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The map label for this gene is mltA [H]

Identifier: 220915190

GI number: 220915190

Start: 77480

End: 78667

Strand: Direct

Name: mltA [H]

Synonym: A2cp1_0069

Alternate gene names: 220915190

Gene position: 77480-78667 (Clockwise)

Preceding gene: 220915189

Following gene: 220915192

Centisome position: 1.54

GC content: 76.6

Gene sequence:

>1188_bases
ATGCGACGCACCCCCCTCGAGCACGCCCTCCTCGCGGCGCTCGCCCTGTCAGTCGCCGCCTGCCGCCACGCGCCCCCGCC
CGCGCCGGCGCGCACCGCCGACGAGGCGCTCCGCGAGGTGCCGCCCTCCGACCTCCCGGCGTTCGCCGACGATCTCGACT
ACGCCGGCCTGGAGGACGCGATCGGCCGCTCCGAGACCTGGCTGGCACGGCTCGCCGCCTCGGATCCGGGCCGGACGTTC
GCCTACGGCAGGGAGCGCGTCCCGCTCGCGCGCGTGCAGGCGACGCTGGCGCGCTTCCGGACGGTCGTGGCGGCGCGGCC
CGCGCCGGCGGCGCTGCGCGAGACGCTCCGCCGCGAGTTCCGCGCGTTCCGCTCCGCCGGCGACGGGCGCGGGACGGTGC
TGTTCACCGGCTACTACCTGCCGGAGCTGCGCGGCGCGCTCGCCCGCGGCGGCCCGTACCGGGTGCCGCTCCACCGCGCG
CCGGACGACCTCGTGGTGGTGCGCGCGCGCGACTTCCCGCAGGTCGCGGAGGACCTCGTCGGCCGGGTGGAGCAGGGCAG
GCTCGTCCCGTACCCGACCCGCGCCGACATCGCGCGCGGCGCGCTCGACGGGAAGGGCGCGGAGCTCTGCTACGTGGACT
CGGCGCTCGACGCGTTCTTCCTCGAGATCCAGGGGAGCGGGGTGGTGCGCCTCGAGGACGGCAGCTCGCGCGTGGTCACG
TACGCCGGCAAGAACGGCCAGCGCTACGCCGCGGTCGGCGCGGAGCTGATCCGGCGCGGCGCGCTCCGGCGCGAGGAGGT
GTCGATGCAGTCGATCCGCGCCTGGCTGCTCGCGCACCCGGAGGAGCAGGCGGCGGTGCTCGCCACCAACCCGTCCTACG
TGTTCTTCCGGTTCGCCGACGACGCCATCGGCGCGCTCGGCGTCCCGGTCACCCCGGACCGCACCATCGCCGCCGACGCG
AAGGTGTTCCCGAAGGGCGGGCTCGCGTTCCTGGAGACGGAGCGGCCGGTGGACGCGACCTCGGCCACCCTGCGCCCGTT
CTCGCGCTTCGTCCTCGACCAGGACGCGGGCGGCGCGATCCGCACCTCCGGGCGCGTGGACCTCTACCTCGGGAGCGGCC
CCTACGCCGCGAACGCCGCCGGCCGCATGAAGCAGCCGGGGCGCCTCTGGTACCTGCTGCTCAGGTAG

Upstream 100 bases:

>100_bases
GCCCGGGCCCGGGCCCGCGCGGGCGCGCCCGCGGCGTAGCCGTCGAGGCGCCGGCGGCCGGCCCGCGCCGCGCGGCCGGA
CCTCTGCTACCTTCGGCCCG

Downstream 100 bases:

>100_bases
GGCTCCCCGCCCGCGGCCGACGGCTCACCGCGGGCGGGATCGCCTCACCGGTGCCGAGCGGCCCGCTCGCCCCGGGCGCA
CCGAGGGGCGAGCGGGTCCC

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MRRTPLEHALLAALALSVAACRHAPPPAPARTADEALREVPPSDLPAFADDLDYAGLEDAIGRSETWLARLAASDPGRTF
AYGRERVPLARVQATLARFRTVVAARPAPAALRETLRREFRAFRSAGDGRGTVLFTGYYLPELRGALARGGPYRVPLHRA
PDDLVVVRARDFPQVAEDLVGRVEQGRLVPYPTRADIARGALDGKGAELCYVDSALDAFFLEIQGSGVVRLEDGSSRVVT
YAGKNGQRYAAVGAELIRRGALRREEVSMQSIRAWLLAHPEEQAAVLATNPSYVFFRFADDAIGALGVPVTPDRTIAADA
KVFPKGGLAFLETERPVDATSATLRPFSRFVLDQDAGGAIRTSGRVDLYLGSGPYAANAAGRMKQPGRLWYLLLR

Sequences:

>Translated_395_residues
MRRTPLEHALLAALALSVAACRHAPPPAPARTADEALREVPPSDLPAFADDLDYAGLEDAIGRSETWLARLAASDPGRTF
AYGRERVPLARVQATLARFRTVVAARPAPAALRETLRREFRAFRSAGDGRGTVLFTGYYLPELRGALARGGPYRVPLHRA
PDDLVVVRARDFPQVAEDLVGRVEQGRLVPYPTRADIARGALDGKGAELCYVDSALDAFFLEIQGSGVVRLEDGSSRVVT
YAGKNGQRYAAVGAELIRRGALRREEVSMQSIRAWLLAHPEEQAAVLATNPSYVFFRFADDAIGALGVPVTPDRTIAADA
KVFPKGGLAFLETERPVDATSATLRPFSRFVLDQDAGGAIRTSGRVDLYLGSGPYAANAAGRMKQPGRLWYLLLR
>Mature_395_residues
MRRTPLEHALLAALALSVAACRHAPPPAPARTADEALREVPPSDLPAFADDLDYAGLEDAIGRSETWLARLAASDPGRTF
AYGRERVPLARVQATLARFRTVVAARPAPAALRETLRREFRAFRSAGDGRGTVLFTGYYLPELRGALARGGPYRVPLHRA
PDDLVVVRARDFPQVAEDLVGRVEQGRLVPYPTRADIARGALDGKGAELCYVDSALDAFFLEIQGSGVVRLEDGSSRVVT
YAGKNGQRYAAVGAELIRRGALRREEVSMQSIRAWLLAHPEEQAAVLATNPSYVFFRFADDAIGALGVPVTPDRTIAADA
KVFPKGGLAFLETERPVDATSATLRPFSRFVLDQDAGGAIRTSGRVDLYLGSGPYAANAAGRMKQPGRLWYLLLR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=298, Percent_Identity=34.2281879194631, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42774; Mature: 42774

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTPLEHALLAALALSVAACRHAPPPAPARTADEALREVPPSDLPAFADDLDYAGLEDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCCHHHH
IGRSETWLARLAASDPGRTFAYGRERVPLARVQATLARFRTVVAARPAPAALRETLRREF
CCCCHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RAFRSAGDGRGTVLFTGYYLPELRGALARGGPYRVPLHRAPDDLVVVRARDFPQVAEDLV
HHHHCCCCCCCEEEEEEECHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCHHHHHHHH
GRVEQGRLVPYPTRADIARGALDGKGAELCYVDSALDAFFLEIQGSGVVRLEDGSSRVVT
HHHHCCCCCCCCCHHHHHHCCCCCCCCEEEEEEHHCCEEEEEECCCCEEEEECCCCEEEE
YAGKNGQRYAAVGAELIRRGALRREEVSMQSIRAWLLAHPEEQAAVLATNPSYVFFRFAD
EECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECC
DAIGALGVPVTPDRTIAADAKVFPKGGLAFLETERPVDATSATLRPFSRFVLDQDAGGAI
CCCCCCCCCCCCCCCEECCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEE
RTSGRVDLYLGSGPYAANAAGRMKQPGRLWYLLLR
EECCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MRRTPLEHALLAALALSVAACRHAPPPAPARTADEALREVPPSDLPAFADDLDYAGLEDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCCHHHH
IGRSETWLARLAASDPGRTFAYGRERVPLARVQATLARFRTVVAARPAPAALRETLRREF
CCCCHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RAFRSAGDGRGTVLFTGYYLPELRGALARGGPYRVPLHRAPDDLVVVRARDFPQVAEDLV
HHHHCCCCCCCEEEEEEECHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCHHHHHHHH
GRVEQGRLVPYPTRADIARGALDGKGAELCYVDSALDAFFLEIQGSGVVRLEDGSSRVVT
HHHHCCCCCCCCCHHHHHHCCCCCCCCEEEEEEHHCCEEEEEECCCCEEEEECCCCEEEE
YAGKNGQRYAAVGAELIRRGALRREEVSMQSIRAWLLAHPEEQAAVLATNPSYVFFRFAD
EECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECC
DAIGALGVPVTPDRTIAADAKVFPKGGLAFLETERPVDATSATLRPFSRFVLDQDAGGAI
CCCCCCCCCCCCCCCEECCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEE
RTSGRVDLYLGSGPYAANAAGRMKQPGRLWYLLLR
EECCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]