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The map label for this gene is guaB [H]

Identifier: 220905068

GI number: 220905068

Start: 2179124

End: 2180581

Strand: Direct

Name: guaB [H]

Synonym: Ddes_1805

Alternate gene names: 220905068

Gene position: 2179124-2180581 (Clockwise)

Preceding gene: 220905062

Following gene: 220905069

Centisome position: 75.84

GC content: 59.67

Gene sequence:

>1458_bases
ATGTTCACCAATCGCGGCAAAGCGCTGACCTTTGACGACATTTTGCTCATTCCCGGCTATTCGGACATTACCCCTGACGC
CGTGGATATAGCCACCTGGCTTACCCCTTCCATTCCCCTGCGCATCCCCCTGCTTTCCGCCGCTATGGATACCGTAACGG
AATCGGCCATGGCCATTTCAATGGCCCGCATGGGGGGCATCGGCATCATCCATAAAAACATGCCCGTGTCCCGGCAGCGC
CTGGAAGTAGAGAGAGTCAAAAAAAGCGAAAGCGGCATGATTCTCGACCCGGTGACCATTTCGCCCAACAACACGGTACA
GGAAGCCCTTGACCTCATGTCGGACTTTCGCGTTTCCGGCCTGCCCGTGGTGGCCGATGACCGCCTGGTGGGCATTCTTA
CCAATCGTGACGTGCGCTTTGTCGAAGACGGCCAGGCCGTGCACGTGGCCGACGTCATGACCAGCGAAAACCTTGTTACC
GTTCCCATGGGCACATCCCTTGCCGAAGCCAAGCAGCATCTGCACGAGCACCGCATTGAAAAACTGCTCGTGGTGGATGA
AGAAGGGCACCTGCGCGGCCTTATCACCATGAAAGACATCGACAAGGTGCAAAAATATCCCAATGCCTGCAAAGACTCCG
CCGGACGCCTGCGCGTAGGCGCGGCCATCGGCATCGGCAAGGATTGCGAAGCCCGCGCCGAGCAGCTGCTTGAGGCCGGA
GCCGACGTGCTGGTGCTTGACTCCGCCCATGGGCATTCTGTCAACGTCATCAAGGCCATCCGTATGGTCAAGGCGTCGTT
TCCCAACTGCCAGCTTGTGGCCGGCAACGTGGCCACCTACGACGGGGCCAAGGCCATTCTTGAAGCCGGAGCCGACACCG
TCAAGGTGGGCATCGGCCCCGGCTCCATCTGCACCACCCGCATTGTGGCGGGCGTGGGCGTGCCCCAGGTCACGGCCATT
ATGGACGGCGGCCGCGCCGCCCGCGAAATGGACCGCTGCTGCATTGCCGACGGCGGCATCAAGTTTTCCGGCGATATCGT
GAAGGCCCTTGTGGTGGGCGCGCATTCTGTCATGGTCGGTTCGCTTTTTGCCGGCACGGAAGAAAGCCCGGGCGAAACCA
TCCTGTACCAGGGCCGCACGTACAAAATCTACCGGGGCATGGGTTCCATTGATGCCATGAAGGAAGGCAGCTCTGACCGC
TACTTCCAGGAAAGGAGCAAAAAACTCGTGCCTGAAGGCATTGTGGGCCGTGTGCCGTACCGTGGCCCGGTTATGGAAGC
CGTGTACCAGCTCATGGGCGGCCTACGCTCGGGCATGGGCTATGTGGGCGCGCACAACCTCACGCAACTGTTTGAAAATA
CTACCTTCTGCGAAATTTCCCCGGCGGGCCTGCGCGAAAGCCATGTGCACGATGTGGTAATCACCAAGGAAGCCCCCAAC
TATCGCATTGAGAACTAG

Upstream 100 bases:

>100_bases
CCGGCCGCAGAGCCACAGCCTACATTGACATACGGCCCGCAAGGGGATACCCTGTTAGACTACAATTTGAACAATTATTC
CAGCATATTACGAGGATGCC

Downstream 100 bases:

>100_bases
GGCCGCTGCGCCGCAAGGCGTACGCCGTGCAGACAGGCAACCGGCGCGTCCCGGCGCGCGAAGCTCATACAGATCGTGAG
GACACTATGCCCAGCAAGGT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MFTNRGKALTFDDILLIPGYSDITPDAVDIATWLTPSIPLRIPLLSAAMDTVTESAMAISMARMGGIGIIHKNMPVSRQR
LEVERVKKSESGMILDPVTISPNNTVQEALDLMSDFRVSGLPVVADDRLVGILTNRDVRFVEDGQAVHVADVMTSENLVT
VPMGTSLAEAKQHLHEHRIEKLLVVDEEGHLRGLITMKDIDKVQKYPNACKDSAGRLRVGAAIGIGKDCEARAEQLLEAG
ADVLVLDSAHGHSVNVIKAIRMVKASFPNCQLVAGNVATYDGAKAILEAGADTVKVGIGPGSICTTRIVAGVGVPQVTAI
MDGGRAAREMDRCCIADGGIKFSGDIVKALVVGAHSVMVGSLFAGTEESPGETILYQGRTYKIYRGMGSIDAMKEGSSDR
YFQERSKKLVPEGIVGRVPYRGPVMEAVYQLMGGLRSGMGYVGAHNLTQLFENTTFCEISPAGLRESHVHDVVITKEAPN
YRIEN

Sequences:

>Translated_485_residues
MFTNRGKALTFDDILLIPGYSDITPDAVDIATWLTPSIPLRIPLLSAAMDTVTESAMAISMARMGGIGIIHKNMPVSRQR
LEVERVKKSESGMILDPVTISPNNTVQEALDLMSDFRVSGLPVVADDRLVGILTNRDVRFVEDGQAVHVADVMTSENLVT
VPMGTSLAEAKQHLHEHRIEKLLVVDEEGHLRGLITMKDIDKVQKYPNACKDSAGRLRVGAAIGIGKDCEARAEQLLEAG
ADVLVLDSAHGHSVNVIKAIRMVKASFPNCQLVAGNVATYDGAKAILEAGADTVKVGIGPGSICTTRIVAGVGVPQVTAI
MDGGRAAREMDRCCIADGGIKFSGDIVKALVVGAHSVMVGSLFAGTEESPGETILYQGRTYKIYRGMGSIDAMKEGSSDR
YFQERSKKLVPEGIVGRVPYRGPVMEAVYQLMGGLRSGMGYVGAHNLTQLFENTTFCEISPAGLRESHVHDVVITKEAPN
YRIEN
>Mature_485_residues
MFTNRGKALTFDDILLIPGYSDITPDAVDIATWLTPSIPLRIPLLSAAMDTVTESAMAISMARMGGIGIIHKNMPVSRQR
LEVERVKKSESGMILDPVTISPNNTVQEALDLMSDFRVSGLPVVADDRLVGILTNRDVRFVEDGQAVHVADVMTSENLVT
VPMGTSLAEAKQHLHEHRIEKLLVVDEEGHLRGLITMKDIDKVQKYPNACKDSAGRLRVGAAIGIGKDCEARAEQLLEAG
ADVLVLDSAHGHSVNVIKAIRMVKASFPNCQLVAGNVATYDGAKAILEAGADTVKVGIGPGSICTTRIVAGVGVPQVTAI
MDGGRAAREMDRCCIADGGIKFSGDIVKALVVGAHSVMVGSLFAGTEESPGETILYQGRTYKIYRGMGSIDAMKEGSSDR
YFQERSKKLVPEGIVGRVPYRGPVMEAVYQLMGGLRSGMGYVGAHNLTQLFENTTFCEISPAGLRESHVHDVVITKEAPN
YRIEN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=455, Percent_Identity=42.4175824175824, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI217035146, Length=450, Percent_Identity=42.2222222222222, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI34328930, Length=450, Percent_Identity=42.2222222222222, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI34328928, Length=450, Percent_Identity=42.2222222222222, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI156616279, Length=450, Percent_Identity=42.2222222222222, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=42.152466367713, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI217035148, Length=450, Percent_Identity=41.5555555555556, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035150, Length=450, Percent_Identity=39.1111111111111, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=38.7755102040816, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=38.7755102040816, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=38.7755102040816, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541956, Length=244, Percent_Identity=38.9344262295082, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI156104880, Length=244, Percent_Identity=36.0655737704918, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1788855, Length=481, Percent_Identity=56.3409563409563, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=36.7713004484305, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=471, Percent_Identity=36.0934182590234, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=37.708830548926, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=38.2352941176471, Blast_Score=161, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=468, Percent_Identity=41.4529914529915, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=456, Percent_Identity=41.6666666666667, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=456, Percent_Identity=42.3245614035088, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=382, Percent_Identity=39.7905759162304, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=42.1052631578947, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641071, Length=460, Percent_Identity=42.6086956521739, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24641073, Length=460, Percent_Identity=42.6086956521739, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI28571163, Length=412, Percent_Identity=42.2330097087379, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52112; Mature: 52112

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTNRGKALTFDDILLIPGYSDITPDAVDIATWLTPSIPLRIPLLSAAMDTVTESAMAIS
CCCCCCCEEEECCEEEECCCCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
MARMGGIGIIHKNMPVSRQRLEVERVKKSESGMILDPVTISPNNTVQEALDLMSDFRVSG
HHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
LPVVADDRLVGILTNRDVRFVEDGQAVHVADVMTSENLVTVPMGTSLAEAKQHLHEHRIE
CCEEECCCEEEEEECCCEEEEECCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHH
KLLVVDEEGHLRGLITMKDIDKVQKYPNACKDSAGRLRVGAAIGIGKDCEARAEQLLEAG
EEEEECCCCCEEEEEEHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCC
ADVLVLDSAHGHSVNVIKAIRMVKASFPNCQLVAGNVATYDGAKAILEAGADTVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCEEECCHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQVTAIMDGGRAAREMDRCCIADGGIKFSGDIVKALVVGAHSVMVG
CCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHEEECCCEEECHHHHHHHHHHHHHHHHH
SLFAGTEESPGETILYQGRTYKIYRGMGSIDAMKEGSSDRYFQERSKKLVPEGIVGRVPY
HHHCCCCCCCCCEEEECCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCC
RGPVMEAVYQLMGGLRSGMGYVGAHNLTQLFENTTFCEISPAGLRESHVHDVVITKEAPN
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCC
YRIEN
CCCCC
>Mature Secondary Structure
MFTNRGKALTFDDILLIPGYSDITPDAVDIATWLTPSIPLRIPLLSAAMDTVTESAMAIS
CCCCCCCEEEECCEEEECCCCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
MARMGGIGIIHKNMPVSRQRLEVERVKKSESGMILDPVTISPNNTVQEALDLMSDFRVSG
HHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
LPVVADDRLVGILTNRDVRFVEDGQAVHVADVMTSENLVTVPMGTSLAEAKQHLHEHRIE
CCEEECCCEEEEEECCCEEEEECCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHH
KLLVVDEEGHLRGLITMKDIDKVQKYPNACKDSAGRLRVGAAIGIGKDCEARAEQLLEAG
EEEEECCCCCEEEEEEHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCC
ADVLVLDSAHGHSVNVIKAIRMVKASFPNCQLVAGNVATYDGAKAILEAGADTVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCEEECCHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQVTAIMDGGRAAREMDRCCIADGGIKFSGDIVKALVVGAHSVMVG
CCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHEEECCCEEECHHHHHHHHHHHHHHHHH
SLFAGTEESPGETILYQGRTYKIYRGMGSIDAMKEGSSDRYFQERSKKLVPEGIVGRVPY
HHHCCCCCCCCCEEEECCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCC
RGPVMEAVYQLMGGLRSGMGYVGAHNLTQLFENTTFCEISPAGLRESHVHDVVITKEAPN
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCC
YRIEN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]