Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 220915392

GI number: 220915392

Start: 304526

End: 306085

Strand: Direct

Name: pccB [H]

Synonym: A2cp1_0271

Alternate gene names: 220915392

Gene position: 304526-306085 (Clockwise)

Preceding gene: 220915391

Following gene: 220915396

Centisome position: 6.06

GC content: 70.64

Gene sequence:

>1560_bases
ATGCCCCATTCCGATCCCGATCCGCGCAGGGCCCTCCTCGACCAGCTCGACGCCGAGGCCGAGAAGGGCGGCGGGGACGA
GCGGGTGGCGCGGCAGCACCGCGAGGGCAAGCTCACCGCCCGCGAGCGCATCGACGCGTTCCTCGACCCGGGCACGTTCG
TGGAGATGGATCGCTTCAAGACCCACCGCTGCGCCGACTTCGGGATGGCCGAGCACAAGGTGCTGGGCGACGGCGTGGTC
ACCGGCTACGGCCTGGTGGAGGGCCGGCAGGTCTTCGTGTTCGCGCAGGACTTCACCGTCTTCGGCGGATCGATCTCCGG
CGCCGTGGCCGAGAAGATCTGCAAGGTGATGGACCGCGCCATGGAGGTGGGCTGCCCGGTGGTCGGCCTGAACGACTCCG
GCGGCGCGCGCATCCAGGAGGGCGTGGTGTCGCTGGCGGGCTACGCCGAGATCTTCCTGCGCAACACGCTCGCCTCCGGC
GTCATCCCGCAGCTCTCGGTGATCATGGGGCCGTGCGCCGGCGGCGCGGTCTACAGCCCGGCCATCACCGACTTCATCTT
CATGGTGAAGGACACCTCGTACATGTTCATCACCGGCCCGGACGTGATCCGGGCGGTGACGCACGCCGAGGTGACGAAGG
AGGACCTGGGCGGCGCGCGCACGCACGCGGCGCGCTCCGGCGTGGCGCACTTCGCGCTCGACACCGAGGAGGCCGCGCTG
CGCGCGGTGCGCGAGCTGCTGTCGTTCCTGCCGCTCAACAACGTGGACGATCCGCCGATCCAGCCCTGCGCCGACGACCC
GGGCCGCCGCGACGAGCTGCTGAAGACCATCGCGCCGGAGAACCCGGGCAAGGCCTACGACATGAAGGAGGTCGTCCGCG
CGGTGGCCGACGACCGGCACTTCTTCGAGGTGGCCGAGCCGTTCGCGCCCAACATCGTGATCGGCTTCGCGCGCCTGAAC
GGGCGGCCGGTGGGCGTGGTGGCGAACCAGCCGGCGGTGCTGGCCGGCGTGCTCGACATCGACGCCTCGGTGAAGGCGGC
GCGCTTCGTGCGCTTCTGCGACGCGTTCAACGTCCCGCTGCTCACGTTCGTGGACGTGCCCGGGTTCCTGCCCGGCACCG
ACCAGGAGTGGAACGGGATCATCGTGCACGGCGCGAAGCTGCTCTACGCCTACGCCGAGGCCACCGTGCCCAAGATCACC
GTCATCACGCGCAAGGCGTACGGCGGCGCGTACGACGTGATGGCGTCGAAGCACATCCGCGCCGACGTGAACCTGGCCTG
GCCGGGCGCGGAGATCGCGGTGATGGGGCCGGAGGGGGCGGTGAACGTCATCTTCCGCAAGGAGCTGCTCGCGGCGAAGG
ACCCGGTCGCCGAGCGCGCGCGCCTGGTGCAGGAGTACCGCGACCGGTTCGCGAGCCCGTACAAGGCGGCCGAGCTCGGC
TACGTGGACGAGGTGATCCGCCCCGAGGACACGCGGCCCCGGGTGATCCGCGCGCTGGAGATGCTGCGCACGAAGCGCCA
GGAGCTCCCGGCGAAGAAGCACGGAAACATCCCGCTCTAG

Upstream 100 bases:

>100_bases
TGACGCGGGCGCGCGAATCCTTGCGCCCCGTGGATCGCGGCGCCTATCCTCCGAGCCCACGGCGAGACCACCGGCCGAAG
CGTCGGCGCGAGGTGCGCAC

Downstream 100 bases:

>100_bases
CCCTTCGACGCCGGCGGCGCCTGCGGCACCGCGTACGCTCAGGTGAGCGGGTCATTGGATTCCGCTCGTCCCGAGCCCGT
CGGAGGACGAGCGCTCACGA

Product: Propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MPHSDPDPRRALLDQLDAEAEKGGGDERVARQHREGKLTARERIDAFLDPGTFVEMDRFKTHRCADFGMAEHKVLGDGVV
TGYGLVEGRQVFVFAQDFTVFGGSISGAVAEKICKVMDRAMEVGCPVVGLNDSGGARIQEGVVSLAGYAEIFLRNTLASG
VIPQLSVIMGPCAGGAVYSPAITDFIFMVKDTSYMFITGPDVIRAVTHAEVTKEDLGGARTHAARSGVAHFALDTEEAAL
RAVRELLSFLPLNNVDDPPIQPCADDPGRRDELLKTIAPENPGKAYDMKEVVRAVADDRHFFEVAEPFAPNIVIGFARLN
GRPVGVVANQPAVLAGVLDIDASVKAARFVRFCDAFNVPLLTFVDVPGFLPGTDQEWNGIIVHGAKLLYAYAEATVPKIT
VITRKAYGGAYDVMASKHIRADVNLAWPGAEIAVMGPEGAVNVIFRKELLAAKDPVAERARLVQEYRDRFASPYKAAELG
YVDEVIRPEDTRPRVIRALEMLRTKRQELPAKKHGNIPL

Sequences:

>Translated_519_residues
MPHSDPDPRRALLDQLDAEAEKGGGDERVARQHREGKLTARERIDAFLDPGTFVEMDRFKTHRCADFGMAEHKVLGDGVV
TGYGLVEGRQVFVFAQDFTVFGGSISGAVAEKICKVMDRAMEVGCPVVGLNDSGGARIQEGVVSLAGYAEIFLRNTLASG
VIPQLSVIMGPCAGGAVYSPAITDFIFMVKDTSYMFITGPDVIRAVTHAEVTKEDLGGARTHAARSGVAHFALDTEEAAL
RAVRELLSFLPLNNVDDPPIQPCADDPGRRDELLKTIAPENPGKAYDMKEVVRAVADDRHFFEVAEPFAPNIVIGFARLN
GRPVGVVANQPAVLAGVLDIDASVKAARFVRFCDAFNVPLLTFVDVPGFLPGTDQEWNGIIVHGAKLLYAYAEATVPKIT
VITRKAYGGAYDVMASKHIRADVNLAWPGAEIAVMGPEGAVNVIFRKELLAAKDPVAERARLVQEYRDRFASPYKAAELG
YVDEVIRPEDTRPRVIRALEMLRTKRQELPAKKHGNIPL
>Mature_518_residues
PHSDPDPRRALLDQLDAEAEKGGGDERVARQHREGKLTARERIDAFLDPGTFVEMDRFKTHRCADFGMAEHKVLGDGVVT
GYGLVEGRQVFVFAQDFTVFGGSISGAVAEKICKVMDRAMEVGCPVVGLNDSGGARIQEGVVSLAGYAEIFLRNTLASGV
IPQLSVIMGPCAGGAVYSPAITDFIFMVKDTSYMFITGPDVIRAVTHAEVTKEDLGGARTHAARSGVAHFALDTEEAALR
AVRELLSFLPLNNVDDPPIQPCADDPGRRDELLKTIAPENPGKAYDMKEVVRAVADDRHFFEVAEPFAPNIVIGFARLNG
RPVGVVANQPAVLAGVLDIDASVKAARFVRFCDAFNVPLLTFVDVPGFLPGTDQEWNGIIVHGAKLLYAYAEATVPKITV
ITRKAYGGAYDVMASKHIRADVNLAWPGAEIAVMGPEGAVNVIFRKELLAAKDPVAERARLVQEYRDRFASPYKAAELGY
VDEVIRPEDTRPRVIRALEMLRTKRQELPAKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=500, Percent_Identity=61.6, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=520, Percent_Identity=59.2307692307692, Blast_Score=623, Evalue=1e-178,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=32.9341317365269, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI134142062, Length=348, Percent_Identity=26.1494252873563, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679974, Length=353, Percent_Identity=24.3626062322946, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI38679971, Length=353, Percent_Identity=24.3626062322946, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI38679960, Length=353, Percent_Identity=24.3626062322946, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679977, Length=353, Percent_Identity=24.3626062322946, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679967, Length=353, Percent_Identity=24.3626062322946, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788655, Length=181, Percent_Identity=28.7292817679558, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=60.1577909270217, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=60.1577909270217, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17552936, Length=522, Percent_Identity=33.3333333333333, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71997163, Length=395, Percent_Identity=23.5443037974684, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586065, Length=511, Percent_Identity=34.6379647749511, Blast_Score=243, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56415; Mature: 56284

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSDPDPRRALLDQLDAEAEKGGGDERVARQHREGKLTARERIDAFLDPGTFVEMDRFK
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHH
THRCADFGMAEHKVLGDGVVTGYGLVEGRQVFVFAQDFTVFGGSISGAVAEKICKVMDRA
HHHHHHCCCHHHEEECCCCEEEEEEECCCEEEEEEECEEEECCCCCHHHHHHHHHHHHHH
MEVGCPVVGLNDSGGARIQEGVVSLAGYAEIFLRNTLASGVIPQLSVIMGPCAGGAVYSP
HHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCH
AITDFIFMVKDTSYMFITGPDVIRAVTHAEVTKEDLGGARTHAARSGVAHFALDTEEAAL
HHHHEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCHHHHH
RAVRELLSFLPLNNVDDPPIQPCADDPGRRDELLKTIAPENPGKAYDMKEVVRAVADDRH
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCH
FFEVAEPFAPNIVIGFARLNGRPVGVVANQPAVLAGVLDIDASVKAARFVRFCDAFNVPL
HHHHHCCCCCCEEEEEEEECCEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHCCCCE
LTFVDVPGFLPGTDQEWNGIIVHGAKLLYAYAEATVPKITVITRKAYGGAYDVMASKHIR
EEEECCCCCCCCCCCCCCEEEEECHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEE
ADVNLAWPGAEIAVMGPEGAVNVIFRKELLAAKDPVAERARLVQEYRDRFASPYKAAELG
ECEEEECCCCEEEEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCC
YVDEVIRPEDTRPRVIRALEMLRTKRQELPAKKHGNIPL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PHSDPDPRRALLDQLDAEAEKGGGDERVARQHREGKLTARERIDAFLDPGTFVEMDRFK
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHH
THRCADFGMAEHKVLGDGVVTGYGLVEGRQVFVFAQDFTVFGGSISGAVAEKICKVMDRA
HHHHHHCCCHHHEEECCCCEEEEEEECCCEEEEEEECEEEECCCCCHHHHHHHHHHHHHH
MEVGCPVVGLNDSGGARIQEGVVSLAGYAEIFLRNTLASGVIPQLSVIMGPCAGGAVYSP
HHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCH
AITDFIFMVKDTSYMFITGPDVIRAVTHAEVTKEDLGGARTHAARSGVAHFALDTEEAAL
HHHHEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCHHHHH
RAVRELLSFLPLNNVDDPPIQPCADDPGRRDELLKTIAPENPGKAYDMKEVVRAVADDRH
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCH
FFEVAEPFAPNIVIGFARLNGRPVGVVANQPAVLAGVLDIDASVKAARFVRFCDAFNVPL
HHHHHCCCCCCEEEEEEEECCEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHCCCCE
LTFVDVPGFLPGTDQEWNGIIVHGAKLLYAYAEATVPKITVITRKAYGGAYDVMASKHIR
EEEECCCCCCCCCCCCCCEEEEECHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEE
ADVNLAWPGAEIAVMGPEGAVNVIFRKELLAAKDPVAERARLVQEYRDRFASPYKAAELG
ECEEEECCCCEEEEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCC
YVDEVIRPEDTRPRVIRALEMLRTKRQELPAKKHGNIPL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]