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The map label for this gene is pntB [H]

Identifier: 220903497

GI number: 220903497

Start: 266427

End: 268928

Strand: Direct

Name: pntB [H]

Synonym: Ddes_0216

Alternate gene names: 220903497

Gene position: 266427-268928 (Clockwise)

Preceding gene: 220903496

Following gene: 220903498

Centisome position: 9.27

GC content: 61.27

Gene sequence:

>2502_bases
ATGAATGCAATAACCTACAACATCATAGCCGGCATTCTTGTGGCTGCCGTCCTGTTCGGCCTTCGCCTCATGAACAAGGT
TCCCACTGCGGTCCGGGGCAACCTCTTTTGCGCCTCTGCCATGGGCCTGGCCATTCTTGTCACCATGTTCAAGGACGGCT
CGCTGGCCTCGCCCGCACTGTGGCTTGCCATTGCTGTAGGCATGACCCTGGGTCTTACCTTGTCCAACAAGGTCAAGATG
ATCCAGATGCCGCAGATGGTGGCCTTTTTGCACGGCATCGGCGGCGGCGCGGCGGCCATCGTGAGCTTTCTTGTGCTCAC
CGACACGGGCGCGCCCTCGGCCTTTGAGCGCGGCAGCGCCTGCCTGGCGCTTGCCATGGGCATGACTACCATAGCCGGTT
CCTTTGTGGCTGCGGGCAAACTGCACCAGATTCTGCCGCAAAAGCCCGTTATTCTGCCCGATCACACCAAAATCATCATG
GCGATTCTTGCGGTTATGGGTTTTTCCGTGCTTATGGGCACGGCCTTTCCGCAGTTTCTGTTCGGTTTCTTCATCTTTTT
GATGTTTGTCACCGGCACGGCCTTCGGCATCGGCTTTACCCTCCGCGTGGGCGGGGCCGACATGCCCATCACCATCTCGC
TGCTGAACTCAATGGGCGGCGTGTGTGCGGCCATTGCCGGTTTTGCGGTCAATGACCCCCTGCTTGTGGCCATCGGCGGT
ATTATCGGCTCGTCCGGCTACCTGCTGACGCGCATCATGTGCCGCGCCATGAACAGGAAACTGCTGTCTATCCTGCTTGG
CGAATCTTCTGTGGTGACCCCGTCGGCCCCGGCCAAAAAGGCTGCTCCTGCCGCCCGGGCTGCTGCCCCGGCCAGGTCCG
TCGAAAGCGAAGCCGCAAAGCTTGTACAGAACGCCAGAAATGTGGTTATCGTGCCCGGTTACGGCATGGCCCTGGCCCAG
GCCCAGTACAAGGTCAAACAGCTTGCCGACCTGCTGGAAAGCAGGGGCGCCAAGGTAAGTTACGGCATCCACCCCGTTGC
CGGGCGCATGCCCGGGCATATGAACGTGCTGCTTGCCGAAGCCAACGTGGACTATGAGCACCTGCTCGAAATGGACACGG
TGAACCCCATGTTCGCAGAGTCCGACCTTGTGATCGTGGTGGGCGCCAACGACGTTGTGAACCCGGCAGCCAACACTGCC
GAAGGCACACCCATCTACGGCATGCCCATCCTCAAGGCCGACGAAGCCAAAAACATCATCATCGCCAACTATGACGACAA
ACCCGGCTACGCGGGCGTGCCCAACCCCCTGTACGGACGTGACGGCGTGATCCTCATGACCGGCGACGCCGGCAAGACCT
TTGACAGGCTGCTGGCCTATGCCCAGGGCAACGGCCCTGCGGACGAGGCCGCTCCCGCCGCCGGTGCGGACAGCAGGGAA
GCCGAAGCCGCAAAGCTTGTACAGAACGCCAGAAATGTGGTTATCGTGCCCGGTTATGGCATGGCCCTGGCCCAGGCCCA
GCACAAGGTCAAGCTGCTTGCCGATGCGCTGGAAAGCAGGGGCGTCAAGGTGAGCTACGGCATCCACCCCGTTGCCGGGC
GCATGCCCGGGCATATGAACGTGCTGCTTGCCGAAGCCAACGTGGACTATGAAAATCTGCTCGAAATGGACACGGTGAAC
CCCATGTTCGCAGAGTCCGACCTTGTGGTGATCATCGGGGCCAACGACGTTGTGAACCCGGCAGCCAACACTGCCGAAGG
CACGCCCATCTACGGCATGCCCATCCTCAAGGCCGATGAATGCAGGAATATCATCGTCTGCAACTATGACGACAAGCCCG
GCTACGCGGGCGTACCCAACCCCTTGTACGAGCGTGACGGCGTGATCCTCATGACCGGCGATGCGGCGAAAACCGTGGAC
CGGCTGGTGAGCTTCGCCCAGGGCGAAAGCCCGGCCGCTCCCGCCGCGGGTACGGACAGCAGGGAAGCCGACGCGGCAAA
GCTTGTGCAGAACGCCAGAAATGTGGTTATCGTGCCCGGTTACGGCATGGCCCTGGCCCAGGCCCAGTACAAGGTCAAAC
AGCTTGCCGACCTGCTGGAAAGCAGGGGCGCCAGGGTAAGTTACGGCATCCATCCCGTGGCCGGGCGCATGCCCGGGCAT
ATGAACGTGCTGCTTGCCGAAGCCAACGTGGACTATGAGCACCTGCTCGAAATGGACACGGTGAACCCCATGTTCGCAGA
GTCCGACCTTGTGATCGTGGTGGGGGCCAACGACGTGGTGAACCCGGCAGCCAACTCTGCCGAAGGCACACCCATCTACG
GCATGCCCATCCTCAAGGCCGACGAAGCCAAAAACATCATCATCGCCAACTATGACGACAAGCCCGGCTATGCGGGGGTA
CCCAATCCCCTGTACGAGCGCGAGGGCGTGATCCTCATGACCGGCGACGCCGGCAAGACCTTTGACAGGCTGCTGGCATA
TGCCCAGGGAGGGCAGGCCTAG

Upstream 100 bases:

>100_bases
ACATTACCCACAAAATGCTGCGCATGGTCGCCGGAAAAAAGAAGTAGCCCTTCTCTGGCCTCTGCATCAACCATAAACCG
GAAGAAAGGGTTGCTGTGAA

Downstream 100 bases:

>100_bases
ACCCGATGTATTTGCCGTCTGGCATAAAGCAAAATGCTCTGCGCGGTCTCCGGAAAAACGCATGTCTCTGGATGTCCTTG
AGGCCCACCCCACTCTGGCC

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 833; Mature: 833

Protein sequence:

>833_residues
MNAITYNIIAGILVAAVLFGLRLMNKVPTAVRGNLFCASAMGLAILVTMFKDGSLASPALWLAIAVGMTLGLTLSNKVKM
IQMPQMVAFLHGIGGGAAAIVSFLVLTDTGAPSAFERGSACLALAMGMTTIAGSFVAAGKLHQILPQKPVILPDHTKIIM
AILAVMGFSVLMGTAFPQFLFGFFIFLMFVTGTAFGIGFTLRVGGADMPITISLLNSMGGVCAAIAGFAVNDPLLVAIGG
IIGSSGYLLTRIMCRAMNRKLLSILLGESSVVTPSAPAKKAAPAARAAAPARSVESEAAKLVQNARNVVIVPGYGMALAQ
AQYKVKQLADLLESRGAKVSYGIHPVAGRMPGHMNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANTA
EGTPIYGMPILKADEAKNIIIANYDDKPGYAGVPNPLYGRDGVILMTGDAGKTFDRLLAYAQGNGPADEAAPAAGADSRE
AEAAKLVQNARNVVIVPGYGMALAQAQHKVKLLADALESRGVKVSYGIHPVAGRMPGHMNVLLAEANVDYENLLEMDTVN
PMFAESDLVVIIGANDVVNPAANTAEGTPIYGMPILKADECRNIIVCNYDDKPGYAGVPNPLYERDGVILMTGDAAKTVD
RLVSFAQGESPAAPAAGTDSREADAAKLVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGARVSYGIHPVAGRMPGH
MNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANSAEGTPIYGMPILKADEAKNIIIANYDDKPGYAGV
PNPLYEREGVILMTGDAGKTFDRLLAYAQGGQA

Sequences:

>Translated_833_residues
MNAITYNIIAGILVAAVLFGLRLMNKVPTAVRGNLFCASAMGLAILVTMFKDGSLASPALWLAIAVGMTLGLTLSNKVKM
IQMPQMVAFLHGIGGGAAAIVSFLVLTDTGAPSAFERGSACLALAMGMTTIAGSFVAAGKLHQILPQKPVILPDHTKIIM
AILAVMGFSVLMGTAFPQFLFGFFIFLMFVTGTAFGIGFTLRVGGADMPITISLLNSMGGVCAAIAGFAVNDPLLVAIGG
IIGSSGYLLTRIMCRAMNRKLLSILLGESSVVTPSAPAKKAAPAARAAAPARSVESEAAKLVQNARNVVIVPGYGMALAQ
AQYKVKQLADLLESRGAKVSYGIHPVAGRMPGHMNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANTA
EGTPIYGMPILKADEAKNIIIANYDDKPGYAGVPNPLYGRDGVILMTGDAGKTFDRLLAYAQGNGPADEAAPAAGADSRE
AEAAKLVQNARNVVIVPGYGMALAQAQHKVKLLADALESRGVKVSYGIHPVAGRMPGHMNVLLAEANVDYENLLEMDTVN
PMFAESDLVVIIGANDVVNPAANTAEGTPIYGMPILKADECRNIIVCNYDDKPGYAGVPNPLYERDGVILMTGDAAKTVD
RLVSFAQGESPAAPAAGTDSREADAAKLVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGARVSYGIHPVAGRMPGH
MNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANSAEGTPIYGMPILKADEAKNIIIANYDDKPGYAGV
PNPLYEREGVILMTGDAGKTFDRLLAYAQGGQA
>Mature_833_residues
MNAITYNIIAGILVAAVLFGLRLMNKVPTAVRGNLFCASAMGLAILVTMFKDGSLASPALWLAIAVGMTLGLTLSNKVKM
IQMPQMVAFLHGIGGGAAAIVSFLVLTDTGAPSAFERGSACLALAMGMTTIAGSFVAAGKLHQILPQKPVILPDHTKIIM
AILAVMGFSVLMGTAFPQFLFGFFIFLMFVTGTAFGIGFTLRVGGADMPITISLLNSMGGVCAAIAGFAVNDPLLVAIGG
IIGSSGYLLTRIMCRAMNRKLLSILLGESSVVTPSAPAKKAAPAARAAAPARSVESEAAKLVQNARNVVIVPGYGMALAQ
AQYKVKQLADLLESRGAKVSYGIHPVAGRMPGHMNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANTA
EGTPIYGMPILKADEAKNIIIANYDDKPGYAGVPNPLYGRDGVILMTGDAGKTFDRLLAYAQGNGPADEAAPAAGADSRE
AEAAKLVQNARNVVIVPGYGMALAQAQHKVKLLADALESRGVKVSYGIHPVAGRMPGHMNVLLAEANVDYENLLEMDTVN
PMFAESDLVVIIGANDVVNPAANTAEGTPIYGMPILKADECRNIIVCNYDDKPGYAGVPNPLYERDGVILMTGDAAKTVD
RLVSFAQGESPAAPAAGTDSREADAAKLVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGARVSYGIHPVAGRMPGH
MNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANSAEGTPIYGMPILKADEAKNIIIANYDDKPGYAGV
PNPLYEREGVILMTGDAGKTFDRLLAYAQGGQA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=427, Percent_Identity=37.0023419203747, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI122939153, Length=427, Percent_Identity=37.0023419203747, Blast_Score=249, Evalue=7e-66,
Organism=Escherichia coli, GI1787886, Length=462, Percent_Identity=39.6103896103896, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17550456, Length=408, Percent_Identity=37.9901960784314, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 87195; Mature: 87195

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAITYNIIAGILVAAVLFGLRLMNKVPTAVRGNLFCASAMGLAILVTMFKDGSLASPAL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEHHHHHHHHHHHHHCCCCCCCHHH
WLAIAVGMTLGLTLSNKVKMIQMPQMVAFLHGIGGGAAAIVSFLVLTDTGAPSAFERGSA
HHHHHHHHHHCEEECCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHEECCCCCHHHHCCCH
CLALAMGMTTIAGSFVAAGKLHQILPQKPVILPDHTKIIMAILAVMGFSVLMGTAFPQFL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FGFFIFLMFVTGTAFGIGFTLRVGGADMPITISLLNSMGGVCAAIAGFAVNDPLLVAIGG
HHHHHHHHHHHHHHHCCEEEEEECCCCCCEEHHHHHCCCHHHHHHHHHCCCCCCEEEEEH
IIGSSGYLLTRIMCRAMNRKLLSILLGESSVVTPSAPAKKAAPAARAAAPARSVESEAAK
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHCCCHHHHHCCHHHHHHHHHH
LVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGAKVSYGIHPVAGRMPGHMNVLLAE
HHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEE
ANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANTAEGTPIYGMPILKADEAKNII
CCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCEE
IANYDDKPGYAGVPNPLYGRDGVILMTGDAGKTFDRLLAYAQGNGPADEAAPAAGADSRE
EEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHCCCCCCCCCHH
AEAAKLVQNARNVVIVPGYGMALAQAQHKVKLLADALESRGVKVSYGIHPVAGRMPGHMN
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEE
VLLAEANVDYENLLEMDTVNPMFAESDLVVIIGANDVVNPAANTAEGTPIYGMPILKADE
EEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCEEHHC
CRNIIVCNYDDKPGYAGVPNPLYERDGVILMTGDAAKTVDRLVSFAQGESPAAPAAGTDS
CCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCC
READAAKLVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGARVSYGIHPVAGRMPGH
CHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
MNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANSAEGTPIYGMPILKA
EEEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEEC
DEAKNIIIANYDDKPGYAGVPNPLYEREGVILMTGDAGKTFDRLLAYAQGGQA
CCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNAITYNIIAGILVAAVLFGLRLMNKVPTAVRGNLFCASAMGLAILVTMFKDGSLASPAL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEHHHHHHHHHHHHHCCCCCCCHHH
WLAIAVGMTLGLTLSNKVKMIQMPQMVAFLHGIGGGAAAIVSFLVLTDTGAPSAFERGSA
HHHHHHHHHHCEEECCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHEECCCCCHHHHCCCH
CLALAMGMTTIAGSFVAAGKLHQILPQKPVILPDHTKIIMAILAVMGFSVLMGTAFPQFL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FGFFIFLMFVTGTAFGIGFTLRVGGADMPITISLLNSMGGVCAAIAGFAVNDPLLVAIGG
HHHHHHHHHHHHHHHCCEEEEEECCCCCCEEHHHHHCCCHHHHHHHHHCCCCCCEEEEEH
IIGSSGYLLTRIMCRAMNRKLLSILLGESSVVTPSAPAKKAAPAARAAAPARSVESEAAK
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHCCCHHHHHCCHHHHHHHHHH
LVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGAKVSYGIHPVAGRMPGHMNVLLAE
HHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEE
ANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANTAEGTPIYGMPILKADEAKNII
CCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCEE
IANYDDKPGYAGVPNPLYGRDGVILMTGDAGKTFDRLLAYAQGNGPADEAAPAAGADSRE
EEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHCCCCCCCCCHH
AEAAKLVQNARNVVIVPGYGMALAQAQHKVKLLADALESRGVKVSYGIHPVAGRMPGHMN
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEE
VLLAEANVDYENLLEMDTVNPMFAESDLVVIIGANDVVNPAANTAEGTPIYGMPILKADE
EEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCEEHHC
CRNIIVCNYDDKPGYAGVPNPLYERDGVILMTGDAAKTVDRLVSFAQGESPAAPAAGTDS
CCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCC
READAAKLVQNARNVVIVPGYGMALAQAQYKVKQLADLLESRGARVSYGIHPVAGRMPGH
CHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
MNVLLAEANVDYEHLLEMDTVNPMFAESDLVIVVGANDVVNPAANSAEGTPIYGMPILKA
EEEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEEC
DEAKNIIIANYDDKPGYAGVPNPLYEREGVILMTGDAGKTFDRLLAYAQGGQA
CCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]