Click here to switch to the map view.

The map label for this gene is serS

Identifier: 220905568

GI number: 220905568

Start: 2773854

End: 2775128

Strand: Direct

Name: serS

Synonym: Ddes_2307

Alternate gene names: 220905568

Gene position: 2773854-2775128 (Clockwise)

Preceding gene: 220905564

Following gene: 220905574

Centisome position: 96.53

GC content: 60.94

Gene sequence:

>1275_bases
ATGATTGATCTTAAACTGGTGCAGAGGCAGCCCGAAGTTTTAGCCAAGGCCCTGGCCGACCGGCATTCGGGTATCAGCGT
AGACGCATTTCTTGAGCTGGACGGCCGCCGCCGCTCCCTGCTTACGGAAGTGGAAGGGCTTAAAAGCAAGCGTAACGAGG
CTTCAGCCCAGGTGGCCGCGCTCAAGCGCTCCGGCCAGGACGCTGCCCCCCTGCTCACCGAACTGTCTTCCCTGTCAGAC
CGCATCAAGGAACTGGACGTGGAAACGACGCAGGTCAAGACTGACGTGGAAAACCTGCTCATGAGCATGCCCAACATTCC
CGACAGCACCGTGCCTGTGGGCGCCGACGAAAACGAAAACGTCGAGGTAGGCCGCTGGGGCGAACCGCGGCAGCTTGACT
TTGAACCTCGCCCGCATGACGACATCGGCACGGCCCTTGGCGGACTGGACTTCGAGCGTGCCGCGCGTCTTACAGGCAGC
CGCTTTGTCGTGTCCCTGGGCTGGGCCGCGCGCCTTGAACGCGCCCTGGTGAACTTTTTTCTCGACAGGCACACCCGGCA
CAATGATTACCTTGAGGTAAGCCCTCCCTATATGGTCAACCGCGCCTCAATGACAGGCACGGCCCAGCTGCCAAAATTTG
AAGAAGACCTCTTCAAGCTGGCCGAGTGGGACTATTTTCTCATCCCCACTGCGGAAGTGCCGCTGACGAACCTGCATGCG
GGCGAAGTGCTTGAAGAGTCCGACCTGCCGCGCGCCTACTGTGCGGCCACGCCCTGCTTCCGTTCCGAAGCGGGCAGCGC
GGGCAAAGACACGCGGGGCATCATTCGCCTGCACCAGTTCACCAAGGTGGAGATGGTACGCTTTGCCCACCCCGAAGACA
GTTTCAACCAGCTTGAGCTTATGCGCGGCCACGCCTGTAACCTGCTGGAACTGCTTGAACTGCCCCACCGTGTCATCACC
CTTTGCACCGGCGATATGGGCTTTGCCGCTGCCAAGACCTATGATGTGGAAGTATGGCTGCCCGCCCAGAAAACCTACCG
TGAGATCTCTTCCTGCTCCAACTGCACGGACTTTCAGGCCCGCCGCGCGGACATCCGCTTCAGGCCCAAGGGCGGCAAAA
CGGCTTTTGTCCACACGCTCAACGGCTCCGGCCTGCCCACCGGGCGTACCATTGCCGCCATTCTGGAAAACGGCCAGCAG
AAAGACGGCAGCGTGGTGCTGCCCAAGGTGCTGGTTCCCTATATGGACGGGGTGGAAAGCATCGAGCCGCGCTAA

Upstream 100 bases:

>100_bases
TTTCTGCCACAGGCCGGACCATACGCATGCCACTACAGCCTTGTGCCGCAATTTTTACCGCGAATCCGGCGCAATACAGC
GCAGATTTTCAGGAGCGGTC

Downstream 100 bases:

>100_bases
TAACGCTTTTCAGGGTACGGCAAACTGCCCTGAAACTGTTTTGACGGCTTTGCATTGATAAAAAACGGGGCTTTGGCGCC
AGGTGCATACCTATTAGGGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIDLKLVQRQPEVLAKALADRHSGISVDAFLELDGRRRSLLTEVEGLKSKRNEASAQVAALKRSGQDAAPLLTELSSLSD
RIKELDVETTQVKTDVENLLMSMPNIPDSTVPVGADENENVEVGRWGEPRQLDFEPRPHDDIGTALGGLDFERAARLTGS
RFVVSLGWAARLERALVNFFLDRHTRHNDYLEVSPPYMVNRASMTGTAQLPKFEEDLFKLAEWDYFLIPTAEVPLTNLHA
GEVLEESDLPRAYCAATPCFRSEAGSAGKDTRGIIRLHQFTKVEMVRFAHPEDSFNQLELMRGHACNLLELLELPHRVIT
LCTGDMGFAAAKTYDVEVWLPAQKTYREISSCSNCTDFQARRADIRFRPKGGKTAFVHTLNGSGLPTGRTIAAILENGQQ
KDGSVVLPKVLVPYMDGVESIEPR

Sequences:

>Translated_424_residues
MIDLKLVQRQPEVLAKALADRHSGISVDAFLELDGRRRSLLTEVEGLKSKRNEASAQVAALKRSGQDAAPLLTELSSLSD
RIKELDVETTQVKTDVENLLMSMPNIPDSTVPVGADENENVEVGRWGEPRQLDFEPRPHDDIGTALGGLDFERAARLTGS
RFVVSLGWAARLERALVNFFLDRHTRHNDYLEVSPPYMVNRASMTGTAQLPKFEEDLFKLAEWDYFLIPTAEVPLTNLHA
GEVLEESDLPRAYCAATPCFRSEAGSAGKDTRGIIRLHQFTKVEMVRFAHPEDSFNQLELMRGHACNLLELLELPHRVIT
LCTGDMGFAAAKTYDVEVWLPAQKTYREISSCSNCTDFQARRADIRFRPKGGKTAFVHTLNGSGLPTGRTIAAILENGQQ
KDGSVVLPKVLVPYMDGVESIEPR
>Mature_424_residues
MIDLKLVQRQPEVLAKALADRHSGISVDAFLELDGRRRSLLTEVEGLKSKRNEASAQVAALKRSGQDAAPLLTELSSLSD
RIKELDVETTQVKTDVENLLMSMPNIPDSTVPVGADENENVEVGRWGEPRQLDFEPRPHDDIGTALGGLDFERAARLTGS
RFVVSLGWAARLERALVNFFLDRHTRHNDYLEVSPPYMVNRASMTGTAQLPKFEEDLFKLAEWDYFLIPTAEVPLTNLHA
GEVLEESDLPRAYCAATPCFRSEAGSAGKDTRGIIRLHQFTKVEMVRFAHPEDSFNQLELMRGHACNLLELLELPHRVIT
LCTGDMGFAAAKTYDVEVWLPAQKTYREISSCSNCTDFQARRADIRFRPKGGKTAFVHTLNGSGLPTGRTIAAILENGQQ
KDGSVVLPKVLVPYMDGVESIEPR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=355, Percent_Identity=34.0845070422535, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI8923421, Length=326, Percent_Identity=33.4355828220859, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI225579074, Length=326, Percent_Identity=33.4355828220859, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=52.2144522144522, Blast_Score=440, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539260, Length=449, Percent_Identity=30.9576837416481, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=29.0220820189274, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=397, Percent_Identity=34.2569269521411, Blast_Score=229, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6321799, Length=415, Percent_Identity=32.289156626506, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24581334, Length=329, Percent_Identity=36.1702127659575, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17737985, Length=377, Percent_Identity=31.0344827586207, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_DESDA (B8J4S2)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480880.1
- GeneID:   7286025
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2307
- HOGENOM:   HBG629391
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47141; Mature: 47141

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKLVQRQPEVLAKALADRHSGISVDAFLELDGRRRSLLTEVEGLKSKRNEASAQVAA
CCCHHHHHCCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LKRSGQDAAPLLTELSSLSDRIKELDVETTQVKTDVENLLMSMPNIPDSTVPVGADENEN
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVGRWGEPRQLDFEPRPHDDIGTALGGLDFERAARLTGSRFVVSLGWAARLERALVNFF
EEECCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCEEEEEECHHHHHHHHHHHHH
LDRHTRHNDYLEVSPPYMVNRASMTGTAQLPKFEEDLFKLAEWDYFLIPTAEVPLTNLHA
HHHCCCCCCEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCH
GEVLEESDLPRAYCAATPCFRSEAGSAGKDTRGIIRLHQFTKVEMVRFAHPEDSFNQLEL
HHHHHHCCCCHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHH
MRGHACNLLELLELPHRVITLCTGDMGFAAAKTYDVEVWLPAQKTYREISSCSNCTDFQA
HHCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEEECCHHHHHHHHHCCCCCCHHH
RRADIRFRPKGGKTAFVHTLNGSGLPTGRTIAAILENGQQKDGSVVLPKVLVPYMDGVES
HCCCEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCHH
IEPR
CCCC
>Mature Secondary Structure
MIDLKLVQRQPEVLAKALADRHSGISVDAFLELDGRRRSLLTEVEGLKSKRNEASAQVAA
CCCHHHHHCCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LKRSGQDAAPLLTELSSLSDRIKELDVETTQVKTDVENLLMSMPNIPDSTVPVGADENEN
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVGRWGEPRQLDFEPRPHDDIGTALGGLDFERAARLTGSRFVVSLGWAARLERALVNFF
EEECCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCEEEEEECHHHHHHHHHHHHH
LDRHTRHNDYLEVSPPYMVNRASMTGTAQLPKFEEDLFKLAEWDYFLIPTAEVPLTNLHA
HHHCCCCCCEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCH
GEVLEESDLPRAYCAATPCFRSEAGSAGKDTRGIIRLHQFTKVEMVRFAHPEDSFNQLEL
HHHHHHCCCCHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHH
MRGHACNLLELLELPHRVITLCTGDMGFAAAKTYDVEVWLPAQKTYREISSCSNCTDFQA
HHCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEEECCHHHHHHHHHCCCCCCHHH
RRADIRFRPKGGKTAFVHTLNGSGLPTGRTIAAILENGQQKDGSVVLPKVLVPYMDGVES
HCCCEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCHH
IEPR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA