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The map label for this gene is hisI [H]

Identifier: 220903641

GI number: 220903641

Start: 439200

End: 439613

Strand: Reverse

Name: hisI [H]

Synonym: Ddes_0361

Alternate gene names: 220903641

Gene position: 439613-439200 (Counterclockwise)

Preceding gene: 220903645

Following gene: 220903640

Centisome position: 15.3

GC content: 60.87

Gene sequence:

>414_bases
ATGACAGCCCCCGAACCGCAGTCTTCCGCCGCCCCCGGCGAGGCTTTCACCCCCGATTTCAGCAAGGGCCTTCTGCCCGC
CATCGCACAGGACCACGCCAGCGGCGAGGTGCTCATGCTGGCGTATATGAATGAAGAAGCCTGGCGTAAAACCCTTGAGA
CCGGCCAGGCTCACTACTGGAGCCGCAGCCGAGAAAAGATCTGGCATAAAGGCGGCACTTCGGGGCATATACAAAAAGTG
CTCGCTGTGCGGCTGGACTGCGACAGCGACACGGTACTGCTGTTTGTGGACCAGGTGGGCGGCGCGGCCTGTCATACGGG
ACGGCGCACCTGCTTTTACCGGGAATGGAAGGATGGCGCCGTCAGCGAGTGCGCCCCGATGGTCTTTGATCCCCAAAAAG
TTTACGGCGTATAA

Upstream 100 bases:

>100_bases
CTTGCGTCCCATGCCTCTTACGAGTACGTTTATTTCCTTTGCCGCCCAACAACGCCCACGTAACGGGCCGCTCAGGGCGC
AGCCTTTTCAAGGAGTGACC

Downstream 100 bases:

>100_bases
AGGAAAGAATCATGAGCGCGGACATAAAACCCATCATCAAGCTCGGCGTGCCCAAAGGCTCGCTGGAAGAAGCCACCATC
AATCTTTTCGAACGTGCGGG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MTAPEPQSSAAPGEAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGHIQKV
LAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYREWKDGAVSECAPMVFDPQKVYGV

Sequences:

>Translated_137_residues
MTAPEPQSSAAPGEAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGHIQKV
LAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYREWKDGAVSECAPMVFDPQKVYGV
>Mature_136_residues
TAPEPQSSAAPGEAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGHIQKVL
AVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYREWKDGAVSECAPMVFDPQKVYGV

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=46.7391304347826, Blast_Score=98, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=109, Percent_Identity=38.5321100917431, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15103; Mature: 14972

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPEPQSSAAPGEAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYW
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCHHH
SRSREKIWHKGGTSGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYREWKDGA
HHHHHHHHHCCCCCHHHHEEHHEEECCCCCEEEEEEECCCCCEECCCCCCEEEECCCCCC
VSECAPMVFDPQKVYGV
HHHCCCCEECHHHHCCC
>Mature Secondary Structure 
TAPEPQSSAAPGEAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCHHH
SRSREKIWHKGGTSGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYREWKDGA
HHHHHHHHHCCCCCHHHHEEHHEEECCCCCEEEEEEECCCCCEECCCCCCEEEECCCCCC
VSECAPMVFDPQKVYGV
HHHCCCCEECHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA