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The map label for this gene is dctA [H]

Identifier: 220904775

GI number: 220904775

Start: 1799444

End: 1800781

Strand: Direct

Name: dctA [H]

Synonym: Ddes_1507

Alternate gene names: 220904775

Gene position: 1799444-1800781 (Clockwise)

Preceding gene: 220904774

Following gene: 220904776

Centisome position: 62.62

GC content: 52.91

Gene sequence:

>1338_bases
ATGCTCAAGTATCTGAAAATTCTTTATGTTCAGGTTTTAATTGCGATCTGTATCGGCATTCTGCTTGGACACTTTTACCC
GCAGTTGGCAGTAAAAATGCAGCCGCTGGGGGCCGGCTTCATCAAGCTCATCAAGATGGTCATTGCCCCGCTGATCTTCT
GTACTGTTGTTACCGGTATTGCGGGCATGCAGGACCTTAAAGCGGTCGGCAAAATCGGCGGGCTCTCTCTTGTCTATTTC
ATGACCATGACTACGCTGGCCCTTATAATAGGCATGGTCGTCGTTAATATCGCGCAGCCGGGCGTGGGCATGAATATTGA
CGTCAACACGTTTGACGCCAGCGCCAAGGGACTCGCCGACCAGTATGCCAGCAAGGCCAAAGATCAGACGCTCGCGGCCT
TTTTGATGAATATCATCCCCAGCACCTTTGTTTCTGCCTTTACCAGCGGCGAAATACTCCAGGTTCTGATGATAGCCATC
CTTTTCGCCTTTGCCCTGAATTTCAGTGGGGAAAAGGGGCAGTTGGTGCTTGATTTCGTCAAAAGTTTTTCCGAAGCGCT
TTTCAAGCTGATCAACATCATCATGCGCGTCGCTCCCGTGGGCGCATTCGGCGCAATGGCCTTCACCATCGGGAAAGAGG
GACTCGGCTCTGTCGTCTCCCTGGGTGAGCTGATCCTCTGTTTCTATCTCACCAGCCTTCTTTTCGTCATTCTCGTCCTC
GGCGCTGTGGCCACCTATTCCGGCTTCAATATTTTCAAATTCATCCGCTATATCAAAGAGGAACTGCTCATTGTGCTCGG
CACGTCTTCCTCAGAATCCGTTTTGCCCAACATGCTCTACAAAATGGAAAAAGCGGGCTGTCAAAAGAGCGTGGTCGATC
TTGTCATCCCCACCGGCTATTCCTTCAACCTTGACGGAACGGCCATATACCTGACCATGGCAGCCATATTTCTGGCGCAG
GCCACCAACACCGCTCTGACCACAGCCGACCAGCTCACACTGCTCATCATCCTCATCATCTCTTCCAAGGGTGCTGCGGC
GGTTACTGGCGGCGGCTTTATCGTACTTGCCGGATCCATAAGCTCCGTAAGCAGCATTCCCCCGGAAAGCCTTGCCATCA
TCTTCGGCATCGACCGCTTCATGTCCGAGGCGCGCGCGCTGACCAATCTGGTCGGCAACGGCGTGGCCTCCATCACCATT
GCCAAAATAACCGGCAAACTTGATCAGGAGCAGCTGCGCCGGGAACTGGACAAAGTCCCCGGACAGACACAGACGATTGT
AGACGAAGATATGGGCGAAAGCCCGGCAGCTATGCGCGAAACAAGCATGACTTCGTAA

Upstream 100 bases:

>100_bases
TGTAGCGACATCCTTCGCACAGGGACCGCAAGACCTGTCCTGAACCCATTGCAGCTTTCAGCCGGTTGCGCTTGCGCACG
CTCAAGCCAAAGGTGGACTT

Downstream 100 bases:

>100_bases
TCGCGGCATAACTGTCCTCCGGCAGCAGCCCGGATCTGGCGCAAACATTGCCGCTTTTCGCCAGATCCGGGCGCGCAGGG
CTGAAACCGCTTTGCCCGGT

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLKYLKILYVQVLIAICIGILLGHFYPQLAVKMQPLGAGFIKLIKMVIAPLIFCTVVTGIAGMQDLKAVGKIGGLSLVYF
MTMTTLALIIGMVVVNIAQPGVGMNIDVNTFDASAKGLADQYASKAKDQTLAAFLMNIIPSTFVSAFTSGEILQVLMIAI
LFAFALNFSGEKGQLVLDFVKSFSEALFKLINIIMRVAPVGAFGAMAFTIGKEGLGSVVSLGELILCFYLTSLLFVILVL
GAVATYSGFNIFKFIRYIKEELLIVLGTSSSESVLPNMLYKMEKAGCQKSVVDLVIPTGYSFNLDGTAIYLTMAAIFLAQ
ATNTALTTADQLTLLIILIISSKGAAAVTGGGFIVLAGSISSVSSIPPESLAIIFGIDRFMSEARALTNLVGNGVASITI
AKITGKLDQEQLRRELDKVPGQTQTIVDEDMGESPAAMRETSMTS

Sequences:

>Translated_445_residues
MLKYLKILYVQVLIAICIGILLGHFYPQLAVKMQPLGAGFIKLIKMVIAPLIFCTVVTGIAGMQDLKAVGKIGGLSLVYF
MTMTTLALIIGMVVVNIAQPGVGMNIDVNTFDASAKGLADQYASKAKDQTLAAFLMNIIPSTFVSAFTSGEILQVLMIAI
LFAFALNFSGEKGQLVLDFVKSFSEALFKLINIIMRVAPVGAFGAMAFTIGKEGLGSVVSLGELILCFYLTSLLFVILVL
GAVATYSGFNIFKFIRYIKEELLIVLGTSSSESVLPNMLYKMEKAGCQKSVVDLVIPTGYSFNLDGTAIYLTMAAIFLAQ
ATNTALTTADQLTLLIILIISSKGAAAVTGGGFIVLAGSISSVSSIPPESLAIIFGIDRFMSEARALTNLVGNGVASITI
AKITGKLDQEQLRRELDKVPGQTQTIVDEDMGESPAAMRETSMTS
>Mature_445_residues
MLKYLKILYVQVLIAICIGILLGHFYPQLAVKMQPLGAGFIKLIKMVIAPLIFCTVVTGIAGMQDLKAVGKIGGLSLVYF
MTMTTLALIIGMVVVNIAQPGVGMNIDVNTFDASAKGLADQYASKAKDQTLAAFLMNIIPSTFVSAFTSGEILQVLMIAI
LFAFALNFSGEKGQLVLDFVKSFSEALFKLINIIMRVAPVGAFGAMAFTIGKEGLGSVVSLGELILCFYLTSLLFVILVL
GAVATYSGFNIFKFIRYIKEELLIVLGTSSSESVLPNMLYKMEKAGCQKSVVDLVIPTGYSFNLDGTAIYLTMAAIFLAQ
ATNTALTTADQLTLLIILIISSKGAAAVTGGGFIVLAGSISSVSSIPPESLAIIFGIDRFMSEARALTNLVGNGVASITI
AKITGKLDQEQLRRELDKVPGQTQTIVDEDMGESPAAMRETSMTS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=437, Percent_Identity=26.3157894736842, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI21314632, Length=452, Percent_Identity=26.3274336283186, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI169790839, Length=466, Percent_Identity=26.6094420600858, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI5032093, Length=403, Percent_Identity=29.0322580645161, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI40254478, Length=481, Percent_Identity=24.948024948025, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI66773030, Length=421, Percent_Identity=25.41567695962, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=29.7101449275362, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=29.7101449275362, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI194239697, Length=468, Percent_Identity=25.4273504273504, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI262359914, Length=375, Percent_Identity=28, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI301601644, Length=180, Percent_Identity=26.1111111111111, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789947, Length=423, Percent_Identity=63.1205673758865, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=37.2093023255814, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI1788024, Length=293, Percent_Identity=21.8430034129693, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=390, Percent_Identity=23.8461538461538, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193206505, Length=489, Percent_Identity=24.1308793456033, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983106, Length=445, Percent_Identity=23.3707865168539, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71983099, Length=445, Percent_Identity=23.3707865168539, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=431, Percent_Identity=24.3619489559165, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=463, Percent_Identity=24.8380129589633, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=427, Percent_Identity=22.248243559719, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583025, Length=422, Percent_Identity=24.8815165876777, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17137668, Length=422, Percent_Identity=24.8815165876777, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24583023, Length=422, Percent_Identity=24.8815165876777, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281360481, Length=428, Percent_Identity=23.8317757009346, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281360483, Length=427, Percent_Identity=23.6533957845433, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137666, Length=427, Percent_Identity=23.6533957845433, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47352; Mature: 47352

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHCCCCCCHHHHHCCCCC
>Mature Secondary Structure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CCCHHHHHHCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA