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The map label for this gene is serA [H]

Identifier: 220903558

GI number: 220903558

Start: 329737

End: 330666

Strand: Reverse

Name: serA [H]

Synonym: Ddes_0277

Alternate gene names: 220903558

Gene position: 330666-329737 (Counterclockwise)

Preceding gene: 220903559

Following gene: 220903556

Centisome position: 11.51

GC content: 59.35

Gene sequence:

>930_bases
GTGAAAATTCTTGTTACTCCCCGTTCTTTTGGCAAAACCAATCCCGAACTGTTTGACCGCCTGACGCAGGCCGGTCTTGA
GGTAGTGCGCAACGATACTGGCGGCATTCTTTCTGCCGACCAGATGCGTGAAAAACTGGCCGGATGCCAGGGCGTCATCC
TGGGGGTAGACCCTATGAGCGCCGATGTGCTGGCCGCCGCGCCGGAGCTTCGGGCCATCGCCAAATACGGCGTGGGCCTG
GATAATATTGACCTTGAGGCCTGCAAGCAGCGCGGCATTGCCGTATCGCGCACCGTAGGGGCCAACAGCAATGCTGTGGC
CGACTATGCGCTGACCCTCATGCTTATGGTAGCGCGCAAGGCCGGGCTTATTGACCGCCGCTGCCGTGAAAAGGACTGGG
GCAAAATCACCAGTATTGACCTGTATGGCAAAACCCTGGGCATCGTAGGCCTTGGAGCCATCGGCCGCTGCGTTGTCAAA
CGGGCGCAGGGCTTCGGCATGAAAATTCTCGGCCATGACATCGCATGGGACGAAGCCTGGGCCAGTGCCGAAGGCGTTGA
GCGCGCAGACATGGACCGCATCTGCCGCGAAGCAGATTTTATTACCCTGCATACAGTGCTGACGGACGAAACCCGCAACT
GCATCAGTACCGGGCGGATAGCCATGATGAAAAAAACCGCGGTTATCATCAATACCGCTCGCGGCGGCCTTATTGATGAA
ACGGCCCTGCTGACCGCCCTGCAGGAAGGCCGCATCTATGGCGCGGGCCTTGATGTTTTTGAGCAGGAACCCCCGGCGGA
CCCGGCCTGGTATGCGCTGGACAATCTGGTCATGGGGTCCCATTGCTCTTCTTCCACTGCCGGAGCCACAGAGACCATGG
GGCGTATGGCCGTGGACAACCTGCTCCGTGACCTTGGCCTGAGCCGTTAG

Upstream 100 bases:

>100_bases
ACAATTTACGGTCTTGGAGTAAGCCTGTAGGCCAGCCGCTCGGCATTTTTGCGGGCTTTTGCCCTGCCCTGCGCCCACTC
CGCCCCCAAGAGGTACTGTT

Downstream 100 bases:

>100_bases
CGTTATGGGCGCCTGAAATATTTTGTGGGGGGAGGGGCATCTTTATAAAAGGCCCCTCCTCCTAAAACGTTTATTCCTGT
TTCCATCTGCTGCAGCAATG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVILGVDPMSADVLAAAPELRAIAKYGVGL
DNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVARKAGLIDRRCREKDWGKITSIDLYGKTLGIVGLGAIGRCVVK
RAQGFGMKILGHDIAWDEAWASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGLIDE
TALLTALQEGRIYGAGLDVFEQEPPADPAWYALDNLVMGSHCSSSTAGATETMGRMAVDNLLRDLGLSR

Sequences:

>Translated_309_residues
MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVILGVDPMSADVLAAAPELRAIAKYGVGL
DNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVARKAGLIDRRCREKDWGKITSIDLYGKTLGIVGLGAIGRCVVK
RAQGFGMKILGHDIAWDEAWASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGLIDE
TALLTALQEGRIYGAGLDVFEQEPPADPAWYALDNLVMGSHCSSSTAGATETMGRMAVDNLLRDLGLSR
>Mature_309_residues
MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVILGVDPMSADVLAAAPELRAIAKYGVGL
DNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVARKAGLIDRRCREKDWGKITSIDLYGKTLGIVGLGAIGRCVVK
RAQGFGMKILGHDIAWDEAWASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGLIDE
TALLTALQEGRIYGAGLDVFEQEPPADPAWYALDNLVMGSHCSSSTAGATETMGRMAVDNLLRDLGLSR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=278, Percent_Identity=37.0503597122302, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4557497, Length=207, Percent_Identity=36.231884057971, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI61743967, Length=207, Percent_Identity=36.231884057971, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI6912396, Length=291, Percent_Identity=30.2405498281787, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI145580578, Length=207, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4557499, Length=207, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI145580575, Length=207, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI87082289, Length=277, Percent_Identity=36.101083032491, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787645, Length=226, Percent_Identity=33.1858407079646, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789279, Length=277, Percent_Identity=28.8808664259928, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788660, Length=217, Percent_Identity=32.258064516129, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=292, Percent_Identity=33.2191780821918, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=202, Percent_Identity=35.6435643564356, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=32.7868852459016, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=313, Percent_Identity=27.4760383386581, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=310, Percent_Identity=27.4193548387097, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=272, Percent_Identity=26.4705882352941, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI19921140, Length=247, Percent_Identity=37.246963562753, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=30.9904153354633, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=30.9904153354633, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=30.9904153354633, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574284, Length=312, Percent_Identity=31.0897435897436, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=30.9904153354633, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=276, Percent_Identity=30.7971014492754, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24585516, Length=275, Percent_Identity=31.2727272727273, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI28571528, Length=307, Percent_Identity=30.6188925081433, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=207, Percent_Identity=34.7826086956522, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646446, Length=237, Percent_Identity=34.1772151898734, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646448, Length=237, Percent_Identity=34.1772151898734, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646452, Length=237, Percent_Identity=34.1772151898734, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24646450, Length=237, Percent_Identity=34.1772151898734, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33188; Mature: 33188

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVILGVDPMS
CEEEECCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCC
ADVLAAAPELRAIAKYGVGLDNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVARK
CHHHHCCHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AGLIDRRCREKDWGKITSIDLYGKTLGIVGLGAIGRCVVKRAQGFGMKILGHDIAWDEAW
CCHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHH
ASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGLIDE
HCCCCCCHHHHHHHHHHCCEEEEEEEECHHHHHHHHHCCEEEEEEEEEEEECCCCCCCHH
TALLTALQEGRIYGAGLDVFEQEPPADPAWYALDNLVMGSHCSSSTAGATETMGRMAVDN
HHHHHHHHHCCEEECCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LLRDLGLSR
HHHHHCCCC
>Mature Secondary Structure
MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVILGVDPMS
CEEEECCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCC
ADVLAAAPELRAIAKYGVGLDNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVARK
CHHHHCCHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AGLIDRRCREKDWGKITSIDLYGKTLGIVGLGAIGRCVVKRAQGFGMKILGHDIAWDEAW
CCHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHH
ASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGLIDE
HCCCCCCHHHHHHHHHHCCEEEEEEEECHHHHHHHHHCCEEEEEEEEEEEECCCCCCCHH
TALLTALQEGRIYGAGLDVFEQEPPADPAWYALDNLVMGSHCSSSTAGATETMGRMAVDN
HHHHHHHHHCCEEECCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LLRDLGLSR
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]