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The map label for this gene is bla2

Identifier: 218904576

GI number: 218904576

Start: 3296750

End: 3297520

Strand: Reverse

Name: bla2

Synonym: BCAH820_3460

Alternate gene names: NA

Gene position: 3297520-3296750 (Counterclockwise)

Preceding gene: 218904577

Following gene: 218904574

Centisome position: 62.19

GC content: 34.11

Gene sequence:

>771_bases
ATGAAAAATACATTATTAAAATTAGGGGTATGTGTTAGTTTACTAGGAATAACTCCATTTGTTAGTACAATTTCTTCTGT
ACAAGCAGAACGAACGGTAGAGCATAAAGTAATAAAAAATGAGACAGGAACTATTTCAATTTCTCAGTTAAACAAAAATG
TTTGGGTTCATACGGAGTTAGGTTATTTTAACGGAGAAGCAGTTCCTTCAAACGGTTTAATCCTTAATACTTCTAAAGGA
TTAGTACTTGTCGATTCTTCTTGGGATGATAAGTTAACGAAGGAATTAATAGAGATGGCAGAAAAGAAATTTAAGAAGAG
TGTAACGGATGTTATTATTACACATGCACACGCTGATCGGATTGGCGGAATAAAAACGTTGAAAGAAAGAGGCATTAAAA
CGCATAGTACAACGTTAACTGCGGAACTAGCAAAGAAAAATGGATATGAAGAACCACTTGGAGACTTACAAGCAATTACG
AAATTGAAGTTTGGAAATATGAAAGTAGAAACGTTTTATCCAGGGAAAGGACATACAGAAGATAATATCGTCGTATGGTT
ACCACAATACAACATGTTAGTTGGAGGCTGTTTAGTGAAGTCTGCGTCCGCGAAAGATTTAGGAAATATTACTGATGCTT
ATGTAAATGAATGGTCTACATCGATTGAGAATGTGCTGAAGCGATATGAAAATATAAATTTTGTAGTACCTGGTCATGGA
GAAGTAGGGGACAAAGGATTACTTTTACATACATTGGATTTGTTAAAATAA

Upstream 100 bases:

>100_bases
AAATACATAAAAAATATGCAAGTAAAGATGGAACAAACATTTGAGCTGAATTGTCTAATATAGGTAATAAATATTTCGTT
TGAAAGAAAGGGTGGAGAAA

Downstream 100 bases:

>100_bases
AAAAGCGAGGAGAAACAATTTCTCCTCGCTTTTTTCTAACTATATTTAAATGCGAAGCTATGCATACTTTACTGAGATTT
TAATTCCAAGTATACAAATA

Product: beta-lactamase II

Products: NA

Alternate protein names: Beta-lactamase II; Cephalosporinase; Penicillinase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTELGYFNGEAVPSNGLILNTSKG
LVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADRIGGIKTLKERGIKTHSTTLTAELAKKNGYEEPLGDLQAIT
KLKFGNMKVETFYPGKGHTEDNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
EVGDKGLLLHTLDLLK

Sequences:

>Translated_256_residues
MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTELGYFNGEAVPSNGLILNTSKG
LVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADRIGGIKTLKERGIKTHSTTLTAELAKKNGYEEPLGDLQAIT
KLKFGNMKVETFYPGKGHTEDNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
EVGDKGLLLHTLDLLK
>Mature_256_residues
MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTELGYFNGEAVPSNGLILNTSKG
LVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADRIGGIKTLKERGIKTHSTTLTAELAKKNGYEEPLGDLQAIT
KLKFGNMKVETFYPGKGHTEDNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
EVGDKGLLLHTLDLLK

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 28175; Mature: 28175

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00743 BETA_LACTAMASE_B_1 ; PS00744 BETA_LACTAMASE_B_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEC
GYFNGEAVPSNGLILNTSKGLVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADR
CCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IGGIKTLKERGIKTHSTTLTAELAKKNGYEEPLGDLQAITKLKFGNMKVETFYPGKGHTE
HCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCC
DNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
CCEEEEECCCCHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
EVGDKGLLLHTLDLLK
CCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEC
GYFNGEAVPSNGLILNTSKGLVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADR
CCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IGGIKTLKERGIKTHSTTLTAELAKKNGYEEPLGDLQAITKLKFGNMKVETFYPGKGHTE
HCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCC
DNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
CCEEEEECCCCHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
EVGDKGLLLHTLDLLK
CCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3131315; 2501295; 1904717 [H]