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The map label for this gene is ahpC [H]

Identifier: 220903877

GI number: 220903877

Start: 729384

End: 729950

Strand: Reverse

Name: ahpC [H]

Synonym: Ddes_0602

Alternate gene names: 220903877

Gene position: 729950-729384 (Counterclockwise)

Preceding gene: 220903880

Following gene: 220903875

Centisome position: 25.4

GC content: 53.62

Gene sequence:

>567_bases
ATGGCAAATCTGATCAATTCCAAGGTTGAACCCTTCAATGTGCAGGCATATCATCTGGGTGAGCTGAAAAATGTATGCGA
CACAGACCTGCTGGGGCACTGGTCCATTTTCTTTTTTTACCCTGCCGACTTTACTTTTGTATGCCCCACAGAGCTTGAAG
ACCTGTCGGACACCTACGAAGACTTCAAAAAACTCAATTGCGAAATTTACTCTGTCTCTACAGACAGCGCCTTTGTGCAT
AAAGCCTGGGCCGATGCTTCCCCAAGCATAGCCAAAATCAGATACCCCATGCTGTCCGACAGTGCGGGCACCCTTTCACG
CGCTTTTCATGTGCTGATTGAAGAGGCCGGTCAGGCCCTGCGCGGCAGCTTTATTGTAAACCCCGAAGGCATCATCAAAG
CTTACGAAGTGCACGACCTCGGCATCGGCCGCAATGCCGAAGAGCTGCTGCGCAAGCTTGAAGCAGCCCAGTTTGTGGCC
CAGCACGGCGATCAGGTATGCCCCGCCCGCTGGAAGCCCGGCAAGTCCACCCTTAAGCCCGGCCTTGACCTGGTGGGCAA
GCTGTAG

Upstream 100 bases:

>100_bases
AGACTTGACATTTTTATTAGGATTGAATACTGTTTTCAAACAGGACGATTCACAACCTTTTCCGGAGCCGTACGCGCGTT
CCGCCTGCAAGGAAAATAAT

Downstream 100 bases:

>100_bases
CCTGTATTTCTCAGTCCCATAGCCTCACCCCTCCTCTGGCACTATCCCCAAACCGGAACCACCCGCTTACGCGGGTGGTT
CCTTTATATCCATCATCGTT

Product: peroxiredoxin

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MANLINSKVEPFNVQAYHLGELKNVCDTDLLGHWSIFFFYPADFTFVCPTELEDLSDTYEDFKKLNCEIYSVSTDSAFVH
KAWADASPSIAKIRYPMLSDSAGTLSRAFHVLIEEAGQALRGSFIVNPEGIIKAYEVHDLGIGRNAEELLRKLEAAQFVA
QHGDQVCPARWKPGKSTLKPGLDLVGKL

Sequences:

>Translated_188_residues
MANLINSKVEPFNVQAYHLGELKNVCDTDLLGHWSIFFFYPADFTFVCPTELEDLSDTYEDFKKLNCEIYSVSTDSAFVH
KAWADASPSIAKIRYPMLSDSAGTLSRAFHVLIEEAGQALRGSFIVNPEGIIKAYEVHDLGIGRNAEELLRKLEAAQFVA
QHGDQVCPARWKPGKSTLKPGLDLVGKL
>Mature_187_residues
ANLINSKVEPFNVQAYHLGELKNVCDTDLLGHWSIFFFYPADFTFVCPTELEDLSDTYEDFKKLNCEIYSVSTDSAFVHK
AWADASPSIAKIRYPMLSDSAGTLSRAFHVLIEEAGQALRGSFIVNPEGIIKAYEVHDLGIGRNAEELLRKLEAAQFVAQ
HGDQVCPARWKPGKSTLKPGLDLVGKL

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=164, Percent_Identity=43.2926829268293, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI32455266, Length=164, Percent_Identity=43.2926829268293, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI32455264, Length=164, Percent_Identity=43.2926829268293, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI32483377, Length=186, Percent_Identity=42.4731182795699, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI5802974, Length=164, Percent_Identity=45.1219512195122, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI5453549, Length=172, Percent_Identity=43.0232558139535, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI32189392, Length=175, Percent_Identity=42.2857142857143, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI33188454, Length=77, Percent_Identity=48.0519480519481, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4758638, Length=163, Percent_Identity=29.4478527607362, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786822, Length=186, Percent_Identity=54.8387096774194, Blast_Score=227, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI32565831, Length=182, Percent_Identity=41.2087912087912, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI193204376, Length=182, Percent_Identity=41.2087912087912, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=38.4180790960452, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25153706, Length=164, Percent_Identity=26.219512195122, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323613, Length=186, Percent_Identity=35.4838709677419, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320661, Length=183, Percent_Identity=34.9726775956284, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319407, Length=164, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357347, Length=186, Percent_Identity=40.3225806451613, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17738015, Length=160, Percent_Identity=41.875, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17157991, Length=162, Percent_Identity=40.1234567901235, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24641739, Length=162, Percent_Identity=40.1234567901235, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24656348, Length=163, Percent_Identity=38.6503067484663, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17864676, Length=163, Percent_Identity=38.6503067484663, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17975518, Length=156, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652434, Length=156, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652436, Length=156, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581278, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20909; Mature: 20778

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLINSKVEPFNVQAYHLGELKNVCDTDLLGHWSIFFFYPADFTFVCPTELEDLSDTYE
CCCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHH
DFKKLNCEIYSVSTDSAFVHKAWADASPSIAKIRYPMLSDSAGTLSRAFHVLIEEAGQAL
HHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RGSFIVNPEGIIKAYEVHDLGIGRNAEELLRKLEAAQFVAQHGDQVCPARWKPGKSTLKP
CCCEEECCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCC
GLDLVGKL
CHHHHCCC
>Mature Secondary Structure 
ANLINSKVEPFNVQAYHLGELKNVCDTDLLGHWSIFFFYPADFTFVCPTELEDLSDTYE
CCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHH
DFKKLNCEIYSVSTDSAFVHKAWADASPSIAKIRYPMLSDSAGTLSRAFHVLIEEAGQAL
HHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RGSFIVNPEGIIKAYEVHDLGIGRNAEELLRKLEAAQFVAQHGDQVCPARWKPGKSTLKP
CCCEEECCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCC
GLDLVGKL
CHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]