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The map label for this gene is mmlH [H]

Identifier: 220915351

GI number: 220915351

Start: 245410

End: 246657

Strand: Direct

Name: mmlH [H]

Synonym: A2cp1_0230

Alternate gene names: 220915351

Gene position: 245410-246657 (Clockwise)

Preceding gene: 220915350

Following gene: 220915352

Centisome position: 4.88

GC content: 71.47

Gene sequence:

>1248_bases
ATGGACTCCCCCGCACAGAGCGCCCGCGCGGGCGCCGGCACCGTATTGAACGCGGCCGTGGTCGTCGCCGCCCTCGGCTA
CTTCGTCGACATCTACGACCTCATCCTCTTCAACATCGTCCGGATCCCCAGCCTCACCGCGATCGGCGTCTCCGGCGACG
CGCTGGTGTCGGAGGGGCTGTCCGTCCTGAACTGGCAGATGGTGGGGATGCTGCTCGGCGGCATCGTCTTCGGGATCGTG
GGCGACAAGCTGGGCCGGCTCCACATCCTGTTCGGCTCCATCACGCTCTACTCGATCGCCACCATCGCGAACGGGTTCGT
GCACGATCTCGCCACCTACAAGGCGCTCCGCTTCGTGGCCGGGCTGGGCCTCGCCGGCGAGCTCGGGGCGGGGGTGACGC
TGGTGGCGGAGATCCTGCCGGCCCGGCTGCGCGGCTACGGCACCATGCTCGTCGCCTCGGTGGGCGTGTCGGGCGCCATC
GTCGGGAACGTGGTGGCGAAGACGCTCGACTGGCGCGTGGCCTACTGGGTGGGCGGCGGGCTCGGGCTCCTGCTGCTCGT
GCTCCGCATCAAGGTGAGCGAGTCGGGGATGTTCCAGGCGCTGCGCCACACCGCCGTGAGGCGGGGCGACTTCCTGGCGG
TGTTCCGCGGGGCCGAGCGCTTCCGCCGCTACCTCTCCTCGATCCTGATCGGCGTGCCGATCTGGTGCTCGAACGCGATC
CTGGTCGCGCTCGCGCCCGAGTTCGGGCGAACGCTGGGCGTGACCGGCCCGGTGACCGCGGGCGACGCGGTGATGTTCTT
CTACGGCGGCCTGGTGCTGGGCGACCTGTCGAGCGGGTTCCTCTCGCAGGTGTGGCGGAGCCGGCGCAAGGTGGTGCTCC
TGTTCGTGGCGCTGCTCGCCGCCGCCAACGTCTTCTACTTCGTGGCCGGCCGCGGCGCGTCGCCGGCGCTGTTCCTCGGC
GCCTGCGGCCTGCTCGGCATCGCGGGCGGCTACTGGGCCATCTTCGTCACCGTGGCCGCCGAGCAGTTCGGCACCAACCT
GCGGGCGACCGTGGCGACCACCGTGCCCAACTTCGTGCGCGGCCTGGTCCCGGTGTGCACGCTCTCCTTCCAGTGGGCCC
GCCCGCACCTCGGGCTGGTGGGCGCGGCGGCGGCGGTGAGCGCGCTCTGGTTCGGCCTCGCGCTCGTGTCCGCGTTCGGC
CTGCGCGAGACGTTCGGCGTCGAGCTCGACTACGTCGAGGCGGACTAG

Upstream 100 bases:

>100_bases
CCCTGCGCGCGGAGCGGGCAGGCGCGCGCCGATTGCGCGGCCCGCGCCGGCGGCGCACGCCTCGACGGGAGGTCTCCGGC
GTGGTCATATCGCCGCACCG

Downstream 100 bases:

>100_bases
GCATGTCGGCGTACGTGGTGGACGTGGAGGCGGACGGGCCCATCCCGGGCAAGTACTCCATGGTCTCGTTCGGCGCGGTG
CGGGTGGAGCCGGGGCTGTC

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDSPAQSARAGAGTVLNAAVVVAALGYFVDIYDLILFNIVRIPSLTAIGVSGDALVSEGLSVLNWQMVGMLLGGIVFGIV
GDKLGRLHILFGSITLYSIATIANGFVHDLATYKALRFVAGLGLAGELGAGVTLVAEILPARLRGYGTMLVASVGVSGAI
VGNVVAKTLDWRVAYWVGGGLGLLLLVLRIKVSESGMFQALRHTAVRRGDFLAVFRGAERFRRYLSSILIGVPIWCSNAI
LVALAPEFGRTLGVTGPVTAGDAVMFFYGGLVLGDLSSGFLSQVWRSRRKVVLLFVALLAAANVFYFVAGRGASPALFLG
ACGLLGIAGGYWAIFVTVAAEQFGTNLRATVATTVPNFVRGLVPVCTLSFQWARPHLGLVGAAAAVSALWFGLALVSAFG
LRETFGVELDYVEAD

Sequences:

>Translated_415_residues
MDSPAQSARAGAGTVLNAAVVVAALGYFVDIYDLILFNIVRIPSLTAIGVSGDALVSEGLSVLNWQMVGMLLGGIVFGIV
GDKLGRLHILFGSITLYSIATIANGFVHDLATYKALRFVAGLGLAGELGAGVTLVAEILPARLRGYGTMLVASVGVSGAI
VGNVVAKTLDWRVAYWVGGGLGLLLLVLRIKVSESGMFQALRHTAVRRGDFLAVFRGAERFRRYLSSILIGVPIWCSNAI
LVALAPEFGRTLGVTGPVTAGDAVMFFYGGLVLGDLSSGFLSQVWRSRRKVVLLFVALLAAANVFYFVAGRGASPALFLG
ACGLLGIAGGYWAIFVTVAAEQFGTNLRATVATTVPNFVRGLVPVCTLSFQWARPHLGLVGAAAAVSALWFGLALVSAFG
LRETFGVELDYVEAD
>Mature_415_residues
MDSPAQSARAGAGTVLNAAVVVAALGYFVDIYDLILFNIVRIPSLTAIGVSGDALVSEGLSVLNWQMVGMLLGGIVFGIV
GDKLGRLHILFGSITLYSIATIANGFVHDLATYKALRFVAGLGLAGELGAGVTLVAEILPARLRGYGTMLVASVGVSGAI
VGNVVAKTLDWRVAYWVGGGLGLLLLVLRIKVSESGMFQALRHTAVRRGDFLAVFRGAERFRRYLSSILIGVPIWCSNAI
LVALAPEFGRTLGVTGPVTAGDAVMFFYGGLVLGDLSSGFLSQVWRSRRKVVLLFVALLAAANVFYFVAGRGASPALFLG
ACGLLGIAGGYWAIFVTVAAEQFGTNLRATVATTVPNFVRGLVPVCTLSFQWARPHLGLVGAAAAVSALWFGLALVSAFG
LRETFGVELDYVEAD

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082231, Length=238, Percent_Identity=27.7310924369748, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082404, Length=212, Percent_Identity=27.8301886792453, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43465; Mature: 43465

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSPAQSARAGAGTVLNAAVVVAALGYFVDIYDLILFNIVRIPSLTAIGVSGDALVSEGL
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCH
SVLNWQMVGMLLGGIVFGIVGDKLGRLHILFGSITLYSIATIANGFVHDLATYKALRFVA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGLAGELGAGVTLVAEILPARLRGYGTMLVASVGVSGAIVGNVVAKTLDWRVAYWVGGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCH
LGLLLLVLRIKVSESGMFQALRHTAVRRGDFLAVFRGAERFRRYLSSILIGVPIWCSNAI
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCEE
LVALAPEFGRTLGVTGPVTAGDAVMFFYGGLVLGDLSSGFLSQVWRSRRKVVLLFVALLA
EEEECHHHCCCCCCCCCCCCCCHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
AANVFYFVAGRGASPALFLGACGLLGIAGGYWAIFVTVAAEQFGTNLRATVATTVPNFVR
HHHHEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
GLVPVCTLSFQWARPHLGLVGAAAAVSALWFGLALVSAFGLRETFGVELDYVEAD
HHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECC
>Mature Secondary Structure
MDSPAQSARAGAGTVLNAAVVVAALGYFVDIYDLILFNIVRIPSLTAIGVSGDALVSEGL
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCH
SVLNWQMVGMLLGGIVFGIVGDKLGRLHILFGSITLYSIATIANGFVHDLATYKALRFVA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGLAGELGAGVTLVAEILPARLRGYGTMLVASVGVSGAIVGNVVAKTLDWRVAYWVGGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCH
LGLLLLVLRIKVSESGMFQALRHTAVRRGDFLAVFRGAERFRRYLSSILIGVPIWCSNAI
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCEE
LVALAPEFGRTLGVTGPVTAGDAVMFFYGGLVLGDLSSGFLSQVWRSRRKVVLLFVALLA
EEEECHHHCCCCCCCCCCCCCCHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
AANVFYFVAGRGASPALFLGACGLLGIAGGYWAIFVTVAAEQFGTNLRATVATTVPNFVR
HHHHEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
GLVPVCTLSFQWARPHLGLVGAAAAVSALWFGLALVSAFGLRETFGVELDYVEAD
HHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]