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The map label for this gene is hisC [H]

Identifier: 220904035

GI number: 220904035

Start: 894931

End: 896091

Strand: Reverse

Name: hisC [H]

Synonym: Ddes_0761

Alternate gene names: 220904035

Gene position: 896091-894931 (Counterclockwise)

Preceding gene: 220904036

Following gene: 220904034

Centisome position: 31.19

GC content: 58.83

Gene sequence:

>1161_bases
ATGTTTCAGATCAGCGTGCGGCAGGAAATTCTTGCCCTCAAGGCCTATGTTCCCGGCCTGTCCATTGCTGAAATCCAGCA
AAAATACGGCCTTGCCCAGGTCATCAAAATGGCCAGCAACGAAAACCCGCTGGGCATGCCGCCCCTGGCCATACAGGCCG
TGCAACGCCATGCCGACATGGGCTTTCGCTACCCCCAGGGCGGCAATCCCCGTCTGGTGGAGGCGCTGGCCCGCAGGCAC
TGCCTTGAGCCTGCCCGCGTAGTCGTTGGCAACGGTTCGGATGAGATCATAGACCTGCTTATCCGCATCATGGCCGAACC
GGGTATACACAACCTCGTATGCTTTGACCCCTGTTTCAGCATTTATCCCATTCAGGGACGCATCGGCGGCGTCGAGGTGC
GGCGGCAGCCTCTCAATGACGACTTTTCCTTTGACTTTGACGCCCTTCTTTCGCATGTGGACGACAACACCCGCCTTGTG
TTTGTGACCACACCCGATAATCCCTCCGGCTATTGTCCCCCGCGTGAAGCCGTGGCGCAACTGGCCCGCCGTCTGGCGGA
AACCGCGCCCCGCTGTCTGCTGGTTGTGGACGAAGCCTATATGGATTTTGCCGAAAATGAGCAGGAATCATCCCTGCTGG
CCAGTGGTATCCTACCGGAAAACACGGCATTTCTCCGCACATTCTCCAAAAGCTTCGGTCTGGCGGGACTGCGCGTGGGC
TACGGCATTCTGCCCCCGGGGCTGGCCGACTTCTGGTGGCGGGCGCGACTGCCTTTTTCCGTCAACATTCTGGCAGAAGA
AGCCGCTTTGGCGGCGCTTGCCGATACGGCCTTTCTTGACGCGACCATGCACACCGTACGCCGGGGCCGCAATGTCCTTA
CTGTAGGGCTGACCGCACTGGGTTGCATGGTCTGGCCCAGCGCGGCCAACTTTGTACTCTTCAGACTGCCGGAAAACACC
CTTGGCGCTCAGGACTGTTTCGAGGCCCTGCTGCGGCGCGGCATTATCATACGCCCGCTCAAAAGCTATAACCTGCCGGA
ACATTTGCGGGTCAGCGTGGGCAACAAGGATGAAAACAGGGCCTTTCTGGCCGCTATGGACGCAATTTTGCTGGAAAAGC
ACAGAGCCGCCAACGGCCTTGAAAACAAGGAGCTGAAATGA

Upstream 100 bases:

>100_bases
TGACATTGTCTGGAACTTCGAGATGACATTGTTCCATCCCGAATAATCTGTCAGACTAAACGCTTGTTGCCGGGTACACC
ATGCCGGTAATGGAGAAAGC

Downstream 100 bases:

>100_bases
GTGCGCGCCTGCCTGTGGTGACGCTGGACGGCCCTGCCGGAGTAGGCAAAACCACCCTGGCCCGCCGCATGGCTGAAAGC
CTGGGGCTTGCCTATCTGGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MFQISVRQEILALKAYVPGLSIAEIQQKYGLAQVIKMASNENPLGMPPLAIQAVQRHADMGFRYPQGGNPRLVEALARRH
CLEPARVVVGNGSDEIIDLLIRIMAEPGIHNLVCFDPCFSIYPIQGRIGGVEVRRQPLNDDFSFDFDALLSHVDDNTRLV
FVTTPDNPSGYCPPREAVAQLARRLAETAPRCLLVVDEAYMDFAENEQESSLLASGILPENTAFLRTFSKSFGLAGLRVG
YGILPPGLADFWWRARLPFSVNILAEEAALAALADTAFLDATMHTVRRGRNVLTVGLTALGCMVWPSAANFVLFRLPENT
LGAQDCFEALLRRGIIIRPLKSYNLPEHLRVSVGNKDENRAFLAAMDAILLEKHRAANGLENKELK

Sequences:

>Translated_386_residues
MFQISVRQEILALKAYVPGLSIAEIQQKYGLAQVIKMASNENPLGMPPLAIQAVQRHADMGFRYPQGGNPRLVEALARRH
CLEPARVVVGNGSDEIIDLLIRIMAEPGIHNLVCFDPCFSIYPIQGRIGGVEVRRQPLNDDFSFDFDALLSHVDDNTRLV
FVTTPDNPSGYCPPREAVAQLARRLAETAPRCLLVVDEAYMDFAENEQESSLLASGILPENTAFLRTFSKSFGLAGLRVG
YGILPPGLADFWWRARLPFSVNILAEEAALAALADTAFLDATMHTVRRGRNVLTVGLTALGCMVWPSAANFVLFRLPENT
LGAQDCFEALLRRGIIIRPLKSYNLPEHLRVSVGNKDENRAFLAAMDAILLEKHRAANGLENKELK
>Mature_386_residues
MFQISVRQEILALKAYVPGLSIAEIQQKYGLAQVIKMASNENPLGMPPLAIQAVQRHADMGFRYPQGGNPRLVEALARRH
CLEPARVVVGNGSDEIIDLLIRIMAEPGIHNLVCFDPCFSIYPIQGRIGGVEVRRQPLNDDFSFDFDALLSHVDDNTRLV
FVTTPDNPSGYCPPREAVAQLARRLAETAPRCLLVVDEAYMDFAENEQESSLLASGILPENTAFLRTFSKSFGLAGLRVG
YGILPPGLADFWWRARLPFSVNILAEEAALAALADTAFLDATMHTVRRGRNVLTVGLTALGCMVWPSAANFVLFRLPENT
LGAQDCFEALLRRGIIIRPLKSYNLPEHLRVSVGNKDENRAFLAAMDAILLEKHRAANGLENKELK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=314, Percent_Identity=29.2993630573248, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786816, Length=262, Percent_Identity=25.5725190839695, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=27.3972602739726, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42634; Mature: 42634

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQISVRQEILALKAYVPGLSIAEIQQKYGLAQVIKMASNENPLGMPPLAIQAVQRHADM
CEEEHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
GFRYPQGGNPRLVEALARRHCLEPARVVVGNGSDEIIDLLIRIMAEPGIHNLVCFDPCFS
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCE
IYPIQGRIGGVEVRRQPLNDDFSFDFDALLSHVDDNTRLVFVTTPDNPSGYCPPREAVAQ
EEEECCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHH
LARRLAETAPRCLLVVDEAYMDFAENEQESSLLASGILPENTAFLRTFSKSFGLAGLRVG
HHHHHHHCCCCEEEEECHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHC
YGILPPGLADFWWRARLPFSVNILAEEAALAALADTAFLDATMHTVRRGRNVLTVGLTAL
CCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
GCMVWPSAANFVLFRLPENTLGAQDCFEALLRRGIIIRPLKSYNLPEHLRVSVGNKDENR
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEEEHHHCCCCHHEEEECCCCCCCH
AFLAAMDAILLEKHRAANGLENKELK
HHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFQISVRQEILALKAYVPGLSIAEIQQKYGLAQVIKMASNENPLGMPPLAIQAVQRHADM
CEEEHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
GFRYPQGGNPRLVEALARRHCLEPARVVVGNGSDEIIDLLIRIMAEPGIHNLVCFDPCFS
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCE
IYPIQGRIGGVEVRRQPLNDDFSFDFDALLSHVDDNTRLVFVTTPDNPSGYCPPREAVAQ
EEEECCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHH
LARRLAETAPRCLLVVDEAYMDFAENEQESSLLASGILPENTAFLRTFSKSFGLAGLRVG
HHHHHHHCCCCEEEEECHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHC
YGILPPGLADFWWRARLPFSVNILAEEAALAALADTAFLDATMHTVRRGRNVLTVGLTAL
CCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
GCMVWPSAANFVLFRLPENTLGAQDCFEALLRRGIIIRPLKSYNLPEHLRVSVGNKDENR
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEEEHHHCCCCHHEEEECCCCCCCH
AFLAAMDAILLEKHRAANGLENKELK
HHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA