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The map label for this gene is ina [H]

Identifier: 220915465

GI number: 220915465

Start: 384969

End: 387260

Strand: Direct

Name: ina [H]

Synonym: A2cp1_0344

Alternate gene names: 220915465

Gene position: 384969-387260 (Clockwise)

Preceding gene: 220915464

Following gene: 220915468

Centisome position: 7.65

GC content: 69.24

Gene sequence:

>2292_bases
ATGCGCACCTCACGCACCACCACGCTGGCCTTGCTCGCGGCGCTGGCGCTCGCGCCATCGGCCGCGTTCGCCGCGTCCGA
CGAGCCGCAGCTCCCGGACGTCGCCGCGACGACCGACAACCCATCGCACCCGCTCGGCGACGCGCAGGCGGCGCGCAAGG
CGATCGCGATCCAGGCGAAGCTCAGCGGGAAGACGAAGGGCAAGACGCACCAGGTGGCACGCGGCCAGTACGTCGAGCTG
GAGCGGCAGGGCGAGGATCGGATCTGGACGGTGGTGGGCGAGTTCGGCGAGCAGGTGAACCCGACCTACGGCGGCACCGC
CGGCCCGCTGCGCAACCAGATCCCCGAGCCCGACCGAACGGTGGACAACGTCACCATCTGGGCCCCGGACTTCAGCCGCG
CGTACTACGAGGACCTGCTCTTCTCGGACGCGCCCGGCGACGTCTCGATGCGGAACTTCTACAAGGAGCTCTCCTCGAAC
CGCTACACGGTGAACGGCGAGGTCACCGACTGGGTGAAGGTCCCGCTCAACGAGGCCAACTACGGCTCGAACTACTGCGG
CGGCATCGTGTGCGCCCGCACCTGGCTGTTCGTCCGTGACGCGGTGAACGCCTGGTACAACGGGCAGATCGCGGCCGGCC
GGACGGTGGCGGAGATCAACGCCTACCTGGCGCAGTACGACGTCTGGGATCGCTACGACTACGACGGCGACGGCAACTTC
AACGAGCCGGACGGCTACATCGATCACTTCCAGGCGATCCACGCGGGCGAGGGCGAGGAGACCGGCGGCGGCGCGCAGGG
CGACGACGCGATCTGGAGCCACCGCTGGTACGCCTTCTACAACAACATCGGCGCCACCGGCCCGGCGTTCAACCGGTACG
GCGGGATCCGGATCGGCGCGAGCGACTTCTGGATCGGCGACTACACCATCGAGCCGGAGAACGGCGGCGTGGGCGTGTTC
GCCCACGAGTTCGGCCACGACCTCGGCCTGCCCGACCTCTACGACACCTCCGGCAACACCGGCGGCGCGGAGAACTCGAC
CGGCTTCTGGACGCTGTACTCGGTGGGCTCCTACGGCGCCTCGGGGCGGCCGGAGGACGGCCTGGGCACGAAGCCGATCC
ACATGAGCGCCTACGAGAAGATCTTCCTCGGCTGGTCGAACTACCAGGTGGTGCGCGCCGGGCAGTACGCGTCGCTGAAG
CTCGGCCCGGCGGAGGCGAACACGAAGCAGGCGCAGACGCTGGTGGTGCTGCTGCCGGACAAGATCGTGGAGAGCGAGAT
CGGGACGCCGTACGCCGGCACGTACTTCTACCACTCCGGCTCCGGCAACGGCCTCGACCACTCCATGACGCGCCAGGTGA
CGCTGCCCGCGGGCGCGTCGCTCGCGGCCAAGGTGAAGTTCGACATCGAGCTGGACTGGGACTACGCGTACCTGACGGTG
AACGGCGCGCCGGTCGCCACCAACCTGTCGAGCTCGACGAACCCGAACGGCCAGAACTTCGGCAACGGGATCACCGGCTC
GACCGGCGGGGCCTGGGTGGACCTCACCGCCGACCTGTCCGCGTGGGCGGGCCAGACCGTGACGCTCGGGTTCCGCTACT
GGACCGACGTGGCGGTGGCCGAGGCGGGCCTGTCGATCGACGACGTCGCGATCTCCGGCCAGCCGCTGGACGGCGCGGAG
ACCGATCCGGGCTGGACCTACGACGGGTTCGTCCGCACGAACGGCACGCTCGCGACGCCGTTCTTCAACGCGTACTTCGC
CGAGTACCGGCAGTACCGCGGCTACGACCAGTCGCTGAAGACCGGGCCGTACACGTTCGGCTACCTGAACGACCCGACCC
TGCAGAACTGGGTGGACCACTTCCCGTACCAGGACGGCCTGCTGGTCTGGTACTACGACACGTCGTTCGAGGACAACAAC
GTGGGCGACGCCTGCGCGAGCGGCCGCTGCGGCGGCCTGTTCCTGCCGGTGGACGCGCACCCCGGGTTGATCCTCCGCCC
GGACAACGGGAAGGCGTGGCGCCCGCGCTTCCAGGCCTTCGACTCGACGTTCGGCCTCGAGCCGACCGACGTGGTGTGCC
TGCACGCGAACAGCCAGCAGGGCTGCTTCGGCGGCCAGCCGGGCAACCCGCTCTTCGACGACACGCAGAGCTACTGGGTG
CCGCCGGATCCCTCGCTCAACCACTCCGGCTGGTCGAGCGTGATCGTGCCGAACACCGGGACCACCATCCGCGTGGTCGG
GACGTCGGCGCAGGGTGACTTCATGCAGGTGGTGGTCGCGCCGAAGCGCTAG

Upstream 100 bases:

>100_bases
GACGTTCGGGTTCCGCCCTTGGGGCGCGGCGCCGGTGGCGCGAAGTGGGGAACACTGCCAGCTCGCCTCACCCACACGCA
CGTTCACTCGGGGGAAATCG

Downstream 100 bases:

>100_bases
CGGTGCGCGGGGCGGGGAGGGGCCGGCACGCCGCCGGTCCCTCCACCGCGCCCGCGCCGCGCGACGGCTCAGGGGACGTA
CACCGCGGGTCCGGGGCGGC

Product: M6 family metalloprotease domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MRTSRTTTLALLAALALAPSAAFAASDEPQLPDVAATTDNPSHPLGDAQAARKAIAIQAKLSGKTKGKTHQVARGQYVEL
ERQGEDRIWTVVGEFGEQVNPTYGGTAGPLRNQIPEPDRTVDNVTIWAPDFSRAYYEDLLFSDAPGDVSMRNFYKELSSN
RYTVNGEVTDWVKVPLNEANYGSNYCGGIVCARTWLFVRDAVNAWYNGQIAAGRTVAEINAYLAQYDVWDRYDYDGDGNF
NEPDGYIDHFQAIHAGEGEETGGGAQGDDAIWSHRWYAFYNNIGATGPAFNRYGGIRIGASDFWIGDYTIEPENGGVGVF
AHEFGHDLGLPDLYDTSGNTGGAENSTGFWTLYSVGSYGASGRPEDGLGTKPIHMSAYEKIFLGWSNYQVVRAGQYASLK
LGPAEANTKQAQTLVVLLPDKIVESEIGTPYAGTYFYHSGSGNGLDHSMTRQVTLPAGASLAAKVKFDIELDWDYAYLTV
NGAPVATNLSSSTNPNGQNFGNGITGSTGGAWVDLTADLSAWAGQTVTLGFRYWTDVAVAEAGLSIDDVAISGQPLDGAE
TDPGWTYDGFVRTNGTLATPFFNAYFAEYRQYRGYDQSLKTGPYTFGYLNDPTLQNWVDHFPYQDGLLVWYYDTSFEDNN
VGDACASGRCGGLFLPVDAHPGLILRPDNGKAWRPRFQAFDSTFGLEPTDVVCLHANSQQGCFGGQPGNPLFDDTQSYWV
PPDPSLNHSGWSSVIVPNTGTTIRVVGTSAQGDFMQVVVAPKR

Sequences:

>Translated_763_residues
MRTSRTTTLALLAALALAPSAAFAASDEPQLPDVAATTDNPSHPLGDAQAARKAIAIQAKLSGKTKGKTHQVARGQYVEL
ERQGEDRIWTVVGEFGEQVNPTYGGTAGPLRNQIPEPDRTVDNVTIWAPDFSRAYYEDLLFSDAPGDVSMRNFYKELSSN
RYTVNGEVTDWVKVPLNEANYGSNYCGGIVCARTWLFVRDAVNAWYNGQIAAGRTVAEINAYLAQYDVWDRYDYDGDGNF
NEPDGYIDHFQAIHAGEGEETGGGAQGDDAIWSHRWYAFYNNIGATGPAFNRYGGIRIGASDFWIGDYTIEPENGGVGVF
AHEFGHDLGLPDLYDTSGNTGGAENSTGFWTLYSVGSYGASGRPEDGLGTKPIHMSAYEKIFLGWSNYQVVRAGQYASLK
LGPAEANTKQAQTLVVLLPDKIVESEIGTPYAGTYFYHSGSGNGLDHSMTRQVTLPAGASLAAKVKFDIELDWDYAYLTV
NGAPVATNLSSSTNPNGQNFGNGITGSTGGAWVDLTADLSAWAGQTVTLGFRYWTDVAVAEAGLSIDDVAISGQPLDGAE
TDPGWTYDGFVRTNGTLATPFFNAYFAEYRQYRGYDQSLKTGPYTFGYLNDPTLQNWVDHFPYQDGLLVWYYDTSFEDNN
VGDACASGRCGGLFLPVDAHPGLILRPDNGKAWRPRFQAFDSTFGLEPTDVVCLHANSQQGCFGGQPGNPLFDDTQSYWV
PPDPSLNHSGWSSVIVPNTGTTIRVVGTSAQGDFMQVVVAPKR
>Mature_763_residues
MRTSRTTTLALLAALALAPSAAFAASDEPQLPDVAATTDNPSHPLGDAQAARKAIAIQAKLSGKTKGKTHQVARGQYVEL
ERQGEDRIWTVVGEFGEQVNPTYGGTAGPLRNQIPEPDRTVDNVTIWAPDFSRAYYEDLLFSDAPGDVSMRNFYKELSSN
RYTVNGEVTDWVKVPLNEANYGSNYCGGIVCARTWLFVRDAVNAWYNGQIAAGRTVAEINAYLAQYDVWDRYDYDGDGNF
NEPDGYIDHFQAIHAGEGEETGGGAQGDDAIWSHRWYAFYNNIGATGPAFNRYGGIRIGASDFWIGDYTIEPENGGVGVF
AHEFGHDLGLPDLYDTSGNTGGAENSTGFWTLYSVGSYGASGRPEDGLGTKPIHMSAYEKIFLGWSNYQVVRAGQYASLK
LGPAEANTKQAQTLVVLLPDKIVESEIGTPYAGTYFYHSGSGNGLDHSMTRQVTLPAGASLAAKVKFDIELDWDYAYLTV
NGAPVATNLSSSTNPNGQNFGNGITGSTGGAWVDLTADLSAWAGQTVTLGFRYWTDVAVAEAGLSIDDVAISGQPLDGAE
TDPGWTYDGFVRTNGTLATPFFNAYFAEYRQYRGYDQSLKTGPYTFGYLNDPTLQNWVDHFPYQDGLLVWYYDTSFEDNN
VGDACASGRCGGLFLPVDAHPGLILRPDNGKAWRPRFQAFDSTFGLEPTDVVCLHANSQQGCFGGQPGNPLFDDTQSYWV
PPDPSLNHSGWSSVIVPNTGTTIRVVGTSAQGDFMQVVVAPKR

Specific function: Neutral metalloprotease that is secreted to degrade antibacterial proteins produced by the insect host for its defense (attacins and cecropins). Probably degrades some unknown crucial protein(s) too, since it is toxic when injected to insect larvae [H]

COG id: COG4412

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M6 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012300
- InterPro:   IPR008757 [H]

Pfam domain/function: PF05547 Peptidase_M6 [H]

EC number: NA

Molecular weight: Translated: 82737; Mature: 82737

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSRTTTLALLAALALAPSAAFAASDEPQLPDVAATTDNPSHPLGDAQAARKAIAIQAK
CCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHEEEEEEEE
LSGKTKGKTHQVARGQYVELERQGEDRIWTVVGEFGEQVNPTYGGTAGPLRNQIPEPDRT
ECCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEHHCCCCCCCCCCCCCCHHHCCCCCCCC
VDNVTIWAPDFSRAYYEDLLFSDAPGDVSMRNFYKELSSNRYTVNGEVTDWVKVPLNEAN
CCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCEEEEEEECCCCCC
YGSNYCGGIVCARTWLFVRDAVNAWYNGQIAAGRTVAEINAYLAQYDVWDRYDYDGDGNF
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCC
NEPDGYIDHFQAIHAGEGEETGGGAQGDDAIWSHRWYAFYNNIGATGPAFNRYGGIRIGA
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHCCEEEEEECCCCCCCCCHHCCCCEEECC
SDFWIGDYTIEPENGGVGVFAHEFGHDLGLPDLYDTSGNTGGAENSTGFWTLYSVGSYGA
CCEEEEEEEECCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
SGRPEDGLGTKPIHMSAYEKIFLGWSNYQVVRAGQYASLKLGPAEANTKQAQTLVVLLPD
CCCCCCCCCCCCEECCCEEEEEEECCCEEEEEECCEEEEEECCCCCCCCCCEEEEEECCC
KIVESEIGTPYAGTYFYHSGSGNGLDHSMTRQVTLPAGASLAAKVKFDIELDWDYAYLTV
HHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEEEEEECCEEEEEE
NGAPVATNLSSSTNPNGQNFGNGITGSTGGAWVDLTADLSAWAGQTVTLGFRYWTDVAVA
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECHHHHCCCEEEEEEEHHHHHHHH
EAGLSIDDVAISGQPLDGAETDPGWTYDGFVRTNGTLATPFFNAYFAEYRQYRGYDQSLK
HCCCCEEEEEECCCCCCCCCCCCCCEECCEEEECCEEECHHHHHHHHHHHHHCCCCCCCC
TGPYTFGYLNDPTLQNWVDHFPYQDGLLVWYYDTSFEDNNVGDACASGRCGGLFLPVDAH
CCCEEEECCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCC
PGLILRPDNGKAWRPRFQAFDSTFGLEPTDVVCLHANSQQGCFGGQPGNPLFDDTQSYWV
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEC
PPDPSLNHSGWSSVIVPNTGTTIRVVGTSAQGDFMQVVVAPKR
CCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEEEECCC
>Mature Secondary Structure
MRTSRTTTLALLAALALAPSAAFAASDEPQLPDVAATTDNPSHPLGDAQAARKAIAIQAK
CCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHEEEEEEEE
LSGKTKGKTHQVARGQYVELERQGEDRIWTVVGEFGEQVNPTYGGTAGPLRNQIPEPDRT
ECCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEHHCCCCCCCCCCCCCCHHHCCCCCCCC
VDNVTIWAPDFSRAYYEDLLFSDAPGDVSMRNFYKELSSNRYTVNGEVTDWVKVPLNEAN
CCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCEEEEEEECCCCCC
YGSNYCGGIVCARTWLFVRDAVNAWYNGQIAAGRTVAEINAYLAQYDVWDRYDYDGDGNF
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCC
NEPDGYIDHFQAIHAGEGEETGGGAQGDDAIWSHRWYAFYNNIGATGPAFNRYGGIRIGA
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHCCEEEEEECCCCCCCCCHHCCCCEEECC
SDFWIGDYTIEPENGGVGVFAHEFGHDLGLPDLYDTSGNTGGAENSTGFWTLYSVGSYGA
CCEEEEEEEECCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
SGRPEDGLGTKPIHMSAYEKIFLGWSNYQVVRAGQYASLKLGPAEANTKQAQTLVVLLPD
CCCCCCCCCCCCEECCCEEEEEEECCCEEEEEECCEEEEEECCCCCCCCCCEEEEEECCC
KIVESEIGTPYAGTYFYHSGSGNGLDHSMTRQVTLPAGASLAAKVKFDIELDWDYAYLTV
HHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEEEEEECCEEEEEE
NGAPVATNLSSSTNPNGQNFGNGITGSTGGAWVDLTADLSAWAGQTVTLGFRYWTDVAVA
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECHHHHCCCEEEEEEEHHHHHHHH
EAGLSIDDVAISGQPLDGAETDPGWTYDGFVRTNGTLATPFFNAYFAEYRQYRGYDQSLK
HCCCCEEEEEECCCCCCCCCCCCCCEECCEEEECCEEECHHHHHHHHHHHHHCCCCCCCC
TGPYTFGYLNDPTLQNWVDHFPYQDGLLVWYYDTSFEDNNVGDACASGRCGGLFLPVDAH
CCCEEEECCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCC
PGLILRPDNGKAWRPRFQAFDSTFGLEPTDVVCLHANSQQGCFGGQPGNPLFDDTQSYWV
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEC
PPDPSLNHSGWSSVIVPNTGTTIRVVGTSAQGDFMQVVVAPKR
CCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2089225; 6421577 [H]