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The map label for this gene is glmU [H]

Identifier: 220904960

GI number: 220904960

Start: 2046769

End: 2048124

Strand: Reverse

Name: glmU [H]

Synonym: Ddes_1696

Alternate gene names: 220904960

Gene position: 2048124-2046769 (Counterclockwise)

Preceding gene: 220904961

Following gene: 220904959

Centisome position: 71.28

GC content: 60.84

Gene sequence:

>1356_bases
ATGCCGAAGAACGCGGCTCTTATTCTGGCGGCGGGCAAGGGTACCCGCATGCATTCCGACAAGCCCAAGGTTTTGCAAAC
ACTGCTGGGCGAGCCTATGCTGGCCTGTGTGCTTGAGGCTTTGCGCCCTGTTTTTGCTGAAGATGTGTGGCTTGTAGCCG
GGCATCGGGCAGAGATGGTCAGGGCGGCCTTTCCGGAAGTTCCCTGTGTTCTTCAGGAGCAGCAACTCGGCACAGGGCAT
GCGCTCATGCAGGCCCTGCCGGCACTTACCAAGGCGGGATACACCCACCTGCTGATCGTCAACGGCGATGCGCCCCTGCT
TTCAGAGGGCCTTGTGCGGCAGTTTCTGGCCGAGGCCGTGGGTGCAGACCTCGCCTTTGCCACCATTGATCTTGACAGCC
CCGGTGCTTATGGCCGCGTGGTGCGGGAAGGGGATGACGTGCGTGCCATTGTCGAGGCCAAGGATTATGATCCGGCTCTT
TACGGCCCACCCACCGGCGAGGTCAACGCGGGCATGTACTATTGTGCGCTGGATGCCGTGGAAAGCCTGCTGCCCCGCCT
GGGCAATGCCAATAAAAGCGGCGAGTATTATATCACTGACCTGATAGGCCTGGCTGTGGCGGAAAAATATGACGTGCAGG
GTGTGCGTTGCGGGCGCGACGACGGACTCATGGGAGTGAACTCTCCTCTGGAACTGGAACGGATGGAAGAAGCCCTGCGC
GAGCGCCGTGTTCATGACCTGCTTGCTGCGGGCGTTATCATCCATGCCGCGGGAAGCGTCCGCGTGGGGCCTCTGGCCCA
TGTGGAAGCCGGGGTAGAAATCACCGGCCCTTGCGAAATTTACGGCCGTTCGCGGATCTTGCGCGGCGCCTCCATAGCCT
CGCACTGTATGCTGCGTGACAGTGTCGTCAGCAGCGGAGCGCGGATACATTCATTCTCGCACCTTGAAGGGGCGGAAGTG
GGTGAAGGCGCGCTGGTCGGGCCGTACGCGCGGCTGCGCCCCGGAGCCGTTCTTGAGGCGCAGTCCCATGTAGGAAATTT
TGTGGAGCTGAAAAAGACGCGCCTGGGGCAAGGGGCCAAGGCCAATCATCTGAGTTACCTTGGCGATGCCGAGATCGGTG
CGGGCAGCAATATCGGCGCGGGAACCATCACCTGCAACTATGATGGAAAAAACAAACATCTCACGCAGATAGGCCGGCGC
GCCTTTATTGGCAGCAATACCGCCCTGGTGGCTCCGGTGAGTGTGGGTGACGAGGCCCTTGTGGGGGCCGGATCGGTCAT
CACCCGCGACGTGCCCGCCGGAGAACTGGGCATTGCCCGTGAAAAACAGAAGAATTTGCCGCGCAGAAAATCCTGA

Upstream 100 bases:

>100_bases
GAAGGGATCCGGCATGGCTTTGCCTTGCCGTTTTTCAGGCAAGAGGCTATTGCATTGCGTGAAGTTCTTCCGCTTTTGCG
CGGAGATGAAGGAGATACTG

Downstream 100 bases:

>100_bases
CGCGTATCCTTTGTTTTCTGCCGGGACGGCACACGGTTTTTCGGCTGCGCCGTTTCTGCGGCGACAAAGGAACTGGAGCC
GGGCAGGCGAGGGCTTGTCC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MPKNAALILAAGKGTRMHSDKPKVLQTLLGEPMLACVLEALRPVFAEDVWLVAGHRAEMVRAAFPEVPCVLQEQQLGTGH
ALMQALPALTKAGYTHLLIVNGDAPLLSEGLVRQFLAEAVGADLAFATIDLDSPGAYGRVVREGDDVRAIVEAKDYDPAL
YGPPTGEVNAGMYYCALDAVESLLPRLGNANKSGEYYITDLIGLAVAEKYDVQGVRCGRDDGLMGVNSPLELERMEEALR
ERRVHDLLAAGVIIHAAGSVRVGPLAHVEAGVEITGPCEIYGRSRILRGASIASHCMLRDSVVSSGARIHSFSHLEGAEV
GEGALVGPYARLRPGAVLEAQSHVGNFVELKKTRLGQGAKANHLSYLGDAEIGAGSNIGAGTITCNYDGKNKHLTQIGRR
AFIGSNTALVAPVSVGDEALVGAGSVITRDVPAGELGIAREKQKNLPRRKS

Sequences:

>Translated_451_residues
MPKNAALILAAGKGTRMHSDKPKVLQTLLGEPMLACVLEALRPVFAEDVWLVAGHRAEMVRAAFPEVPCVLQEQQLGTGH
ALMQALPALTKAGYTHLLIVNGDAPLLSEGLVRQFLAEAVGADLAFATIDLDSPGAYGRVVREGDDVRAIVEAKDYDPAL
YGPPTGEVNAGMYYCALDAVESLLPRLGNANKSGEYYITDLIGLAVAEKYDVQGVRCGRDDGLMGVNSPLELERMEEALR
ERRVHDLLAAGVIIHAAGSVRVGPLAHVEAGVEITGPCEIYGRSRILRGASIASHCMLRDSVVSSGARIHSFSHLEGAEV
GEGALVGPYARLRPGAVLEAQSHVGNFVELKKTRLGQGAKANHLSYLGDAEIGAGSNIGAGTITCNYDGKNKHLTQIGRR
AFIGSNTALVAPVSVGDEALVGAGSVITRDVPAGELGIAREKQKNLPRRKS
>Mature_450_residues
PKNAALILAAGKGTRMHSDKPKVLQTLLGEPMLACVLEALRPVFAEDVWLVAGHRAEMVRAAFPEVPCVLQEQQLGTGHA
LMQALPALTKAGYTHLLIVNGDAPLLSEGLVRQFLAEAVGADLAFATIDLDSPGAYGRVVREGDDVRAIVEAKDYDPALY
GPPTGEVNAGMYYCALDAVESLLPRLGNANKSGEYYITDLIGLAVAEKYDVQGVRCGRDDGLMGVNSPLELERMEEALRE
RRVHDLLAAGVIIHAAGSVRVGPLAHVEAGVEITGPCEIYGRSRILRGASIASHCMLRDSVVSSGARIHSFSHLEGAEVG
EGALVGPYARLRPGAVLEAQSHVGNFVELKKTRLGQGAKANHLSYLGDAEIGAGSNIGAGTITCNYDGKNKHLTQIGRRA
FIGSNTALVAPVSVGDEALVGAGSVITRDVPAGELGIAREKQKNLPRRKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=42.7937915742794, Blast_Score=311, Evalue=6e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 47651; Mature: 47520

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKNAALILAAGKGTRMHSDKPKVLQTLLGEPMLACVLEALRPVFAEDVWLVAGHRAEMV
CCCCCEEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCHHHHH
RAAFPEVPCVLQEQQLGTGHALMQALPALTKAGYTHLLIVNGDAPLLSEGLVRQFLAEAV
HHHCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHH
GADLAFATIDLDSPGAYGRVVREGDDVRAIVEAKDYDPALYGPPTGEVNAGMYYCALDAV
CCCEEEEEEECCCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHH
ESLLPRLGNANKSGEYYITDLIGLAVAEKYDVQGVRCGRDDGLMGVNSPLELERMEEALR
HHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHH
ERRVHDLLAAGVIIHAAGSVRVGPLAHVEAGVEITGPCEIYGRSRILRGASIASHCMLRD
HHHHHHHHHHHHHEEECCCEEECCHHHHCCCCEECCCHHHHCCHHHHCCCHHHHHHHHHH
SVVSSGARIHSFSHLEGAEVGEGALVGPYARLRPGAVLEAQSHVGNFVELKKTRLGQGAK
HHHHCCCCEEEECCCCCCCCCCCCEECCHHHCCCCCEEEEHHHCCCHHHHHHHHCCCCCC
ANHLSYLGDAEIGAGSNIGAGTITCNYDGKNKHLTQIGRRAFIGSNTALVAPVSVGDEAL
CCCCEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHEECCCCEEEEEECCCCCHH
VGAGSVITRDVPAGELGIAREKQKNLPRRKS
CCCCCEEECCCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
PKNAALILAAGKGTRMHSDKPKVLQTLLGEPMLACVLEALRPVFAEDVWLVAGHRAEMV
CCCCEEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCHHHHH
RAAFPEVPCVLQEQQLGTGHALMQALPALTKAGYTHLLIVNGDAPLLSEGLVRQFLAEAV
HHHCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHH
GADLAFATIDLDSPGAYGRVVREGDDVRAIVEAKDYDPALYGPPTGEVNAGMYYCALDAV
CCCEEEEEEECCCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHH
ESLLPRLGNANKSGEYYITDLIGLAVAEKYDVQGVRCGRDDGLMGVNSPLELERMEEALR
HHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHH
ERRVHDLLAAGVIIHAAGSVRVGPLAHVEAGVEITGPCEIYGRSRILRGASIASHCMLRD
HHHHHHHHHHHHHEEECCCEEECCHHHHCCCCEECCCHHHHCCHHHHCCCHHHHHHHHHH
SVVSSGARIHSFSHLEGAEVGEGALVGPYARLRPGAVLEAQSHVGNFVELKKTRLGQGAK
HHHHCCCCEEEECCCCCCCCCCCCEECCHHHCCCCCEEEEHHHCCCHHHHHHHHCCCCCC
ANHLSYLGDAEIGAGSNIGAGTITCNYDGKNKHLTQIGRRAFIGSNTALVAPVSVGDEAL
CCCCEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHEECCCCEEEEEECCCCCHH
VGAGSVITRDVPAGELGIAREKQKNLPRRKS
CCCCCEEECCCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA