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The map label for this gene is atoC [H]

Identifier: 220915484

GI number: 220915484

Start: 409524

End: 411188

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_0365

Alternate gene names: 220915484

Gene position: 409524-411188 (Clockwise)

Preceding gene: 220915483

Following gene: 220915486

Centisome position: 8.14

GC content: 70.45

Gene sequence:

>1665_bases
ATGAAGCTCCACGACATTCACCTGCTGGACCTCTTCGACGTGGGCACCGAGCAGGGCTGGCTCAGCATGCGCCAGCAGCG
CATGGTGGTGCACAGCGCGGCGGCGGTCAGCATCATGCGGGCGCAGCTGATCCGCAGCCTGGGCCAGGACGCGGCGCGGG
CCATCGTGTTTCGCTGGGGCTTCGCCCAGGGGTACTTCGACGCGATGATGTGCTCCGACCACCTGGCGAGCTTGCAGCCG
GTGGACCGATTCGTGTTCGGCTGCACGCTCCACACCATGGAAGGCATGGTCCGGGTGGCGCCCAAGGTCATCGAGGCGAA
GGGGCCCGGCAAGCTGCACATGGAGGCGAACTGGTGGCACTGCGCCGAGGCCGACGACCACGCCCGCGTGTTCGGAGCTG
GCATGACGAGCTCGTGCTGGGCCACCCTGGGCTACGCCTCCGGGTTCGGCACGTACGTGATCGGGGCGCTCATCCTGTTC
GAGGAGGTCGCGTGTCGCTGCTCCGGCGCGCAGTGCTGCTCGGTGGTGGGCAACGATCTGGACGGCTGGGGTGATCGCGC
CGCGGAGATCGAGGCGCGCTACACGCTCGCGGGCGAGACCTCGTTCTCGCAGCAGTGGAAGGAGATCCACGCGGAGTGCG
AGCACGCCCGCGCCATCGGGACGGCTGCGGCGAGCGCCAAGTCCGCGCCCACCGCCACCGTGACCACGGTGAACGGCCCC
GACCGCACCACCGCACCGCTCAACTTCGTGGTGTGCAGCCAGGCCATGACGGACCTGCTGGTCCTCGCGGAGCGGGTCGC
GCCGCTCGAGATGAACGTGCTCATCGAGGGCGAGAGCGGGACCGGCAAGGAGTTCCTGGCCCGGTTCATCCACGAGAAGA
GCATGCGCGGCGACGCGCCGATGGTCGCCATCAACTGCGCCGCGCTCACCGAGGGGCTGCTCGAGTCGGAGCTGTTCGGC
CACGCTCGAGGCGCGTTCACCGGCGCGGTGCGCGACAAGCCGGGGCTGTTCGAGCACGCCGGCCGAGGCACGATCCTCCT
CGACGAGATCGGCGAGATGCCGCTGTGCCTCCAGGCGAAGCTGCTGCGCGCGCTGGAGAGCCGCGAGTTCCGGCGCGTCG
GCAGCGAGAAGGTGCTGCGGCTGGACGCGCGGGTGGTCGCCTCCACGAACCGGGACCTCCGGCAGCAGGTGCAGACGGGC
GCATTCCGCGAGGACCTGTTCTACCGGCTGGGCGGGTTCGTGCTCACCATCCCGCCGCTCCGGGAGCGGCGGGAGGAGAT
CCCCGCGCTGGCGCACTACTTCCTGCACTCCACCGCACGGCGCTGGAACAAGGGCGTGCAGACCATCAGCCCGGGCGCGA
TGCGGTGCCTGATGAGCTACTCCTGGCCCGGGAACGTCCGGGAGCTGCAGCACGCCATCGAGCGCGCCACGGTCGTCGCT
TCCCAGTCGGTGCTCACGGTGAAGGACCTGAACCCCGAGGTCGCCGGGCGCCTCGGAGACCCCGCGCCCGACGGCGATCT
GGACGTCGAGGCGAACGAGCGGCAGCTCATCGAGGAGGCGCTCCGCCGCTACCACGGCAACCGGAAGGAGGCCGCGGCCG
CGCTGCGCATCAGCCCGGTCACGCTCTGGCGCCGCGTGCGCAAGTACGGGCTCTCGCTCAGCTGA

Upstream 100 bases:

>100_bases
CGATCTCCTGTGCGCGCCGGGACGCTGACCTGTCGCCACCCGGGCCTCGAGGTGCACGGCGGCGCCTGGAGCGAAGCATC
GATCCACCGGAAGGCGAACC

Downstream 100 bases:

>100_bases
CCCCCTCCCCGACGCGGAGCGCGGTGAGCGCCGCGGACTGCAGGTCACGCGCCTTGGCGGCGCTGCCGGCCGGTGCGGGC
GCGATCGCCAGCTCCGCATG

Product: Fis family sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MKLHDIHLLDLFDVGTEQGWLSMRQQRMVVHSAAAVSIMRAQLIRSLGQDAARAIVFRWGFAQGYFDAMMCSDHLASLQP
VDRFVFGCTLHTMEGMVRVAPKVIEAKGPGKLHMEANWWHCAEADDHARVFGAGMTSSCWATLGYASGFGTYVIGALILF
EEVACRCSGAQCCSVVGNDLDGWGDRAAEIEARYTLAGETSFSQQWKEIHAECEHARAIGTAAASAKSAPTATVTTVNGP
DRTTAPLNFVVCSQAMTDLLVLAERVAPLEMNVLIEGESGTGKEFLARFIHEKSMRGDAPMVAINCAALTEGLLESELFG
HARGAFTGAVRDKPGLFEHAGRGTILLDEIGEMPLCLQAKLLRALESREFRRVGSEKVLRLDARVVASTNRDLRQQVQTG
AFREDLFYRLGGFVLTIPPLRERREEIPALAHYFLHSTARRWNKGVQTISPGAMRCLMSYSWPGNVRELQHAIERATVVA
SQSVLTVKDLNPEVAGRLGDPAPDGDLDVEANERQLIEEALRRYHGNRKEAAAALRISPVTLWRRVRKYGLSLS

Sequences:

>Translated_554_residues
MKLHDIHLLDLFDVGTEQGWLSMRQQRMVVHSAAAVSIMRAQLIRSLGQDAARAIVFRWGFAQGYFDAMMCSDHLASLQP
VDRFVFGCTLHTMEGMVRVAPKVIEAKGPGKLHMEANWWHCAEADDHARVFGAGMTSSCWATLGYASGFGTYVIGALILF
EEVACRCSGAQCCSVVGNDLDGWGDRAAEIEARYTLAGETSFSQQWKEIHAECEHARAIGTAAASAKSAPTATVTTVNGP
DRTTAPLNFVVCSQAMTDLLVLAERVAPLEMNVLIEGESGTGKEFLARFIHEKSMRGDAPMVAINCAALTEGLLESELFG
HARGAFTGAVRDKPGLFEHAGRGTILLDEIGEMPLCLQAKLLRALESREFRRVGSEKVLRLDARVVASTNRDLRQQVQTG
AFREDLFYRLGGFVLTIPPLRERREEIPALAHYFLHSTARRWNKGVQTISPGAMRCLMSYSWPGNVRELQHAIERATVVA
SQSVLTVKDLNPEVAGRLGDPAPDGDLDVEANERQLIEEALRRYHGNRKEAAAALRISPVTLWRRVRKYGLSLS
>Mature_554_residues
MKLHDIHLLDLFDVGTEQGWLSMRQQRMVVHSAAAVSIMRAQLIRSLGQDAARAIVFRWGFAQGYFDAMMCSDHLASLQP
VDRFVFGCTLHTMEGMVRVAPKVIEAKGPGKLHMEANWWHCAEADDHARVFGAGMTSSCWATLGYASGFGTYVIGALILF
EEVACRCSGAQCCSVVGNDLDGWGDRAAEIEARYTLAGETSFSQQWKEIHAECEHARAIGTAAASAKSAPTATVTTVNGP
DRTTAPLNFVVCSQAMTDLLVLAERVAPLEMNVLIEGESGTGKEFLARFIHEKSMRGDAPMVAINCAALTEGLLESELFG
HARGAFTGAVRDKPGLFEHAGRGTILLDEIGEMPLCLQAKLLRALESREFRRVGSEKVLRLDARVVASTNRDLRQQVQTG
AFREDLFYRLGGFVLTIPPLRERREEIPALAHYFLHSTARRWNKGVQTISPGAMRCLMSYSWPGNVRELQHAIERATVVA
SQSVLTVKDLNPEVAGRLGDPAPDGDLDVEANERQLIEEALRRYHGNRKEAAAALRISPVTLWRRVRKYGLSLS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=315, Percent_Identity=46.6666666666667, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1790437, Length=313, Percent_Identity=44.7284345047923, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI87082117, Length=325, Percent_Identity=45.2307692307692, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=42.8571428571429, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=45.5696202531646, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789087, Length=310, Percent_Identity=44.5161290322581, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788905, Length=238, Percent_Identity=50, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1790299, Length=341, Percent_Identity=40.1759530791789, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1786524, Length=288, Percent_Identity=42.3611111111111, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=38.1877022653722, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787583, Length=310, Percent_Identity=38.0645161290323, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789828, Length=231, Percent_Identity=37.2294372294372, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI87081858, Length=290, Percent_Identity=32.4137931034483, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 60964; Mature: 60964

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHDIHLLDLFDVGTEQGWLSMRQQRMVVHSAAAVSIMRAQLIRSLGQDAARAIVFRWG
CCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
FAQGYFDAMMCSDHLASLQPVDRFVFGCTLHTMEGMVRVAPKVIEAKGPGKLHMEANWWH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEE
CAEADDHARVFGAGMTSSCWATLGYASGFGTYVIGALILFEEVACRCSGAQCCSVVGNDL
CCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
DGWGDRAAEIEARYTLAGETSFSQQWKEIHAECEHARAIGTAAASAKSAPTATVTTVNGP
CCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
DRTTAPLNFVVCSQAMTDLLVLAERVAPLEMNVLIEGESGTGKEFLARFIHEKSMRGDAP
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
MVAINCAALTEGLLESELFGHARGAFTGAVRDKPGLFEHAGRGTILLDEIGEMPLCLQAK
EEEEEHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHCCCCEEEHHHHCCCCHHHHHH
LLRALESREFRRVGSEKVLRLDARVVASTNRDLRQQVQTGAFREDLFYRLGGFVLTIPPL
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCEEEECCCH
RERREEIPALAHYFLHSTARRWNKGVQTISPGAMRCLMSYSWPGNVRELQHAIERATVVA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SQSVLTVKDLNPEVAGRLGDPAPDGDLDVEANERQLIEEALRRYHGNRKEAAAALRISPV
CCCEEEEECCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHEECHH
TLWRRVRKYGLSLS
HHHHHHHHHCCCCC
>Mature Secondary Structure
MKLHDIHLLDLFDVGTEQGWLSMRQQRMVVHSAAAVSIMRAQLIRSLGQDAARAIVFRWG
CCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
FAQGYFDAMMCSDHLASLQPVDRFVFGCTLHTMEGMVRVAPKVIEAKGPGKLHMEANWWH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEE
CAEADDHARVFGAGMTSSCWATLGYASGFGTYVIGALILFEEVACRCSGAQCCSVVGNDL
CCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
DGWGDRAAEIEARYTLAGETSFSQQWKEIHAECEHARAIGTAAASAKSAPTATVTTVNGP
CCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
DRTTAPLNFVVCSQAMTDLLVLAERVAPLEMNVLIEGESGTGKEFLARFIHEKSMRGDAP
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
MVAINCAALTEGLLESELFGHARGAFTGAVRDKPGLFEHAGRGTILLDEIGEMPLCLQAK
EEEEEHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHCCCCEEEHHHHCCCCHHHHHH
LLRALESREFRRVGSEKVLRLDARVVASTNRDLRQQVQTGAFREDLFYRLGGFVLTIPPL
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHCCEEEECCCH
RERREEIPALAHYFLHSTARRWNKGVQTISPGAMRCLMSYSWPGNVRELQHAIERATVVA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SQSVLTVKDLNPEVAGRLGDPAPDGDLDVEANERQLIEEALRRYHGNRKEAAAALRISPV
CCCEEEEECCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHEECHH
TLWRRVRKYGLSLS
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]