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The map label for this gene is ahpC [H]

Identifier: 220915456

GI number: 220915456

Start: 375553

End: 376089

Strand: Direct

Name: ahpC [H]

Synonym: A2cp1_0335

Alternate gene names: 220915456

Gene position: 375553-376089 (Clockwise)

Preceding gene: 220915454

Following gene: 220915457

Centisome position: 7.47

GC content: 68.34

Gene sequence:

>537_bases
ATGCTGACCGTGGGCGACCGCTTCCCCGAGTTCTCGCTGCAGGCCGTGACCAGCCTGGAGAGCGGCAACGAGTTCGAGAC
CCTCACGCAGGCGAGCCACCCGGGCAAGTGGAAGGTGGTGTTCCTCTGGCCGATGGACTTCACCTTCATCTGCCCGACCG
AGATCGCCGAGTTCGGCCGCCGCAACGGCGAGTTCCAGGACCGCGACACCCAGGTGCTCGGGGCGAGCATCGACACCCAC
TACGTCCACCTCGCCTGGCGCAAGAGCCACCCTGATCTGAAGCACCTGCCCTTCCCCATGCTCGCCGACACCCGGCGCGA
GCTCTCGAGCGCGCTCGGCGTGCTGCACAGGGACGGCGTGGCGCTCCGCGCGACGTTCATCGTCGACCCGGAGGGCGTCA
TCCGGCACGTGTCGGTGAACGACCTCTCGGTCGGGCGCAACGTGGACGAGGTCCTCCGCACGCTCGACGCCCTGCAGACG
GACGAGCTCTGCCCCTGCAACTGGAAGAAGGGCGAGTCCACGCTCCAGGTGGCCTGA

Upstream 100 bases:

>100_bases
CGAAACGATGTAATGGCTCAATCAGAAGCCCGCGGGCATGTTGTGTCCCGTCGCGGCGATGGACGCCGCGCCCGAACCGA
TTCGACGAGGAGAGACACCG

Downstream 100 bases:

>100_bases
GCCATGGCCGCCCTCGACGCGATCCGGGAGGCGCTCCCCGAGCCGGCCCGGGACATCAAGCTGAACCTGCAGGCGGTGCT
GCAGCCCGGGACGCTCACCC

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MLTVGDRFPEFSLQAVTSLESGNEFETLTQASHPGKWKVVFLWPMDFTFICPTEIAEFGRRNGEFQDRDTQVLGASIDTH
YVHLAWRKSHPDLKHLPFPMLADTRRELSSALGVLHRDGVALRATFIVDPEGVIRHVSVNDLSVGRNVDEVLRTLDALQT
DELCPCNWKKGESTLQVA

Sequences:

>Translated_178_residues
MLTVGDRFPEFSLQAVTSLESGNEFETLTQASHPGKWKVVFLWPMDFTFICPTEIAEFGRRNGEFQDRDTQVLGASIDTH
YVHLAWRKSHPDLKHLPFPMLADTRRELSSALGVLHRDGVALRATFIVDPEGVIRHVSVNDLSVGRNVDEVLRTLDALQT
DELCPCNWKKGESTLQVA
>Mature_178_residues
MLTVGDRFPEFSLQAVTSLESGNEFETLTQASHPGKWKVVFLWPMDFTFICPTEIAEFGRRNGEFQDRDTQVLGASIDTH
YVHLAWRKSHPDLKHLPFPMLADTRRELSSALGVLHRDGVALRATFIVDPEGVIRHVSVNDLSVGRNVDEVLRTLDALQT
DELCPCNWKKGESTLQVA

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=181, Percent_Identity=40.8839779005525, Blast_Score=148, Evalue=2e-36,
Organism=Homo sapiens, GI32455266, Length=181, Percent_Identity=40.8839779005525, Blast_Score=148, Evalue=2e-36,
Organism=Homo sapiens, GI32455264, Length=181, Percent_Identity=40.8839779005525, Blast_Score=148, Evalue=2e-36,
Organism=Homo sapiens, GI32189392, Length=181, Percent_Identity=42.5414364640884, Blast_Score=145, Evalue=1e-35,
Organism=Homo sapiens, GI32483377, Length=176, Percent_Identity=41.4772727272727, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI5802974, Length=176, Percent_Identity=41.4772727272727, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI5453549, Length=161, Percent_Identity=42.2360248447205, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4758638, Length=156, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI33188454, Length=88, Percent_Identity=37.5, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786822, Length=181, Percent_Identity=34.2541436464088, Blast_Score=122, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193204376, Length=181, Percent_Identity=41.4364640883978, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32565831, Length=181, Percent_Identity=41.4364640883978, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17554494, Length=176, Percent_Identity=38.0681818181818, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25153706, Length=192, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323613, Length=160, Percent_Identity=45, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320661, Length=160, Percent_Identity=43.125, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319407, Length=155, Percent_Identity=31.6129032258064, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17738015, Length=168, Percent_Identity=42.8571428571429, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357347, Length=184, Percent_Identity=38.0434782608696, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24656348, Length=175, Percent_Identity=40.5714285714286, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17864676, Length=175, Percent_Identity=40.5714285714286, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17157991, Length=175, Percent_Identity=38.2857142857143, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24641739, Length=175, Percent_Identity=38.2857142857143, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17975518, Length=161, Percent_Identity=35.4037267080745, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652436, Length=161, Percent_Identity=35.4037267080745, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652434, Length=161, Percent_Identity=35.4037267080745, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581278, Length=184, Percent_Identity=33.1521739130435, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20060; Mature: 20060

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVGDRFPEFSLQAVTSLESGNEFETLTQASHPGKWKVVFLWPMDFTFICPTEIAEFGR
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEECCCEEEECHHHHHHHHH
RNGEFQDRDTQVLGASIDTHYVHLAWRKSHPDLKHLPFPMLADTRRELSSALGVLHRDGV
CCCCCCCCCCEEEECCCCCEEEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCE
ALRATFIVDPEGVIRHVSVNDLSVGRNVDEVLRTLDALQTDELCPCNWKKGESTLQVA
EEEEEEEECCHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MLTVGDRFPEFSLQAVTSLESGNEFETLTQASHPGKWKVVFLWPMDFTFICPTEIAEFGR
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEECCCEEEECHHHHHHHHH
RNGEFQDRDTQVLGASIDTHYVHLAWRKSHPDLKHLPFPMLADTRRELSSALGVLHRDGV
CCCCCCCCCCEEEECCCCCEEEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCE
ALRATFIVDPEGVIRHVSVNDLSVGRNVDEVLRTLDALQTDELCPCNWKKGESTLQVA
EEEEEEEECCHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]