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The map label for this gene is aroE [H]

Identifier: 220905358

GI number: 220905358

Start: 2525904

End: 2526830

Strand: Direct

Name: aroE [H]

Synonym: Ddes_2096

Alternate gene names: 220905358

Gene position: 2525904-2526830 (Clockwise)

Preceding gene: 220905357

Following gene: 220905359

Centisome position: 87.91

GC content: 65.05

Gene sequence:

>927_bases
ATGAATGCCGTAACAGCAGAAGCCAGCATTCCCGCAGCCACGCACGCTCCCGCCCCGGGCATCGGTCGGGACGGGGCAGA
CGCGCTCCTGTACGGTGTTGTGGGCTGGCCGCTGACGCAGAGCCTTTCTCCCCTGCTGCACAATACCGGCTTCAAGACTC
TCGGCCTGCCCGGTCTTTATCTGCGGTGGGAAGTACCGCCGCAGCGGCTGGCCGCATTTGTGGACAGCGTGCGCCTGCTC
AACATCCGCGGCTGCTCCGTTACCATTCCGCACAAAGTTGCCCTGCTGCCCCTGCTGGATGAGGTCAGCCCTCTGGCCCG
GCGTGTGGGCGCGGTCAACACCATCTACTGGCGTGGCGGTCTGCTTTACGGCGACAATACTGATGTCGCGGGGTTTATGG
CCCCGCTGGCGCAGGAAGCGCTTGGCGGCGCGAATGTGCTTGTTCTGGGCGCAGGCGGCGCGGCCCGGGCCGTGGCGGCC
GGTCTGACTGCCCTTGAGCCGGGCAGCAGGCCCGAAAATATTTATGTGGCTACACCCTCCGACCGTTCGCACCTGCCCCT
GGCCGAAGAATTCGGCCTGAAGCCGCTGAACTGGAGCCGCCGCCACGATGTGCCGGCGCTTCTGGTCGTCAATACCACTC
CCCTGGGCATGCGGGGCAAGGCCGAAGGCGAAAGCCCCTATTCATTTGAGACCACAGGTAAAAACCTGGGGCCACATGCT
GCCGGGGCAACGGCCATTGCCTATGATATTGTATATAACCCGTTGAAAACACGCTTCTTGCAGGAGGCCGCCCGGGCGGG
CAGGCGCTGCCTGACGGGGCTGGACATGTTTTTCGGTCAGGGAGATGCCCAGTTCCGCCTGTGGACGGGCCAGCCCCTGC
CCCTGAACGCGCGGCACGCGCTGGAGACCGCGCTGGCCGCAAGCTAG

Upstream 100 bases:

>100_bases
CATGCGTTATGCTGCGCCATATTTTTATCCGCAAAGATACCGTCTGCCGCGCCTCCCGCAGGCAGGCAATACGGAAACCG
CAGGAACGGAGAGCCGGACA

Downstream 100 bases:

>100_bases
GGCATGGCGCCTCTAAAAGTGCGGGGTCTCAACAGATTGCAGACGCCGCCACAGCGCTGAGCAGTACAAGTGCACTACGG
TGCGCCGTTACCGCAATGCC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNAVTAEASIPAATHAPAPGIGRDGADALLYGVVGWPLTQSLSPLLHNTGFKTLGLPGLYLRWEVPPQRLAAFVDSVRLL
NIRGCSVTIPHKVALLPLLDEVSPLARRVGAVNTIYWRGGLLYGDNTDVAGFMAPLAQEALGGANVLVLGAGGAARAVAA
GLTALEPGSRPENIYVATPSDRSHLPLAEEFGLKPLNWSRRHDVPALLVVNTTPLGMRGKAEGESPYSFETTGKNLGPHA
AGATAIAYDIVYNPLKTRFLQEAARAGRRCLTGLDMFFGQGDAQFRLWTGQPLPLNARHALETALAAS

Sequences:

>Translated_308_residues
MNAVTAEASIPAATHAPAPGIGRDGADALLYGVVGWPLTQSLSPLLHNTGFKTLGLPGLYLRWEVPPQRLAAFVDSVRLL
NIRGCSVTIPHKVALLPLLDEVSPLARRVGAVNTIYWRGGLLYGDNTDVAGFMAPLAQEALGGANVLVLGAGGAARAVAA
GLTALEPGSRPENIYVATPSDRSHLPLAEEFGLKPLNWSRRHDVPALLVVNTTPLGMRGKAEGESPYSFETTGKNLGPHA
AGATAIAYDIVYNPLKTRFLQEAARAGRRCLTGLDMFFGQGDAQFRLWTGQPLPLNARHALETALAAS
>Mature_308_residues
MNAVTAEASIPAATHAPAPGIGRDGADALLYGVVGWPLTQSLSPLLHNTGFKTLGLPGLYLRWEVPPQRLAAFVDSVRLL
NIRGCSVTIPHKVALLPLLDEVSPLARRVGAVNTIYWRGGLLYGDNTDVAGFMAPLAQEALGGANVLVLGAGGAARAVAA
GLTALEPGSRPENIYVATPSDRSHLPLAEEFGLKPLNWSRRHDVPALLVVNTTPLGMRGKAEGESPYSFETTGKNLGPHA
AGATAIAYDIVYNPLKTRFLQEAARAGRRCLTGLDMFFGQGDAQFRLWTGQPLPLNARHALETALAAS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=286, Percent_Identity=30.4195804195804, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789675, Length=264, Percent_Identity=28.4090909090909, Blast_Score=78, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320332, Length=288, Percent_Identity=30.2083333333333, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 32522; Mature: 32522

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTAEASIPAATHAPAPGIGRDGADALLYGVVGWPLTQSLSPLLHNTGFKTLGLPGLY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCCEE
LRWEVPPQRLAAFVDSVRLLNIRGCSVTIPHKVALLPLLDEVSPLARRVGAVNTIYWRGG
EEECCCHHHHHHHHHCEEEEEECCCEEECCCCEEEHHHHHHHHHHHHHHCCCEEEEEECE
LLYGDNTDVAGFMAPLAQEALGGANVLVLGAGGAARAVAAGLTALEPGSRPENIYVATPS
EEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCHHHCCCCCCCCEEEEECCC
DRSHLPLAEEFGLKPLNWSRRHDVPALLVVNTTPLGMRGKAEGESPYSFETTGKNLGPHA
CCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCC
AGATAIAYDIVYNPLKTRFLQEAARAGRRCLTGLDMFFGQGDAQFRLWTGQPLPLNARHA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
LETALAAS
HHHHHHCC
>Mature Secondary Structure
MNAVTAEASIPAATHAPAPGIGRDGADALLYGVVGWPLTQSLSPLLHNTGFKTLGLPGLY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCCEE
LRWEVPPQRLAAFVDSVRLLNIRGCSVTIPHKVALLPLLDEVSPLARRVGAVNTIYWRGG
EEECCCHHHHHHHHHCEEEEEECCCEEECCCCEEEHHHHHHHHHHHHHHCCCEEEEEECE
LLYGDNTDVAGFMAPLAQEALGGANVLVLGAGGAARAVAAGLTALEPGSRPENIYVATPS
EEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCHHHCCCCCCCCEEEEECCC
DRSHLPLAEEFGLKPLNWSRRHDVPALLVVNTTPLGMRGKAEGESPYSFETTGKNLGPHA
CCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCC
AGATAIAYDIVYNPLKTRFLQEAARAGRRCLTGLDMFFGQGDAQFRLWTGQPLPLNARHA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
LETALAAS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA