVGYPVILKAA
AGGGGRGMKICRDRSQIRQLFETASTEALAAFGDGSMYLERYVEMPRHIELQIVADEHGNIIHLGERECSVQRRHQKLIE
ESPSPAVTPELRREMGEVALKAMRKIGYNNVGTIEFLMDEKGRYYFMEMNTRIQVEHPVTEQVYGLDLLREQIRLAAGEK
LERSQASVVPQAHSIECRVNAEDPVTFAPSPGRITGYHQPGGYGVRVDTMAYEQYKVQPYYDSLVAKLIVTGANREIALR
RAMRALNEYVIEGIKTNIPFHKRVLTFPAFTAGQYDTRIVEQILNPPAPEETPASKVAGA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=47.4157303370787, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=47.4157303370787, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=47.4157303370787, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=45.3514739229025, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI106049528, Length=465, Percent_Identity=43.4408602150538, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=465, Percent_Identity=43.4408602150538, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=465, Percent_Identity=43.4408602150538, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38679974, Length=522, Percent_Identity=28.1609195402299, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI38679971, Length=522, Percent_Identity=28.1609195402299, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI38679977, Length=522, Percent_Identity=28.1609195402299, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI38679967, Length=522, Percent_Identity=28.1609195402299, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI38679960, Length=522, Percent_Identity=28.1609195402299, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=26.2135922330097, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=54.3820224719101, Blast_Score=485, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=45.3932584269663, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=45.8797327394209, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=44.6153846153846, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=26.9387755102041, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=25.9187620889749, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=25.9187620889749, Blast_Score=172, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.75, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=44.1964285714286, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=40.3153153153153, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=28.3582089552239, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324343, Length=538, Percent_Identity=26.2081784386617, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.7706013363029, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651757, Length=467, Percent_Identity=43.0406852248394, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=429, Percent_Identity=41.7249417249417, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=27.8978388998035, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=27.8978388998035, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=27.8978388998035, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=27.8978388998035, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50724; Mature: 50724

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKVLIANRGEIALRVLRACKELGVATVAVHSTADAESLHVRFADEAICIGPPQSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCCC
LNPRALLAAADVTGADALHPGYGFLSENAEFAAMVEKMGLKFIGPRPEMIRLMGNKVAAR
CCCHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCHHHHH
EAAEQAGLPLLPGARGKLADAEEAERIAEQVGYPVILKAAAGGGGRGMKICRDRSQIRQL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
FETASTEALAAFGDGSMYLERYVEMPRHIELQIVADEHGNIIHLGERECSVQRRHQKLIE
HHHCCCHHEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHH
ESPSPAVTPELRREMGEVALKAMRKIGYNNVGTIEFLMDEKGRYYFMEMNTRIQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCEEEECCCCH
EQVYGLDLLREQIRLAAGEKLERSQASVVPQAHSIECRVNAEDPVTFAPSPGRITGYHQP
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCEEEEECC
GGYGVRVDTMAYEQYKVQPYYDSLVAKLIVTGANREIALRRAMRALNEYVIEGIKTNIPF
CCCEEEEEEEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
HKRVLTFPAFTAGQYDTRIVEQILNPPAPEETPASKVAGA
HHHEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MFKKVLIANRGEIALRVLRACKELGVATVAVHSTADAESLHVRFADEAICIGPPQSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCCC
LNPRALLAAADVTGADALHPGYGFLSENAEFAAMVEKMGLKFIGPRPEMIRLMGNKVAAR
CCCHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCHHHHH
EAAEQAGLPLLPGARGKLADAEEAERIAEQVGYPVILKAAAGGGGRGMKICRDRSQIRQL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
FETASTEALAAFGDGSMYLERYVEMPRHIELQIVADEHGNIIHLGERECSVQRRHQKLIE
HHHCCCHHEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHH
ESPSPAVTPELRREMGEVALKAMRKIGYNNVGTIEFLMDEKGRYYFMEMNTRIQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCEEEECCCCH
EQVYGLDLLREQIRLAAGEKLERSQASVVPQAHSIECRVNAEDPVTFAPSPGRITGYHQP
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCEEEEECC
GGYGVRVDTMAYEQYKVQPYYDSLVAKLIVTGANREIALRRAMRALNEYVIEGIKTNIPF
CCCEEEEEEEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
HKRVLTFPAFTAGQYDTRIVEQILNPPAPEETPASKVAGA
HHHEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]