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The map label for this gene is qor [C]

Identifier: 218904522

GI number: 218904522

Start: 3246353

End: 3247348

Strand: Direct

Name: qor [C]

Synonym: BCAH820_3406

Alternate gene names: 218904522

Gene position: 3246353-3247348 (Clockwise)

Preceding gene: 218904511

Following gene: 218904531

Centisome position: 61.22

GC content: 38.25

Gene sequence:

>996_bases
ATGAAAGCACAAATTATCCATTCTTTTGGAGATTCATCTGTATTTCAATTAGAAGAAGTTGCAAAACCAAAACTTTTACC
CGGTCATGTTCTAATTCATGTAAAAGCAACAAGTGTAAATCCAATCGATACGAAAATGCGCAGTGGGGCTGTTTCATCAG
TTGCTCCTGAATTTCCAGCTATATTACACGGGGATGTAGCAGGTATTGTTATAGAAGTAGGAGAAGGCGTTTCAAAATTC
AAAACTGGTGATGAAGTATATGGATGTGCCGGAGGTTTTAAAGAAACTGGTGGTGCACTTGCAGAGTTTATGCTTGCTGA
TGCGCGATTAATTGCTCATAAACCTAAAAATATAACAATGGAAGAAGCAGCTGCCCTACCATTAGTTGCAATTACAGCTT
GGGAATCTTTATTTGATCGTGCAAATATTAAATCAAGTCAAAATGTGCTCATTCACGGAGCTACTGGTGGCGTAGGACAC
GTAGCCATTCAATTAGCTAAATGGGCTGGTGCGAAAGTTTTTACAACTGCTTCTCAGCAAAACAAAATGGAAATAGCCCA
TCGTCTGGGAGCTGACGTAGCCATTAATTATAAAGAAGAATCTGTTCAAGAATATGTTCAAAAACATACGAATGGCAACG
GATTTGAAGTTATATTTGATACAGTAGGTGGCAAAAATCTTGATAACTCTTTCGAAGCTGCTGCAGTCAACGGAACTGTC
GTAACAATTGCAGCTCGTTCAACCCATGACCTCTCTCCTTTACACGCAAAAGGACTCTCTCTGCACGTTACTTTTATGGC
GTTAAAAATATTACATACAGATAAGCGTAATGATTGCGGAGAAATCTTAACGAAAATAACGCAAATTGTAGAAGAAGGAA
AACTTCGCCCATTGCTAGATTCTAAATCTTTTACGTTCGATGAAGTCGCACAAGCACATGAATATTTGGAGTCGAATAAA
GCAATAGGAAAAATAGTGTTGAAAAACGTTTGGTAA

Upstream 100 bases:

>100_bases
TCCTCTTCTTTATATAAAATGCTCCATATCCAAATTCAAAATATTATACTTAATTCTCGTACTTTGCTATGCTATAACCA
CGAACAGGAGGTAAGGACCA

Downstream 100 bases:

>100_bases
CTTTCACTTCATAATACAACTATTGTTGAAAAATAATAGAGGGATCGCTTTAAGCGGTCATATTTTTTCTTAAGAGATAC
CACAACGCTAAAAGCTCCCT

Product: oxidoreductase, zinc-binding dehydrogenase family

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPAILHGDVAGIVIEVGEGVSKF
KTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNITMEEAAALPLVAITAWESLFDRANIKSSQNVLIHGATGGVGH
VAIQLAKWAGAKVFTTASQQNKMEIAHRLGADVAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLDSKSFTFDEVAQAHEYLESNK
AIGKIVLKNVW

Sequences:

>Translated_331_residues
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPAILHGDVAGIVIEVGEGVSKF
KTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNITMEEAAALPLVAITAWESLFDRANIKSSQNVLIHGATGGVGH
VAIQLAKWAGAKVFTTASQQNKMEIAHRLGADVAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLDSKSFTFDEVAQAHEYLESNK
AIGKIVLKNVW
>Mature_331_residues
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPAILHGDVAGIVIEVGEGVSKF
KTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNITMEEAAALPLVAITAWESLFDRANIKSSQNVLIHGATGGVGH
VAIQLAKWAGAKVFTTASQQNKMEIAHRLGADVAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLDSKSFTFDEVAQAHEYLESNK
AIGKIVLKNVW

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=361, Percent_Identity=33.5180055401662, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI22538446, Length=327, Percent_Identity=32.1100917431193, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI22538444, Length=327, Percent_Identity=32.1100917431193, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI194239674, Length=329, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI13236495, Length=329, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI194239676, Length=329, Percent_Identity=27.0516717325228, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI18379349, Length=323, Percent_Identity=28.1733746130031, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI41872631, Length=238, Percent_Identity=28.9915966386555, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI24308257, Length=350, Percent_Identity=25.1428571428571, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI197927207, Length=192, Percent_Identity=25.5208333333333, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI28557745, Length=246, Percent_Identity=30.4878048780488, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI90669511, Length=195, Percent_Identity=29.7435897435897, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI226059159, Length=144, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI226059133, Length=144, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI226056130, Length=144, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790485, Length=328, Percent_Identity=30.4878048780488, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87082125, Length=367, Percent_Identity=24.7956403269755, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=331, Percent_Identity=29.3051359516616, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71987554, Length=359, Percent_Identity=29.8050139275766, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI212642053, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556000, Length=197, Percent_Identity=29.4416243654822, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17536829, Length=249, Percent_Identity=27.3092369477912, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323801, Length=330, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319520, Length=336, Percent_Identity=27.3809523809524, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=28.5198555956679, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=253, Percent_Identity=28.0632411067194, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320948, Length=399, Percent_Identity=23.3082706766917, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319401, Length=262, Percent_Identity=26.7175572519084, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=256, Percent_Identity=26.171875, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=23.4604105571848, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24581341, Length=368, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24581339, Length=368, Percent_Identity=26.3586956521739, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24581345, Length=242, Percent_Identity=29.3388429752066, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920632, Length=236, Percent_Identity=27.5423728813559, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330659, Length=236, Percent_Identity=27.5423728813559, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35556; Mature: 35556

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPA
CCCEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHCCCHHHCCCCCCC
ILHGDVAGIVIEVGEGVSKFKTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNITM
CCCCCCEEEEEECCCCHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCH
EEAAALPLVAITAWESLFDRANIKSSQNVLIHGATGGVGHVAIQLAKWAGAKVFTTASQQ
HHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCH
NKMEIAHRLGADVAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
HHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCEE
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLD
EEEEECCCCCCCCHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SKSFTFDEVAQAHEYLESNKAIGKIVLKNVW
CCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPA
CCCEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHCCCHHHCCCCCCC
ILHGDVAGIVIEVGEGVSKFKTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNITM
CCCCCCEEEEEECCCCHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCH
EEAAALPLVAITAWESLFDRANIKSSQNVLIHGATGGVGHVAIQLAKWAGAKVFTTASQQ
HHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCH
NKMEIAHRLGADVAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
HHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCEE
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLD
EEEEECCCCCCCCHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SKSFTFDEVAQAHEYLESNKAIGKIVLKNVW
CCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA