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The map label for this gene is guaA [H]

Identifier: 220905069

GI number: 220905069

Start: 2180668

End: 2182203

Strand: Direct

Name: guaA [H]

Synonym: Ddes_1806

Alternate gene names: 220905069

Gene position: 2180668-2182203 (Clockwise)

Preceding gene: 220905068

Following gene: 220905070

Centisome position: 75.89

GC content: 60.42

Gene sequence:

>1536_bases
ATGCCCAGCAAGGTCATTATAATAGACTACGGCTCACAGGTTACCCAGCTTATCGCACGCCGTGTGCGTGAGGCCGGGGT
ATACTCCGAAATTCATTCCTGCGTGACCACCGCCCAGCAGGTGGCCGCCATGAAGCCCCAGGCCATCATCCTTTCCGGCG
GCCCCGCCAGCGTGGGCGAAGCCGACGCACCGGCGCTGGACCCCGGTTTTCTTGAACTGGGTGTGCCCGTGCTCGGCATC
TGCTATGGCATGCAGCTTCTGGCCCGCGAGATGGGCGGGCAGCTGGCCCAGTCTCTCACGCGCGAATACGGCCCGGCCGA
CCTCAATTTCACCGCACCCTGCGCCCTGTGGGAAGGTATCACCGCACCCACCCGCGTATGGATGAGCCATGGCGACAAGG
TGATGGCCCCGCCGCCCGGCTTTACGGTTACTGGCAGCACCAGCACCCTTGAAGTGGCCGCCATGGCCGATGAGACCCGC
AAAATCTACGCCGTGCAGTTCCATCCCGAAGTGCACCACAGCGTGGACGGCGAGCGCATGCTGCACAACTTCCTGTTCAA
GGTCACGGGCATCAAGCCCGACTGGACCATGTCCTCCTTTGTGGAGCGCGTAGTCAAGGAAATGGCCGAGCAGGTGGGCG
ACAAGCACGTGGTCTGCGCCCTTTCGGGCGGTATCGACTCCACAGTGGTGGCCGTGCTGCTGCACAGGGCCATAGGCAAG
CGCCTGCACTGCATCTTTGTGGACAACGGCCTGCTGCGTCTTGGCGAAGGTGATGAGGTGGTCAGCTACCTGCGCGAGCA
TTTTGACCTCAACCTCAACTTCGTGCAGGCGCAGGAGCGCTTTCTTTCCAAGCTCAAAGGCGTGGAAGACCCCGAAAAGA
AACGCAAAATCATCGGCCACACCTTTATTGAAATTTTTGATGAAGAAGCCAACAAGCTGGATCAGGTGGACTTTCTGGCT
CAGGGAACCCTGTATCCCGACGTCATTGAATCCATTTCCCACAAGGGACCCAGCGCCGTCATCAAGAGTCACCACAATGT
GGGCGGCCTGCCCGACACAATGAAGCTCAAGCTTATTGAACCCCTGCGTGAACTCTTCAAGGACGAAGTGCGCAAAGTGG
CGGCCGAACTCGGCATGCCCGACTCCATCGTGTGGCGGCATCCCTTCCCTGGTCCCGGCCTTGCCATCCGTGTGCTTGGC
GAAGTGAGCGAAGAACGCCTCAACATCCTGCGCCAGGCCGACAGGATCGTGCAGCAGGAACTGCGCGAATCCGGCTGGTA
TCGTAAGGTCTGGCAGGGCTTTGCCGTGCTGCTACCCCTCAAGACCGTGGGCGTTATGGGCGACGGGCGCACCTATGAAC
ATGTGGTGGCCCTGCGCGTGGTCGACAGCGTTGACGCCATGACAGCAGACTGGGCGCGCCTGCCCGCTGATCTCATCGAG
CGCATGTCGGGCCGCATCATCAATGAAGTCAAGGGCGTCAACCGTGTGGTTTACGATGTGTCCTCCAAACCGCCCAGCAC
CATTGAATGGGAATAG

Upstream 100 bases:

>100_bases
GCATTGAGAACTAGGGCCGCTGCGCCGCAAGGCGTACGCCGTGCAGACAGGCAACCGGCGCGTCCCGGCGCGCGAAGCTC
ATACAGATCGTGAGGACACT

Downstream 100 bases:

>100_bases
GAGAACCGCATGTTCGGTATAGGCAGCACGGAACTTCTGGTCATCCTTGTGGTGGCCCTGATTGTGTTGGGTCCCAAGAG
CCTTGCCAATGTGTCGCGCA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MPSKVIIIDYGSQVTQLIARRVREAGVYSEIHSCVTTAQQVAAMKPQAIILSGGPASVGEADAPALDPGFLELGVPVLGI
CYGMQLLAREMGGQLAQSLTREYGPADLNFTAPCALWEGITAPTRVWMSHGDKVMAPPPGFTVTGSTSTLEVAAMADETR
KIYAVQFHPEVHHSVDGERMLHNFLFKVTGIKPDWTMSSFVERVVKEMAEQVGDKHVVCALSGGIDSTVVAVLLHRAIGK
RLHCIFVDNGLLRLGEGDEVVSYLREHFDLNLNFVQAQERFLSKLKGVEDPEKKRKIIGHTFIEIFDEEANKLDQVDFLA
QGTLYPDVIESISHKGPSAVIKSHHNVGGLPDTMKLKLIEPLRELFKDEVRKVAAELGMPDSIVWRHPFPGPGLAIRVLG
EVSEERLNILRQADRIVQQELRESGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVVALRVVDSVDAMTADWARLPADLIE
RMSGRIINEVKGVNRVVYDVSSKPPSTIEWE

Sequences:

>Translated_511_residues
MPSKVIIIDYGSQVTQLIARRVREAGVYSEIHSCVTTAQQVAAMKPQAIILSGGPASVGEADAPALDPGFLELGVPVLGI
CYGMQLLAREMGGQLAQSLTREYGPADLNFTAPCALWEGITAPTRVWMSHGDKVMAPPPGFTVTGSTSTLEVAAMADETR
KIYAVQFHPEVHHSVDGERMLHNFLFKVTGIKPDWTMSSFVERVVKEMAEQVGDKHVVCALSGGIDSTVVAVLLHRAIGK
RLHCIFVDNGLLRLGEGDEVVSYLREHFDLNLNFVQAQERFLSKLKGVEDPEKKRKIIGHTFIEIFDEEANKLDQVDFLA
QGTLYPDVIESISHKGPSAVIKSHHNVGGLPDTMKLKLIEPLRELFKDEVRKVAAELGMPDSIVWRHPFPGPGLAIRVLG
EVSEERLNILRQADRIVQQELRESGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVVALRVVDSVDAMTADWARLPADLIE
RMSGRIINEVKGVNRVVYDVSSKPPSTIEWE
>Mature_510_residues
PSKVIIIDYGSQVTQLIARRVREAGVYSEIHSCVTTAQQVAAMKPQAIILSGGPASVGEADAPALDPGFLELGVPVLGIC
YGMQLLAREMGGQLAQSLTREYGPADLNFTAPCALWEGITAPTRVWMSHGDKVMAPPPGFTVTGSTSTLEVAAMADETRK
IYAVQFHPEVHHSVDGERMLHNFLFKVTGIKPDWTMSSFVERVVKEMAEQVGDKHVVCALSGGIDSTVVAVLLHRAIGKR
LHCIFVDNGLLRLGEGDEVVSYLREHFDLNLNFVQAQERFLSKLKGVEDPEKKRKIIGHTFIEIFDEEANKLDQVDFLAQ
GTLYPDVIESISHKGPSAVIKSHHNVGGLPDTMKLKLIEPLRELFKDEVRKVAAELGMPDSIVWRHPFPGPGLAIRVLGE
VSEERLNILRQADRIVQQELRESGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVVALRVVDSVDAMTADWARLPADLIER
MSGRIINEVKGVNRVVYDVSSKPPSTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=551, Percent_Identity=36.2976406533575, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1788854, Length=517, Percent_Identity=54.1586073500967, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1789760, Length=155, Percent_Identity=30.9677419354839, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=37.2791519434629, Blast_Score=318, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=37.2791519434629, Blast_Score=318, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=37.2791519434629, Blast_Score=317, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=50.7722007722008, Blast_Score=532, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=33.9416058394161, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56492; Mature: 56361

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKVIIIDYGSQVTQLIARRVREAGVYSEIHSCVTTAQQVAAMKPQAIILSGGPASVGE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
ADAPALDPGFLELGVPVLGICYGMQLLAREMGGQLAQSLTREYGPADLNFTAPCALWEGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCC
TAPTRVWMSHGDKVMAPPPGFTVTGSTSTLEVAAMADETRKIYAVQFHPEVHHSVDGERM
CHHHHHHHHCCCEEECCCCCEEEECCCCEEEEEEECCCCCEEEEEEECCHHHHCCCHHHH
LHNFLFKVTGIKPDWTMSSFVERVVKEMAEQVGDKHVVCALSGGIDSTVVAVLLHRAIGK
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
RLHCIFVDNGLLRLGEGDEVVSYLREHFDLNLNFVQAQERFLSKLKGVEDPEKKRKIIGH
CEEEEEEECCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
TFIEIFDEEANKLDQVDFLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPDTMKLKLIE
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHH
PLRELFKDEVRKVAAELGMPDSIVWRHPFPGPGLAIRVLGEVSEERLNILRQADRIVQQE
HHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LRESGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVVALRVVDSVDAMTADWARLPADLIE
HHHCCHHHHHHHHHHHEEHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RMSGRIINEVKGVNRVVYDVSSKPPSTIEWE
HHHHHHHHHHHHHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure 
PSKVIIIDYGSQVTQLIARRVREAGVYSEIHSCVTTAQQVAAMKPQAIILSGGPASVGE
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
ADAPALDPGFLELGVPVLGICYGMQLLAREMGGQLAQSLTREYGPADLNFTAPCALWEGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCC
TAPTRVWMSHGDKVMAPPPGFTVTGSTSTLEVAAMADETRKIYAVQFHPEVHHSVDGERM
CHHHHHHHHCCCEEECCCCCEEEECCCCEEEEEEECCCCCEEEEEEECCHHHHCCCHHHH
LHNFLFKVTGIKPDWTMSSFVERVVKEMAEQVGDKHVVCALSGGIDSTVVAVLLHRAIGK
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
RLHCIFVDNGLLRLGEGDEVVSYLREHFDLNLNFVQAQERFLSKLKGVEDPEKKRKIIGH
CEEEEEEECCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
TFIEIFDEEANKLDQVDFLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPDTMKLKLIE
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHH
PLRELFKDEVRKVAAELGMPDSIVWRHPFPGPGLAIRVLGEVSEERLNILRQADRIVQQE
HHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LRESGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVVALRVVDSVDAMTADWARLPADLIE
HHHCCHHHHHHHHHHHEEHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RMSGRIINEVKGVNRVVYDVSSKPPSTIEWE
HHHHHHHHHHHHHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA