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The map label for this gene is degP [H]

Identifier: 220915534

GI number: 220915534

Start: 469344

End: 470795

Strand: Direct

Name: degP [H]

Synonym: A2cp1_0415

Alternate gene names: 220915534

Gene position: 469344-470795 (Clockwise)

Preceding gene: 220915531

Following gene: 220915535

Centisome position: 9.33

GC content: 77.13

Gene sequence:

>1452_bases
ATGGCGAGCGGCGGGCAGGGGTGGAAGGCGATGGCGCTGGCGGCGGCGCTCGGGGTGCTCGGCACGCCGGGGACGGCGGC
CGCGGGCCCGAAGGCCGCGGGCGCGGCGCCGGCGCAGGTGCCCGCGAAGGCGAAGGCGCCGGCCGGCACCGGCCTCCTGC
GCGCGCTCGACGCCGCGCTCGGCGAGGTGATCGAGAAGATCTCGCCCGCGGTGGTGCAGGTCACGGTGAGCGGGTACGCG
CCCGCCGACGAGACCGCCTCCGGCGCGATCGTGCGCCAGCGCGTGCTCGGGTCCGGCGTCGTGGTGGACCCGAACGGCTA
CGTCGTCACGAACGCGCACGTGGTCGCGGGCGCGCAGCGGGTCCGGATCCTGCTGCCGGAGGGGCGCGGCCCGGCGGCGC
ACACCGCCCGCCGCATCTACGACGCGCGGGTCATCGGGGTCGAGCCGGAGATCGACCTCGCCCTCCTCAAGATCGACGCG
CGGAACCTGCCGGTGCTGGCGCTCGGGCGGCGCGAGGTCCGCCCCGGCCAGCTCGTGTTCGCGGTCGGCAGCCCGGAGGG
CCTCGCCAGCACCGTGACCATGGGCGTGGTCTCGTCGGTGGCGCGGCAGCCGGACCCGGCGCGGCCGGTCGTCTACATCC
AGACCGACGCGCCCATCAACCCGGGGAACAGCGGCGGGCCGCTGGTGGACACCGATGGCAACGTGGTCGGCATCAACACG
TTCATCCTCACGCAGGGCGGCGGGAGCGAGGGGCTGGGCTTCGCGATCCCCTCCGACGTGGTGAAGTACGTGTACGAGAG
CCTGCGGCGCCACGGGCGCGTGGAGCACAGCATGATCGGGCTCGCCGCCCAGGGCATCACCCCGGGGCTGGCGGCCGGGC
TCCGGCTCTCGCAGGACTGGGGCGTGGTGGTGGGGGACGTGGCCCCGGGCAGCCCGGCGGAGAAGGCCGGGGTGCTGGCC
GGCGACGTCATCGTGTCGGTGGACGGGCGGCCCATCGACGGGATGCCCTCGCTGGCGCCGGCGATCTACCTGCACCCGGC
GGACGCGCCGCTCGCGCTGGTGCTCCGGCGCGGCGAGGACGTGCTCTCCGTGAAGGTGGCCGGCGTGGAGCCGCGCCGCC
CGGCCGAGCGGCTCGCCGAGGTGGCGGACCTGGCGCGCAGCACCGTCCCGCGGCTCGGGGTGGTGGCGATGGACCTCGAC
GCGCAGGCGCGCGCCGCCATGCCCGAGCTGCGCTCGCCGGCGGGCGTGGTGGTGGTGGCGCGGGTGCCCGAGGCCGGGCA
GGCGGGCGCCGCGCTCGAGCCCGGCGACGTGATTCACGCGGTGAACCGGACGCCCGTCGCCTCGCTCGCCGCGCTCAAGG
CGGCGGTGGCCGCGCTCCCCCCCGGCGGTCCGGGCGTCCTGCGGGTGGAGCGCCGCGGCCAGCTGAGCTGGATCGAGCTC
GACCTCGACTGA

Upstream 100 bases:

>100_bases
CGATCGCGCACGATCCGTCACGCATTCCTCGCTTGCCTGGGGGCGGCCGGCGTGGAGACTTCCGCCCCAGGCCCGGCGGT
CCGGGCGGGAGAGGACGGCC

Downstream 100 bases:

>100_bases
TCGGGGTGGGAGGGGGCGGCCGGCCGCCCCGACCGGCCGCGCGCCGGGGCGGACGCCCCGGGCGGACCCGGGCGGACCTT
GCAACGCGCGCCGCGCCCCC

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MASGGQGWKAMALAAALGVLGTPGTAAAGPKAAGAAPAQVPAKAKAPAGTGLLRALDAALGEVIEKISPAVVQVTVSGYA
PADETASGAIVRQRVLGSGVVVDPNGYVVTNAHVVAGAQRVRILLPEGRGPAAHTARRIYDARVIGVEPEIDLALLKIDA
RNLPVLALGRREVRPGQLVFAVGSPEGLASTVTMGVVSSVARQPDPARPVVYIQTDAPINPGNSGGPLVDTDGNVVGINT
FILTQGGGSEGLGFAIPSDVVKYVYESLRRHGRVEHSMIGLAAQGITPGLAAGLRLSQDWGVVVGDVAPGSPAEKAGVLA
GDVIVSVDGRPIDGMPSLAPAIYLHPADAPLALVLRRGEDVLSVKVAGVEPRRPAERLAEVADLARSTVPRLGVVAMDLD
AQARAAMPELRSPAGVVVVARVPEAGQAGAALEPGDVIHAVNRTPVASLAALKAAVAALPPGGPGVLRVERRGQLSWIEL
DLD

Sequences:

>Translated_483_residues
MASGGQGWKAMALAAALGVLGTPGTAAAGPKAAGAAPAQVPAKAKAPAGTGLLRALDAALGEVIEKISPAVVQVTVSGYA
PADETASGAIVRQRVLGSGVVVDPNGYVVTNAHVVAGAQRVRILLPEGRGPAAHTARRIYDARVIGVEPEIDLALLKIDA
RNLPVLALGRREVRPGQLVFAVGSPEGLASTVTMGVVSSVARQPDPARPVVYIQTDAPINPGNSGGPLVDTDGNVVGINT
FILTQGGGSEGLGFAIPSDVVKYVYESLRRHGRVEHSMIGLAAQGITPGLAAGLRLSQDWGVVVGDVAPGSPAEKAGVLA
GDVIVSVDGRPIDGMPSLAPAIYLHPADAPLALVLRRGEDVLSVKVAGVEPRRPAERLAEVADLARSTVPRLGVVAMDLD
AQARAAMPELRSPAGVVVVARVPEAGQAGAALEPGDVIHAVNRTPVASLAALKAAVAALPPGGPGVLRVERRGQLSWIEL
DLD
>Mature_482_residues
ASGGQGWKAMALAAALGVLGTPGTAAAGPKAAGAAPAQVPAKAKAPAGTGLLRALDAALGEVIEKISPAVVQVTVSGYAP
ADETASGAIVRQRVLGSGVVVDPNGYVVTNAHVVAGAQRVRILLPEGRGPAAHTARRIYDARVIGVEPEIDLALLKIDAR
NLPVLALGRREVRPGQLVFAVGSPEGLASTVTMGVVSSVARQPDPARPVVYIQTDAPINPGNSGGPLVDTDGNVVGINTF
ILTQGGGSEGLGFAIPSDVVKYVYESLRRHGRVEHSMIGLAAQGITPGLAAGLRLSQDWGVVVGDVAPGSPAEKAGVLAG
DVIVSVDGRPIDGMPSLAPAIYLHPADAPLALVLRRGEDVLSVKVAGVEPRRPAERLAEVADLARSTVPRLGVVAMDLDA
QARAAMPELRSPAGVVVVARVPEAGQAGAALEPGDVIHAVNRTPVASLAALKAAVAALPPGGPGVLRVERRGQLSWIELD
LD

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=332, Percent_Identity=37.0481927710843, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI22129776, Length=384, Percent_Identity=35.15625, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI24308541, Length=333, Percent_Identity=34.2342342342342, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI7019477, Length=328, Percent_Identity=35.6707317073171, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI1786356, Length=372, Percent_Identity=34.4086021505376, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789629, Length=477, Percent_Identity=31.8658280922432, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789630, Length=317, Percent_Identity=34.7003154574132, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24646839, Length=298, Percent_Identity=33.5570469798658, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48917; Mature: 48786

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGGQGWKAMALAAALGVLGTPGTAAAGPKAAGAAPAQVPAKAKAPAGTGLLRALDAAL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GEVIEKISPAVVQVTVSGYAPADETASGAIVRQRVLGSGVVVDPNGYVVTNAHVVAGAQR
HHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEECCEEEECCEE
VRILLPEGRGPAAHTARRIYDARVIGVEPEIDLALLKIDARNLPVLALGRREVRPGQLVF
EEEEEECCCCCHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEE
AVGSPEGLASTVTMGVVSSVARQPDPARPVVYIQTDAPINPGNSGGPLVDTDGNVVGINT
EECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCEEEEEE
FILTQGGGSEGLGFAIPSDVVKYVYESLRRHGRVEHSMIGLAAQGITPGLAAGLRLSQDW
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCCHHHHCCEECCCC
GVVVGDVAPGSPAEKAGVLAGDVIVSVDGRPIDGMPSLAPAIYLHPADAPLALVLRRGED
CEEEECCCCCCCCHHCCEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEECCCC
VLSVKVAGVEPRRPAERLAEVADLARSTVPRLGVVAMDLDAQARAAMPELRSPAGVVVVA
EEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCHHHCCCCCEEEEE
RVPEAGQAGAALEPGDVIHAVNRTPVASLAALKAAVAALPPGGPGVLRVERRGQLSWIEL
ECCCCCCCCCCCCCCHHEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEE
DLD
ECC
>Mature Secondary Structure 
ASGGQGWKAMALAAALGVLGTPGTAAAGPKAAGAAPAQVPAKAKAPAGTGLLRALDAAL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GEVIEKISPAVVQVTVSGYAPADETASGAIVRQRVLGSGVVVDPNGYVVTNAHVVAGAQR
HHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEECCCCEEEECCEEEECCEE
VRILLPEGRGPAAHTARRIYDARVIGVEPEIDLALLKIDARNLPVLALGRREVRPGQLVF
EEEEEECCCCCHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEE
AVGSPEGLASTVTMGVVSSVARQPDPARPVVYIQTDAPINPGNSGGPLVDTDGNVVGINT
EECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCEEEEEE
FILTQGGGSEGLGFAIPSDVVKYVYESLRRHGRVEHSMIGLAAQGITPGLAAGLRLSQDW
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCCHHHHCCEECCCC
GVVVGDVAPGSPAEKAGVLAGDVIVSVDGRPIDGMPSLAPAIYLHPADAPLALVLRRGED
CEEEECCCCCCCCHHCCEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEECCCC
VLSVKVAGVEPRRPAERLAEVADLARSTVPRLGVVAMDLDAQARAAMPELRSPAGVVVVA
EEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCHHHCCCCCEEEEE
RVPEAGQAGAALEPGDVIHAVNRTPVASLAALKAAVAALPPGGPGVLRVERRGQLSWIEL
ECCCCCCCCCCCCCCHHEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEE
DLD
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]