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The map label for this gene is folE2

Identifier: 220905029

GI number: 220905029

Start: 2134846

End: 2135628

Strand: Direct

Name: folE2

Synonym: Ddes_1766

Alternate gene names: 220905029

Gene position: 2134846-2135628 (Clockwise)

Preceding gene: 220905028

Following gene: 220905030

Centisome position: 74.3

GC content: 59.26

Gene sequence:

>783_bases
ATGGAAGACGTGCAAAGCCATGCCCCGCAAATCCCCCTGAACATAGACCGCGTGGGCGTGCGAGAGCTTCGGCTGCCCCT
GCTCGTGCGCGACCGTACCCGAGGCACGCAACAGACCGTGGCCAGTGTGGACCTTGGCGTGGACCTGCCCTCCGAATTCA
AGGGTACCCACATGAGCCGCTTTGTGGAAGCACTGGAACAGTGGAATGATGAAATCAGCTACCAGTCGGTACGCCGCCTG
CTGCAGGACATCAGGCAGCGCCTGGAAGCCCGGCGGGCTTACGCGCGCTTCTGTTTTCCCTACTTCATCAGCAAGGCCGC
CCCGGCTTCGGGCAGTCCGGCGCTGGTAAGTTACCAGTGCCGCCTCACCGGCGAACTTGACGATGCGGGACAGCATTTTA
TTCTAGAAGTAGACGTGCCCGTCATGACTGTCTGCCCCTGCTCCAAAGCCATCAGCAACGAAGGCGCGCACAGCCAGCGG
GCCATGGTACGCATGCGTCTGCGCATGAAAGCATTCTCCTGGCTCGAAGACTTCATAGACATAGCCGAAGCCTCCGGTTC
ATCGGCCGTCTACACGCTGCTCAAACGCGAAGACGAAAAATACGTCACCGAGCACGCCTTTGCCCATCCCACATTTGTGG
AAGACGTAGTGCGCAATGTAGCGCAGCGGCTGTCGGAACACGGCCAGGTGGAGTGGTTCAGCGTGGAGGTGGAAAGTATG
GAATCCATACACAATCATAACGCCTTCGCCCGCATTGAGCGGCATATCAGCGACAGGAGCTGA

Upstream 100 bases:

>100_bases
AGCCCAAGCGCATGCGCGCTCTGGCCGACAAGCTGATCGCCTGCCGCGGCGTCAAGCACGGCACGTTTACCGGCACTACC
ACAGGAGAGGATCTGGCATA

Downstream 100 bases:

>100_bases
AACCGGGGCTGTCCGCCAAGGCAAAAAAATTTTGCAATCGTTTGCCGGTTGTGCTAGTGCAGCGCTAAGGGTTGTTTTTA
CATGCGCCGCCCGCGCCAAA

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MEDVQSHAPQIPLNIDRVGVRELRLPLLVRDRTRGTQQTVASVDLGVDLPSEFKGTHMSRFVEALEQWNDEISYQSVRRL
LQDIRQRLEARRAYARFCFPYFISKAAPASGSPALVSYQCRLTGELDDAGQHFILEVDVPVMTVCPCSKAISNEGAHSQR
AMVRMRLRMKAFSWLEDFIDIAEASGSSAVYTLLKREDEKYVTEHAFAHPTFVEDVVRNVAQRLSEHGQVEWFSVEVESM
ESIHNHNAFARIERHISDRS

Sequences:

>Translated_260_residues
MEDVQSHAPQIPLNIDRVGVRELRLPLLVRDRTRGTQQTVASVDLGVDLPSEFKGTHMSRFVEALEQWNDEISYQSVRRL
LQDIRQRLEARRAYARFCFPYFISKAAPASGSPALVSYQCRLTGELDDAGQHFILEVDVPVMTVCPCSKAISNEGAHSQR
AMVRMRLRMKAFSWLEDFIDIAEASGSSAVYTLLKREDEKYVTEHAFAHPTFVEDVVRNVAQRLSEHGQVEWFSVEVESM
ESIHNHNAFARIERHISDRS
>Mature_260_residues
MEDVQSHAPQIPLNIDRVGVRELRLPLLVRDRTRGTQQTVASVDLGVDLPSEFKGTHMSRFVEALEQWNDEISYQSVRRL
LQDIRQRLEARRAYARFCFPYFISKAAPASGSPALVSYQCRLTGELDDAGQHFILEVDVPVMTVCPCSKAISNEGAHSQR
AMVRMRLRMKAFSWLEDFIDIAEASGSSAVYTLLKREDEKYVTEHAFAHPTFVEDVVRNVAQRLSEHGQVEWFSVEVESM
ESIHNHNAFARIERHISDRS

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_DESDA (B8J1Q5)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480341.1
- GeneID:   7285478
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1766
- HOGENOM:   HBG626871
- ProtClustDB:   PRK13674
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 29705; Mature: 29705

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVQSHAPQIPLNIDRVGVRELRLPLLVRDRTRGTQQTVASVDLGVDLPSEFKGTHMSR
CCCHHHHCCCCCCCCCHHCHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCHHHCCHHHHH
FVEALEQWNDEISYQSVRRLLQDIRQRLEARRAYARFCFPYFISKAAPASGSPALVSYQC
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
RLTGELDDAGQHFILEVDVPVMTVCPCSKAISNEGAHSQRAMVRMRLRMKAFSWLEDFID
EEECCCCCCCCEEEEEECCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IAEASGSSAVYTLLKREDEKYVTEHAFAHPTFVEDVVRNVAQRLSEHGQVEWFSVEVESM
HHHCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHH
ESIHNHNAFARIERHISDRS
HHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEDVQSHAPQIPLNIDRVGVRELRLPLLVRDRTRGTQQTVASVDLGVDLPSEFKGTHMSR
CCCHHHHCCCCCCCCCHHCHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCHHHCCHHHHH
FVEALEQWNDEISYQSVRRLLQDIRQRLEARRAYARFCFPYFISKAAPASGSPALVSYQC
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
RLTGELDDAGQHFILEVDVPVMTVCPCSKAISNEGAHSQRAMVRMRLRMKAFSWLEDFID
EEECCCCCCCCEEEEEECCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IAEASGSSAVYTLLKREDEKYVTEHAFAHPTFVEDVVRNVAQRLSEHGQVEWFSVEVESM
HHHCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHH
ESIHNHNAFARIERHISDRS
HHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA