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The map label for this gene is folP [H]

Identifier: 220904980

GI number: 220904980

Start: 2075280

End: 2076182

Strand: Reverse

Name: folP [H]

Synonym: Ddes_1716

Alternate gene names: 220904980

Gene position: 2076182-2075280 (Counterclockwise)

Preceding gene: 220904981

Following gene: 220904979

Centisome position: 72.25

GC content: 61.79

Gene sequence:

>903_bases
ATGAAAAATTCATTCCCGGTAGCGCCCGTAACGGGCGCAGCCTGGCATGTCATGGGGGGGCGGGCGTTGAAGACGCCCTC
CCCCTTTGGCGTTATGGGCATTGTCAATCTTACTCCTGATTCCTTTTACGATGGTGGCGCGCATCACCTTCCTCCGGCCG
GTCTACGGCATGCCCTGAGCCTGCTTGACGAAGGCGCTGATGTTCTTGACCTGGGGGCCGAATCGTCCCGGCCGGGAGCC
GCCGAGCTTTCACCGGATGAAGAGATCCGCCGCCTTACACCCGTGCTTATGGGGCTGCGCCGCAAGGCCCCCTGGGCGGT
GGTTTCTGTTGATACGTATCATGCCGCCACTGCCGCCGCCGTGCTGGAGCAGGGGGCGGCTATCATCAACGATATTTCGG
CGTGTGCTTTTGATCCGGCCCTGCTGGATGTGCTTGTGCAGTACCGGCCGGGCTATGTGCTCATGCACAGTCAGGGGCGG
CCCGAGATCATGCAGCACAATCCGCAGTATGGGGATGTGCGGCGTGAAGTGCGGGAGTTTTTTGAGCGCAATCTTGCGCG
TCTGGTGCGGGCGGGAATGCCCGAAGACCGCATCATTCTTGACCCCGGCATAGGTTTCGGCAAAACGCTGGCTCATAACC
TGGAATTGCTGGCGCACCCCGAAGACTGGCTGGACCTGGGGCGACCTGTGCTCATGGCCCTTTCAATGAAGTCTGTTTTT
GGCGGCCTGCTTTTACTGCCGCCGGGCGAACGGGGTACGGCTACCGTCGCAGCAACGGCATTGCTGCGTGCACGGGGCGT
TTTCTGGCACAGAGTGCATCAGGTGGCTGCTGCCCGGCAAGGGCTGGCGGTTGCCACGGCTTTCACTCCCGGCCCCTTGC
CGGGTGGCCCATCTGTAGAGTAA

Upstream 100 bases:

>100_bases
GCAGTGAAGATGCCCCGGCAGCTCCGGCGGAAGCGGAAAGTGCTGGAAGCGGCGAAGTGGCCGCCAAGAATGGTGAAGAC
GACAACAAGCGAAATCAGTA

Downstream 100 bases:

>100_bases
AATACAAAAAGGGCACGCCGGTGCGTGTCCTTTTTTTCATGCTACTGCGGCAGGCCCCCAGGCTGCCAATGGCAGCATGC
AGGGGCTGCTGGCCGAGTGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKNSFPVAPVTGAAWHVMGGRALKTPSPFGVMGIVNLTPDSFYDGGAHHLPPAGLRHALSLLDEGADVLDLGAESSRPGA
AELSPDEEIRRLTPVLMGLRRKAPWAVVSVDTYHAATAAAVLEQGAAIINDISACAFDPALLDVLVQYRPGYVLMHSQGR
PEIMQHNPQYGDVRREVREFFERNLARLVRAGMPEDRIILDPGIGFGKTLAHNLELLAHPEDWLDLGRPVLMALSMKSVF
GGLLLLPPGERGTATVAATALLRARGVFWHRVHQVAAARQGLAVATAFTPGPLPGGPSVE

Sequences:

>Translated_300_residues
MKNSFPVAPVTGAAWHVMGGRALKTPSPFGVMGIVNLTPDSFYDGGAHHLPPAGLRHALSLLDEGADVLDLGAESSRPGA
AELSPDEEIRRLTPVLMGLRRKAPWAVVSVDTYHAATAAAVLEQGAAIINDISACAFDPALLDVLVQYRPGYVLMHSQGR
PEIMQHNPQYGDVRREVREFFERNLARLVRAGMPEDRIILDPGIGFGKTLAHNLELLAHPEDWLDLGRPVLMALSMKSVF
GGLLLLPPGERGTATVAATALLRARGVFWHRVHQVAAARQGLAVATAFTPGPLPGGPSVE
>Mature_300_residues
MKNSFPVAPVTGAAWHVMGGRALKTPSPFGVMGIVNLTPDSFYDGGAHHLPPAGLRHALSLLDEGADVLDLGAESSRPGA
AELSPDEEIRRLTPVLMGLRRKAPWAVVSVDTYHAATAAAVLEQGAAIINDISACAFDPALLDVLVQYRPGYVLMHSQGR
PEIMQHNPQYGDVRREVREFFERNLARLVRAGMPEDRIILDPGIGFGKTLAHNLELLAHPEDWLDLGRPVLMALSMKSVF
GGLLLLPPGERGTATVAATALLRARGVFWHRVHQVAAARQGLAVATAFTPGPLPGGPSVE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=269, Percent_Identity=38.6617100371747, Blast_Score=185, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=27.4691358024691, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 32105; Mature: 32105

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSFPVAPVTGAAWHVMGGRALKTPSPFGVMGIVNLTPDSFYDGGAHHLPPAGLRHALS
CCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
LLDEGADVLDLGAESSRPGAAELSPDEEIRRLTPVLMGLRRKAPWAVVSVDTYHAATAAA
HHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHH
VLEQGAAIINDISACAFDPALLDVLVQYRPGYVLMHSQGRPEIMQHNPQYGDVRREVREF
HHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHH
FERNLARLVRAGMPEDRIILDPGIGFGKTLAHNLELLAHPEDWLDLGRPVLMALSMKSVF
HHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHCHHEEECCHHHHHCCCHHHHHHHHHHHH
GGLLLLPPGERGTATVAATALLRARGVFWHRVHQVAAARQGLAVATAFTPGPLPGGPSVE
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKNSFPVAPVTGAAWHVMGGRALKTPSPFGVMGIVNLTPDSFYDGGAHHLPPAGLRHALS
CCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
LLDEGADVLDLGAESSRPGAAELSPDEEIRRLTPVLMGLRRKAPWAVVSVDTYHAATAAA
HHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHH
VLEQGAAIINDISACAFDPALLDVLVQYRPGYVLMHSQGRPEIMQHNPQYGDVRREVREF
HHHHCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHH
FERNLARLVRAGMPEDRIILDPGIGFGKTLAHNLELLAHPEDWLDLGRPVLMALSMKSVF
HHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHCHHEEECCHHHHHCCCHHHHHHHHHHHH
GGLLLLPPGERGTATVAATALLRARGVFWHRVHQVAAARQGLAVATAFTPGPLPGGPSVE
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]