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The map label for this gene is yvgN [H]

Identifier: 218904528

GI number: 218904528

Start: 3255875

End: 3256150

Strand: Reverse

Name: yvgN [H]

Synonym: BCAH820_3412

Alternate gene names: 218904528

Gene position: 3256150-3255875 (Counterclockwise)

Preceding gene: 218904529

Following gene: 218904527

Centisome position: 61.41

GC content: 34.42

Gene sequence:

>276_bases
ATGGAAGCATGGTCACCATTAATGCAAGGTCAATTATTAGATAATGAAACATTACAAGAGATTGCTGAGAAACACGGTAA
AACAACAGCGCAAGTTATTTTACGTTGGGATCTTCAAAATGGAGTTATTACAATTCCAAAATCAACGAAAGAACACCGTA
TTATTGCAAATGCTGATGTGTTTAACTTTGAGTTAACAAAAGAAGATATGGAGAAAATCGATGCGTTAAATGAAAATCAC
CGCGTTGGTCCAGATCCTGATAACTTTGATTTCTAA

Upstream 100 bases:

>100_bases
GGGGGCAATACTATGCCAATAATTGAGTTAAATACTTGGCCAACGATGTCAACAGAAGAAAAAAGAATTACAAGCTTTCT
GTAAAGAACAAGGTATTCAA

Downstream 100 bases:

>100_bases
GATTAAAGAATGAGTAAAAAGAGTGCAAAGTTGCACTCTTTTTTATTTTCTATTCAATAGAATGTTTCTGTTTATATTAT
AACTTCTAAATGATTTTAGG

Product: 2,5-diketo-d-gluconic acid reductase A

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 91; Mature: 91

Protein sequence:

>91_residues
MEAWSPLMQGQLLDNETLQEIAEKHGKTTAQVILRWDLQNGVITIPKSTKEHRIIANADVFNFELTKEDMEKIDALNENH
RVGPDPDNFDF

Sequences:

>Translated_91_residues
MEAWSPLMQGQLLDNETLQEIAEKHGKTTAQVILRWDLQNGVITIPKSTKEHRIIANADVFNFELTKEDMEKIDALNENH
RVGPDPDNFDF
>Mature_91_residues
MEAWSPLMQGQLLDNETLQEIAEKHGKTTAQVILRWDLQNGVITIPKSTKEHRIIANADVFNFELTKEDMEKIDALNENH
RVGPDPDNFDF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=79, Percent_Identity=41.7721518987342, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI5174391, Length=79, Percent_Identity=41.7721518987342, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI310109924, Length=95, Percent_Identity=40, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI93277124, Length=75, Percent_Identity=44, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI310109922, Length=95, Percent_Identity=40, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI223468663, Length=78, Percent_Identity=43.5897435897436, Blast_Score=69, Evalue=5e-13,
Organism=Homo sapiens, GI5453543, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI300116271, Length=78, Percent_Identity=41.025641025641, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI5174695, Length=78, Percent_Identity=41.025641025641, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI45446745, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI4503285, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI310109920, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI4502049, Length=79, Percent_Identity=41.7721518987342, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI24497585, Length=70, Percent_Identity=47.1428571428571, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI291291012, Length=88, Percent_Identity=40.9090909090909, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI24497583, Length=68, Percent_Identity=47.0588235294118, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082198, Length=90, Percent_Identity=44.4444444444444, Blast_Score=92, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71998625, Length=79, Percent_Identity=43.0379746835443, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537077, Length=71, Percent_Identity=49.2957746478873, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537075, Length=80, Percent_Identity=45, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17537079, Length=80, Percent_Identity=41.25, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321896, Length=77, Percent_Identity=40.2597402597403, Blast_Score=64, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221378297, Length=71, Percent_Identity=50.7042253521127, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24644950, Length=71, Percent_Identity=50.7042253521127, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24663317, Length=64, Percent_Identity=50, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 10462; Mature: 10462

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAWSPLMQGQLLDNETLQEIAEKHGKTTAQVILRWDLQNGVITIPKSTKEHRIIANADV
CCCCCHHHCCCCCCHHHHHHHHHHHCCCEEHEEEEEECCCCEEECCCCCCCCEEEECCCE
FNFELTKEDMEKIDALNENHRVGPDPDNFDF
EEEEECHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEAWSPLMQGQLLDNETLQEIAEKHGKTTAQVILRWDLQNGVITIPKSTKEHRIIANADV
CCCCCHHHCCCCCCHHHHHHHHHHHCCCEEHEEEEEECCCCEEECCCCCCCCEEEECCCE
FNFELTKEDMEKIDALNENHRVGPDPDNFDF
EEEEECHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]