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The map label for this gene is mutM [H]

Identifier: 220915420

GI number: 220915420

Start: 334540

End: 335382

Strand: Direct

Name: mutM [H]

Synonym: A2cp1_0299

Alternate gene names: 220915420

Gene position: 334540-335382 (Clockwise)

Preceding gene: 220915419

Following gene: 220915421

Centisome position: 6.65

GC content: 77.46

Gene sequence:

>843_bases
ATGCCGGAGCTCCCCGAGGTCGAGATCGCGGCGCGGAACCTCCGCCGCTGGGCGGAGGGCCGCCGCGTCGAGGAGGTCGG
CTGGGATCCCCGGGCGCGCCGGATCTTCCGCCCGGCGACGCCCGCCGCGTTCGCCCGCGCGCTGGAGGGCGCCCGGTTCG
CCGGGATCCGGCGCATCGGCAAGCACCTGCTCGTCGCGCTCGAGCGCGGCGGCGCGCCGGTCGGGCTGCTCGCGCACCTC
GGCATGACCGGCAAGTGGGTGCTCCGCGGCGCCGAAGAGCCGGCGCCGCGCCACGCGCGGGCCTGGCTGCGCCTGGACGG
CGGCGGGGTGCTGCACTTCCAGGACTCGCGCCTGTTCGGGCGGCTGCGGACCGTGCCCGGCGCGCGCTTCGAGGACGTGC
CGGAGGTCGCGGCGCTCGGCCCGGATCCGCTGGAGCACGGCATCGACCCGGCCGCGCTGGCCGGCGCGCTCGCGAAGAGC
CGGCTGCCGGTGAAGGTCAAGCTCCTCGACCAGCGGCTCCTGCCCGGCGTCGGGAACATCCACGCCAGCGAGGCCTGCTT
CCGGGCGCGCGTCGATCCGCGCCGGCCGTCGCGGGCGCTGTCGCGCGCCGAGGCGAAGGCGCTCGCCGCGGCCATCCTGG
CCTCCTTCCGCATGACGCTCGACGCGGAGGACGGGCCGGAGATCACCTACGTCGAGGAGCCCGGGGCGGAGAACCCGTTC
CTCGTGTACGCGCGCGAGGGCGAGCCCTGCCCGCGCTGCCGGAAGGGCGGCCGGACCTCGCCCATCGCGCGGGTGGTGCA
GGCGCAGCGCTCCACCTTCTTCTGCCCCCGCTGCCAGCGGTAG

Upstream 100 bases:

>100_bases
CGCCGGAGAGAGCCGCTGCGCGCTCTACCCGCACCGCCACGGGACGGACGGCTTCTTCTTCGCGGCGTTTGCGAAGCGCG
CGTAGCCGGGGACCTCGCGC

Downstream 100 bases:

>100_bases
ACTGCGGGCGATGCGCCCCGAGGATCTCCCCCGCCTGTCCGTCGCCGAGCTGCGCGCCCGGCTGCTCGACCGCGGCGAGG
CGCTGGGCGACGCGTGCGAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPELPEVEIAARNLRRWAEGRRVEEVGWDPRARRIFRPATPAAFARALEGARFAGIRRIGKHLLVALERGGAPVGLLAHL
GMTGKWVLRGAEEPAPRHARAWLRLDGGGVLHFQDSRLFGRLRTVPGARFEDVPEVAALGPDPLEHGIDPAALAGALAKS
RLPVKVKLLDQRLLPGVGNIHASEACFRARVDPRRPSRALSRAEAKALAAAILASFRMTLDAEDGPEITYVEEPGAENPF
LVYAREGEPCPRCRKGGRTSPIARVVQAQRSTFFCPRCQR

Sequences:

>Translated_280_residues
MPELPEVEIAARNLRRWAEGRRVEEVGWDPRARRIFRPATPAAFARALEGARFAGIRRIGKHLLVALERGGAPVGLLAHL
GMTGKWVLRGAEEPAPRHARAWLRLDGGGVLHFQDSRLFGRLRTVPGARFEDVPEVAALGPDPLEHGIDPAALAGALAKS
RLPVKVKLLDQRLLPGVGNIHASEACFRARVDPRRPSRALSRAEAKALAAAILASFRMTLDAEDGPEITYVEEPGAENPF
LVYAREGEPCPRCRKGGRTSPIARVVQAQRSTFFCPRCQR
>Mature_279_residues
PELPEVEIAARNLRRWAEGRRVEEVGWDPRARRIFRPATPAAFARALEGARFAGIRRIGKHLLVALERGGAPVGLLAHLG
MTGKWVLRGAEEPAPRHARAWLRLDGGGVLHFQDSRLFGRLRTVPGARFEDVPEVAALGPDPLEHGIDPAALAGALAKSR
LPVKVKLLDQRLLPGVGNIHASEACFRARVDPRRPSRALSRAEAKALAAAILASFRMTLDAEDGPEITYVEEPGAENPFL
VYAREGEPCPRCRKGGRTSPIARVVQAQRSTFFCPRCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=284, Percent_Identity=31.3380281690141, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786932, Length=285, Percent_Identity=27.0175438596491, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30692; Mature: 30561

Theoretical pI: Translated: 11.11; Mature: 11.11

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEIAARNLRRWAEGRRVEEVGWDPRARRIFRPATPAAFARALEGARFAGIRRIG
CCCCCCHHHHHHHHHHHHHCCEEHHCCCCHHHHHEECCCCHHHHHHHHCCHHHHHHHHHH
KHLLVALERGGAPVGLLAHLGMTGKWVLRGAEEPAPRHARAWLRLDGGGVLHFQDSRLFG
HHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCEEEEEECCHHHH
RLRTVPGARFEDVPEVAALGPDPLEHGIDPAALAGALAKSRLPVKVKLLDQRLLPGVGNI
HHHCCCCCCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCC
HASEACFRARVDPRRPSRALSRAEAKALAAAILASFRMTLDAEDGPEITYVEEPGAENPF
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCE
LVYAREGEPCPRCRKGGRTSPIARVVQAQRSTFFCPRCQR
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEIAARNLRRWAEGRRVEEVGWDPRARRIFRPATPAAFARALEGARFAGIRRIG
CCCCCHHHHHHHHHHHHHCCEEHHCCCCHHHHHEECCCCHHHHHHHHCCHHHHHHHHHH
KHLLVALERGGAPVGLLAHLGMTGKWVLRGAEEPAPRHARAWLRLDGGGVLHFQDSRLFG
HHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCEEEEEECCHHHH
RLRTVPGARFEDVPEVAALGPDPLEHGIDPAALAGALAKSRLPVKVKLLDQRLLPGVGNI
HHHCCCCCCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCC
HASEACFRARVDPRRPSRALSRAEAKALAAAILASFRMTLDAEDGPEITYVEEPGAENPF
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCE
LVYAREGEPCPRCRKGGRTSPIARVVQAQRSTFFCPRCQR
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA