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The map label for this gene is dnaX [H]

Identifier: 220905406

GI number: 220905406

Start: 2584842

End: 2587067

Strand: Direct

Name: dnaX [H]

Synonym: Ddes_2144

Alternate gene names: 220905406

Gene position: 2584842-2587067 (Clockwise)

Preceding gene: 220905405

Following gene: 220905407

Centisome position: 89.96

GC content: 65.41

Gene sequence:

>2226_bases
ATGAAGCATCTCTCCCTCGCCTCGCGCTACCGCCCCCAGACCTTTGCCCAGGTGGCGGGACAGGATATGGTAAAAGCCGT
CCTTTCCCGTGCCGCCGCCGAGGACAGGCCCGCTGCGGCCTATCTTTTGAGCGGTACGCGCGGCGTGGGCAAGACCACCA
TTGCCCGCATTTTCGCCAAGGCCCTCAATTGCGAGCATTCCCCCGGTCCCGAACCGTGCAACGAATGTGCCCAGTGCCGC
AAGATCACCCAGGGCGTGCACGTGGACGTAACGGAAATTGACGGCGCGTCCAACAACAGTGTGGAAGATGCCCGCTCGCT
GCGCGAAACCATCGGCTACGCCGCCATGGAAGGCCGTTACAAGGTCTTCATCATCGACGAAGCCCACATGCTCACGCGCA
ACGCCTTCAACGCCCTGCTGAAAACTCTTGAAGAGCCGCCGGAGCGCGTGGTCTTCATCTTTGCCACCACCGAGGCACAC
AAGTTCCCCGTGACCATTGTGAGCCGCTGCCAGCATTTCGTGTTCCGCCACCTGAGCAAAGACGCTCTGGTCGAGCACCT
TTCCGGTGTGCTGCGCAAGGAAAATGTCACCTTTGAAGACAGCGCCGTACGCCTGCTGGCCCGCCGCGCGGCGGGCAGTG
TACGCGACAGCATGTCCCTGCTGGACCAGACCCTGGCCCTGGGCGGCGAACAACTCACAGCCGCCGCCACGCGGCAGGTG
CTGGGCCTGGCCGGACAGGAAATGTTCGCTGAACTTTTCGAGGCCCTGCACGCGCAGGACTGCCCCGCCGTGGCCGGACT
CTGCCGTCAGATATTGCAGCAGGGCGTGGATATCGGCTTTTTCGTGCGAGAACTGGCCGGCAACCTGCGCAATCTTTTTC
TTTTGCGGCAAGGCGGCGCGGCAGTGGCTTCCAGCCTGCAACTGCCCGCTGACGAGGCTGCCCTGTGGCAGGGGCTAGCA
CCGCGTTTTTCCACGGCCCACCTGCATGCAGCATGGCAGATGACGCTGGACGCCCAGCGCGGCATCGTGCAAAGCCCGGA
ACCGGCAGCCGCCCTGGAACTGCTGCTGCTTAACCTGGCCCTGCTGCCGCAACTGCTGCCCGTTGGGCAGGTAACGCCGG
ACCAGATGCCCGCGGGTCCCCCAGGCGCGGCCCCGGCCGACGCAAACCAACCGCCTTCCGGCTCCACGTCCGGTCCCGCT
TCCAGCATGCCGCATGGCGGATACAGGTCGGGGCAGCCGCCACACGCAGGAGCAGAAGCGGCCCGCCACAACGCCGGAAC
GCCGGACGACGCCCCGGCCGCTTCGGGCATGGGCAAAAGCGCAGCCCGCCCACGGGCCACCACCACTGCCGCCCGCCCCA
CCACAGATGGCGAAGAGGCCGAAACACCCGACCCTGCTCCAGCCTGTGACCACAGCCGGAACCAGCCGTCCGGGCAGGAC
GAAAATCTCACCCGGGGCCAAAACAGTCCGCACAGCAATCAGGGGCGCCACCCGGACAAATCCCATACAAGTGACCAGCG
TGACGTGCGGGCCGAAGGCCGGACAACGCCCCCGTACAGTGCTCACCGTCGCGCCCCAGGCAATGGCTTTTCCACCCCGC
CGGACGCGCCCCAAGACGGAGCGCCAGCGCAGACACCCCATACGGAAGCCCCCGGCCCTGATATGGACGGCGCACCCTGG
ACAGGCCAGGACGAAGATTATGCGCCCTACGAAGATGACGCCCTGACGGAAAGCCCGGTTGCGCAAAACTGGCCGGGCCG
CCGGAACGCCACAAGGCGGACGGACAGTTCCGGGCAAAGTGCTACAGGCCAGGACCGCAGGGACAGGCAGACGCAACAAG
ACGCCCCGGCTGCAGCACCGGCCAGCCCCGGCGGGCGTAGCCGCAACTGGCAGAATTTTTACGATTTCTGCGTGGCGGAA
CAGGCTGCCTCGCGCCCCGTTCCGGCTCCTTACGTACTGCGCGGCATAGGGGTGGACTGGCAAGGCAGTACGCTGCGTTT
GCAGCCCAGAACAGAAACGCAGCTGCATCAGCTTGAAAAACAGGCCAAAGCCCTGTATGCCGCACTGGCCGCCTATGGCG
CGCCGGAAACGCAGGTAGAGATTATCGCCCCCAAGCCGCACCGGCCGGAGGCGGACCTTATTGCCGAGTTCAGCCGCAAG
GAAGAGCTGCAGCCATGCTTTGAGGTGCTGAACGCCTCGCTGAAAGGCTGCCGCCCCATAGACTAG

Upstream 100 bases:

>100_bases
TCGTCAAGGGCCAGAACCCCAAGTACGCCGGCTGGCTGCACCACTATAAAGTCTAGCTCAACAGGCGCGCCCGGCCCGCC
GGGCGCGCCGTCAGAAAATC

Downstream 100 bases:

>100_bases
CCGCATCCCCACGGGGAGAGAAAAGACGACAGGGCATGCTCACAGCCGCAACAGCCCGGCGACCCGGGCTGCCCGCGGCA
AGGCGGCCCGCAGCGGTTTT

Product: DNA polymerase III subunits gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MKHLSLASRYRPQTFAQVAGQDMVKAVLSRAAAEDRPAAAYLLSGTRGVGKTTIARIFAKALNCEHSPGPEPCNECAQCR
KITQGVHVDVTEIDGASNNSVEDARSLRETIGYAAMEGRYKVFIIDEAHMLTRNAFNALLKTLEEPPERVVFIFATTEAH
KFPVTIVSRCQHFVFRHLSKDALVEHLSGVLRKENVTFEDSAVRLLARRAAGSVRDSMSLLDQTLALGGEQLTAAATRQV
LGLAGQEMFAELFEALHAQDCPAVAGLCRQILQQGVDIGFFVRELAGNLRNLFLLRQGGAAVASSLQLPADEAALWQGLA
PRFSTAHLHAAWQMTLDAQRGIVQSPEPAAALELLLLNLALLPQLLPVGQVTPDQMPAGPPGAAPADANQPPSGSTSGPA
SSMPHGGYRSGQPPHAGAEAARHNAGTPDDAPAASGMGKSAARPRATTTAARPTTDGEEAETPDPAPACDHSRNQPSGQD
ENLTRGQNSPHSNQGRHPDKSHTSDQRDVRAEGRTTPPYSAHRRAPGNGFSTPPDAPQDGAPAQTPHTEAPGPDMDGAPW
TGQDEDYAPYEDDALTESPVAQNWPGRRNATRRTDSSGQSATGQDRRDRQTQQDAPAAAPASPGGRSRNWQNFYDFCVAE
QAASRPVPAPYVLRGIGVDWQGSTLRLQPRTETQLHQLEKQAKALYAALAAYGAPETQVEIIAPKPHRPEADLIAEFSRK
EELQPCFEVLNASLKGCRPID

Sequences:

>Translated_741_residues
MKHLSLASRYRPQTFAQVAGQDMVKAVLSRAAAEDRPAAAYLLSGTRGVGKTTIARIFAKALNCEHSPGPEPCNECAQCR
KITQGVHVDVTEIDGASNNSVEDARSLRETIGYAAMEGRYKVFIIDEAHMLTRNAFNALLKTLEEPPERVVFIFATTEAH
KFPVTIVSRCQHFVFRHLSKDALVEHLSGVLRKENVTFEDSAVRLLARRAAGSVRDSMSLLDQTLALGGEQLTAAATRQV
LGLAGQEMFAELFEALHAQDCPAVAGLCRQILQQGVDIGFFVRELAGNLRNLFLLRQGGAAVASSLQLPADEAALWQGLA
PRFSTAHLHAAWQMTLDAQRGIVQSPEPAAALELLLLNLALLPQLLPVGQVTPDQMPAGPPGAAPADANQPPSGSTSGPA
SSMPHGGYRSGQPPHAGAEAARHNAGTPDDAPAASGMGKSAARPRATTTAARPTTDGEEAETPDPAPACDHSRNQPSGQD
ENLTRGQNSPHSNQGRHPDKSHTSDQRDVRAEGRTTPPYSAHRRAPGNGFSTPPDAPQDGAPAQTPHTEAPGPDMDGAPW
TGQDEDYAPYEDDALTESPVAQNWPGRRNATRRTDSSGQSATGQDRRDRQTQQDAPAAAPASPGGRSRNWQNFYDFCVAE
QAASRPVPAPYVLRGIGVDWQGSTLRLQPRTETQLHQLEKQAKALYAALAAYGAPETQVEIIAPKPHRPEADLIAEFSRK
EELQPCFEVLNASLKGCRPID
>Mature_741_residues
MKHLSLASRYRPQTFAQVAGQDMVKAVLSRAAAEDRPAAAYLLSGTRGVGKTTIARIFAKALNCEHSPGPEPCNECAQCR
KITQGVHVDVTEIDGASNNSVEDARSLRETIGYAAMEGRYKVFIIDEAHMLTRNAFNALLKTLEEPPERVVFIFATTEAH
KFPVTIVSRCQHFVFRHLSKDALVEHLSGVLRKENVTFEDSAVRLLARRAAGSVRDSMSLLDQTLALGGEQLTAAATRQV
LGLAGQEMFAELFEALHAQDCPAVAGLCRQILQQGVDIGFFVRELAGNLRNLFLLRQGGAAVASSLQLPADEAALWQGLA
PRFSTAHLHAAWQMTLDAQRGIVQSPEPAAALELLLLNLALLPQLLPVGQVTPDQMPAGPPGAAPADANQPPSGSTSGPA
SSMPHGGYRSGQPPHAGAEAARHNAGTPDDAPAASGMGKSAARPRATTTAARPTTDGEEAETPDPAPACDHSRNQPSGQD
ENLTRGQNSPHSNQGRHPDKSHTSDQRDVRAEGRTTPPYSAHRRAPGNGFSTPPDAPQDGAPAQTPHTEAPGPDMDGAPW
TGQDEDYAPYEDDALTESPVAQNWPGRRNATRRTDSSGQSATGQDRRDRQTQQDAPAAAPASPGGRSRNWQNFYDFCVAE
QAASRPVPAPYVLRGIGVDWQGSTLRLQPRTETQLHQLEKQAKALYAALAAYGAPETQVEIIAPKPHRPEADLIAEFSRK
EELQPCFEVLNASLKGCRPID

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=278, Percent_Identity=23.3812949640288, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI31881687, Length=278, Percent_Identity=23.3812949640288, Blast_Score=74, Evalue=7e-13,
Organism=Escherichia coli, GI1786676, Length=369, Percent_Identity=39.5663956639566, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI18859927, Length=235, Percent_Identity=26.3829787234043, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 79446; Mature: 79446

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLSLASRYRPQTFAQVAGQDMVKAVLSRAAAEDRPAAAYLLSGTRGVGKTTIARIFAK
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHEECCCCCCHHHHHHHHHHH
ALNCEHSPGPEPCNECAQCRKITQGVHVDVTEIDGASNNSVEDARSLRETIGYAAMEGRY
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
KVFIIDEAHMLTRNAFNALLKTLEEPPERVVFIFATTEAHKFPVTIVSRCQHFVFRHLSK
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCH
DALVEHLSGVLRKENVTFEDSAVRLLARRAAGSVRDSMSLLDQTLALGGEQLTAAATRQV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGLAGQEMFAELFEALHAQDCPAVAGLCRQILQQGVDIGFFVRELAGNLRNLFLLRQGGA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEHCCCCCH
AVASSLQLPADEAALWQGLAPRFSTAHLHAAWQMTLDAQRGIVQSPEPAAALELLLLNLA
HHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHEEHHHHCCCCCCCCHHHHHHHHHHHHH
LLPQLLPVGQVTPDQMPAGPPGAAPADANQPPSGSTSGPASSMPHGGYRSGQPPHAGAEA
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ARHNAGTPDDAPAASGMGKSAARPRATTTAARPTTDGEEAETPDPAPACDHSRNQPSGQD
HHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ENLTRGQNSPHSNQGRHPDKSHTSDQRDVRAEGRTTPPYSAHRRAPGNGFSTPPDAPQDG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCC
APAQTPHTEAPGPDMDGAPWTGQDEDYAPYEDDALTESPVAQNWPGRRNATRRTDSSGQS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATGQDRRDRQTQQDAPAAAPASPGGRSRNWQNFYDFCVAEQAASRPVPAPYVLRGIGVDW
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCC
QGSTLRLQPRTETQLHQLEKQAKALYAALAAYGAPETQVEIIAPKPHRPEADLIAEFSRK
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHH
EELQPCFEVLNASLKGCRPID
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKHLSLASRYRPQTFAQVAGQDMVKAVLSRAAAEDRPAAAYLLSGTRGVGKTTIARIFAK
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHEECCCCCCHHHHHHHHHHH
ALNCEHSPGPEPCNECAQCRKITQGVHVDVTEIDGASNNSVEDARSLRETIGYAAMEGRY
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
KVFIIDEAHMLTRNAFNALLKTLEEPPERVVFIFATTEAHKFPVTIVSRCQHFVFRHLSK
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCH
DALVEHLSGVLRKENVTFEDSAVRLLARRAAGSVRDSMSLLDQTLALGGEQLTAAATRQV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGLAGQEMFAELFEALHAQDCPAVAGLCRQILQQGVDIGFFVRELAGNLRNLFLLRQGGA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEHCCCCCH
AVASSLQLPADEAALWQGLAPRFSTAHLHAAWQMTLDAQRGIVQSPEPAAALELLLLNLA
HHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHEEHHHHCCCCCCCCHHHHHHHHHHHHH
LLPQLLPVGQVTPDQMPAGPPGAAPADANQPPSGSTSGPASSMPHGGYRSGQPPHAGAEA
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ARHNAGTPDDAPAASGMGKSAARPRATTTAARPTTDGEEAETPDPAPACDHSRNQPSGQD
HHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ENLTRGQNSPHSNQGRHPDKSHTSDQRDVRAEGRTTPPYSAHRRAPGNGFSTPPDAPQDG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCC
APAQTPHTEAPGPDMDGAPWTGQDEDYAPYEDDALTESPVAQNWPGRRNATRRTDSSGQS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATGQDRRDRQTQQDAPAAAPASPGGRSRNWQNFYDFCVAEQAASRPVPAPYVLRGIGVDW
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCC
QGSTLRLQPRTETQLHQLEKQAKALYAALAAYGAPETQVEIIAPKPHRPEADLIAEFSRK
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHH
EELQPCFEVLNASLKGCRPID
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]