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The map label for this gene is 220903412

Identifier: 220903412

GI number: 220903412

Start: 162945

End: 164366

Strand: Reverse

Name: 220903412

Synonym: Ddes_0126

Alternate gene names: NA

Gene position: 164366-162945 (Counterclockwise)

Preceding gene: 220903413

Following gene: 220903411

Centisome position: 5.72

GC content: 65.19

Gene sequence:

>1422_bases
ATGACTGAGCAACGGGCCGGGCAGCGCCCGGCGGCACACTCTTTTGACCAGGCGGGCGCGAAGGCGGCCCTTCGCGCCGC
CAGACGGCTGGGAGTCGTCTTTTTTCCGGCTTTTGACTGGGCCATTTCCCCCACACATCCGGAACGGGAGGAGCGCCTGC
TCTATACGCGCGACCAGCTTGTGGAAGAAGGGCTTTTTGATATTCCCGGCATTACGGAATACCGGCCCGCGTTCGCAAGC
CATGCGCAGCTTGAGCGTGCGCACTTCTGCCTGCCCACAACCAGCGCCGTGAGCACGGATTCACACCTGGCGGCGGCTGG
CGGGGCCATACGCGCCGCTCGCCTTGTGCTTGACGGGCATGAAGACCGCGCCTTTGCCCTGGTGCGCCCACCGGGACATC
ATGCCATGCGCGTGGTGCACGGCAACCGGGGCTTCTGCAATATCAACAACGAAGCCGTCATGGCCGAATACATCCGCGAC
CACTATCCGCATCCGGACGGCCGCCCCCTGCGCATCGCCATTGTGGATACAGACGTGCACCACGGCGACGGCACGCAGGA
CGTATTCTGGAACGACCCGCACACCCTTTTCATCTCCCTGCATCAGGACGGCCGCACCCTGTACCCCGGCACGGGCTTTC
TGCACGAATGCGGCGGCCCCGGCGCTCTGGGCCGCACCATAAACATACCCCTGCCGCCAGAAACCTGCGACGCGGGCTAT
CTGTACGCGGTCGAGCACGCCGTGCTGCCCATTCTTGAAGACTTCAAGCCGGATTTCATTATCAATTCCGCCGGGCAGGA
CAATCATTTCACCGACCCGCTGGCCAACATGAAGCTTTCCGCACAGGGCTATGCGGCCCTGACGCGCCTGCTCAACCCGC
ATGTGGCCGTGCTTGAGGGCGGCTACGCCATACGCGGTGCCCTGCCCTATGTGAACCTGGGCATCTGCCTTGCGCTGGCA
GGCATTGACGCGGGGGACGTTCGCGAGCCGGGCTGGTCGCCCGAATCCACACTGCAGAGCGCCAGTGTCGGGCAGTACAT
CGCCCGCCTGTGCGAAGAAGTGCGCGACTGTTACTTCAAGCCTCCTGCCACGCCGTCAGAAGGGCAAGCGGAAGGCCAGG
GGCAGGACCGCTGGTGGGTGCGGCAAAAACATGTCTTTTATGATACGGATATGCTCAGCGAAGGGCAGAACGAAGCCTGG
CGGCTCTGCCCGGACTGCTCCGGGCTGGGCCGTATCGAAACGGCTTCGGAGCGCGTGGCGCGCTCCCTGTGTCTGCTTGT
TCCGCGCCATGCCTGCCCGGCCTGCCGCGAGCGGGGCCGTGACCTTGCAAGCCAGGCCCGCAGGGCGGGCCGCCATGCCC
ACGTGCTGCTGCTGGACGGCGACCTGATCGCGCCCGATACCAGCCGGGAAGGCCCGCGGTAA

Upstream 100 bases:

>100_bases
GAAAGCAACCTGGCGTATTCCCTGGGTCTTTCGCAGATGGGCCGCATGGTGACCTACGCCCGCTACGGCGCGGACATCTT
CGACGCTCTGGACGAGAACG

Downstream 100 bases:

>100_bases
CGACGAAAAAGGCAGTACAAACAATGCGGTTGACGGATTGGGCCTTTACAGGCATATAGCCGGACTTTGCGCCCGCAAGC
GGCAGACCGCGCCGAGGCGC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTEQRAGQRPAAHSFDQAGAKAALRAARRLGVVFFPAFDWAISPTHPEREERLLYTRDQLVEEGLFDIPGITEYRPAFAS
HAQLERAHFCLPTTSAVSTDSHLAAAGGAIRAARLVLDGHEDRAFALVRPPGHHAMRVVHGNRGFCNINNEAVMAEYIRD
HYPHPDGRPLRIAIVDTDVHHGDGTQDVFWNDPHTLFISLHQDGRTLYPGTGFLHECGGPGALGRTINIPLPPETCDAGY
LYAVEHAVLPILEDFKPDFIINSAGQDNHFTDPLANMKLSAQGYAALTRLLNPHVAVLEGGYAIRGALPYVNLGICLALA
GIDAGDVREPGWSPESTLQSASVGQYIARLCEEVRDCYFKPPATPSEGQAEGQGQDRWWVRQKHVFYDTDMLSEGQNEAW
RLCPDCSGLGRIETASERVARSLCLLVPRHACPACRERGRDLASQARRAGRHAHVLLLDGDLIAPDTSREGPR

Sequences:

>Translated_473_residues
MTEQRAGQRPAAHSFDQAGAKAALRAARRLGVVFFPAFDWAISPTHPEREERLLYTRDQLVEEGLFDIPGITEYRPAFAS
HAQLERAHFCLPTTSAVSTDSHLAAAGGAIRAARLVLDGHEDRAFALVRPPGHHAMRVVHGNRGFCNINNEAVMAEYIRD
HYPHPDGRPLRIAIVDTDVHHGDGTQDVFWNDPHTLFISLHQDGRTLYPGTGFLHECGGPGALGRTINIPLPPETCDAGY
LYAVEHAVLPILEDFKPDFIINSAGQDNHFTDPLANMKLSAQGYAALTRLLNPHVAVLEGGYAIRGALPYVNLGICLALA
GIDAGDVREPGWSPESTLQSASVGQYIARLCEEVRDCYFKPPATPSEGQAEGQGQDRWWVRQKHVFYDTDMLSEGQNEAW
RLCPDCSGLGRIETASERVARSLCLLVPRHACPACRERGRDLASQARRAGRHAHVLLLDGDLIAPDTSREGPR
>Mature_472_residues
TEQRAGQRPAAHSFDQAGAKAALRAARRLGVVFFPAFDWAISPTHPEREERLLYTRDQLVEEGLFDIPGITEYRPAFASH
AQLERAHFCLPTTSAVSTDSHLAAAGGAIRAARLVLDGHEDRAFALVRPPGHHAMRVVHGNRGFCNINNEAVMAEYIRDH
YPHPDGRPLRIAIVDTDVHHGDGTQDVFWNDPHTLFISLHQDGRTLYPGTGFLHECGGPGALGRTINIPLPPETCDAGYL
YAVEHAVLPILEDFKPDFIINSAGQDNHFTDPLANMKLSAQGYAALTRLLNPHVAVLEGGYAIRGALPYVNLGICLALAG
IDAGDVREPGWSPESTLQSASVGQYIARLCEEVRDCYFKPPATPSEGQAEGQGQDRWWVRQKHVFYDTDMLSEGQNEAWR
LCPDCSGLGRIETASERVARSLCLLVPRHACPACRERGRDLASQARRAGRHAHVLLLDGDLIAPDTSREGPR

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=209, Percent_Identity=41.1483253588517, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI30795202, Length=212, Percent_Identity=39.1509433962264, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI30795204, Length=212, Percent_Identity=39.1509433962264, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI17158039, Length=212, Percent_Identity=39.1509433962264, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148539870, Length=273, Percent_Identity=31.8681318681319, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI169234807, Length=295, Percent_Identity=30.8474576271186, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI153085395, Length=214, Percent_Identity=38.3177570093458, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI20070354, Length=251, Percent_Identity=35.4581673306773, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI62750349, Length=211, Percent_Identity=36.0189573459716, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI62750347, Length=211, Percent_Identity=36.0189573459716, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI226529806, Length=251, Percent_Identity=32.2709163346614, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13128862, Length=179, Percent_Identity=25.6983240223464, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI13128860, Length=180, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI8923769, Length=208, Percent_Identity=27.8846153846154, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI262073088, Length=165, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI293336691, Length=189, Percent_Identity=24.3386243386243, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209491, Length=210, Percent_Identity=39.5238095238095, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540334, Length=298, Percent_Identity=31.5436241610738, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=298, Percent_Identity=31.5436241610738, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=211, Percent_Identity=33.6492890995261, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25154020, Length=207, Percent_Identity=31.4009661835749, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=209, Percent_Identity=33.4928229665072, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25154022, Length=218, Percent_Identity=29.3577981651376, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=221, Percent_Identity=29.8642533936652, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508561, Length=298, Percent_Identity=24.8322147651007, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561978, Length=181, Percent_Identity=29.2817679558011, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324307, Length=370, Percent_Identity=29.4594594594595, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321244, Length=208, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323999, Length=180, Percent_Identity=30, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641720, Length=210, Percent_Identity=39.0476190476191, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI281360799, Length=210, Percent_Identity=39.0476190476191, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI281360801, Length=210, Percent_Identity=39.0476190476191, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24642144, Length=217, Percent_Identity=36.405529953917, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24642146, Length=217, Percent_Identity=36.405529953917, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24642142, Length=217, Percent_Identity=36.405529953917, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281360899, Length=217, Percent_Identity=36.405529953917, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24644244, Length=179, Percent_Identity=27.3743016759777, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657891, Length=180, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 51933; Mature: 51802

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQRAGQRPAAHSFDQAGAKAALRAARRLGVVFFPAFDWAISPTHPEREERLLYTRDQL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCEECCCCCCHHHHHHHHHHHH
VEEGLFDIPGITEYRPAFASHAQLERAHFCLPTTSAVSTDSHLAAAGGAIRAARLVLDGH
HHCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCHHHHCCCHHEEEEEEEECC
EDRAFALVRPPGHHAMRVVHGNRGFCNINNEAVMAEYIRDHYPHPDGRPLRIAIVDTDVH
CCCEEEEECCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCC
HGDGTQDVFWNDPHTLFISLHQDGRTLYPGTGFLHECGGPGALGRTINIPLPPETCDAGY
CCCCCCCCEECCCCEEEEEEECCCCEECCCCCCHHHCCCCCCCCCEEECCCCCCCCCCCE
LYAVEHAVLPILEDFKPDFIINSAGQDNHFTDPLANMKLSAQGYAALTRLLNPHVAVLEG
EEHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHCCEECCCHHHHHHHHHCCCEEEEEC
GYAIRGALPYVNLGICLALAGIDAGDVREPGWSPESTLQSASVGQYIARLCEEVRDCYFK
CEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPATPSEGQAEGQGQDRWWVRQKHVFYDTDMLSEGQNEAWRLCPDCSGLGRIETASERVA
CCCCCCCCCCCCCCCCCEEEEECEEEECCHHHHCCCCCCEEECCCCCCCCCCHHHHHHHH
RSLCLLVPRHACPACRERGRDLASQARRAGRHAHVLLLDGDLIAPDTSREGPR
HHHHHHCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEEECCCEECCCCCCCCCC
>Mature Secondary Structure 
TEQRAGQRPAAHSFDQAGAKAALRAARRLGVVFFPAFDWAISPTHPEREERLLYTRDQL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCEECCCCCCHHHHHHHHHHHH
VEEGLFDIPGITEYRPAFASHAQLERAHFCLPTTSAVSTDSHLAAAGGAIRAARLVLDGH
HHCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCHHHHCCCHHEEEEEEEECC
EDRAFALVRPPGHHAMRVVHGNRGFCNINNEAVMAEYIRDHYPHPDGRPLRIAIVDTDVH
CCCEEEEECCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCC
HGDGTQDVFWNDPHTLFISLHQDGRTLYPGTGFLHECGGPGALGRTINIPLPPETCDAGY
CCCCCCCCEECCCCEEEEEEECCCCEECCCCCCHHHCCCCCCCCCEEECCCCCCCCCCCE
LYAVEHAVLPILEDFKPDFIINSAGQDNHFTDPLANMKLSAQGYAALTRLLNPHVAVLEG
EEHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHCCEECCCHHHHHHHHHCCCEEEEEC
GYAIRGALPYVNLGICLALAGIDAGDVREPGWSPESTLQSASVGQYIARLCEEVRDCYFK
CEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPATPSEGQAEGQGQDRWWVRQKHVFYDTDMLSEGQNEAWRLCPDCSGLGRIETASERVA
CCCCCCCCCCCCCCCCCEEEEECEEEECCHHHHCCCCCCEEECCCCCCCCCCHHHHHHHH
RSLCLLVPRHACPACRERGRDLASQARRAGRHAHVLLLDGDLIAPDTSREGPR
HHHHHHCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEEECCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]