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The map label for this gene is lspA [H]

Identifier: 220903665

GI number: 220903665

Start: 471894

End: 472430

Strand: Direct

Name: lspA [H]

Synonym: Ddes_0386

Alternate gene names: 220903665

Gene position: 471894-472430 (Clockwise)

Preceding gene: 220903664

Following gene: 220903666

Centisome position: 16.42

GC content: 60.34

Gene sequence:

>537_bases
ATGCGCAGGCGTTACCGAATCCTCGGGGGCATGGCCCTGCTGGCGCTGGTGCTTGACCAGCTCACCAAGTATGTTGTCAT
GCAGACCATACCGGAACACCGCTCTGTGCCGGTTATTGAAGGTCTGTTTGACCTTGTGAACATCCGCAACAGGGGAGCGG
CCTTCGGCTTTCTGAACCGTTCGGACATCGAATGGCAGTTCTGGCTGTTCCTCGGGGCTACGGTGGTGGCCGTATGGGCC
ATACTGATGCTGGTGCGCAGCTCGCATGACGAACCCTGGCTTTTTGCCGGGCTGGGCCTGGTCATGGGCGGCGCTCTGGG
CAACCTGGTGGACCGCATCCGCTTTCGGGCGGTGGTGGACTTTCTGGATGTCTACTGGGGCGACTGGCATTGGCCAGCCT
TTAACGTGGCGGATTCGGCCATCTTTGTGGGGGCCGCTCTGGCATGCGTCATCATGTGGCGCAAACCGCCCGAAAACGGT
AACGAAAAGGGCAGCAAAGCCGGAAAATCCTCCGGCAAAAGAGGGAGGGCCGCATGA

Upstream 100 bases:

>100_bases
CGCTGCTGGATTTACAGCACCGAACTCGGCTCCGACGCTTCGCATCCCGCCTTGTGTCCGCGCTGCACAGCGGTTATCAA
GGGTATGGAATCCTGAGAAC

Downstream 100 bases:

>100_bases
TCTTTCATTGGTGGCATGTGGTACTGGTCATGATCCCTATGATCCCCACATTGTGGAGTATCATACACATATGGGGGCAT
GAGTTTTCCACGCCCCAGCA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MRRRYRILGGMALLALVLDQLTKYVVMQTIPEHRSVPVIEGLFDLVNIRNRGAAFGFLNRSDIEWQFWLFLGATVVAVWA
ILMLVRSSHDEPWLFAGLGLVMGGALGNLVDRIRFRAVVDFLDVYWGDWHWPAFNVADSAIFVGAALACVIMWRKPPENG
NEKGSKAGKSSGKRGRAA

Sequences:

>Translated_178_residues
MRRRYRILGGMALLALVLDQLTKYVVMQTIPEHRSVPVIEGLFDLVNIRNRGAAFGFLNRSDIEWQFWLFLGATVVAVWA
ILMLVRSSHDEPWLFAGLGLVMGGALGNLVDRIRFRAVVDFLDVYWGDWHWPAFNVADSAIFVGAALACVIMWRKPPENG
NEKGSKAGKSSGKRGRAA
>Mature_178_residues
MRRRYRILGGMALLALVLDQLTKYVVMQTIPEHRSVPVIEGLFDLVNIRNRGAAFGFLNRSDIEWQFWLFLGATVVAVWA
ILMLVRSSHDEPWLFAGLGLVMGGALGNLVDRIRFRAVVDFLDVYWGDWHWPAFNVADSAIFVGAALACVIMWRKPPENG
NEKGSKAGKSSGKRGRAA

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=138, Percent_Identity=41.304347826087, Blast_Score=94, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 19903; Mature: 19903

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRYRILGGMALLALVLDQLTKYVVMQTIPEHRSVPVIEGLFDLVNIRNRGAAFGFLNR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
SDIEWQFWLFLGATVVAVWAILMLVRSSHDEPWLFAGLGLVMGGALGNLVDRIRFRAVVD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLDVYWGDWHWPAFNVADSAIFVGAALACVIMWRKPPENGNEKGSKAGKSSGKRGRAA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRRYRILGGMALLALVLDQLTKYVVMQTIPEHRSVPVIEGLFDLVNIRNRGAAFGFLNR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
SDIEWQFWLFLGATVVAVWAILMLVRSSHDEPWLFAGLGLVMGGALGNLVDRIRFRAVVD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLDVYWGDWHWPAFNVADSAIFVGAALACVIMWRKPPENGNEKGSKAGKSSGKRGRAA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA