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The map label for this gene is ccrA [H]

Identifier: 220915499

GI number: 220915499

Start: 425820

End: 426602

Strand: Direct

Name: ccrA [H]

Synonym: A2cp1_0380

Alternate gene names: 220915499

Gene position: 425820-426602 (Clockwise)

Preceding gene: 220915496

Following gene: 220915503

Centisome position: 8.47

GC content: 75.48

Gene sequence:

>783_bases
ATGCGAATGCTGCTCACCGTCGCGCTCGCGGTCCTCCCCTTCGCGAGCCTGGCCGACGCTCACGCGCACGGCGAGGCGGA
GATCGACCTCGGCCAGCGCGTCTGGGCCCGGCCCATCTCGCGCGATGCCTGGATCATCCGGTCGGTGAGCCCGATCGCTG
GGTTCGGGGACGTCGAGTCGAACGCGGTCCTCGTGGCGGGCGCCGCCGAGTCCGTGCTCATCGACACGCCGGCGACCGAG
GCGCAGACCGCACCCGTGCTCGCGTGGGCCGCGGAGACGCTGCGCCGGCCGGTGCGCCACCTCGTCGTCACGCACTGGCA
CGCCGACCGGATGGGCGGGATCGGGCTCGCGCGGCCGAACCGGATCCGGACGTACGCGCTCGGGAAGACGCGCGCGCTCG
CGCAGCGCCACGGCCTGGTGGTCCCGGAGCGCGAGCTGCGGCCCGAGGAGCGACTCGCCCTCGCGGGCGTGAAGCTCGAG
ACCTGGTACCCCGGGCACGGGCACACCGCCGACAACCTCGTGGTGTGGCTGCCCGCGAACGGGCTGCTCGTGGGCGGGTG
CTTCGTCAAGGCGGCGGAGGCGAGGACGCTCGGGAACCTCGAGGAGATCGATCCGGTGCAGTGGGCGAAGGGCGCCGCCG
CGGCCGCGCGTCGCTATCCGCAGCCTCGGACGGTGGTCCCGGGCCACGGCGCGGCCGGCGGTCCGGAGCTGCTGCGGCAC
ACCGCGGAGCTGGCCCAGGCGTACGCGGCGGAGCACGGACGCGAGGGCGAGCGGCGCCGGTGA

Upstream 100 bases:

>100_bases
CCCCGTCGGCCCGAGCCGGGATCGCGTGCGGCGCCGTGCGCCGCGGACGACCCGACTCAGCGCTTCCTGCTCGCGCCGAA
GGCCGCTAGCTTCGCCGCCC

Downstream 100 bases:

>100_bases
GGCGGGGAGCCGGATCGCCGGGGAGGCGATCCCGTGCACGTCAAAGGCAATCCCCGGTCAGGAGGCAGGCGGTGGCGATG
CCCGCCACCCCGGCGTACGA

Product: beta-lactamase

Products: NA

Alternate protein names: Cephalosporinase; Imipenem-cefoxitin hydrolyzing enzyme; Penicillinase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MRMLLTVALAVLPFASLADAHAHGEAEIDLGQRVWARPISRDAWIIRSVSPIAGFGDVESNAVLVAGAAESVLIDTPATE
AQTAPVLAWAAETLRRPVRHLVVTHWHADRMGGIGLARPNRIRTYALGKTRALAQRHGLVVPERELRPEERLALAGVKLE
TWYPGHGHTADNLVVWLPANGLLVGGCFVKAAEARTLGNLEEIDPVQWAKGAAAAARRYPQPRTVVPGHGAAGGPELLRH
TAELAQAYAAEHGREGERRR

Sequences:

>Translated_260_residues
MRMLLTVALAVLPFASLADAHAHGEAEIDLGQRVWARPISRDAWIIRSVSPIAGFGDVESNAVLVAGAAESVLIDTPATE
AQTAPVLAWAAETLRRPVRHLVVTHWHADRMGGIGLARPNRIRTYALGKTRALAQRHGLVVPERELRPEERLALAGVKLE
TWYPGHGHTADNLVVWLPANGLLVGGCFVKAAEARTLGNLEEIDPVQWAKGAAAAARRYPQPRTVVPGHGAAGGPELLRH
TAELAQAYAAEHGREGERRR
>Mature_260_residues
MRMLLTVALAVLPFASLADAHAHGEAEIDLGQRVWARPISRDAWIIRSVSPIAGFGDVESNAVLVAGAAESVLIDTPATE
AQTAPVLAWAAETLRRPVRHLVVTHWHADRMGGIGLARPNRIRTYALGKTRALAQRHGLVVPERELRPEERLALAGVKLE
TWYPGHGHTADNLVVWLPANGLLVGGCFVKAAEARTLGNLEEIDPVQWAKGAAAAARRYPQPRTVVPGHGAAGGPELLRH
TAELAQAYAAEHGREGERRR

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 28034; Mature: 28034

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00744 BETA_LACTAMASE_B_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMLLTVALAVLPFASLADAHAHGEAEIDLGQRVWARPISRDAWIIRSVSPIAGFGDVES
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCEEEEEECCCCCCCCCCCC
NAVLVAGAAESVLIDTPATEAQTAPVLAWAAETLRRPVRHLVVTHWHADRMGGIGLARPN
CEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECHHCCCCCCCCCCC
RIRTYALGKTRALAQRHGLVVPERELRPEERLALAGVKLETWYPGHGHTADNLVVWLPAN
CEEEEECCHHHHHHHHCCCCCCHHHCCHHHHHEEECEEEEEEECCCCCCCCCEEEEECCC
GLLVGGCFVKAAEARTLGNLEEIDPVQWAKGAAAAARRYPQPRTVVPGHGAAGGPELLRH
CEEEEHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHH
TAELAQAYAAEHGREGERRR
HHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRMLLTVALAVLPFASLADAHAHGEAEIDLGQRVWARPISRDAWIIRSVSPIAGFGDVES
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCEEEEEECCCCCCCCCCCC
NAVLVAGAAESVLIDTPATEAQTAPVLAWAAETLRRPVRHLVVTHWHADRMGGIGLARPN
CEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECHHCCCCCCCCCCC
RIRTYALGKTRALAQRHGLVVPERELRPEERLALAGVKLETWYPGHGHTADNLVVWLPAN
CEEEEECCHHHHHHHHCCCCCCHHHCCHHHHHEEECEEEEEEECCCCCCCCCEEEEECCC
GLLVGGCFVKAAEARTLGNLEEIDPVQWAKGAAAAARRYPQPRTVVPGHGAAGGPELLRH
CEEEEHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHH
TAELAQAYAAEHGREGERRR
HHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2121094; 1956298; 2110145; 8805566; 9416622; 9578564; 10210203 [H]