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The map label for this gene is phoR [H]

Identifier: 220903844

GI number: 220903844

Start: 687006

End: 689015

Strand: Direct

Name: phoR [H]

Synonym: Ddes_0568

Alternate gene names: 220903844

Gene position: 687006-689015 (Clockwise)

Preceding gene: 220903843

Following gene: 220903845

Centisome position: 23.91

GC content: 62.94

Gene sequence:

>2010_bases
ATGCTTTCATTCAGAACCAGAATTTTTGGCGGCATGCTGGCCGTGGCCCTGGTTTCCATTGGTGTGGCCGTATTTTACGG
CAAGGCCTGGTTTGAAAAGGTGCAGCTTGAGGCGGCGCGCGAACGCCTTGTGCGCGAAACAGCGCTGGCCGGAGTCATTC
TGGATGGCCTTGGCGATCACACCGCCGGGCTGACGCGTCTGGCTGCTGTTCTTGATATGCCAGAAGAGCGCCTTTCGCTG
CTGGATCCGCAGGGGCATGTGCTTGGCGATACCGCGCCGGATGCGCAGCCCGTGACCAGGCTGGACAACCATGCCGACAG
GCCCGAAGTGCGCGAGGCCATGAGGGGGGCGCCGGGTTTTGCCATCCGTCCCAGCGGCACATTGGGCAAAGATCTGGCCT
ATGCCGCTGTGGTTCTGCAAAATGGCGATATCCTGCGCGTTTCTGTGCCCCTGGCGAGCCTCAGGCAGATTATCGACAGC
CGCCTTGCCGTATTCACGCAGATCGGCGTGATCACCGTTATCCTTTCCCTGATTCTGGCCGGGCTACTTTCCGGGGCGCT
GCGCCGCTCTTTGCGACAGATGGTGTCTGTGGTGGAGGGCATTTCACTGGGCAATTTTCAGCGCCGCCTGCGGCGCATCC
CCGGTTGCGAGTTTGCCCCCCTGGCCGATGCCGTGAACCGCATGGCCGAAAACATTGAGGAACACGTGCGCACTGCGGCG
GAACAGACCGCCCAGCTTGAAAGCATACTGGACACTATGAGTGACGGTGTGCTGGTACTTGGGCCGCGCGGGCGTATCCG
TCGCTGCAACAGGGCGCTGGTGCGCGAATTTCCTGCTGCTGCATCGGCCCTGGGCGCCCAGGTGGTGGAGGTCATCCCCT
CACCCCCCCTGCAAAACGCCGTGGACGAACTTATGGCCGAAGCCGAAGCCCATGCTGAAGCCCGTCAGCGGGCGGCGGTC
CTGACTGCCGCGGCACGGCATATTACCGTTCAGCAGGATGACGAGGCAAGCTCTGGTTCTTCCGCTGCTGCGGTTTCTGT
CTCTGCCCCGGTGGCCCAAGACCAGGCCTTGGCATCGTTCCCGACCTCCATCGGCTCCGCAGGGCCGGCCACGCATGGCG
CGGAGGCGGAAAACGACAAAATTCCTGCTCACGACGAAGCTTTTACTGCGGAAGGCGGGCGCGTACAGCGCTATTTGCAC
CTTGAGCTGCCTTCGGGCCAGGCCATGTCGGTCTGCATTTCCCTGCCGCCTGCGGCGGAGATGGCGGGTGGAGGGCAGGT
GGGTGCCGTGGCCGTATTCCACGACATAACGGAACTCATGCGGCTTGAACGTGTACGGCGCGATTTTGTTGCCAACGTGT
CGCACGAACTGCGCACGCCGCTCACGGCCATACAGGGGTATGCCGAAACCCTCACCAGTCTTGACGGGCCACCGGAATGC
CGCCGCTTTGGTGAAATAATCCTTAAAAACGGAGCCTGCCTTTCACGCATGGTTGATGACCTGCTGACGCTGGCCCGCCT
TGAGGGCAAGAGCGGCAGCCTTGAGCTTGCTCCCACAGACCCGCGGGAGGCTCTGGCCCAGGCAACGGGCATGTGCCGCG
AAGTGCTGGAGCATCGCCGCTGCCGGGTCGAGTCGCACCTTTCCGCAGACTGCCGGGTGATGGCAAGCCTGCCCCATTTG
ACGCAGGTTTTCCGTAATCTTCTGGAAAATGCAGGGCGCTACGCGCCCGAGGGCGGCAGCATCCGCGTGACGGCGCGTCA
GGTGGGCGACAGTGTGGCCTTTCGCATTGCCGACGACGGCCCGGGTATACCCCGGCAGGACCTGGAACGGATATTCGAGC
GCTTCTATCAGGTAGAGCGCCACCGGGGGCAAGCCAGCACCGGCCTTGGGCTTGCCATCTGCAAGCATATCATTGAGCGG
CACGGCGGCAGTATCCGGGCGGAAAGCCCCGCCACGGACGGCAGCACGGCCCTTGTTTTTACTCTCACTTCCGCCCACGG
AGCAGCATAG

Upstream 100 bases:

>100_bases
GGCTACAGGATAAAGGAATAGCCGCCTGGATCACGGGTAGGCTTGCCGGCCTGTGACGTGTCCGGGCAGATACGGCGGCA
CAGCCGCATTGGCGGAAGAT

Downstream 100 bases:

>100_bases
TCATGAAGGAATACCTGCAGGCACGCAACGTCAGCGTTTACTACGGGCAGCACAAGGCCCTGCATGAGGTCAGCCTGGAC
TTTGAGCCGTGCCGGGTTAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MLSFRTRIFGGMLAVALVSIGVAVFYGKAWFEKVQLEAARERLVRETALAGVILDGLGDHTAGLTRLAAVLDMPEERLSL
LDPQGHVLGDTAPDAQPVTRLDNHADRPEVREAMRGAPGFAIRPSGTLGKDLAYAAVVLQNGDILRVSVPLASLRQIIDS
RLAVFTQIGVITVILSLILAGLLSGALRRSLRQMVSVVEGISLGNFQRRLRRIPGCEFAPLADAVNRMAENIEEHVRTAA
EQTAQLESILDTMSDGVLVLGPRGRIRRCNRALVREFPAAASALGAQVVEVIPSPPLQNAVDELMAEAEAHAEARQRAAV
LTAAARHITVQQDDEASSGSSAAAVSVSAPVAQDQALASFPTSIGSAGPATHGAEAENDKIPAHDEAFTAEGGRVQRYLH
LELPSGQAMSVCISLPPAAEMAGGGQVGAVAVFHDITELMRLERVRRDFVANVSHELRTPLTAIQGYAETLTSLDGPPEC
RRFGEIILKNGACLSRMVDDLLTLARLEGKSGSLELAPTDPREALAQATGMCREVLEHRRCRVESHLSADCRVMASLPHL
TQVFRNLLENAGRYAPEGGSIRVTARQVGDSVAFRIADDGPGIPRQDLERIFERFYQVERHRGQASTGLGLAICKHIIER
HGGSIRAESPATDGSTALVFTLTSAHGAA

Sequences:

>Translated_669_residues
MLSFRTRIFGGMLAVALVSIGVAVFYGKAWFEKVQLEAARERLVRETALAGVILDGLGDHTAGLTRLAAVLDMPEERLSL
LDPQGHVLGDTAPDAQPVTRLDNHADRPEVREAMRGAPGFAIRPSGTLGKDLAYAAVVLQNGDILRVSVPLASLRQIIDS
RLAVFTQIGVITVILSLILAGLLSGALRRSLRQMVSVVEGISLGNFQRRLRRIPGCEFAPLADAVNRMAENIEEHVRTAA
EQTAQLESILDTMSDGVLVLGPRGRIRRCNRALVREFPAAASALGAQVVEVIPSPPLQNAVDELMAEAEAHAEARQRAAV
LTAAARHITVQQDDEASSGSSAAAVSVSAPVAQDQALASFPTSIGSAGPATHGAEAENDKIPAHDEAFTAEGGRVQRYLH
LELPSGQAMSVCISLPPAAEMAGGGQVGAVAVFHDITELMRLERVRRDFVANVSHELRTPLTAIQGYAETLTSLDGPPEC
RRFGEIILKNGACLSRMVDDLLTLARLEGKSGSLELAPTDPREALAQATGMCREVLEHRRCRVESHLSADCRVMASLPHL
TQVFRNLLENAGRYAPEGGSIRVTARQVGDSVAFRIADDGPGIPRQDLERIFERFYQVERHRGQASTGLGLAICKHIIER
HGGSIRAESPATDGSTALVFTLTSAHGAA
>Mature_669_residues
MLSFRTRIFGGMLAVALVSIGVAVFYGKAWFEKVQLEAARERLVRETALAGVILDGLGDHTAGLTRLAAVLDMPEERLSL
LDPQGHVLGDTAPDAQPVTRLDNHADRPEVREAMRGAPGFAIRPSGTLGKDLAYAAVVLQNGDILRVSVPLASLRQIIDS
RLAVFTQIGVITVILSLILAGLLSGALRRSLRQMVSVVEGISLGNFQRRLRRIPGCEFAPLADAVNRMAENIEEHVRTAA
EQTAQLESILDTMSDGVLVLGPRGRIRRCNRALVREFPAAASALGAQVVEVIPSPPLQNAVDELMAEAEAHAEARQRAAV
LTAAARHITVQQDDEASSGSSAAAVSVSAPVAQDQALASFPTSIGSAGPATHGAEAENDKIPAHDEAFTAEGGRVQRYLH
LELPSGQAMSVCISLPPAAEMAGGGQVGAVAVFHDITELMRLERVRRDFVANVSHELRTPLTAIQGYAETLTSLDGPPEC
RRFGEIILKNGACLSRMVDDLLTLARLEGKSGSLELAPTDPREALAQATGMCREVLEHRRCRVESHLSADCRVMASLPHL
TQVFRNLLENAGRYAPEGGSIRVTARQVGDSVAFRIADDGPGIPRQDLERIFERFYQVERHRGQASTGLGLAICKHIIER
HGGSIRAESPATDGSTALVFTLTSAHGAA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=221, Percent_Identity=37.5565610859729, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI48994928, Length=358, Percent_Identity=27.6536312849162, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=31.7796610169492, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=35.1219512195122, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI145693157, Length=221, Percent_Identity=31.2217194570136, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786912, Length=209, Percent_Identity=32.0574162679426, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=29.0178571428571, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=255, Percent_Identity=30.9803921568627, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87081816, Length=213, Percent_Identity=32.8638497652582, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=30.6976744186047, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1789403, Length=204, Percent_Identity=35.2941176470588, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=31.3304721030043, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=254, Percent_Identity=28.3464566929134, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1789808, Length=242, Percent_Identity=29.3388429752066, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=230, Percent_Identity=27.3913043478261, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=217, Percent_Identity=27.1889400921659, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI87082128, Length=255, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=219, Percent_Identity=27.8538812785388, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71517; Mature: 71517

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFRTRIFGGMLAVALVSIGVAVFYGKAWFEKVQLEAARERLVRETALAGVILDGLGDH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TAGLTRLAAVLDMPEERLSLLDPQGHVLGDTAPDAQPVTRLDNHADRPEVREAMRGAPGF
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCCCCC
AIRPSGTLGKDLAYAAVVLQNGDILRVSVPLASLRQIIDSRLAVFTQIGVITVILSLILA
EECCCCCCCHHHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLSGALRRSLRQMVSVVEGISLGNFQRRLRRIPGCEFAPLADAVNRMAENIEEHVRTAA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EQTAQLESILDTMSDGVLVLGPRGRIRRCNRALVREFPAAASALGAQVVEVIPSPPLQNA
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VDELMAEAEAHAEARQRAAVLTAAARHITVQQDDEASSGSSAAAVSVSAPVAQDQALASF
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHC
PTSIGSAGPATHGAEAENDKIPAHDEAFTAEGGRVQRYLHLELPSGQAMSVCISLPPAAE
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCHHH
MAGGGQVGAVAVFHDITELMRLERVRRDFVANVSHELRTPLTAIQGYAETLTSLDGPPEC
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
RRFGEIILKNGACLSRMVDDLLTLARLEGKSGSLELAPTDPREALAQATGMCREVLEHRR
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
CRVESHLSADCRVMASLPHLTQVFRNLLENAGRYAPEGGSIRVTARQVGDSVAFRIADDG
HHHHHHCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCEEEEECCCC
PGIPRQDLERIFERFYQVERHRGQASTGLGLAICKHIIERHGGSIRAESPATDGSTALVF
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEE
TLTSAHGAA
EEECCCCCC
>Mature Secondary Structure
MLSFRTRIFGGMLAVALVSIGVAVFYGKAWFEKVQLEAARERLVRETALAGVILDGLGDH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TAGLTRLAAVLDMPEERLSLLDPQGHVLGDTAPDAQPVTRLDNHADRPEVREAMRGAPGF
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCCCCC
AIRPSGTLGKDLAYAAVVLQNGDILRVSVPLASLRQIIDSRLAVFTQIGVITVILSLILA
EECCCCCCCHHHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLSGALRRSLRQMVSVVEGISLGNFQRRLRRIPGCEFAPLADAVNRMAENIEEHVRTAA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EQTAQLESILDTMSDGVLVLGPRGRIRRCNRALVREFPAAASALGAQVVEVIPSPPLQNA
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VDELMAEAEAHAEARQRAAVLTAAARHITVQQDDEASSGSSAAAVSVSAPVAQDQALASF
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHC
PTSIGSAGPATHGAEAENDKIPAHDEAFTAEGGRVQRYLHLELPSGQAMSVCISLPPAAE
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCHHH
MAGGGQVGAVAVFHDITELMRLERVRRDFVANVSHELRTPLTAIQGYAETLTSLDGPPEC
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
RRFGEIILKNGACLSRMVDDLLTLARLEGKSGSLELAPTDPREALAQATGMCREVLEHRR
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
CRVESHLSADCRVMASLPHLTQVFRNLLENAGRYAPEGGSIRVTARQVGDSVAFRIADDG
HHHHHHCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCEEEEECCCC
PGIPRQDLERIFERFYQVERHRGQASTGLGLAICKHIIERHGGSIRAESPATDGSTALVF
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEE
TLTSAHGAA
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]