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The map label for this gene is trmI [H]

Identifier: 220905181

GI number: 220905181

Start: 2312935

End: 2313843

Strand: Direct

Name: trmI [H]

Synonym: Ddes_1919

Alternate gene names: 220905181

Gene position: 2312935-2313843 (Clockwise)

Preceding gene: 220905180

Following gene: 220905183

Centisome position: 80.49

GC content: 62.16

Gene sequence:

>909_bases
ATGATTCCCTACGGTTCTCTTGTTGTCTATGTGACCCCCAAGGGCCGCCGCTATACCAAAAAACTGACCGAAGGTCAGGA
CTGGCACAGCAATGACGGCGCTTTGTCGGCCGCTGATGTGGCCCGCTGCGACTTTGGCAGCGTGATCTACACCAACCAGC
AAGTGCCCATACAGGTCATGGAAGCTACCCTTTATGACCGCCTCAAGACGCTCAAACGCCAGACACAGATCATCTACCCC
AAAGATATCGCCTATATCTGCCTGCGCCTAGGGGCCGGACCGGGCCGCACCATCATTGAAGCGGGCTGCGGCTCCGGGGG
CCTGACAACAGGCCTTTCATGGTTCTGCGGTCCCACGGGGCGCGTGGTCAGCCACGAGGCCCGCGAAGAATTTATGGCGT
TGGCCCGCCGCAATCTTGAGTGGGCAGGCGTGGGCCAGAACGTGGAGCTGCACCACCGCGATGTGGCCGAAGGCTTTGCC
GTTACCGGCGCGGACGCGCTCTTTCTGGACGTGCGCACGCCCTGGGAATATCTGGACCATGCACTTGCGGCCGTGCGCCC
CGGCGCAAGTTTCGGCTTTTTGCTGCCCACAGTGGATCAGGTGAGCAAGCTTTTGCTGGGCCTTGAGCGCGGCCCCTTTG
CCGATGTGGAAGTCTGCGAGATTCTCATTCGCCGCTGGAAGCCGGTGGCCGACCGCCTGCGCCCCGAAGACCGCATGAAC
GCCCACACGGGCTTTCTGGTCTTTGCCCGCCAGCAGGAGCGCAATCAGGACTTTGAATCGCGCAAGCCCCTCGGCACACG
TGAACGCAAACAGGAAGCCGCACGTCTGGCCCGGCTGGGGCTGGATAACGCCGCCCCGCAGGACGGCGCAGCCGCACGGG
ATATGACAGAAGACCAGAATCTGGCATAG

Upstream 100 bases:

>100_bases
ACCCCGGCGCAGACCGGAGCCGTGTTTTTACAGAGGGGGCCGCACGGCCCCCTCATGATGCCCGATACCGCGCGTCAGCG
CCGCAACACAAAGGAAATTC

Downstream 100 bases:

>100_bases
CGCCCGCCCCTGTTGCGGGCAAACCCGGCACGATGATGTTTTTCACGCAACAAATGGATATTATGTAATAAAAACCCCGC
TCCGGCAGGACTGTGCACAA

Product: tRNA methyltransferase complex GCD14 subunit

Products: NA

Alternate protein names: tRNA(m1A58)-methyltransferase; tRNA(m1A58)MTase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIPYGSLVVYVTPKGRRYTKKLTEGQDWHSNDGALSAADVARCDFGSVIYTNQQVPIQVMEATLYDRLKTLKRQTQIIYP
KDIAYICLRLGAGPGRTIIEAGCGSGGLTTGLSWFCGPTGRVVSHEAREEFMALARRNLEWAGVGQNVELHHRDVAEGFA
VTGADALFLDVRTPWEYLDHALAAVRPGASFGFLLPTVDQVSKLLLGLERGPFADVEVCEILIRRWKPVADRLRPEDRMN
AHTGFLVFARQQERNQDFESRKPLGTRERKQEAARLARLGLDNAAPQDGAAARDMTEDQNLA

Sequences:

>Translated_302_residues
MIPYGSLVVYVTPKGRRYTKKLTEGQDWHSNDGALSAADVARCDFGSVIYTNQQVPIQVMEATLYDRLKTLKRQTQIIYP
KDIAYICLRLGAGPGRTIIEAGCGSGGLTTGLSWFCGPTGRVVSHEAREEFMALARRNLEWAGVGQNVELHHRDVAEGFA
VTGADALFLDVRTPWEYLDHALAAVRPGASFGFLLPTVDQVSKLLLGLERGPFADVEVCEILIRRWKPVADRLRPEDRMN
AHTGFLVFARQQERNQDFESRKPLGTRERKQEAARLARLGLDNAAPQDGAAARDMTEDQNLA
>Mature_302_residues
MIPYGSLVVYVTPKGRRYTKKLTEGQDWHSNDGALSAADVARCDFGSVIYTNQQVPIQVMEATLYDRLKTLKRQTQIIYP
KDIAYICLRLGAGPGRTIIEAGCGSGGLTTGLSWFCGPTGRVVSHEAREEFMALARRNLEWAGVGQNVELHHRDVAEGFA
VTGADALFLDVRTPWEYLDHALAAVRPGASFGFLLPTVDQVSKLLLGLERGPFADVEVCEILIRRWKPVADRLRPEDRMN
AHTGFLVFARQQERNQDFESRKPLGTRERKQEAARLARLGLDNAAPQDGAAARDMTEDQNLA

Specific function: Catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. Is required for cell growth at extreme temperatures [H]

COG id: COG2519

COG function: function code J; tRNA(1-methyladenosine) methyltransferase and related methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TrmI family [H]

Homologues:

Organism=Homo sapiens, GI123173772, Length=241, Percent_Identity=27.8008298755187, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI222831587, Length=243, Percent_Identity=27.9835390946502, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17509459, Length=169, Percent_Identity=31.9526627218935, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322336, Length=221, Percent_Identity=28.0542986425339, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24650257, Length=251, Percent_Identity=27.8884462151394, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014816 [H]

Pfam domain/function: PF08704 GCD14 [H]

EC number: =2.1.1.36 [H]

Molecular weight: Translated: 33540; Mature: 33540

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPYGSLVVYVTPKGRRYTKKLTEGQDWHSNDGALSAADVARCDFGSVIYTNQQVPIQVM
CCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCEEHHHHHHCCCCCEEEECCCCCHHHH
EATLYDRLKTLKRQTQIIYPKDIAYICLRLGAGPGRTIIEAGCGSGGLTTGLSWFCGPTG
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHCCHHHCCCCC
RVVSHEAREEFMALARRNLEWAGVGQNVELHHRDVAEGFAVTGADALFLDVRTPWEYLDH
CHHHHHHHHHHHHHHHCCCCEECCCCCCEECHHHHHCCCEECCCCEEEEECCCCHHHHHH
ALAAVRPGASFGFLLPTVDQVSKLLLGLERGPFADVEVCEILIRRWKPVADRLRPEDRMN
HHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHCC
AHTGFLVFARQQERNQDFESRKPLGTRERKQEAARLARLGLDNAAPQDGAAARDMTEDQN
CCCCEEEEEECHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCC
LA
CC
>Mature Secondary Structure
MIPYGSLVVYVTPKGRRYTKKLTEGQDWHSNDGALSAADVARCDFGSVIYTNQQVPIQVM
CCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCEEHHHHHHCCCCCEEEECCCCCHHHH
EATLYDRLKTLKRQTQIIYPKDIAYICLRLGAGPGRTIIEAGCGSGGLTTGLSWFCGPTG
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHCCHHHCCCCC
RVVSHEAREEFMALARRNLEWAGVGQNVELHHRDVAEGFAVTGADALFLDVRTPWEYLDH
CHHHHHHHHHHHHHHHCCCCEECCCCCCEECHHHHHCCCEECCCCEEEEECCCCHHHHHH
ALAAVRPGASFGFLLPTVDQVSKLLLGLERGPFADVEVCEILIRRWKPVADRLRPEDRMN
HHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHCC
AHTGFLVFARQQERNQDFESRKPLGTRERKQEAARLARLGLDNAAPQDGAAARDMTEDQN
CCCCEEEEEECHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCC
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA