Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 218904896

GI number: 218904896

Start: 3610083

End: 3612026

Strand: Reverse

Name: mutL [H]

Synonym: BCAH820_3780

Alternate gene names: 218904896

Gene position: 3612026-3610083 (Counterclockwise)

Preceding gene: 218904897

Following gene: 218904895

Centisome position: 68.12

GC content: 38.63

Gene sequence:

>1944_bases
ATGGGGAAAATTCGCAAACTCGATGACCAACTCTCTAACTTAATTGCGGCAGGGGAAGTAGTAGAGCGCCCTGCCTCAGT
CGTAAAAGAACTTGTGGAAAATTCTATCGATGCGAATAGTACATCTATTGAAATCCACTTAGAAGAAGCTGGTTTATCGA
AAATTCGCATCATTGATAACGGAGATGGCATTGCAGAAGAAGATTGTATCGTTGCTTTTGAACGACATGCGACGAGCAAA
ATTAAAGATGAAAACGATCTGTTTCGCATAAGAACACTCGGTTTCCGCGGTGAGGCATTGCCAAGTATTGCCTCAGTTAG
TGAATTAGAATTAATCACTAGCACCGGTGATGCTCCTGGTACACACCTTATTATTAAAGGTGGAGACATTATAAAGCAGG
AAAAAACAGCGAGCCGAAAAGGAACAGATATTACAGTACAAAACTTATTCTTTAATACACCAGCGCGTCTTAAATATATG
AAAACCATTCATACAGAACTTGGGAATATTACAGATATTGTGTATCGTATTGCAATGTCGCATCCAGAAGTATCATTAAA
GCTATTTCATAATGAAAAGAAATTGCTTCATACATCAGGAAATGGTGATGTAAGACAAGTACTTGCATCGATTTATAGCA
TTCAAGTTGCAAAGAAGCTTGTTCCAATTGAAGCTGAATCTTTAGATTTCACAATTCAAGGTTATGTAACATTACCAGAA
GTAACGAGAGCATCTCGTAATTATATGTCAACAATCGTAAATGGCCGTTACGTTCGAAATTTTGTATTAATGAAAGCTAT
TCAGCAAGGATACCATACATTACTGCCAGTCGGACGATATCCAATCGGTTTCTTATCAATTGAAATGGATCCAATGCTTG
TTGACGTTAACGTACATCCAGCGAAATTAGAAGTTCGTTTTAGTAAAGAACAAGAATTACTAAAGCTGATTGAAGAAACA
TTGCAAGCAGCATTCAAAAAAATACAGCTCATTCCAGATGCAGGTGTAACAACGAAGAAAAAAGAAAAAGATGAAAGTGT
GCAAGAACAGTTTCAGTTTGAGCATGCGAAGCCGAAAGAACCATCTATGCCGGAGATCGTTTTACCGACGGGCATGGATG
AAAAACAAGAAGAACCGCAGGCTGTGAAACAGCCAACACAACTGTGGCAACCGCCGAAGCAAGAATGGCAACCACCACAA
TCGCTTGTAAGAGAAGAACAAAGTTGGCAACCATCCACTAAACCGATAATTGAAGAGCCAATTCAAGAAGAGAAATCGTG
GGACAGTAACGAAGAGGGCTTTGAACTAGAGGAATTAGAAGAAGAAGTTCGGGAAATAAAAGAGATTGAAATGAACGGGA
ATGACTTACCACCGCTTTATCCAATTGGACAAATGCATGGAACATATATTTTCGCTCAAAATGATAAAGGCTTATATATG
ATTGACCAGCATGCCGCGCAGGAACGTATTAATTATGAATACTTCCGTGATAAAGTAGGAAGGGTAGCGCAAGAAGTACA
AGAACTACTCGTACCATATCGTATTGATTTATCTCTTACTGAATTTTTACGTGTTGAAGAGCAACTAGAAGAACTAAAGA
AAGTCGGTCTATTCTTGGAGCAATTCGGCCATCAATCCTTTATCGTTCGCTCGCATCCAACGTGGTTCCCGAAAGGGCAA
GAAACAGAAATTATCGATGAAATGATGGAGCAGGTCGTTAAACTAAAAAAAGTTGATATTAAAAAATTACGTGAAGAAGC
AGCCATCATGATGAGCTGTAAAGCTTCAATTAAAGCAAATCAATATTTAACGAACGATCAAATATTTGCTTTACTGGAAG
AACTTCGTACAACAACAAACCCATACACATGCCCGCACGGAAGACCAATTCTTGTGCATCATTCTACTTATGAGTTGGAG
AAGATGTTTAAGAGGGTTATGTAG

Upstream 100 bases:

>100_bases
CGCAAATTAAAAAAATTGATTTACTTGATATGACACCTTTAGAAGCGATGAACGAACTGTATCGCTTACAAAAAAAGTTA
AAGAAAGGATGAGTAAGTAG

Downstream 100 bases:

>100_bases
GGGACATGTTCATAGAGAAAAAATGATGTCTGGTTAGTTTAGTAAAATATAGAGAGAAATAAAAAGGAGCGATAGTAACA
AGTCGCTCCTTTTTAGTATA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MGKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSK
IKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPGTHLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYM
KTIHTELGNITDIVYRIAMSHPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIQGYVTLPE
VTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLKLIEET
LQAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKEPSMPEIVLPTGMDEKQEEPQAVKQPTQLWQPPKQEWQPPQ
SLVREEQSWQPSTKPIIEEPIQEEKSWDSNEEGFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYM
IDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPTWFPKGQ
ETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELE
KMFKRVM

Sequences:

>Translated_647_residues
MGKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSK
IKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPGTHLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYM
KTIHTELGNITDIVYRIAMSHPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIQGYVTLPE
VTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLKLIEET
LQAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKEPSMPEIVLPTGMDEKQEEPQAVKQPTQLWQPPKQEWQPPQ
SLVREEQSWQPSTKPIIEEPIQEEKSWDSNEEGFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYM
IDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPTWFPKGQ
ETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELE
KMFKRVM
>Mature_646_residues
GKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSKI
KDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPGTHLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYMK
TIHTELGNITDIVYRIAMSHPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIQGYVTLPEV
TRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLKLIEETL
QAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKEPSMPEIVLPTGMDEKQEEPQAVKQPTQLWQPPKQEWQPPQS
LVREEQSWQPSTKPIIEEPIQEEKSWDSNEEGFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYMI
DQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPTWFPKGQE
TEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELEK
MFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=35.9756097560976, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=29.1793313069909, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=29.1793313069909, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=28.5714285714286, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=28.5714285714286, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=30, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI263191589, Length=232, Percent_Identity=29.3103448275862, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=27.0358306188925, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI91992160, Length=357, Percent_Identity=24.9299719887955, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=357, Percent_Identity=24.9299719887955, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=314, Percent_Identity=42.9936305732484, Blast_Score=219, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=34.472049689441, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=363, Percent_Identity=27.8236914600551, Blast_Score=132, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=353, Percent_Identity=34.2776203966006, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=29.0055248618785, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6325093, Length=212, Percent_Identity=27.8301886792453, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=33.9449541284404, Blast_Score=189, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=27.3743016759777, Blast_Score=114, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 74046; Mature: 73915

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEC
GDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPG
CCCCCCCCHHEEEHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHEEECCCCCCC
THLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMS
CEEEEECCCHHHHHHHCCCCCCCEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIQGYVTLPE
CCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHH
VTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEEECCEEEEEECCC
AKLEVRFSKEQELLKLIEETLQAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKE
EEEEEEECCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
PSMPEIVLPTGMDEKQEEPQAVKQPTQLWQPPKQEWQPPQSLVREEQSWQPSTKPIIEEP
CCCCEEEECCCCCCCCCCCHHHHCCHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHH
IQEEKSWDSNEEGFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYM
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEE
IDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLE
EEHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
QFGHQSFIVRSHPTWFPKGQETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKAN
HHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELEKMFKRVM
CEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
GKIRKLDDQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEC
GDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELITSTGDAPG
CCCCCCCCHHEEEHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHEEECCCCCCC
THLIIKGGDIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMS
CEEEEECCCHHHHHHHCCCCCCCEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPEVSLKLFHNEKKLLHTSGNGDVRQVLASIYSIQVAKKLVPIEAESLDFTIQGYVTLPE
CCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHH
VTRASRNYMSTIVNGRYVRNFVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEEECCEEEEEECCC
AKLEVRFSKEQELLKLIEETLQAAFKKIQLIPDAGVTTKKKEKDESVQEQFQFEHAKPKE
EEEEEEECCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
PSMPEIVLPTGMDEKQEEPQAVKQPTQLWQPPKQEWQPPQSLVREEQSWQPSTKPIIEEP
CCCCEEEECCCCCCCCCCCHHHHCCHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHH
IQEEKSWDSNEEGFELEELEEEVREIKEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLYM
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEE
IDQHAAQERINYEYFRDKVGRVAQEVQELLVPYRIDLSLTEFLRVEEQLEELKKVGLFLE
EEHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
QFGHQSFIVRSHPTWFPKGQETEIIDEMMEQVVKLKKVDIKKLREEAAIMMSCKASIKAN
HHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QYLTNDQIFALLEELRTTTNPYTCPHGRPILVHHSTYELEKMFKRVM
CEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA