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The map label for this gene is era [H]

Identifier: 218905437

GI number: 218905437

Start: 4106642

End: 4107547

Strand: Reverse

Name: era [H]

Synonym: BCAH820_4322

Alternate gene names: 218905437

Gene position: 4107547-4106642 (Counterclockwise)

Preceding gene: 218905438

Following gene: 218905436

Centisome position: 77.46

GC content: 35.43

Gene sequence:

>906_bases
ATGAATAGAAAAGGTTATAAATCAGGTTTTGTCTCTATTATTGGCAGACCGAATGTTGGGAAATCTACATTTTTAAATCG
TATTATTGGTCAAAAAATTGCTATTATGAGTGACAAGCCACAAACAACTCGTAATAAAATTCAAGGCGTATATACAGAAA
ATGATTCACAAGTAATTTTCATTGATACACCAGGAATACATAAACCTAAACATAAACTAGGCGACTTCATGGTGAAGATG
GCGCAAACGACATTAAAAGAAGTTGATATCGTTCTGTTTATGGTTAATGCTGTCGAAGGCTTTGGTCGTGGTGAAGAATT
CATCATTGAGAAGTTAAAAGAAACGAAACAACCAGTATTTCTAGTTATTAATAAAATTGACCAAGTTCACCCAGAACAAT
TATTAGAGTTAATTGATCAATATCGCAAATTACATGACTTTGCAGAAATCGTACCAATTTCTGCATTAGACGGTAATAAT
GTGGAAGCTCTAATTGGAACAATTAAAAAGTATTTACCGGAAGGACCACAATACTACCCAGATAATCAAGTAACGGATCA
TCCGGAGAGATTTATTATTGCAGAGCTTATTCGTGAGAAAGTACTACATTTAACACGTGAAGAAGTGCCGCATTCTGTAG
CTGTTGTTATCGATGCAATTCAAAAACGCGAGGGCGGAGCGGTTTATATCAATGCAACGATTGTTGTTGAACGTCCATCG
CAAAAAGGGATTATTATCGGAAAACAAGGGAAGATGTTAAAAGAAGTAGGTAAGCGAGCTCGTTTTGATATTGAAGCATT
ACTTGGTTCTAAAGTATTTTTAGAAGTATGGGTAAAAGTGCAAAAAGATTGGCGTAATAAAATGTCTCAGCTTCGTGACC
TTGGTTTCCGCGAAGACGAGTATTAA

Upstream 100 bases:

>100_bases
AAACAGGATACGAAAGTATACCTATCAAATTTACATGGTGACGTTCAAGAGACAACAGTCGGAGAATTGTTACCAGGAGC
ATTTTTAGCGGAGGATTTAC

Downstream 100 bases:

>100_bases
AATAGAGTAAAGCTGTAATCAGCGGATGTTTTGTTCATCCGCTGATTATTGGTTTTTATGAGTTTTGATAAATTAGGAAA
AATTTTTCTCACATGAAAAT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: Bex protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIFIDTPGIHKPKHKLGDFMVKM
AQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVFLVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNN
VEALIGTIKKYLPEGPQYYPDNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDEY

Sequences:

>Translated_301_residues
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIFIDTPGIHKPKHKLGDFMVKM
AQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVFLVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNN
VEALIGTIKKYLPEGPQYYPDNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDEY
>Mature_301_residues
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIFIDTPGIHKPKHKLGDFMVKM
AQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVFLVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNN
VEALIGTIKKYLPEGPQYYPDNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. Binds both GDP and GTP. Complements

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=326, Percent_Identity=26.6871165644172, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=40.4761904761905, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87082120, Length=179, Percent_Identity=34.0782122905028, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323665, Length=196, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646434, Length=312, Percent_Identity=25.3205128205128, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34362; Mature: 34362

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIF
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHCEEEECCCCEEEE
IDTPGIHKPKHKLGDFMVKMAQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVF
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEE
LVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNNVEALIGTIKKYLPEGPQYYP
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
DNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCC
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDE
CCCEEECCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Y
C
>Mature Secondary Structure
MNRKGYKSGFVSIIGRPNVGKSTFLNRIIGQKIAIMSDKPQTTRNKIQGVYTENDSQVIF
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHCEEEECCCCEEEE
IDTPGIHKPKHKLGDFMVKMAQTTLKEVDIVLFMVNAVEGFGRGEEFIIEKLKETKQPVF
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEE
LVINKIDQVHPEQLLELIDQYRKLHDFAEIVPISALDGNNVEALIGTIKKYLPEGPQYYP
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
DNQVTDHPERFIIAELIREKVLHLTREEVPHSVAVVIDAIQKREGGAVYINATIVVERPS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCC
QKGIIIGKQGKMLKEVGKRARFDIEALLGSKVFLEVWVKVQKDWRNKMSQLRDLGFREDE
CCCEEECCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 2526291 [H]