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The map label for this gene is adk

Identifier: 220905218

GI number: 220905218

Start: 2359896

End: 2360567

Strand: Direct

Name: adk

Synonym: Ddes_1956

Alternate gene names: 220905218

Gene position: 2359896-2360567 (Clockwise)

Preceding gene: 220905217

Following gene: 220905219

Centisome position: 82.13

GC content: 53.87

Gene sequence:

>672_bases
GTGAACATTCTGATTTTCGGCCCCAACGGCAGCGGCAAAGGCACTCAAGGCGATCTTATCAAGCAGAAGTACAATCTCGC
CCACATCGAATCCGGCGCCATCTTCCGTGAACACATCGGCGGCGGTACGGAACTGGGCAAGAAAGCCAAGGCCTATATTG
ACCGTGGCGACCTTGTGCCCGACGAAATCACCATTCCTATGGTTCTTGAAACCCTGAAGACCAAAGGCCAGCACGGCTGG
CTGCTGGATGGTTTTCCCCGCAATATGGTGCAGGCCGAAAAACTGTGGGAAGCCCTGCAGAAAGAAGGCATGCGCCTTGA
CTACGTGGTAGAAATCCTGCTGCCCCGCGAAACGGCAAAAAACCGTATCATGGGCCGCCGCCTGTGCAAGAACAACAATA
ACCACCCCAACAATATTTTCATTGAGGCCATCAAGCCCAATGGCGATGTCTGTCGCGTCTGTGGCGGTACCCTTTCGAGC
CGGTCCGATGACCAGGACGAAACCGCCATCAACAAGCGCCACGATATTTACTACAACACCACCGATGGAACCCTGGCCGC
CGCCTATTTCTTCAAAAAGCTGGCTGATCAGGGCAAAACCAAATACATTGAGCTTAACGGCGAAGGCAGCATCGAATCCA
TCAAGGAAACCCTGCTGTCCAAGCTGGCCTAA

Upstream 100 bases:

>100_bases
TCTTCCTGCCTCCCGTTGACAGGAGCGGCTTTAGGGTCTAGGTTGGCGATGTGTTCTTTTTTGCACAATCAAAATTGCGG
TTCCGCCAAGGAGAGTGACG

Downstream 100 bases:

>100_bases
CGGCCTTTCCGGCACGGGCTGCGAGCTGGTTTCACTGAAAAGCAGCCTGTGCAAAACCCGCCCCGATGACCGCAAAAAAA
GATTCCCGCAGACCATGCGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNILIFGPNGSGKGTQGDLIKQKYNLAHIESGAIFREHIGGGTELGKKAKAYIDRGDLVPDEITIPMVLETLKTKGQHGW
LLDGFPRNMVQAEKLWEALQKEGMRLDYVVEILLPRETAKNRIMGRRLCKNNNNHPNNIFIEAIKPNGDVCRVCGGTLSS
RSDDQDETAINKRHDIYYNTTDGTLAAAYFFKKLADQGKTKYIELNGEGSIESIKETLLSKLA

Sequences:

>Translated_223_residues
MNILIFGPNGSGKGTQGDLIKQKYNLAHIESGAIFREHIGGGTELGKKAKAYIDRGDLVPDEITIPMVLETLKTKGQHGW
LLDGFPRNMVQAEKLWEALQKEGMRLDYVVEILLPRETAKNRIMGRRLCKNNNNHPNNIFIEAIKPNGDVCRVCGGTLSS
RSDDQDETAINKRHDIYYNTTDGTLAAAYFFKKLADQGKTKYIELNGEGSIESIKETLLSKLA
>Mature_223_residues
MNILIFGPNGSGKGTQGDLIKQKYNLAHIESGAIFREHIGGGTELGKKAKAYIDRGDLVPDEITIPMVLETLKTKGQHGW
LLDGFPRNMVQAEKLWEALQKEGMRLDYVVEILLPRETAKNRIMGRRLCKNNNNHPNNIFIEAIKPNGDVCRVCGGTLSS
RSDDQDETAINKRHDIYYNTTDGTLAAAYFFKKLADQGKTKYIELNGEGSIESIKETLLSKLA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=36, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4502013, Length=179, Percent_Identity=35.195530726257, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI7524346, Length=179, Percent_Identity=35.195530726257, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI310110345, Length=170, Percent_Identity=36.4705882352941, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI53832003, Length=170, Percent_Identity=36.4705882352941, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI8051579, Length=170, Percent_Identity=36.4705882352941, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI53832001, Length=170, Percent_Identity=36.4705882352941, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4502011, Length=214, Percent_Identity=30.3738317757009, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI28144899, Length=214, Percent_Identity=25.7009345794392, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI28144897, Length=214, Percent_Identity=25.7009345794392, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1786680, Length=223, Percent_Identity=35.4260089686099, Blast_Score=126, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17552384, Length=182, Percent_Identity=36.8131868131868, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=222, Percent_Identity=29.2792792792793, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17567503, Length=223, Percent_Identity=27.8026905829596, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17533833, Length=88, Percent_Identity=38.6363636363636, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=196, Percent_Identity=34.1836734693878, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321018, Length=181, Percent_Identity=35.3591160220994, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI22026816, Length=182, Percent_Identity=38.4615384615385, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17737899, Length=183, Percent_Identity=35.5191256830601, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24645822, Length=183, Percent_Identity=35.5191256830601, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221459597, Length=125, Percent_Identity=29.6, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356893, Length=125, Percent_Identity=29.6, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_DESDA (B8J2T3)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480530.1
- GeneID:   7285672
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1956
- HOGENOM:   HBG630208
- ProtClustDB:   PRK14529
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 24851; Mature: 24851

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIFGPNGSGKGTQGDLIKQKYNLAHIESGAIFREHIGGGTELGKKAKAYIDRGDLVP
CEEEEECCCCCCCCCCCHHHHHHHCCEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCC
DEITIPMVLETLKTKGQHGWLLDGFPRNMVQAEKLWEALQKEGMRLDYVVEILLPRETAK
CCCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEHHHEECCCCHHHH
NRIMGRRLCKNNNNHPNNIFIEAIKPNGDVCRVCGGTLSSRSDDQDETAINKRHDIYYNT
HHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHCCCCCEEEEC
TDGTLAAAYFFKKLADQGKTKYIELNGEGSIESIKETLLSKLA
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNILIFGPNGSGKGTQGDLIKQKYNLAHIESGAIFREHIGGGTELGKKAKAYIDRGDLVP
CEEEEECCCCCCCCCCCHHHHHHHCCEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCC
DEITIPMVLETLKTKGQHGWLLDGFPRNMVQAEKLWEALQKEGMRLDYVVEILLPRETAK
CCCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEHHHEECCCCHHHH
NRIMGRRLCKNNNNHPNNIFIEAIKPNGDVCRVCGGTLSSRSDDQDETAINKRHDIYYNT
HHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHCCCCCEEEEC
TDGTLAAAYFFKKLADQGKTKYIELNGEGSIESIKETLLSKLA
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA