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The map label for this gene is htrA [H]

Identifier: 218904727

GI number: 218904727

Start: 3450265

End: 3451506

Strand: Reverse

Name: htrA [H]

Synonym: BCAH820_3611

Alternate gene names: 218904727

Gene position: 3451506-3450265 (Counterclockwise)

Preceding gene: 218904728

Following gene: 218904726

Centisome position: 65.09

GC content: 37.04

Gene sequence:

>1242_bases
ATGGGATATTACGACGGACCAAATTTAAATGAAGAGCATAGTGAAACGAGAGAAGTGAGAAAATCGGGCAGTAAAAAAGG
CTATTTTTTCACAGGTTTAGTCGGAGCTGTAGTTGGGGCTGTTTCAATTAGTTTTGCGGCACCATATATGCCATGGGCTC
AAAATAATGGAGCGGCTGTATCATCTTTTAGTTCAGATTCAAAAGTTGAAGGTACTGTAGTTCCTGTTGTCAATAAAGCA
AAAAATGAAACGGATTTACCTGGTATGATTGAAGGCGCGAAAGATGTTGTTGTTGGTGTTATTAATATGCAACAAAGCAT
TGATCCATTTGCAATGCAACCGACAGGTCAAGAACAACAAGCTGGTTCAGGATCAGGTGTTATTTATAAAAAAGCAGGAA
ATAAAGCATATATTGTAACGAACAATCATGTAGTAGATGGTGCAAATAAACTTGCTGTAAAACTGAGCGATGGCAAGAAG
GTAGATGCAAAGCTTGTAGGGAAAGACCCTTGGTTAGATTTAGCTGTTGTTGAAATTGATGGTGCTAATGTTAATAAAGT
TGCCACTTTAGGTGATTCAAGTAAACTTCGTGCGGGTGAAAAAGCAATTGCAATCGGTAACCCATTAGGATTTGACGGAA
GTGTAACGGAAGGTATTATTAGTAGTAAAGAACGTGAAATTCCAGTAGATATCGATGGCGATAAGCGTGCAGATTGGAAT
GCTCAAGTTATTCAAACAGATGCAGCAATTAACCCTGGGAACAGTGGTGGTGCGTTATTTAACCAAAACGGAGAAATAAT
TGGGATTAATTCAAGTAAAATTGCACAACAAGAAGTTGAAGGAATTGGATTTGCTATTCCAATTAATATCGCAAAACCAG
TTATTGAATCACTTGAAAAAGACGGAGTAGTGAAACGTCCAGCTCTTGGAGTAGGTGTCGTTTCATTAGAAGATGTGCAA
GCTTATGCAGTAAATCAATTGAAAGTGCCAAAAGAAGTAACAAACGGCGTTGTATTAGGTAAAATTTACCCAATATCACC
TGCAGAAAAAGCTGGTTTAGAGCAATATGATATTGTAGTAGCATTAGATAATCAAAAAGTAGAAAACTCACTTCAATTCC
GTAAATATTTATATGAGAAGAAAAAAGTAGGCGAGAAAGTGGAAGTTACATTCTACCGTAACGGTCAAAAAATGACGAAA
ACAGCTACTTTAGCAGATAACTCAGCTACAAAGAATCAATAA

Upstream 100 bases:

>100_bases
TAAGTGTATTTTTTTAATTGGATTTCACGATGAGTTCACAAGAAGGACACAAAACGTGACTATACTGAAAATACGAATTC
ACCAGAGAGGGGAAGTAAAC

Downstream 100 bases:

>100_bases
TCGGAATAAAAGAAAGTCTCTTTCATATTGAAAGAGACTTTCTTTATCGGCTATACTAAAGGAATAGGAGGGATTAATTA
TGACAATTGAAAACCCAACT

Product: serine protease HtrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAAVSSFSSDSKVEGTVVPVVNKA
KNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKK
VDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWN
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQ
AYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTK
TATLADNSATKNQ

Sequences:

>Translated_413_residues
MGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAAVSSFSSDSKVEGTVVPVVNKA
KNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKK
VDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWN
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQ
AYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTK
TATLADNSATKNQ
>Mature_412_residues
GYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAAVSSFSSDSKVEGTVVPVVNKAK
NETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKKV
DAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWNA
QVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQA
YAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTKT
ATLADNSATKNQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=283, Percent_Identity=34.982332155477, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=33.1081081081081, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI22129776, Length=291, Percent_Identity=30.9278350515464, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=32.0754716981132, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786356, Length=286, Percent_Identity=39.1608391608392, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789629, Length=284, Percent_Identity=36.9718309859155, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789630, Length=293, Percent_Identity=33.1058020477816, Blast_Score=148, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24646839, Length=335, Percent_Identity=33.7313432835821, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43869; Mature: 43738

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAAV
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
SSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQ
EECCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCEEEEEEEEHHCCCCCEEECCCCCHHC
AGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEID
CCCCCCEEEEECCCEEEEEECCEEECCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEEC
GANVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWN
CCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCC
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEK
CEEEEECCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
DGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVV
CCCEECCCCCEEEEEEHHHHHHHHHHEECCHHHHCCEEEEEEECCCCHHHCCCCEEEEEE
ALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ
EECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
GYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGAAV
CCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
SSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQ
EECCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCEEEEEEEEHHCCCCCEEECCCCCHHC
AGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEID
CCCCCCEEEEECCCEEEEEECCEEECCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEEC
GANVNKVATLGDSSKLRAGEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWN
CCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCC
AQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEK
CEEEEECCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
DGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVV
CCCEECCCCCEEEEEEHHHHHHHHHHEECCHHHHCCEEEEEEECCCCHHHCCCCEEEEEE
ALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ
EECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]