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The map label for this gene is luxQ [H]

Identifier: 220904867

GI number: 220904867

Start: 1925975

End: 1928032

Strand: Direct

Name: luxQ [H]

Synonym: Ddes_1601

Alternate gene names: 220904867

Gene position: 1925975-1928032 (Clockwise)

Preceding gene: 220904866

Following gene: 220904868

Centisome position: 67.03

GC content: 53.79

Gene sequence:

>2058_bases
ATGCCAGTTCACAGCAAGGCCCCAGACGGTCCCGGCGTCAACCCTATGATTCTGGCGTTGGAAATTTCCAGCTCGGCACT
TTTGCATTATCACAAAGCCCCCTTTTTGCACGCCAGCCTCGCCAGTATGGGTGAAACCTTGCACTGCGGACAGGTGGTTC
TTCTTGAATACGCCAACAGCCGGTGGGCCGAGCCTTTTGTATGGACAAGCTCCGTACCCAGCGCCGCCTGCCCGCTGCCC
CTGCCAACGCTGGACGACATGGCCCCCCTGCTCGACACCTTCTTGCAGCGTAAAGAACTTTGCATTTCTGATACCGGGCA
GATGCCCGAAGGACCGCAAAAAAAGTTTTTTCTCGCGCGTCAGGTCAGGGCTGCCCTTTGCATTCCCATTGTTCACGAAG
GCGGGCTTTGTGGCGGCATCTGCCTCACCAGGCGCATTTCCGGGCAAGGCTGGTCACAGGATGACGTAAATATATGCCAC
CTGCTGAGCAACATCCTGGCCATGGTGCTCACCCATTTTCGTCTTTACGGCAGGTTGCGTCAAAAGCACAAACAGCTTCG
TGACATTCTTGACGCATTTCCCAATCCCGTATGCATCGTGGATATGGAAACGAACAGGATTCTTTTTTCCAATAAAAGCG
TTGCAGAAACATTTCCCACACCGCAAGAAAGCGAAGACGACAAATGTCATAAAAGGCTTATGGGCCGGGACAGCCCCTGC
CCCTACTGCACCAACCCCATTATTCGCCGCACAGGCGAAGCCTACCAGTGGACCTACCAGAACGAGGTCACCAACCGCAC
GTATACCGTGGTAGACAAGGTGATCAAATGGGACAATGACAGGCCCGTGCGGCTTTCCATCAGCACGGATATAACCGACA
TCCTGCGCACCCGGCATGAAAAACAGTCAGCCGTTATTGCCTCTCAGGCCAAAACGGAATTTCTGGCCCACATGAGCCAC
GAAATCCGTACACCGCTCAACGGTATCATCGGCCTCACTCATCTGGCCCTGCAAAGTGGCCCGGATGGGGAACTCAAGGA
ATATCTGCTGAAAATCCGCTCTTCTTCCACAAACCTGCTGGCTATCATCAATGATGTTCTCGATCTTTCAAAAATCGAGG
CCAACAAGATGGAGCTGGAAAACGTCAATTTTATGGTAGAGGAAGTACTGGATTTTGTTCACACATCCGTGCGCTTTGCC
ATGGAACAGAAAGGGCTTGAGTACCAATGCCACCTGGATGACGATGTGCCTCTCAAGCTCTGGGGCGACAGCCTGCGCCT
CAAACAGGTGCTGCTCAACCTCATGAGCAACGCGGTCAAGTTTACCGCCAGGGGCAAGGTGGGGCTGCGCATCCACCGGC
AACAGGACGACGATGGTGACTGGCTGCACTTTGAGGTGTCAGATACGGGCATGGGCATAAGCCACGAATACCAGCAGCAC
CTTTTTGATCCCTATACGCAGGCCAACTCGAGCATCAGCCGCCGCTTTGGCGGCACGGGCCTGGGCCTGAGCATATGCAA
ACGTATTGCCGAGCTTATGCAGGGCAGCCTGTGGTGCGAAAGCAGGCTTGGCGAAGGTTCGCGATTTCATCTGCGCATAC
CATGTACCGCCGCCCGCAATATCTATTGCGAAACCAGCGATGAGGCGCATGGAGTTTTGCCCCTGCAGAACGCCGCAGAC
CTCAAGATACTTCTGGTAGAAGACAACGAGATCAATCAGGAAATAGCCAGAGCCATGCTGCGCCACCTCGATATTGAGTG
CGACCTTGCCCATAACGGCCGTGAAGCCGTACACATGGCGCTGCAAACATGCTATGACATGATATTTATGGATGTATATA
TGCCTGTTATGGACGGCCTGCATGCCACCCGTGAAATCCGCCGTAATCTGCCCAAAGCGCCACATGGCAAAGCTCTGCCC
ATCATCGCAATGACAGCCGTAGCCATGCCCGAAACTATGGATGAAATCATGGATTCAGGTATGGACGACTACCTTGCCAA
ACCTTTTAATCTGGTAACGCTGCGCAACAAGATAGTTCAGTGGCTTGGCCTCTGCTGA

Upstream 100 bases:

>100_bases
GACTTTTTCCATGCCGTAGCCAGGTGATCCTGTTTTCCCGGGCGGCAGCTATGTTATCAGGCAAATGTCGCTGGAAATCT
TAACCTTTACGGAGTGCCGC

Downstream 100 bases:

>100_bases
ACAAACCCGCGCCGCTTCAAGCCCCTGCAAAAAACATGTCCGCCAAGATATCCAAGACCAATGCCGCCCGTCAGCTGGAA
AAACAGGGCATAGCCCATAC

Product: GAF sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MPVHSKAPDGPGVNPMILALEISSSALLHYHKAPFLHASLASMGETLHCGQVVLLEYANSRWAEPFVWTSSVPSAACPLP
LPTLDDMAPLLDTFLQRKELCISDTGQMPEGPQKKFFLARQVRAALCIPIVHEGGLCGGICLTRRISGQGWSQDDVNICH
LLSNILAMVLTHFRLYGRLRQKHKQLRDILDAFPNPVCIVDMETNRILFSNKSVAETFPTPQESEDDKCHKRLMGRDSPC
PYCTNPIIRRTGEAYQWTYQNEVTNRTYTVVDKVIKWDNDRPVRLSISTDITDILRTRHEKQSAVIASQAKTEFLAHMSH
EIRTPLNGIIGLTHLALQSGPDGELKEYLLKIRSSSTNLLAIINDVLDLSKIEANKMELENVNFMVEEVLDFVHTSVRFA
MEQKGLEYQCHLDDDVPLKLWGDSLRLKQVLLNLMSNAVKFTARGKVGLRIHRQQDDDGDWLHFEVSDTGMGISHEYQQH
LFDPYTQANSSISRRFGGTGLGLSICKRIAELMQGSLWCESRLGEGSRFHLRIPCTAARNIYCETSDEAHGVLPLQNAAD
LKILLVEDNEINQEIARAMLRHLDIECDLAHNGREAVHMALQTCYDMIFMDVYMPVMDGLHATREIRRNLPKAPHGKALP
IIAMTAVAMPETMDEIMDSGMDDYLAKPFNLVTLRNKIVQWLGLC

Sequences:

>Translated_685_residues
MPVHSKAPDGPGVNPMILALEISSSALLHYHKAPFLHASLASMGETLHCGQVVLLEYANSRWAEPFVWTSSVPSAACPLP
LPTLDDMAPLLDTFLQRKELCISDTGQMPEGPQKKFFLARQVRAALCIPIVHEGGLCGGICLTRRISGQGWSQDDVNICH
LLSNILAMVLTHFRLYGRLRQKHKQLRDILDAFPNPVCIVDMETNRILFSNKSVAETFPTPQESEDDKCHKRLMGRDSPC
PYCTNPIIRRTGEAYQWTYQNEVTNRTYTVVDKVIKWDNDRPVRLSISTDITDILRTRHEKQSAVIASQAKTEFLAHMSH
EIRTPLNGIIGLTHLALQSGPDGELKEYLLKIRSSSTNLLAIINDVLDLSKIEANKMELENVNFMVEEVLDFVHTSVRFA
MEQKGLEYQCHLDDDVPLKLWGDSLRLKQVLLNLMSNAVKFTARGKVGLRIHRQQDDDGDWLHFEVSDTGMGISHEYQQH
LFDPYTQANSSISRRFGGTGLGLSICKRIAELMQGSLWCESRLGEGSRFHLRIPCTAARNIYCETSDEAHGVLPLQNAAD
LKILLVEDNEINQEIARAMLRHLDIECDLAHNGREAVHMALQTCYDMIFMDVYMPVMDGLHATREIRRNLPKAPHGKALP
IIAMTAVAMPETMDEIMDSGMDDYLAKPFNLVTLRNKIVQWLGLC
>Mature_684_residues
PVHSKAPDGPGVNPMILALEISSSALLHYHKAPFLHASLASMGETLHCGQVVLLEYANSRWAEPFVWTSSVPSAACPLPL
PTLDDMAPLLDTFLQRKELCISDTGQMPEGPQKKFFLARQVRAALCIPIVHEGGLCGGICLTRRISGQGWSQDDVNICHL
LSNILAMVLTHFRLYGRLRQKHKQLRDILDAFPNPVCIVDMETNRILFSNKSVAETFPTPQESEDDKCHKRLMGRDSPCP
YCTNPIIRRTGEAYQWTYQNEVTNRTYTVVDKVIKWDNDRPVRLSISTDITDILRTRHEKQSAVIASQAKTEFLAHMSHE
IRTPLNGIIGLTHLALQSGPDGELKEYLLKIRSSSTNLLAIINDVLDLSKIEANKMELENVNFMVEEVLDFVHTSVRFAM
EQKGLEYQCHLDDDVPLKLWGDSLRLKQVLLNLMSNAVKFTARGKVGLRIHRQQDDDGDWLHFEVSDTGMGISHEYQQHL
FDPYTQANSSISRRFGGTGLGLSICKRIAELMQGSLWCESRLGEGSRFHLRIPCTAARNIYCETSDEAHGVLPLQNAADL
KILLVEDNEINQEIARAMLRHLDIECDLAHNGREAVHMALQTCYDMIFMDVYMPVMDGLHATREIRRNLPKAPHGKALPI
IAMTAVAMPETMDEIMDSGMDDYLAKPFNLVTLRNKIVQWLGLC

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=390, Percent_Identity=34.6153846153846, Blast_Score=221, Evalue=2e-58,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=42.4489795918367, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=41.8410041841004, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788713, Length=529, Percent_Identity=29.4896030245747, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87081816, Length=402, Percent_Identity=31.8407960199005, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=32.1739130434783, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=30.9734513274336, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=26.9961977186312, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=29.5652173913043, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788393, Length=209, Percent_Identity=29.1866028708134, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=27.8761061946903, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=31.9327731092437, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789808, Length=270, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87082012, Length=118, Percent_Identity=32.2033898305085, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=36.9747899159664, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=31.4516129032258, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=31.3559322033898, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=211, Percent_Identity=25.1184834123223, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=153, Percent_Identity=37.2549019607843, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323034, Length=175, Percent_Identity=32.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322000, Length=120, Percent_Identity=30.8333333333333, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 77154; Mature: 77023

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVHSKAPDGPGVNPMILALEISSSALLHYHKAPFLHASLASMGETLHCGQVVLLEYANS
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCC
RWAEPFVWTSSVPSAACPLPLPTLDDMAPLLDTFLQRKELCISDTGQMPEGPQKKFFLAR
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
QVRAALCIPIVHEGGLCGGICLTRRISGQGWSQDDVNICHLLSNILAMVLTHFRLYGRLR
HHHHHHHEEEEECCCCCCHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKHKQLRDILDAFPNPVCIVDMETNRILFSNKSVAETFPTPQESEDDKCHKRLMGRDSPC
HHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHCCCCCCCCHHHHHHHHCCCCCCC
PYCTNPIIRRTGEAYQWTYQNEVTNRTYTVVDKVIKWDNDRPVRLSISTDITDILRTRHE
CCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
KQSAVIASQAKTEFLAHMSHEIRTPLNGIIGLTHLALQSGPDGELKEYLLKIRSSSTNLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHH
AIINDVLDLSKIEANKMELENVNFMVEEVLDFVHTSVRFAMEQKGLEYQCHLDDDVPLKL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEE
WGDSLRLKQVLLNLMSNAVKFTARGKVGLRIHRQQDDDGDWLHFEVSDTGMGISHEYQQH
CCCHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHH
LFDPYTQANSSISRRFGGTGLGLSICKRIAELMQGSLWCESRLGEGSRFHLRIPCTAARN
HCCCHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCHHCCC
IYCETSDEAHGVLPLQNAADLKILLVEDNEINQEIARAMLRHLDIECDLAHNGREAVHMA
EEEECCCCCCCEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHH
LQTCYDMIFMDVYMPVMDGLHATREIRRNLPKAPHGKALPIIAMTAVAMPETMDEIMDSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCC
MDDYLAKPFNLVTLRNKIVQWLGLC
CHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVHSKAPDGPGVNPMILALEISSSALLHYHKAPFLHASLASMGETLHCGQVVLLEYANS
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCC
RWAEPFVWTSSVPSAACPLPLPTLDDMAPLLDTFLQRKELCISDTGQMPEGPQKKFFLAR
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
QVRAALCIPIVHEGGLCGGICLTRRISGQGWSQDDVNICHLLSNILAMVLTHFRLYGRLR
HHHHHHHEEEEECCCCCCHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKHKQLRDILDAFPNPVCIVDMETNRILFSNKSVAETFPTPQESEDDKCHKRLMGRDSPC
HHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHCCCCCCCCHHHHHHHHCCCCCCC
PYCTNPIIRRTGEAYQWTYQNEVTNRTYTVVDKVIKWDNDRPVRLSISTDITDILRTRHE
CCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
KQSAVIASQAKTEFLAHMSHEIRTPLNGIIGLTHLALQSGPDGELKEYLLKIRSSSTNLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHH
AIINDVLDLSKIEANKMELENVNFMVEEVLDFVHTSVRFAMEQKGLEYQCHLDDDVPLKL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEE
WGDSLRLKQVLLNLMSNAVKFTARGKVGLRIHRQQDDDGDWLHFEVSDTGMGISHEYQQH
CCCHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHH
LFDPYTQANSSISRRFGGTGLGLSICKRIAELMQGSLWCESRLGEGSRFHLRIPCTAARN
HCCCHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCHHCCC
IYCETSDEAHGVLPLQNAADLKILLVEDNEINQEIARAMLRHLDIECDLAHNGREAVHMA
EEEECCCCCCCEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHH
LQTCYDMIFMDVYMPVMDGLHATREIRRNLPKAPHGKALPIIAMTAVAMPETMDEIMDSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCC
MDDYLAKPFNLVTLRNKIVQWLGLC
CHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]