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The map label for this gene is comFA [H]

Identifier: 218906368

GI number: 218906368

Start: 4974351

End: 4975700

Strand: Reverse

Name: comFA [H]

Synonym: BCAH820_5282

Alternate gene names: 218906368

Gene position: 4975700-4974351 (Counterclockwise)

Preceding gene: 218906369

Following gene: 218906367

Centisome position: 93.83

GC content: 40.22

Gene sequence:

>1350_bases
ATGCTCGCTGGAAAGCAGTTACTATTAGAAGAACTCCCTTCAGATTTACGGAGAGAATTAAGTGATTTGAAAAAGGAGGG
AGAGGTCATATGTGTACAAGGCGTAATAAAGAAGGCTTCTAAATATATATGTCAGCGCTGCGGAAATATAGAGCAGCGGC
TATTTGCATCATTTTTATGTAAAAGGTGCAGTAAAGTATGTACGTATTGCCGGAAGTGTATAACGATGGGGAGAGTTAGT
GAATGTGCTGTACTTGTTCGCGGGATTCATGAAAGAAAAGGAGAAAGGGAATTACATTCGTTACAGTGGAAAGGGAGTTT
GTCTCTTGGTCAGGAGCTGGCGGCGCAAGGTGTTATAGAAGCTATTAAGCAAAAAGAATCTTTTTTTATTTGGGCTGTGT
GCGGGGCTGGAAAAACAGAAATGTTATTTTACGGTATAGAAGAGGCACTTCAAAAAGGAGGAAGAGTGTGTATCGCAACG
CCAAGGACGGACGTTGTACTGGAATTAGTACCGAGATTACAAGAAGTGTTTCCAAGTATAAATGTAGCTGCTTTATACGG
AGGGAGTGTAGATCGTGAAAAAGATGCAGCGTTAGTCGTTGCAACGACGCATCAATTGTTACGTTATTATAGAGCGTTTC
ATGTAATGATTGTAGATGAGATTGATGCCTTCCCGTATCATGCGGATCAAATGTTACAGTATGCAGTGCAGCAAGCGATG
AAAGAGAAAGCAGCGCGTATTTATTTAACGGCAACCCCTGATGAAAAGTGGAAGCGCAATTTCAGAACGGGGAAACAAAA
AGGTATCATTGTCTCTGGACGATACCATCGTCATCCGTTACCAGTTCCTCTATTTAGCTGGTGCGGAAATTGGAAGAAAA
GCCTCCATCATAAAAAAATTCCTCGTGTGTTACTACAATGGTTAAAAATGTACGTAAACAAAAAATACCCTATTTTTTTA
TTTGTTCCTCATGTGCGATATATAGAAGAAATAGGCCTGTTATTGAAAGGGTTGGATCATAGAATCGATGGCGTACATGC
AGAAGATCCGATGAGAAAAGAAAAAGTGGAAGCATTTCGAAAGGGAGACATTCCGTTATTAGTTACAACGACAATTTTAG
AAAGAGGGGTAACTGTGAAGAACTTACAAGTGGCTGTGTTAGGGGCTGAAGAAGAAATATTTTCAGAAAGTGCGCTCGTA
CAAATTGCAGGCCGAGCAGGTCGTAGTTTTGAAGAACCGTATGGTGAGGTTGTTTATTTTCATTACGGTAAGACAGAGTC
GATGGTACGTGCGAAAAGACATATTCAAAGTATGAACAAAAGTGCGAAAGAACAAGGATTAATTGATTAA

Upstream 100 bases:

>100_bases
TAAAGTCGATAGCTTACTATTTTATAAGTAGGTTATCGGCTTTTTTGAGTTTTTACGAGATTATAAGAAAGGTTTATAGT
AATGCTGGGGGTGGTTGCTG

Downstream 100 bases:

>100_bases
TGCATTGTTTACTTTGTGATGAATATATTTTGGAAACAGTTAGTTGGTACACTTTCTTTGTAAAGTCTCATAAAAAATAT
GTATGTGATAGATGTGAGCG

Product: comF operon protein 1

Products: NA

Alternate protein names: ATP-dependent helicase ComFA [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLCKRCSKVCTYCRKCITMGRVS
ECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGGRVCIAT
PRTDVVLELVPRLQEVFPSINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHADQMLQYAVQQAM
KEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKIPRVLLQWLKMYVNKKYPIFL
FVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFRKGDIPLLVTTTILERGVTVKNLQVAVLGAEEEIFSESALV
QIAGRAGRSFEEPYGEVVYFHYGKTESMVRAKRHIQSMNKSAKEQGLID

Sequences:

>Translated_449_residues
MLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLCKRCSKVCTYCRKCITMGRVS
ECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGGRVCIAT
PRTDVVLELVPRLQEVFPSINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHADQMLQYAVQQAM
KEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKIPRVLLQWLKMYVNKKYPIFL
FVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFRKGDIPLLVTTTILERGVTVKNLQVAVLGAEEEIFSESALV
QIAGRAGRSFEEPYGEVVYFHYGKTESMVRAKRHIQSMNKSAKEQGLID
>Mature_449_residues
MLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLCKRCSKVCTYCRKCITMGRVS
ECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIEAIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGGRVCIAT
PRTDVVLELVPRLQEVFPSINVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHADQMLQYAVQQAM
KEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKIPRVLLQWLKMYVNKKYPIFL
FVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFRKGDIPLLVTTTILERGVTVKNLQVAVLGAEEEIFSESALV
QIAGRAGRSFEEPYGEVVYFHYGKTESMVRAKRHIQSMNKSAKEQGLID

Specific function: Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel [H]

COG id: COG4098

COG function: function code L; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 51163; Mature: 51163

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLC
CCCCHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KRCSKVCTYCRKCITMGRVSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
AIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGGRVCIATPRTDVVLELVPRLQEVFPSI
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCC
NVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHADQMLQYAVQQAM
CEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
KEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKI
HHHHCEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHH
PRVLLQWLKMYVNKKYPIFLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFR
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
KGDIPLLVTTTILERGVTVKNLQVAVLGAEEEIFSESALVQIAGRAGRSFEEPYGEVVYF
CCCCCEEEHHHHHHCCCEEECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
HYGKTESMVRAKRHIQSMNKSAKEQGLID
EECCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLAGKQLLLEELPSDLRRELSDLKKEGEVICVQGVIKKASKYICQRCGNIEQRLFASFLC
CCCCHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KRCSKVCTYCRKCITMGRVSECAVLVRGIHERKGERELHSLQWKGSLSLGQELAAQGVIE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
AIKQKESFFIWAVCGAGKTEMLFYGIEEALQKGGRVCIATPRTDVVLELVPRLQEVFPSI
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCC
NVAALYGGSVDREKDAALVVATTHQLLRYYRAFHVMIVDEIDAFPYHADQMLQYAVQQAM
CEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
KEKAARIYLTATPDEKWKRNFRTGKQKGIIVSGRYHRHPLPVPLFSWCGNWKKSLHHKKI
HHHHCEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHH
PRVLLQWLKMYVNKKYPIFLFVPHVRYIEEIGLLLKGLDHRIDGVHAEDPMRKEKVEAFR
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
KGDIPLLVTTTILERGVTVKNLQVAVLGAEEEIFSESALVQIAGRAGRSFEEPYGEVVYF
CCCCCEEEHHHHHHCCCEEECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
HYGKTESMVRAKRHIQSMNKSAKEQGLID
EECCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8412657; 9384377 [H]