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The map label for this gene is lysR [H]

Identifier: 220914868

GI number: 220914868

Start: 242707

End: 243609

Strand: Reverse

Name: lysR [H]

Synonym: Mnod_8014

Alternate gene names: 220914868

Gene position: 243609-242707 (Counterclockwise)

Preceding gene: 220914869

Following gene: 220914867

Centisome position: 53.18

GC content: 61.02

Gene sequence:

>903_bases
ATGAAACTTCTTTACCTTGCCGCTTTCCGCGCAGTTATGTTGACAGGGACGGTGAGCGCGGCTGCCGAGGTCTTGGGGCG
GAGCCAACCCGCAGTAAGCCGCCTGCTCGACAAGCTGGAGGCAGAACTCGGTGCGAAGTTGTTCGAACGCAGGCGCGGGT
TGGTCGTGCCGACACGCACCGCCCAGCTTCTGCTCGACGAGGTGGAGCGGGCCTACGTCTCGTTGGAGTCGCTCAAGACC
TTCGCTTCCCGGGTCGCCGAGGGCGAAAGCAGCCGGATCTCGGCCGCCGTGCTGCCAGCCCTGGGACTGAATTTCATCCC
CGCCACCCTGGCAGCCTTTGCACGGGAATGGCCCAAAACTCGGGTCCTTCTCAACGTTCAGATGTCCGTGCAGGTGGAGG
AATGGGCGGCTGCTCAGCAAGTCGATTTCGGCTTGGCGGAGATGCCATTCAAACGTTCCGGTTTCCGCACTGAGATCTTC
AGTGATCAACCTTACCTGCTCGCGGTTCCGCGGGATCACCCGCTTGCTCAGCGATCTCAGGTTGGGCCGTCGGACGTCCG
AGGGGTGCCGTTCATCGTGGGATCGTCATTCACAGCGATGGGACAGTTGCTGGCTCAGGCTTTCAGGACATGCGGTGTGC
CGCTGGAGGCACAGTACGAAGCCCCGCTTTCGATGACCGTCTACGAATTGGTCAAGCAAGGCGTGGGTATCGGCCTAGTG
GATCCGTATACCGCCCTGAAGCAACTGGACAGCCGCGTGCAACTCGTACGCTTTGTGCCGACAATACCTTTCAACGTCGC
GCTCCTGCGCCCTGAATCCCGTCCAGCCAACCCTGCTGCAGACGCTCTGCTGGATTTTTTGGCCTCGGAACGTGATCGCT
TGATGTCGGGCTTTCCGGGCTGA

Upstream 100 bases:

>100_bases
CCGCATCACCGGCGCCTGTACAATGGGTCTTGTGGTGGGGAGTTGTGCAATCCCGTGCGATAACAGTCCACAAGATCGGA
GCAATCTCAGGTCAAAATCA

Downstream 100 bases:

>100_bases
GCCCGATATGCGTAAGTCGCATAACGCTCCACGAACATTCAATTTTGCGCATTTCGCTTTCCGAGGTTAGCTCTGGCAGG
TCGTCGGTTTTGAGGAAGGG

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKLLYLAAFRAVMLTGTVSAAAEVLGRSQPAVSRLLDKLEAELGAKLFERRRGLVVPTRTAQLLLDEVERAYVSLESLKT
FASRVAEGESSRISAAVLPALGLNFIPATLAAFAREWPKTRVLLNVQMSVQVEEWAAAQQVDFGLAEMPFKRSGFRTEIF
SDQPYLLAVPRDHPLAQRSQVGPSDVRGVPFIVGSSFTAMGQLLAQAFRTCGVPLEAQYEAPLSMTVYELVKQGVGIGLV
DPYTALKQLDSRVQLVRFVPTIPFNVALLRPESRPANPAADALLDFLASERDRLMSGFPG

Sequences:

>Translated_300_residues
MKLLYLAAFRAVMLTGTVSAAAEVLGRSQPAVSRLLDKLEAELGAKLFERRRGLVVPTRTAQLLLDEVERAYVSLESLKT
FASRVAEGESSRISAAVLPALGLNFIPATLAAFAREWPKTRVLLNVQMSVQVEEWAAAQQVDFGLAEMPFKRSGFRTEIF
SDQPYLLAVPRDHPLAQRSQVGPSDVRGVPFIVGSSFTAMGQLLAQAFRTCGVPLEAQYEAPLSMTVYELVKQGVGIGLV
DPYTALKQLDSRVQLVRFVPTIPFNVALLRPESRPANPAADALLDFLASERDRLMSGFPG
>Mature_300_residues
MKLLYLAAFRAVMLTGTVSAAAEVLGRSQPAVSRLLDKLEAELGAKLFERRRGLVVPTRTAQLLLDEVERAYVSLESLKT
FASRVAEGESSRISAAVLPALGLNFIPATLAAFAREWPKTRVLLNVQMSVQVEEWAAAQQVDFGLAEMPFKRSGFRTEIF
SDQPYLLAVPRDHPLAQRSQVGPSDVRGVPFIVGSSFTAMGQLLAQAFRTCGVPLEAQYEAPLSMTVYELVKQGVGIGLV
DPYTALKQLDSRVQLVRFVPTIPFNVALLRPESRPANPAADALLDFLASERDRLMSGFPG

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=300, Percent_Identity=34.3333333333333, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI145693105, Length=301, Percent_Identity=23.9202657807309, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788748, Length=299, Percent_Identity=26.4214046822742, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788887, Length=304, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790399, Length=223, Percent_Identity=26.9058295964126, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI2367136, Length=229, Percent_Identity=25.764192139738, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87081904, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI157672245, Length=282, Percent_Identity=24.113475177305, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32761; Mature: 32761

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLYLAAFRAVMLTGTVSAAAEVLGRSQPAVSRLLDKLEAELGAKLFERRRGLVVPTRT
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
AQLLLDEVERAYVSLESLKTFASRVAEGESSRISAAVLPALGLNFIPATLAAFAREWPKT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
RVLLNVQMSVQVEEWAAAQQVDFGLAEMPFKRSGFRTEIFSDQPYLLAVPRDHPLAQRSQ
EEEEEEEEEEEHHHHHHHHHHCCCHHHCCCCCCCCEEEEECCCCEEEECCCCCCCHHHHC
VGPSDVRGVPFIVGSSFTAMGQLLAQAFRTCGVPLEAQYEAPLSMTVYELVKQGVGIGLV
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
DPYTALKQLDSRVQLVRFVPTIPFNVALLRPESRPANPAADALLDFLASERDRLMSGFPG
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLLYLAAFRAVMLTGTVSAAAEVLGRSQPAVSRLLDKLEAELGAKLFERRRGLVVPTRT
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
AQLLLDEVERAYVSLESLKTFASRVAEGESSRISAAVLPALGLNFIPATLAAFAREWPKT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
RVLLNVQMSVQVEEWAAAQQVDFGLAEMPFKRSGFRTEIFSDQPYLLAVPRDHPLAQRSQ
EEEEEEEEEEEHHHHHHHHHHCCCHHHCCCCCCCCEEEEECCCCEEEECCCCCCCHHHHC
VGPSDVRGVPFIVGSSFTAMGQLLAQAFRTCGVPLEAQYEAPLSMTVYELVKQGVGIGLV
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
DPYTALKQLDSRVQLVRFVPTIPFNVALLRPESRPANPAADALLDFLASERDRLMSGFPG
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]