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The map label for this gene is 220905152

Identifier: 220905152

GI number: 220905152

Start: 2279144

End: 2280214

Strand: Reverse

Name: 220905152

Synonym: Ddes_1890

Alternate gene names: NA

Gene position: 2280214-2279144 (Counterclockwise)

Preceding gene: 220905156

Following gene: 220905151

Centisome position: 79.35

GC content: 56.12

Gene sequence:

>1071_bases
ATGAAACTCATGGATATATTTGCTGTTCCTGCCCCCGAAGTGTGTATTCCCGTCCCCTATGTGATTGCCGAAGCCGGGGT
GAACCATGAGGGCAGCATGGACATTGCCCGCAGGCTCATTGACGAAGCCGCCGAAGGCGGCGCGCAGGCCATCAAGTTTC
AGACCTACAAGGCGGGAACCCTGGCCTCCAAGGATTCTCCGGCCTACTGGGACACCAGCAAGGAACCCACCCGGAGCCAG
TACGAGCTGTTTAAAAAGCATGATTCGTTCTGGAAAAATGAATTTGAAGCTCTCAAAAAATACTGTGATGCGGCGGGCAT
TGCCTTCATGTCCACGCCGTTTGATGTTGAATCAGCCCATTTTCTCAATGATCTTATGGATGTGTTCAAGATTTCCTCAT
CGGATATCACTAACAAGCCCTTTATTCGCATTCTCTGCGATTTCGACAAGCCCATCCTGCTTTCCACAGGTGCGGCCCAC
CTGCACGAAATTGCCGAAGCTGTGGAATGGATCGAGGCAAAAGGCAACAAGCTTGCCCTGCTGCATTGTGTGCTCAACTA
TCCCACGGCAGACGAAAACGCGGCTCTGGGCATGATTCCGGCTCTCGCCCGCCACTTTCCGCAGCATGCCATCGGCTATT
CCGACCACACCCTGCCCAGGGACATGCATATTCTTGAAACAGCCACCCTGCTGGGCGCCCGAGTGCTTGAGAAGCATTTT
ACCCACGACAAGTCCCTGCCGGGTAATGACCATTACCACGCTATGGACAAGAATGACCTGCGTCGTTTCTTTGAAAGGCT
TAACGCCACTCTTGCTAGTGTGGGCGACCTGAGCCTGCGCGCCCTGCCGGAAGAAGAACCTGCCAGGCAGCATGCCCGAC
GCTCTCTGGTTACGGCGCGGGCCATACCTGCCGGTACGCCTGTCACCGCCGCCGACCTGACATGGAAGCGCCCGGCCCAC
GGCATCTCGCCGCGTAATTATGACGAGGTGCTGGGCATGCGCGCCCGCCACGATCTGGCGGAAGACACGGTGCTGCACTG
GTCTGATCTGGAAAACGGACACAAGGGTTAA

Upstream 100 bases:

>100_bases
TATTCAATATGATTATGTGCTGTGCCTCGCTGCGCTGCTTTTCTTTTGCCCGGCAAGGGAGTATACTGAAACCCTAAAAT
TCACCAGTGAGGAAATGAGC

Downstream 100 bases:

>100_bases
TCATGGATCACGGGCGCAGCATACTCGTTCTTGGGCGCATGCCCCGGGGGGCAGAACCGGAAACGCACCGGCCTGCCGGG
CCTTGGTGCTTTGTAGAGCA

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKLMDIFAVPAPEVCIPVPYVIAEAGVNHEGSMDIARRLIDEAAEGGAQAIKFQTYKAGTLASKDSPAYWDTSKEPTRSQ
YELFKKHDSFWKNEFEALKKYCDAAGIAFMSTPFDVESAHFLNDLMDVFKISSSDITNKPFIRILCDFDKPILLSTGAAH
LHEIAEAVEWIEAKGNKLALLHCVLNYPTADENAALGMIPALARHFPQHAIGYSDHTLPRDMHILETATLLGARVLEKHF
THDKSLPGNDHYHAMDKNDLRRFFERLNATLASVGDLSLRALPEEEPARQHARRSLVTARAIPAGTPVTAADLTWKRPAH
GISPRNYDEVLGMRARHDLAEDTVLHWSDLENGHKG

Sequences:

>Translated_356_residues
MKLMDIFAVPAPEVCIPVPYVIAEAGVNHEGSMDIARRLIDEAAEGGAQAIKFQTYKAGTLASKDSPAYWDTSKEPTRSQ
YELFKKHDSFWKNEFEALKKYCDAAGIAFMSTPFDVESAHFLNDLMDVFKISSSDITNKPFIRILCDFDKPILLSTGAAH
LHEIAEAVEWIEAKGNKLALLHCVLNYPTADENAALGMIPALARHFPQHAIGYSDHTLPRDMHILETATLLGARVLEKHF
THDKSLPGNDHYHAMDKNDLRRFFERLNATLASVGDLSLRALPEEEPARQHARRSLVTARAIPAGTPVTAADLTWKRPAH
GISPRNYDEVLGMRARHDLAEDTVLHWSDLENGHKG
>Mature_356_residues
MKLMDIFAVPAPEVCIPVPYVIAEAGVNHEGSMDIARRLIDEAAEGGAQAIKFQTYKAGTLASKDSPAYWDTSKEPTRSQ
YELFKKHDSFWKNEFEALKKYCDAAGIAFMSTPFDVESAHFLNDLMDVFKISSSDITNKPFIRILCDFDKPILLSTGAAH
LHEIAEAVEWIEAKGNKLALLHCVLNYPTADENAALGMIPALARHFPQHAIGYSDHTLPRDMHILETATLLGARVLEKHF
THDKSLPGNDHYHAMDKNDLRRFFERLNATLASVGDLSLRALPEEEPARQHARRSLVTARAIPAGTPVTAADLTWKRPAH
GISPRNYDEVLGMRARHDLAEDTVLHWSDLENGHKG

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=335, Percent_Identity=27.7611940298507, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21357081, Length=349, Percent_Identity=29.7994269340974, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 39696; Mature: 39696

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLMDIFAVPAPEVCIPVPYVIAEAGVNHEGSMDIARRLIDEAAEGGAQAIKFQTYKAGT
CCCHHEECCCCCCHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHEEEEEEECCCC
LASKDSPAYWDTSKEPTRSQYELFKKHDSFWKNEFEALKKYCDAAGIAFMSTPFDVESAH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHH
FLNDLMDVFKISSSDITNKPFIRILCDFDKPILLSTGAAHLHEIAEAVEWIEAKGNKLAL
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEE
LHCVLNYPTADENAALGMIPALARHFPQHAIGYSDHTLPRDMHILETATLLGARVLEKHF
EEEEECCCCCCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
THDKSLPGNDHYHAMDKNDLRRFFERLNATLASVGDLSLRALPEEEPARQHARRSLVTAR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
AIPAGTPVTAADLTWKRPAHGISPRNYDEVLGMRARHDLAEDTVLHWSDLENGHKG
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEHHHCCCCCCC
>Mature Secondary Structure
MKLMDIFAVPAPEVCIPVPYVIAEAGVNHEGSMDIARRLIDEAAEGGAQAIKFQTYKAGT
CCCHHEECCCCCCHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHEEEEEEECCCC
LASKDSPAYWDTSKEPTRSQYELFKKHDSFWKNEFEALKKYCDAAGIAFMSTPFDVESAH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHH
FLNDLMDVFKISSSDITNKPFIRILCDFDKPILLSTGAAHLHEIAEAVEWIEAKGNKLAL
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEE
LHCVLNYPTADENAALGMIPALARHFPQHAIGYSDHTLPRDMHILETATLLGARVLEKHF
EEEEECCCCCCCCCHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
THDKSLPGNDHYHAMDKNDLRRFFERLNATLASVGDLSLRALPEEEPARQHARRSLVTAR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
AIPAGTPVTAADLTWKRPAHGISPRNYDEVLGMRARHDLAEDTVLHWSDLENGHKG
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]