Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 220903370

GI number: 220903370

Start: 109907

End: 111439

Strand: Direct

Name: atoC [H]

Synonym: Ddes_0084

Alternate gene names: 220903370

Gene position: 109907-111439 (Clockwise)

Preceding gene: 220903369

Following gene: 220903371

Centisome position: 3.82

GC content: 63.8

Gene sequence:

>1533_bases
ATGGCCCGTATTCTGGTGGTGGATGACGAAGCCCTTATGCGCACCATGGCTGAAGTGGTGTGTACGCGCATGGGTCATGA
GGTGCTGCTGGCCGAGAGTGTCAGCCAGGGGCTGGAGCTTGGCCGCCAGGGTGTGGATGTGGTCCTGCTTGATGTCTGGC
TGCCCGATGGCAACGGCCTTGAGTGGCAGGGCGACTTTGCCCATCTGCCCGGTATGCCCGATGTGGTCATCATCACGGGA
CACGGCGACGGCGATGCCGCCGAGGCGGCCCTGCGTTCCGGAGCCTGGGAGTTTCTGACCAAGCCGCTCAAGGTGCGGGA
TATAGAGCAATGTCTGCGCCATGTGCTGACTTTTCGCGAAAATCGGGTTCCGGGTCCGGAGTCGCTGCTGGTGGACAGCG
GCCATGTGCTGGGCACGGGCATGGGTATGAGCCGCGCCCTCAAGCTTCTGGCCCAGGCCGCGCAAAGCGAGGTCAACGTG
CTTTTGCTGGGCGAAACGGGCGTGGGCAAGGAAGTTTTTGCCAAGGCGCTGTACCGCAACAGTGCGCGTGCCGCCAGACC
CTTTGTTACCGTAGACTGTGCCTCTCTGCCGGATAACCTTGTGGAAAGCCATCTTTTCGGCCACAGCCGTGGGGCGTTTA
CCGGGGCCGACCGCGCCCGGGAGGGGCTTTTACTGTCGGCAAACAAGGGTACGCTTTTTCTTGATGAGGTGGGTGATCTG
CCCCAGACCATACAGGGGGCCTTTTTGCGGGCGCTGGAATTGCGGCGCTTCAGGCCGGTGGGTGATGTACGCGAGGTCAG
CAGCGACTTTCGCCTTGTGGCCGCCACCAACAGGGATATTGAAAGCATGGCCCGGGAAGGGACATTTCGTGCCGACCTGC
TCTACCGGCTTCAGGGCATGACCATTGTCATTCCGCCCCTGCGCGAGCGCAGGGACGAGATCCCCGCGCTCACACGGCAG
GCCGCAAGCCGGTTTTGCCTGCATAATGACCTGCCGCCCAAGGCTGTGTCGGACGCCATGCTGGATGTACTTATGGAATA
TTCCTGGCCCGGCAATGTGCGCGAGCTGATTCACAGTGTCGAGCGCGCCTGTCTTGCGGCCGGGCAGGGAGATGAGCTTT
TGCCTGCACATTTGCCCACGCGCATGCGTGTGGATGAGGCCCGTCGCCGTATGGGGCGCGGCCCGGACAGCGGCATTGCC
GATGTTGCGGGCGGCGGGCAGGCCGCTGCGTGTGGCTTTTCCGGGGCGCTCTACGGGGCCGGGTCGTCCGCGTCCTTTGG
GCAGCCTGCAGTTGGAGAGGGCGCTTCCGGCAGGCATGCGGGCGGCTCTGCGGCCTCTGTCCTGCATCCGGGGCTGCCCC
CTGTGGCGGCGGGTGACGATCTGCCGGATTTGCGCCAATGGAAAGCACGCGCTGAAGAAGTTTATGTGCGGAGCATCTGG
GGCGCCAGCAACGGCGACGCGCGCACGGCTGCCGGAATGGCCGGAGTCTCGCGCGGGCACTGGTATGAGCTTATGAAAAA
GCACGGTCTGTAG

Upstream 100 bases:

>100_bases
TCGAGGCTGAACCGGGCTGCATGCAGAGCCAGGAAGTATCCGTACACAGCGCCGGGGCTGCCCTTTGCTCCGGCGCGGCA
TCACAGAAAGGAGAGTGCTG

Downstream 100 bases:

>100_bases
CTGCAGGGGCATCCGGCGCTCAAAGGTCGTACGTCGCCCGGCGGCATACGGACGGTCTGTCGGCACATGTGCTGCCAATG
CCCTGTGCGGTCGGGCGGGC

Product: putative Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MARILVVDDEALMRTMAEVVCTRMGHEVLLAESVSQGLELGRQGVDVVLLDVWLPDGNGLEWQGDFAHLPGMPDVVIITG
HGDGDAAEAALRSGAWEFLTKPLKVRDIEQCLRHVLTFRENRVPGPESLLVDSGHVLGTGMGMSRALKLLAQAAQSEVNV
LLLGETGVGKEVFAKALYRNSARAARPFVTVDCASLPDNLVESHLFGHSRGAFTGADRAREGLLLSANKGTLFLDEVGDL
PQTIQGAFLRALELRRFRPVGDVREVSSDFRLVAATNRDIESMAREGTFRADLLYRLQGMTIVIPPLRERRDEIPALTRQ
AASRFCLHNDLPPKAVSDAMLDVLMEYSWPGNVRELIHSVERACLAAGQGDELLPAHLPTRMRVDEARRRMGRGPDSGIA
DVAGGGQAAACGFSGALYGAGSSASFGQPAVGEGASGRHAGGSAASVLHPGLPPVAAGDDLPDLRQWKARAEEVYVRSIW
GASNGDARTAAGMAGVSRGHWYELMKKHGL

Sequences:

>Translated_510_residues
MARILVVDDEALMRTMAEVVCTRMGHEVLLAESVSQGLELGRQGVDVVLLDVWLPDGNGLEWQGDFAHLPGMPDVVIITG
HGDGDAAEAALRSGAWEFLTKPLKVRDIEQCLRHVLTFRENRVPGPESLLVDSGHVLGTGMGMSRALKLLAQAAQSEVNV
LLLGETGVGKEVFAKALYRNSARAARPFVTVDCASLPDNLVESHLFGHSRGAFTGADRAREGLLLSANKGTLFLDEVGDL
PQTIQGAFLRALELRRFRPVGDVREVSSDFRLVAATNRDIESMAREGTFRADLLYRLQGMTIVIPPLRERRDEIPALTRQ
AASRFCLHNDLPPKAVSDAMLDVLMEYSWPGNVRELIHSVERACLAAGQGDELLPAHLPTRMRVDEARRRMGRGPDSGIA
DVAGGGQAAACGFSGALYGAGSSASFGQPAVGEGASGRHAGGSAASVLHPGLPPVAAGDDLPDLRQWKARAEEVYVRSIW
GASNGDARTAAGMAGVSRGHWYELMKKHGL
>Mature_509_residues
ARILVVDDEALMRTMAEVVCTRMGHEVLLAESVSQGLELGRQGVDVVLLDVWLPDGNGLEWQGDFAHLPGMPDVVIITGH
GDGDAAEAALRSGAWEFLTKPLKVRDIEQCLRHVLTFRENRVPGPESLLVDSGHVLGTGMGMSRALKLLAQAAQSEVNVL
LLGETGVGKEVFAKALYRNSARAARPFVTVDCASLPDNLVESHLFGHSRGAFTGADRAREGLLLSANKGTLFLDEVGDLP
QTIQGAFLRALELRRFRPVGDVREVSSDFRLVAATNRDIESMAREGTFRADLLYRLQGMTIVIPPLRERRDEIPALTRQA
ASRFCLHNDLPPKAVSDAMLDVLMEYSWPGNVRELIHSVERACLAAGQGDELLPAHLPTRMRVDEARRRMGRGPDSGIAD
VAGGGQAAACGFSGALYGAGSSASFGQPAVGEGASGRHAGGSAASVLHPGLPPVAAGDDLPDLRQWKARAEEVYVRSIWG
ASNGDARTAAGMAGVSRGHWYELMKKHGL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=394, Percent_Identity=36.8020304568528, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1790437, Length=364, Percent_Identity=39.2857142857143, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1788905, Length=371, Percent_Identity=39.622641509434, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1790299, Length=386, Percent_Identity=35.7512953367876, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1789087, Length=241, Percent_Identity=45.2282157676349, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082117, Length=232, Percent_Identity=41.8103448275862, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87082152, Length=260, Percent_Identity=41.5384615384615, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789233, Length=255, Percent_Identity=38.0392156862745, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87081872, Length=238, Percent_Identity=39.4957983193277, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1787583, Length=246, Percent_Identity=35.7723577235772, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786524, Length=249, Percent_Identity=37.7510040160643, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789828, Length=227, Percent_Identity=40.5286343612335, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87081858, Length=242, Percent_Identity=32.6446280991736, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54707; Mature: 54576

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILVVDDEALMRTMAEVVCTRMGHEVLLAESVSQGLELGRQGVDVVLLDVWLPDGNGL
CEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
EWQGDFAHLPGMPDVVIITGHGDGDAAEAALRSGAWEFLTKPLKVRDIEQCLRHVLTFRE
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHH
NRVPGPESLLVDSGHVLGTGMGMSRALKLLAQAAQSEVNVLLLGETGVGKEVFAKALYRN
CCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHC
SARAARPFVTVDCASLPDNLVESHLFGHSRGAFTGADRAREGLLLSANKGTLFLDEVGDL
CCHHCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCEEEECCCCEEEHHHHCCC
PQTIQGAFLRALELRRFRPVGDVREVSSDFRLVAATNRDIESMAREGTFRADLLYRLQGM
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCHHHHHHCCCHHHHHHHHHCCC
TIVIPPLRERRDEIPALTRQAASRFCLHNDLPPKAVSDAMLDVLMEYSWPGNVRELIHSV
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ERACLAAGQGDELLPAHLPTRMRVDEARRRMGRGPDSGIADVAGGGQAAACGFSGALYGA
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCCCCEEECCCCCCEECC
GSSASFGQPAVGEGASGRHAGGSAASVLHPGLPPVAAGDDLPDLRQWKARAEEVYVRSIW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GASNGDARTAAGMAGVSRGHWYELMKKHGL
CCCCCCCHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ARILVVDDEALMRTMAEVVCTRMGHEVLLAESVSQGLELGRQGVDVVLLDVWLPDGNGL
EEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
EWQGDFAHLPGMPDVVIITGHGDGDAAEAALRSGAWEFLTKPLKVRDIEQCLRHVLTFRE
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHH
NRVPGPESLLVDSGHVLGTGMGMSRALKLLAQAAQSEVNVLLLGETGVGKEVFAKALYRN
CCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHC
SARAARPFVTVDCASLPDNLVESHLFGHSRGAFTGADRAREGLLLSANKGTLFLDEVGDL
CCHHCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCEEEECCCCEEEHHHHCCC
PQTIQGAFLRALELRRFRPVGDVREVSSDFRLVAATNRDIESMAREGTFRADLLYRLQGM
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCHHHHHHCCCHHHHHHHHHCCC
TIVIPPLRERRDEIPALTRQAASRFCLHNDLPPKAVSDAMLDVLMEYSWPGNVRELIHSV
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ERACLAAGQGDELLPAHLPTRMRVDEARRRMGRGPDSGIADVAGGGQAAACGFSGALYGA
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCCCCEEECCCCCCEECC
GSSASFGQPAVGEGASGRHAGGSAASVLHPGLPPVAAGDDLPDLRQWKARAEEVYVRSIW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GASNGDARTAAGMAGVSRGHWYELMKKHGL
CCCCCCCHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]