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The map label for this gene is fadI [H]

Identifier: 220915555

GI number: 220915555

Start: 490451

End: 491758

Strand: Direct

Name: fadI [H]

Synonym: A2cp1_0436

Alternate gene names: 220915555

Gene position: 490451-491758 (Clockwise)

Preceding gene: 220915553

Following gene: 220915556

Centisome position: 9.75

GC content: 74.31

Gene sequence:

>1308_bases
ATGGGCATGAACGGTTCTCCTCCGCCCGGCCGGCGGGCCGCGGTCGTGGCCGGCCTTCGCACGCCGTTCGTGAAGGCGGG
CACCGACTTCAAGGACCTCTCCGCCACCGACCTCGGCGCGCTGGTGGTGAACGAGCTGGTGGTGCGGAGCGGGCTGCCGC
CGGAGGCGTTCGACTCCGTCATCTTCGGCCAGGTCATCCCCTCGCCCACGGTCACGCTCATCGGCCGGGAGATGGTCCTG
CGCACCCAACTGCCGCGGAGCGTGCAGGCGCACACCGTGGCGCGCGCCTGCGCGACCTCGATCCAGGCGGCCACCGACGC
CGCCGACCAGATCCGGCTCGGCCACTCCGACTGCGCCATCGCCGGCGGCGCCGAGTCGGTCTCGGACGCGCCCATCTTCG
CCTCGCGCCCGCTGGCGCAGGCGCTGGTGGAGCTGAGCCGCGCGCGCACGCTCGCCGAGCGCGCCCGCATCCTCGCCGGC
CTGCGCCCGAAGGACTTCACGCCCACGCCGCCCGCGCTGAAGGAGCCCACCACCGGGCTCACCATGGGCGAGAGCGCCGA
GAGGATGGCGCAGGTGAACGGCATCTCGCGCGCGGCGCAGGACCGGCTCGCGTACGAGAGCCACCGCCGCGCCGCCGAGG
CCTGGGACGCGGGCCGCTTCGACGAGGAGGTCATGCACGTTCCGGTGCCGCCGCGGTACGATCACGTGGCGGCCCGCGAC
AACATCGTCCGCAAGGACACCACCGTCGAGGCGCTCGCGAAGCTCCGCCCGGTGTTCGACCGGAAGTACGGGACCATCAC
CGCCGGCAACGCCTCGCCGCTCACCGACGGCGCGGCGGCGCTCGTGATCATGAGCGAGGAGCGGGCGAAGGCGCTCGGGA
TGAAGCCGCTCGGCTTCCTGAAGGCCTACGCCTACGCCGCGCTCGACCCGCGCGACCAGCTGCTGCAGGGGCCGGCCTAC
GCCGCGCCGGTGGCGCTGGAGCGGGCCGGGCTCCGGCTCGCCGACATGGACCTCGTCGACATGCACGAGGCCTTCGCCGC
GCAGGTGCTCTCGAACCTGCAGGCGTTCGCCTCGAAGGACTTCGCCGAGCGCGAGCTGGGCCGGTCGGAGCCGCTCGGCG
AGGTGGACCCCGCGAAGCTGAACGTGAACGGCGGCTCGATCGCGCTCGGCCACCCGTTCGCCGCCACCGGGGCGCGCATG
ATCCTGCAGACGCTCCGCGAGCTGGGGCGCCGCGGCGGGCAGCACGCGCTCATCACGGTGTGCGCGGCGGGCGGCCTGGG
CGCGGCGGTGGTGCTCGAGCGGGAGTGA

Upstream 100 bases:

>100_bases
CCCCGGGGGGGAGCAGCGGTCCTTGGTTGACGCTTCGCGCCATGCTCACTAAATCTGGCCAGGCAACCGACCGATTCCCG
AGTCAACCGGAGCTGCGCTC

Downstream 100 bases:

>100_bases
CTCGCCCCCGGCGCCCGCCCCGCGGCGGCGCGCCGGCGTGCACGGAGGACGCATGATGTCGGCTGAGGCGATGACGGCGG
GCCAGGGCGCGTCGAGGTAC

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MGMNGSPPPGRRAAVVAGLRTPFVKAGTDFKDLSATDLGALVVNELVVRSGLPPEAFDSVIFGQVIPSPTVTLIGREMVL
RTQLPRSVQAHTVARACATSIQAATDAADQIRLGHSDCAIAGGAESVSDAPIFASRPLAQALVELSRARTLAERARILAG
LRPKDFTPTPPALKEPTTGLTMGESAERMAQVNGISRAAQDRLAYESHRRAAEAWDAGRFDEEVMHVPVPPRYDHVAARD
NIVRKDTTVEALAKLRPVFDRKYGTITAGNASPLTDGAAALVIMSEERAKALGMKPLGFLKAYAYAALDPRDQLLQGPAY
AAPVALERAGLRLADMDLVDMHEAFAAQVLSNLQAFASKDFAERELGRSEPLGEVDPAKLNVNGGSIALGHPFAATGARM
ILQTLRELGRRGGQHALITVCAAGGLGAAVVLERE

Sequences:

>Translated_435_residues
MGMNGSPPPGRRAAVVAGLRTPFVKAGTDFKDLSATDLGALVVNELVVRSGLPPEAFDSVIFGQVIPSPTVTLIGREMVL
RTQLPRSVQAHTVARACATSIQAATDAADQIRLGHSDCAIAGGAESVSDAPIFASRPLAQALVELSRARTLAERARILAG
LRPKDFTPTPPALKEPTTGLTMGESAERMAQVNGISRAAQDRLAYESHRRAAEAWDAGRFDEEVMHVPVPPRYDHVAARD
NIVRKDTTVEALAKLRPVFDRKYGTITAGNASPLTDGAAALVIMSEERAKALGMKPLGFLKAYAYAALDPRDQLLQGPAY
AAPVALERAGLRLADMDLVDMHEAFAAQVLSNLQAFASKDFAERELGRSEPLGEVDPAKLNVNGGSIALGHPFAATGARM
ILQTLRELGRRGGQHALITVCAAGGLGAAVVLERE
>Mature_434_residues
GMNGSPPPGRRAAVVAGLRTPFVKAGTDFKDLSATDLGALVVNELVVRSGLPPEAFDSVIFGQVIPSPTVTLIGREMVLR
TQLPRSVQAHTVARACATSIQAATDAADQIRLGHSDCAIAGGAESVSDAPIFASRPLAQALVELSRARTLAERARILAGL
RPKDFTPTPPALKEPTTGLTMGESAERMAQVNGISRAAQDRLAYESHRRAAEAWDAGRFDEEVMHVPVPPRYDHVAARDN
IVRKDTTVEALAKLRPVFDRKYGTITAGNASPLTDGAAALVIMSEERAKALGMKPLGFLKAYAYAALDPRDQLLQGPAYA
APVALERAGLRLADMDLVDMHEAFAAQVLSNLQAFASKDFAERELGRSEPLGEVDPAKLNVNGGSIALGHPFAATGARMI
LQTLRELGRRGGQHALITVCAAGGLGAAVVLERE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=40.8450704225352, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI167614485, Length=425, Percent_Identity=34.5882352941176, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4557237, Length=430, Percent_Identity=30.4651162790698, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4501853, Length=427, Percent_Identity=33.0210772833724, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=31.1720698254364, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=256, Percent_Identity=26.953125, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=52.5821596244132, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI87082165, Length=426, Percent_Identity=36.8544600938967, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788554, Length=429, Percent_Identity=36.3636363636364, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787663, Length=428, Percent_Identity=38.0841121495327, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI48994986, Length=433, Percent_Identity=34.6420323325635, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=419, Percent_Identity=41.527446300716, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI133906874, Length=426, Percent_Identity=34.2723004694836, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=425, Percent_Identity=30.3529411764706, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=429, Percent_Identity=29.8368298368298, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=428, Percent_Identity=24.5327102803738, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325229, Length=430, Percent_Identity=30.9302325581395, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322031, Length=410, Percent_Identity=29.5121951219512, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=40.4109589041096, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24655093, Length=421, Percent_Identity=31.5914489311164, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24640423, Length=421, Percent_Identity=30.6413301662708, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17648125, Length=422, Percent_Identity=30.8056872037915, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46038; Mature: 45907

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMNGSPPPGRRAAVVAGLRTPFVKAGTDFKDLSATDLGALVVNELVVRSGLPPEAFDSV
CCCCCCCCCCCCCEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
IFGQVIPSPTVTLIGREMVLRTQLPRSVQAHTVARACATSIQAATDAADQIRLGHSDCAI
HHHHHCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCEE
AGGAESVSDAPIFASRPLAQALVELSRARTLAERARILAGLRPKDFTPTPPALKEPTTGL
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TMGESAERMAQVNGISRAAQDRLAYESHRRAAEAWDAGRFDEEVMHVPVPPRYDHVAARD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHC
NIVRKDTTVEALAKLRPVFDRKYGTITAGNASPLTDGAAALVIMSEERAKALGMKPLGFL
CHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEEECHHHHHCCCCHHHHH
KAYAYAALDPRDQLLQGPAYAAPVALERAGLRLADMDLVDMHEAFAAQVLSNLQAFASKD
HHHHHHHCCCHHHHHCCCCHHCCHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCC
FAERELGRSEPLGEVDPAKLNVNGGSIALGHPFAATGARMILQTLRELGRRGGQHALITV
HHHHHCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEE
CAAGGLGAAVVLERE
EECCCCCEEEEEECC
>Mature Secondary Structure 
GMNGSPPPGRRAAVVAGLRTPFVKAGTDFKDLSATDLGALVVNELVVRSGLPPEAFDSV
CCCCCCCCCCCCEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
IFGQVIPSPTVTLIGREMVLRTQLPRSVQAHTVARACATSIQAATDAADQIRLGHSDCAI
HHHHHCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCEE
AGGAESVSDAPIFASRPLAQALVELSRARTLAERARILAGLRPKDFTPTPPALKEPTTGL
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TMGESAERMAQVNGISRAAQDRLAYESHRRAAEAWDAGRFDEEVMHVPVPPRYDHVAARD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHC
NIVRKDTTVEALAKLRPVFDRKYGTITAGNASPLTDGAAALVIMSEERAKALGMKPLGFL
CHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEEECHHHHHCCCCHHHHH
KAYAYAALDPRDQLLQGPAYAAPVALERAGLRLADMDLVDMHEAFAAQVLSNLQAFASKD
HHHHHHHCCCHHHHHCCCCHHCCHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCC
FAERELGRSEPLGEVDPAKLNVNGGSIALGHPFAATGARMILQTLRELGRRGGQHALITV
HHHHHCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEE
CAAGGLGAAVVLERE
EECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA