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The map label for this gene is ytcI [H]

Identifier: 218905875

GI number: 218905875

Start: 4509822

End: 4511408

Strand: Reverse

Name: ytcI [H]

Synonym: BCAH820_4763

Alternate gene names: 218905875

Gene position: 4511408-4509822 (Counterclockwise)

Preceding gene: 218905876

Following gene: 218905874

Centisome position: 85.08

GC content: 41.02

Gene sequence:

>1587_bases
ATGAAGAGAGAGGAATTGTTGGCACCACCGTCTTATAATTTAGTTTCTGAAATAGAGAAATATACAGGTGATAAAGAGAA
GCTTGCTTTAATTTGGCAAGATGATAAAGGGAATCGACGAGAAGTTACATACGCTGAGTTAATGAAAGGTGCAAATAAAA
TTGGAAACGCTTTTATAAAGAGTGGTCTGCAAAAAGGGGACAAGCTCCTCATTATGATGCCGCGTTTAATTGAAGCGTAC
ATGACGTATATCGCTGCGATTAAAGCAGGATTTGTCGTAATTCCGAGTTCGGAAATGTTACGCAAAAAGGATATCGAATA
TCGCATTGGACACGGGGAAGTAAAAGCAATCGTAAGTTATGAGCCTTACATTGGACAGTTTGATGATATAGAAGCGATGG
AATCCCTTCAAAAGTTCGTTCTGAGCGAGCAGTCAGTAGATGGATGGATCAATTTAAAAACAGCGTTAGAAACAGAAAGT
GACATGTTAGAAATGGCGAAGACAGATAAAGAAGATATGGTCTTTTTATCTTACACGTCAGGAACGACAGGAAACCCAAA
AGGTGTTGTTCATACGCATGCGTGGGCATACGCTCACTTACGTACGAGCGCTCCGAATTGGCTCGGAATTGAAGAGAATG
ATGTTGTATGGGCAACAGCTAGTCCAGGCTGGCAGAAGTGGATTTGGAGCCCGTTTTTAGCAACTCTAGGCTCGGGGGCA
ACAGGATTTGTATACCACGGTAAGTTTGAACCAAAAACGTATTTAAATTTATTAGACGATAATAAGGTGAATGTGCTTTG
TTGTACGCCAACTGAGTATAGATTAATGGCAAAGGTAGAGAATTTAAGCGAGTACAATTTAGAAGCGTTACATAGCGCTG
TATCCGCAGGTGAGCCGTTAAATAGAGAAGTCATTGAAACGTTCCAAAAGCACTTTCATATTACAGTGAGAGACGGCTAT
GGGCAAACGGAAAACACATTGCTTGTTGGTGTAATGAAAGGGATGGATATTAGACCAGGATCAATGGGGAAACCGACGCC
AGGCAACCACGTTGATATTGTAGATGAGGAAGGGATGCCAGTAAGGGTAGGCGAAGTTGGTGATATTGCGGTTCACATTG
AAACACCAGCCCTCTTTAAACAATACTATAAAGACGATGAGCGCACAGCGATGCAATTCCGCGGTGATTATTATATTACC
GGTGATAAAGCGAAGAAAGATGAAGACGGCTATTTCTGGTTTGAAGGGCGCGGTGATGATATTATTATTAGCTCTGGTTA
TACAATCGGGCCGTTTGAAGTAGAAGATGCGCTCGTAAAGCACCCTTATGTAAGAGAATGTGCGGTTGTCGCAAGCCCTG
ATGAAATTCGCGGAAGTGTCGTGAAGGCATTTATCGTATTAAGAGAGAATATAGAAAAGAACGAAGAAATATTAATTCCA
ATACTCCAACAACACGTCAAGGAACTTACTGCACCATATAAATACCCTCGCAAAATTGAATTTGTAGATGAACTACCAAA
AACGATTTCTGGAAAAATCCGCCGTATTGAACTTAGAAAACAAGAGATGGAGATTCCGTCAAAATAA

Upstream 100 bases:

>100_bases
TATTCGACAGAACTAAAAAATTTGTCAAAAGATGAGGGTTCAAAATTGACAGAAAATTCTTTATTATATAAGGGAGGCAT
AAAGAAAAAGGAGGATGTTT

Downstream 100 bases:

>100_bases
ATTTGAAAACAGTGAAGGAAATAGTTGAATGAAATGGCAAACAATGATAATATAAAAACGAACACAAGTTCGATTTTATA
AATTGAAAAAAGAGGTGTCC

Product: putative acetyl-CoA synthetase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKREELLAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAY
MTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQFDDIEAMESLQKFVLSEQSVDGWINLKTALETES
DMLEMAKTDKEDMVFLSYTSGTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGA
TGFVYHGKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIETFQKHFHITVRDGY
GQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYIT
GDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEEILIP
ILQQHVKELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK

Sequences:

>Translated_528_residues
MKREELLAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAY
MTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQFDDIEAMESLQKFVLSEQSVDGWINLKTALETES
DMLEMAKTDKEDMVFLSYTSGTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGA
TGFVYHGKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIETFQKHFHITVRDGY
GQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYIT
GDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEEILIP
ILQQHVKELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK
>Mature_528_residues
MKREELLAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAY
MTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQFDDIEAMESLQKFVLSEQSVDGWINLKTALETES
DMLEMAKTDKEDMVFLSYTSGTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGA
TGFVYHGKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIETFQKHFHITVRDGY
GQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYIT
GDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEEILIP
ILQQHVKELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=538, Percent_Identity=40.5204460966543, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI38505220, Length=515, Percent_Identity=40.5825242718447, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=38.5633270321361, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI157311624, Length=535, Percent_Identity=37.0093457943925, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI157311622, Length=535, Percent_Identity=37.0093457943925, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI58082049, Length=535, Percent_Identity=37.0093457943925, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI115511026, Length=530, Percent_Identity=36.4150943396226, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI42544134, Length=366, Percent_Identity=32.7868852459016, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI195947378, Length=421, Percent_Identity=28.7410926365796, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI13375727, Length=552, Percent_Identity=28.6231884057971, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI28416953, Length=533, Percent_Identity=28.8930581613508, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI253970489, Length=577, Percent_Identity=27.3830155979203, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI8923896, Length=567, Percent_Identity=27.689594356261, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI156151445, Length=543, Percent_Identity=26.1510128913444, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI187761345, Length=531, Percent_Identity=25.9887005649718, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI187761343, Length=531, Percent_Identity=25.9887005649718, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI31982927, Length=542, Percent_Identity=20.8487084870849, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1790505, Length=532, Percent_Identity=28.1954887218045, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1788107, Length=491, Percent_Identity=25.8655804480652, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI221142682, Length=504, Percent_Identity=24.8015873015873, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1786529, Length=550, Percent_Identity=26.5454545454545, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI145693145, Length=502, Percent_Identity=26.6932270916335, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786810, Length=502, Percent_Identity=25.0996015936255, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789201, Length=365, Percent_Identity=25.2054794520548, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71983001, Length=558, Percent_Identity=27.9569892473118, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17559526, Length=535, Percent_Identity=25.981308411215, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71982997, Length=558, Percent_Identity=27.9569892473118, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=521, Percent_Identity=26.1036468330134, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32563687, Length=513, Percent_Identity=25.9259259259259, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17557194, Length=528, Percent_Identity=26.3257575757576, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=526, Percent_Identity=25.6653992395437, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71994690, Length=524, Percent_Identity=26.1450381679389, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994694, Length=524, Percent_Identity=26.1450381679389, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994703, Length=524, Percent_Identity=26.1450381679389, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560308, Length=536, Percent_Identity=25.3731343283582, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=515, Percent_Identity=23.3009708737864, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=380, Percent_Identity=26.3157894736842, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=529, Percent_Identity=23.8185255198488, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=495, Percent_Identity=23.2323232323232, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI115534440, Length=542, Percent_Identity=23.8007380073801, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319264, Length=558, Percent_Identity=27.9569892473118, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6323182, Length=561, Percent_Identity=25.8467023172906, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319699, Length=348, Percent_Identity=26.7241379310345, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667955, Length=558, Percent_Identity=28.3154121863799, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI62472339, Length=527, Percent_Identity=28.842504743833, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24667959, Length=365, Percent_Identity=33.1506849315069, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355225, Length=536, Percent_Identity=26.865671641791, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24581924, Length=511, Percent_Identity=27.2015655577299, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21355181, Length=519, Percent_Identity=26.3969171483622, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18859661, Length=508, Percent_Identity=26.9685039370079, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922652, Length=506, Percent_Identity=24.1106719367589, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24656500, Length=505, Percent_Identity=23.5643564356436, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356947, Length=483, Percent_Identity=22.1532091097308, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648260, Length=358, Percent_Identity=26.2569832402235, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653035, Length=363, Percent_Identity=24.2424242424242, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24648257, Length=504, Percent_Identity=23.2142857142857, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20130357, Length=355, Percent_Identity=26.1971830985915, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161076582, Length=368, Percent_Identity=23.6413043478261, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573631, Length=543, Percent_Identity=21.9152854511971, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356441, Length=386, Percent_Identity=22.020725388601, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20130353, Length=543, Percent_Identity=21.9152854511971, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281365686, Length=318, Percent_Identity=21.0691823899371, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648253, Length=376, Percent_Identity=22.0744680851064, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648255, Length=388, Percent_Identity=21.6494845360825, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358303, Length=322, Percent_Identity=20.4968944099379, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 59803; Mature: 59803

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREELLAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIK
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
SGLQKGDKLLIMMPRLIEAYMTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSY
HHHCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCCEEECCCCEEEEEEE
EPYIGQFDDIEAMESLQKFVLSEQSVDGWINLKTALETESDMLEMAKTDKEDMVFLSYTS
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCEEEEEECC
GTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGA
CCCCCCCCEEEECEEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
TGFVYHGKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPL
CEEEEECCCCCHHHHEEECCCCEEEEEECCCCHHHHHHHHCCHHCCHHHHHHHHHCCCCC
NREVIETFQKHFHITVRDGYGQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMP
CHHHHHHHHHCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCC
VRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKKDEDGYFWFEGRGDD
EEECCCCEEEEEEECHHHHHHHHCCCCHHEEEECCCEEEECCCCCCCCCCEEEEECCCCE
IIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEEILIP
EEEECCCEECCCHHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEHH
ILQQHVKELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK
HHHHHHHHHHCCCCCCCEEHHHHHCCHHHCCCEEEEEEEHHHCCCCCC
>Mature Secondary Structure
MKREELLAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIK
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
SGLQKGDKLLIMMPRLIEAYMTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSY
HHHCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCCEEECCCCEEEEEEE
EPYIGQFDDIEAMESLQKFVLSEQSVDGWINLKTALETESDMLEMAKTDKEDMVFLSYTS
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCEEEEEECC
GTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGA
CCCCCCCCEEEECEEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
TGFVYHGKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPL
CEEEEECCCCCHHHHEEECCCCEEEEEECCCCHHHHHHHHCCHHCCHHHHHHHHHCCCCC
NREVIETFQKHFHITVRDGYGQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMP
CHHHHHHHHHCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCC
VRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKKDEDGYFWFEGRGDD
EEECCCCEEEEEEECHHHHHHHHCCCCHHEEEECCCEEEECCCCCCCCCCEEEEECCCCE
IIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEEILIP
EEEECCCEECCCHHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEHH
ILQQHVKELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK
HHHHHHHHHHCCCCCCCEEHHHHHCCHHHCCCEEEEEEEHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]