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The map label for this gene is opuE [H]

Identifier: 220915171

GI number: 220915171

Start: 56004

End: 57635

Strand: Direct

Name: opuE [H]

Synonym: A2cp1_0049

Alternate gene names: 220915171

Gene position: 56004-57635 (Clockwise)

Preceding gene: 220915168

Following gene: 220915172

Centisome position: 1.11

GC content: 73.04

Gene sequence:

>1632_bases
GTGAACCTGGAGCTGCTCACGCTCGCCGTCGGCGCGTACGCCGCCGTGCTCGCCTTCCTGGGCTGGCTCGGGTACCGCCG
CACGCGCAGCGCCGCCGACTACCTGGTGGGCGGTCGCGAGATCCACCCGGTGCTGATGGCGCTCGCCTACGGCTCCACGT
TCATCTCCACCTCCGCCATCGTGGGCTTCGCGGGCGTCGCCGCGCTCATGGGCATGGGCCTGCTCTGGCTCACCATGCTC
AACATCCTGCTGGGCGTGTTCGTCGCGTTCGTGGTGTTCGGCCGCCCCACCCGGCGGCTCGGCGCCGCGCTCGACGCGCA
CACCTTCCCGGAGCTGCTCGGGCGCCGGTACCGGTCCCGCTTCATCCAGGGCTTCGCCGGCGGGACCATCGCGCTGCTCA
TGCCGCTCTACGCCGCCGCGGTGCTCATCGGCGGGGCGCGCTTCCTCGAGGTGCAGCTCCACCTCGACTACCAGGTGGCG
CTGTTCGTGTTCGCGGCCATCACCGTCGGCTACGTGCTGTTCGGCGGGCTGAAGGGCGTCGTCTACACCGACGCGTTCCA
GGCGGTGCTGATGGTGTGCGGCATGCTGGTGCTGCTCGTCGCCACCTACGCGCAGGTGGGCGGGCTCTCGGCGCACCAGG
CGCTCACCGATCTCGCCGACCAGGTCCCGCCGGCGCTCCGCGCGCAGGGCCACCGCGGCTGGACCGCCATGCCCGCGGCC
GGCTCGCCGCTCTGGTGGCAGATGGTGTCCACCATCGTCCTCGGCGTCGGCATCGGCGTCCTCGCCCAGCCGCAGCTCAC
CGTCCGGTTCATGACCGTGAAGAGCGGGCGCGAGCTGCACCGCGCGCTCGTGCCGGGCGGCCTCTTCCTGCTGCTCATGG
CCGGCGTCGCCTACGTGGTCGGCTCGCTCACCAACCTCTGGTACTTCCAGCGCACCGGCAAGATCGCGCTCGCGATCATG
ACCGACCCGGCCACCGGCAAGCCCAACGTGGACCGGCTCATGCCGCTCTACACGCAGGCGGCCATGCCGGAGTGGTTCGC
GTACCTGTTCATGCTGGCGCTGCTCGCCGCGGCGATGTCCACGCTCTCGGCGCAGTTCCACGCCATCGGCACCGCCATCG
GGCGCGACCTCTACGAGCAGGCGTTCCGGCTGGGCGGCGGGGCCGAGCGCACCGTGCTGCTGGCGCGCGGCGGGATCCTG
GCGGGCTTCGCCGGCACGGTGCTCCTCGCCTGGAACCTCGGCCCCGGCGTCATCGCCATCGCCACCGCGCTCTTCTTCGG
CATGTGCGCGGCGACGTTCCTGCCGGCGTTCGTCTCGGCGCTGTTCTGGGCCCGCTCCACCCGCGCCGGCGTGATCGCCG
GGATGCTGGCCGGCTTCGCCGCCTGGGCGCTGTGGGTGCTGTTCGTGCACGAGCGCGAGTCGGCGGCGCTGGGCGTGGTG
AAGGCGCTGACCGGCCGGACCAGCCTCGGCGCCGGCACCACCTGGGCGCTCGTCGATCCGATCGTGGTGGCGCTGCCGAT
CGCGGCGCTGGTGACGGTGGTGGGCTCGCTGCTCGGCCGCGCGGCGCCCGCCGCGGACGCGGCCGGGCCGGCCCGGACCG
AAGAAGGGGGGCTCGATGCTGGGCTTCGGTGA

Upstream 100 bases:

>100_bases
CGCCCCCCTTTGGAAGGCGTTTGGAGTCCCGCGTGGGGCCAGCTACCATGGCGGGCTCGGTCGCCCTGCACCCGCCGCAC
CTGACCAGAGGGGGTCACGC

Downstream 100 bases:

>100_bases
CCTCGGCGTAACGGCGGCGTTCGTGCTCACGCTCGCGAGCGCGGCGCTGTGCGTGGTGTACGGGCTCCTCCACTGGAACG
ACGACGACGCCCCCCTGCCC

Product: Na+/solute symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MNLELLTLAVGAYAAVLAFLGWLGYRRTRSAADYLVGGREIHPVLMALAYGSTFISTSAIVGFAGVAALMGMGLLWLTML
NILLGVFVAFVVFGRPTRRLGAALDAHTFPELLGRRYRSRFIQGFAGGTIALLMPLYAAAVLIGGARFLEVQLHLDYQVA
LFVFAAITVGYVLFGGLKGVVYTDAFQAVLMVCGMLVLLVATYAQVGGLSAHQALTDLADQVPPALRAQGHRGWTAMPAA
GSPLWWQMVSTIVLGVGIGVLAQPQLTVRFMTVKSGRELHRALVPGGLFLLLMAGVAYVVGSLTNLWYFQRTGKIALAIM
TDPATGKPNVDRLMPLYTQAAMPEWFAYLFMLALLAAAMSTLSAQFHAIGTAIGRDLYEQAFRLGGGAERTVLLARGGIL
AGFAGTVLLAWNLGPGVIAIATALFFGMCAATFLPAFVSALFWARSTRAGVIAGMLAGFAAWALWVLFVHERESAALGVV
KALTGRTSLGAGTTWALVDPIVVALPIAALVTVVGSLLGRAAPAADAAGPARTEEGGLDAGLR

Sequences:

>Translated_543_residues
MNLELLTLAVGAYAAVLAFLGWLGYRRTRSAADYLVGGREIHPVLMALAYGSTFISTSAIVGFAGVAALMGMGLLWLTML
NILLGVFVAFVVFGRPTRRLGAALDAHTFPELLGRRYRSRFIQGFAGGTIALLMPLYAAAVLIGGARFLEVQLHLDYQVA
LFVFAAITVGYVLFGGLKGVVYTDAFQAVLMVCGMLVLLVATYAQVGGLSAHQALTDLADQVPPALRAQGHRGWTAMPAA
GSPLWWQMVSTIVLGVGIGVLAQPQLTVRFMTVKSGRELHRALVPGGLFLLLMAGVAYVVGSLTNLWYFQRTGKIALAIM
TDPATGKPNVDRLMPLYTQAAMPEWFAYLFMLALLAAAMSTLSAQFHAIGTAIGRDLYEQAFRLGGGAERTVLLARGGIL
AGFAGTVLLAWNLGPGVIAIATALFFGMCAATFLPAFVSALFWARSTRAGVIAGMLAGFAAWALWVLFVHERESAALGVV
KALTGRTSLGAGTTWALVDPIVVALPIAALVTVVGSLLGRAAPAADAAGPARTEEGGLDAGLR
>Mature_543_residues
MNLELLTLAVGAYAAVLAFLGWLGYRRTRSAADYLVGGREIHPVLMALAYGSTFISTSAIVGFAGVAALMGMGLLWLTML
NILLGVFVAFVVFGRPTRRLGAALDAHTFPELLGRRYRSRFIQGFAGGTIALLMPLYAAAVLIGGARFLEVQLHLDYQVA
LFVFAAITVGYVLFGGLKGVVYTDAFQAVLMVCGMLVLLVATYAQVGGLSAHQALTDLADQVPPALRAQGHRGWTAMPAA
GSPLWWQMVSTIVLGVGIGVLAQPQLTVRFMTVKSGRELHRALVPGGLFLLLMAGVAYVVGSLTNLWYFQRTGKIALAIM
TDPATGKPNVDRLMPLYTQAAMPEWFAYLFMLALLAAAMSTLSAQFHAIGTAIGRDLYEQAFRLGGGAERTVLLARGGIL
AGFAGTVLLAWNLGPGVIAIATALFFGMCAATFLPAFVSALFWARSTRAGVIAGMLAGFAAWALWVLFVHERESAALGVV
KALTGRTSLGAGTTWALVDPIVVALPIAALVTVVGSLLGRAAPAADAAGPARTEEGGLDAGLR

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=468, Percent_Identity=25.8547008547009, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4507035, Length=445, Percent_Identity=25.3932584269663, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1787251, Length=470, Percent_Identity=27.2340425531915, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI87082237, Length=507, Percent_Identity=26.8244575936884, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790503, Length=439, Percent_Identity=21.6400911161731, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 57106; Mature: 57106

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]