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The map label for this gene is cysK [H]

Identifier: 220903435

GI number: 220903435

Start: 187216

End: 188136

Strand: Reverse

Name: cysK [H]

Synonym: Ddes_0149

Alternate gene names: 220903435

Gene position: 188136-187216 (Counterclockwise)

Preceding gene: 220903437

Following gene: 220903434

Centisome position: 6.55

GC content: 61.78

Gene sequence:

>921_bases
ATGCTCACCAACATTCTTCAGGCCATCGGCAATACGCCCATGCTGCGTCTTGACCTTTCAAAAGACATGCCCGGTACGGT
CTGGCTCAAACTTGAAAACCGCAACCCCGGCGGCTCCATCAAAGACCGTGTGGCATTTCACCTCATTGAAAACGCCCTTC
AGTGGGGCGAACTTGAGCCGGGCGGCCTGGTGGTTGAAGCCACCAGCGGCAACATGGGCATCGGCATCGCCCTGGTTTCA
GCCGTGCGCGGCCTGCGCTGCGTGCTCGCCATGCCCGAATCCATGAGCCTTGAAAGACGCAACCTGCTCAGGGGCCTTGG
TGCGGAACTGGTGCTTACCCCCGCTGCCAGGGGCATGACCGGAGCAGTGGAAGAAGCTCGCCGCATCGCTGAAGAACAGG
GGGGATTCATCCCCGGACAGTTCACCAATCCCGAGGCGGTGCAGGCCCATTACAAGACCACCGGGCCGGAAATTTACAGC
GACAGCGTGGGCAAAATGGACGTTCTGGTGGCCGGCGTCGGTTCCGGCTCATCCATCACGGGCGCAGGGCGCTTTCTTAA
AGAACGCATACCCGGCTTCAGGGTCATTGCCGTTGAACCCGCTGCCTCTCCGGTAATCTCGGGAGGCGCGGCATCGCCGC
ACCTCATTCAGGGCATTGGCGCGGGCTTTATTCCCGCCATCCTCGACCGTTCCCTGCTGGACGAGATCCTGCTGGCCGAC
GGCGAAGAAGCCCTGGATACGGCTCGCCTGCTCATGCGCCAGGGCATTGTGGCGGGCATATCCACCGGAGCCAATGTGCG
CGCCGCCCTGCAGGTGGCGGCACGCCAGGAAATGGCGGGCAAAAACATCGTTACTTTCGCCTGCGATACGGGCGAGCGGT
ACATGTCCACCAGACTGTTTACCGACATGGCCCAGGCCTGA

Upstream 100 bases:

>100_bases
TTCTTCTAACTGTTAAGCAAAATGCGGTCATTGTAAAGCTTCCCCTGCCGCCCTCAGGACTTTCGGGAATTTCTCCACCA
CATTACGAGGTGTTCGCGCC

Downstream 100 bases:

>100_bases
GCCGCACTGCCAGGCCCCGCAGACCGCTTGCGGGGCTTTACGGCTGAAAAGCCGCCCCGAAACCGGACCGCAGTGCGGTC
GGCATTTTCCTGCGAGGCAG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLTNILQAIGNTPMLRLDLSKDMPGTVWLKLENRNPGGSIKDRVAFHLIENALQWGELEPGGLVVEATSGNMGIGIALVS
AVRGLRCVLAMPESMSLERRNLLRGLGAELVLTPAARGMTGAVEEARRIAEEQGGFIPGQFTNPEAVQAHYKTTGPEIYS
DSVGKMDVLVAGVGSGSSITGAGRFLKERIPGFRVIAVEPAASPVISGGAASPHLIQGIGAGFIPAILDRSLLDEILLAD
GEEALDTARLLMRQGIVAGISTGANVRAALQVAARQEMAGKNIVTFACDTGERYMSTRLFTDMAQA

Sequences:

>Translated_306_residues
MLTNILQAIGNTPMLRLDLSKDMPGTVWLKLENRNPGGSIKDRVAFHLIENALQWGELEPGGLVVEATSGNMGIGIALVS
AVRGLRCVLAMPESMSLERRNLLRGLGAELVLTPAARGMTGAVEEARRIAEEQGGFIPGQFTNPEAVQAHYKTTGPEIYS
DSVGKMDVLVAGVGSGSSITGAGRFLKERIPGFRVIAVEPAASPVISGGAASPHLIQGIGAGFIPAILDRSLLDEILLAD
GEEALDTARLLMRQGIVAGISTGANVRAALQVAARQEMAGKNIVTFACDTGERYMSTRLFTDMAQA
>Mature_306_residues
MLTNILQAIGNTPMLRLDLSKDMPGTVWLKLENRNPGGSIKDRVAFHLIENALQWGELEPGGLVVEATSGNMGIGIALVS
AVRGLRCVLAMPESMSLERRNLLRGLGAELVLTPAARGMTGAVEEARRIAEEQGGFIPGQFTNPEAVQAHYKTTGPEIYS
DSVGKMDVLVAGVGSGSSITGAGRFLKERIPGFRVIAVEPAASPVISGGAASPHLIQGIGAGFIPAILDRSLLDEILLAD
GEEALDTARLLMRQGIVAGISTGANVRAALQVAARQEMAGKNIVTFACDTGERYMSTRLFTDMAQA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=40.6349206349206, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=40.6349206349206, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=40.6349206349206, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=46.7320261437908, Blast_Score=238, Evalue=3e-64,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=39.5348837209302, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI115535073, Length=302, Percent_Identity=49.6688741721854, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=47.1760797342193, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=42.3452768729642, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=42.4749163879599, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=41.8604651162791, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=44.1860465116279, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=324, Percent_Identity=36.4197530864198, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=35.2201257861635, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17561716, Length=121, Percent_Identity=44.6280991735537, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=322, Percent_Identity=30.7453416149068, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321449, Length=322, Percent_Identity=35.4037267080745, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643623, Length=314, Percent_Identity=32.1656050955414, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20129101, Length=314, Percent_Identity=32.1656050955414, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32218; Mature: 32218

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNILQAIGNTPMLRLDLSKDMPGTVWLKLENRNPGGSIKDRVAFHLIENALQWGELEP
CHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GGLVVEATSGNMGIGIALVSAVRGLRCVLAMPESMSLERRNLLRGLGAELVLTPAARGMT
CCEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCH
GAVEEARRIAEEQGGFIPGQFTNPEAVQAHYKTTGPEIYSDSVGKMDVLVAGVGSGSSIT
HHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCHHCCCCCCEEEEEEECCCCCCCC
GAGRFLKERIPGFRVIAVEPAASPVISGGAASPHLIQGIGAGFIPAILDRSLLDEILLAD
HHHHHHHHHCCCEEEEEECCCCCCEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCC
GEEALDTARLLMRQGIVAGISTGANVRAALQVAARQEMAGKNIVTFACDTGERYMSTRLF
CHHHHHHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
TDMAQA
HHHHCC
>Mature Secondary Structure
MLTNILQAIGNTPMLRLDLSKDMPGTVWLKLENRNPGGSIKDRVAFHLIENALQWGELEP
CHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GGLVVEATSGNMGIGIALVSAVRGLRCVLAMPESMSLERRNLLRGLGAELVLTPAARGMT
CCEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCH
GAVEEARRIAEEQGGFIPGQFTNPEAVQAHYKTTGPEIYSDSVGKMDVLVAGVGSGSSIT
HHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCHHCCCCCCEEEEEEECCCCCCCC
GAGRFLKERIPGFRVIAVEPAASPVISGGAASPHLIQGIGAGFIPAILDRSLLDEILLAD
HHHHHHHHHCCCEEEEEECCCCCCEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCC
GEEALDTARLLMRQGIVAGISTGANVRAALQVAARQEMAGKNIVTFACDTGERYMSTRLF
CHHHHHHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
TDMAQA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA