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The map label for this gene is ugd [H]

Identifier: 218906376

GI number: 218906376

Start: 4982024

End: 4983394

Strand: Reverse

Name: ugd [H]

Synonym: BCAH820_5290

Alternate gene names: 218906376

Gene position: 4983394-4982024 (Counterclockwise)

Preceding gene: 218906380

Following gene: 218906375

Centisome position: 93.98

GC content: 35.89

Gene sequence:

>1371_bases
ATGTATTCGTATATTTTCTATTGTATGTTCCTGTGCGAAAAGGAAATGAAAATTACGATAATAGGTACCGGATATGTTGG
ATTGATTACTGGGGTAGGATTGGCAGTATTGGGACATTCGGTTACATGTTTTGATATAAATGATGAGAAAATTGAACGGA
TAAAACAAGGGGATCTGCCTATTTATGAAGCTGGCTTATATGAATTAATACATGATGCGTGTGAGAATAATCGTTTAACT
TTTACAACAAGTAAAGAGGAAGCATTTAAAGATGCAGAATTTATATTTATTGCAGTTGGAACGCCATCGTTATTAGATGG
GACAGCGGATTTAACATATATTCAAAACGCATGTGTTGATATTGGGACATATGCGACTAAAGACATTATTGTTGTTACAA
AAAGTACTGTTCCTGTAGGGACGAATGGTGCTATGAGGGGATGGATTGAGGAGACATTACAAAACAGACATGAATTACAT
ATTGTATCGAATCCTGAATTTTTACGGGAGGGTTCAGGGATTTACGATTTTTTTCGGGGAGATCGTATTGTAATTGGGGC
CGATAATGAGGAAGCGGCACGAAAAGTGGAGAATTTATATAGTGAATTACACTTAAAAACATATGTTACAGATATAAAAA
GTGCAGAGATGATTAAATATGCATCGAATGCTTTTTTAGCGACAAAAATTAGTTTTATCAATGAAATTTCAAATATATGT
GAGAAGGTAGGAGCAAATGTATTAGACGTCGCAAAAGGGATGGGAATGGATAAAAGAATTGGAGCGTCTTTTTTAAATGC
GGGCATTGGTTACGGGGGATCGTGTTTTCCGAAAGATACGAAAGCGCTTGTGCAAATTGCAGGGAATGTGGCACATGATT
TTCGCTTGTTAAAAGCCGTCATTGAAGTGAATAATAAACAACAGTTATTATTGATTGAGAAAGCGAAGAAAGTAATAAAT
ATGAACAAGAAGCGGATTGCGGTGCTGGGAGCGGCATTTAAACCGAATACAGATGATATAAGAGATGCACCGTCCCTTAT
TATGATACAAGAGTTAATAAATCTAGGTGCGGACATAGTTCTATATGACCCGAAGGCGATTCAAAATATGAAAAATATCT
TTGGGGAGACTATACAATATAGTGAATGTCTAGATGAATCGATTAGAGGAGCGAGTGCGGCTTTTATCATGACAGAATGG
GAAGCTATCCGGACTTATCCGTTAGAAAAGTACGTACAACTTATGAGAGAACCTATTTTATTCGATGGAAGAAATTGCTA
TACTAATGAAGATGTCAAGAAGCAAGGAATAGATTATTATTCTGTTGGAAGAGAAAGTATTTATAAGAGGGATTTTTCCG
TTATTCGTTAA

Upstream 100 bases:

>100_bases
CAAAAACTTAAAAAAGAATGAAGAAAGTAATTCATATAATAAAGAAGTAAAAGAGTTTTCTCATTTTTAAGGTGAGAGGA
GGATGCACAGGGAGAATTCT

Downstream 100 bases:

>100_bases
AAAGGTATGTATTCATGTATATTCTTATATGTCATAATAGGATTTGTAACTAGTGAAAGAAAAGAGGCAATGAAATGACT
GAACGTTTAAAAGTAATGAC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MYSYIFYCMFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDACENNRLT
FTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELH
IVSNPEFLREGSGIYDFFRGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFINEISNIC
EKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEKAKKVIN
MNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSECLDESIRGASAAFIMTEW
EAIRTYPLEKYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR

Sequences:

>Translated_456_residues
MYSYIFYCMFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDACENNRLT
FTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELH
IVSNPEFLREGSGIYDFFRGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFINEISNIC
EKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEKAKKVIN
MNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSECLDESIRGASAAFIMTEW
EAIRTYPLEKYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR
>Mature_456_residues
MYSYIFYCMFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDACENNRLT
FTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELH
IVSNPEFLREGSGIYDFFRGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFINEISNIC
EKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEKAKKVIN
MNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSECLDESIRGASAAFIMTEW
EAIRTYPLEKYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=472, Percent_Identity=34.9576271186441, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI296040443, Length=467, Percent_Identity=31.2633832976445, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=34.5945945945946, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1788340, Length=361, Percent_Identity=31.0249307479224, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI48994968, Length=354, Percent_Identity=30.5084745762712, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=467, Percent_Identity=32.762312633833, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17136908, Length=466, Percent_Identity=34.1201716738197, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51022; Mature: 51022

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSYIFYCMFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLP
CHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCC
IYEAGLYELIHDACENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVD
EEHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHH
IGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELHIVSNPEFLREGSGIYDFFRG
HCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHCC
DRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFINEISNIC
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAV
HHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IEVNNKQQLLLIEKAKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIV
HHCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHHCCCCEE
LYDPKAIQNMKNIFGETIQYSECLDESIRGASAAFIMTEWEAIRTYPLEKYVQLMREPIL
EECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHHHHCCCE
FDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR
ECCCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MYSYIFYCMFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLP
CHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCC
IYEAGLYELIHDACENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVD
EEHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHH
IGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELHIVSNPEFLREGSGIYDFFRG
HCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHCC
DRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFINEISNIC
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAV
HHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IEVNNKQQLLLIEKAKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIV
HHCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHHCCCCEE
LYDPKAIQNMKNIFGETIQYSECLDESIRGASAAFIMTEWEAIRTYPLEKYVQLMREPIL
EECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHHHHCCCE
FDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR
ECCCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]