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The map label for this gene is pbp [H]

Identifier: 218904339

GI number: 218904339

Start: 3061010

End: 3063085

Strand: Reverse

Name: pbp [H]

Synonym: BCAH820_3223

Alternate gene names: 218904339

Gene position: 3063085-3061010 (Counterclockwise)

Preceding gene: 218904340

Following gene: 218904338

Centisome position: 57.76

GC content: 41.71

Gene sequence:

>2076_bases
ATGGAAAATAAATTATCTGGAGTGTTAGCCGCTACCTTAGCTCTAACGATGAGCCTACCAACAGGAGCGATAGCGTCTTC
TAGCAGTAAGACTCCGGTTGTATCTAGCCAAGAAGTTGCTAGCAAAGATTTGGAGAAGATTGCTGCAGAGAACGCTGCAC
TGCTCACGAAGTCCTATGAGACGACTAGTGTACAGTATGCGCTGATTGATAATGGTAAACTTATTTTGTCAGGACAGACA
GGCAAGAATGACATAGAGGGGAAAGAGCCATTAACCAAAGATACTCTATATGGAATTGGTTCAACCAGTAAAGTATATAC
GGCTGCGGCTGTTATGAAACTAGTAGACGAAGGAAAAGTTGATTTGGATGCCCCTGTTGCCCGCTATATTCCTGATTTCA
AAATGAAAGATAAACGATATAAGCGTATTACACCGCGTATGCTGTTGAATCACTCCTCGGGTTTGCAAGGTTCGACGTTC
AATAATGCATTTTTATTTAAAGATAATGATGTTTATGCCCATGATATCTTGTTGCAACAATTGTCCAACCAAAACTTGAA
GGCAGACCCTGGCGCGTTCTCAGTATACTGTAATGACGGTTTTACACTGGCTGAGATTTTGGTAGAAAGAGTCAGTGGTA
TGAGTTTTACTGAATTTCTACATCAAAAGTTTACAGAGCCATTAAAACTGAATCATACGATAACATCGCAAGATAAATGG
GAAGACGAAAAGCGGGCTGGACTGTATTCTCCGACATACCAGGGACAGCTACCAAGTGAAATGGTGAATCTGATTGGTAC
GGGAGGAATCTCTTCTACTGCAGAAGATGTGGTGCGATTCTCACAAATATTTATGGGACAGGGAAAAGAAATTCTCTCTA
ATAAAGCAGTCAAGGCGATGGAACAAGAAGAATATAAAAAAGGAATGTGGCCGGGAGATAGCGGAAATGTGTTCAACTAT
GGTCTTGGCTGGGATAGTGTGAAACTATACCCATTCAGTGAATATGGGATAAAAGCGTTGACTAAGGGTGGGGATACGAT
ACTGCAACATGCTACATTGGTCGTGCTTCCAGAACAGAAGATGGCAGCAGCTGTATTGTCCTCCGGCGGCTCCAGCATGA
CAAATCAACTGTTGGCAAACAAATTACTGCTAGCTAGGCTTAAAGAGAAAGGAACAATTAAGGATATAAAACCAGATAAA
TCCTTCGGCAAGCCCGTCAAGGCTAAAGTGCCTCAAGACGTGGTAAAAAAAGCGGGTTTTTATGGAAATAGCCGCAGCCA
TTTCAAAATAGAAATTACGAAGAAGGGAGAACTGTTTTTACCAACTAACCCGGAAGAAAAATATGTATATACGGCGGATG
GAAGCTTTATAAATGAGAAGGGTACTTCCAAGCTTAACTTCGTTACTGAGAAGAATGGAAAAGTTTATTTGAGAGAGAGC
ACATATGAATTATCGCCGGGATTGGGGCAAACTGTGCTGACTCAATATTTAGCCCAAAAATTAGAAAACAATGTGTTACC
GAAGAAAACAGCTGCTGCATGGGCGAAGCGCGAGGGCGGAAAGTTCTACCTCGTTAACGAAAAATTTAATTCTATGAACT
ATCTAGGACAACTAATGCCTCTTAACACACAAATTACGATCAAGGATGGGTATTGGGACGGCAAAAAAATTACAGGTCCG
AATACGGCGACGCATCAAATTCAGATTCCTGTGATGTATGGGCGGGATACGACGGAAGCTCATTTTTATACAGAGAATGG
TACTGAATATATGGAGATGGCCAGCTTTTTATACGTCAGTGAATCTAACGTAAAATCCCTTGATGCAGGTCAATTATCGA
AAGTTACACTGCAAAAAAATGGGCATGCGAAATGGTTTACAATCCCGCAAGAGGCAGCAGGGAAAACGATGAATGTGGAG
TTGCCATCAGGAAGTTCATTCGCGGTGTATGATGAGAATGGAGTATGCGTCAATTTTAGCGTTGTTAGTAATAATAACAA
AGTGAAACTACCAGAGAACGGAACGGTTGTATTTGCTGGCGCACCGAACTCCGAATTTACAGTCGCATTGAACTAG

Upstream 100 bases:

>100_bases
ACGACAGTAGAGATAAAGCCAGAATAGTAGTTTATGTAATGTTTGTAATTGAACAAATAAAAGATGAAATCGATCATTTA
TCTAAGGAGGAATTTTTCTT

Downstream 100 bases:

>100_bases
CTACAACTCGGGATAGACTTCAATAAAACAGTACGACATGGAAAAGATATTTTATTTGTATCTTAAGTATTCCCTTAAAT
GCTATTACACTTAAATTCTT

Product: putative penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDAPVARYIPDFKMKDKRYKRITPRMLLNHSSGLQGSTF
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGLYSPTYQGQLPSEMVNLIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTILQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDK
SFGKPVKAKVPQDVVKKAGFYGNSRSHFKIEITKKGELFLPTNPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
TYELSPGLGQTVLTQYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSMNYLGQLMPLNTQITIKDGYWDGKKITGP
NTATHQIQIPVMYGRDTTEAHFYTENGTEYMEMASFLYVSESNVKSLDAGQLSKVTLQKNGHAKWFTIPQEAAGKTMNVE
LPSGSSFAVYDENGVCVNFSVVSNNNKVKLPENGTVVFAGAPNSEFTVALN

Sequences:

>Translated_691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDAPVARYIPDFKMKDKRYKRITPRMLLNHSSGLQGSTF
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGLYSPTYQGQLPSEMVNLIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTILQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDK
SFGKPVKAKVPQDVVKKAGFYGNSRSHFKIEITKKGELFLPTNPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
TYELSPGLGQTVLTQYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSMNYLGQLMPLNTQITIKDGYWDGKKITGP
NTATHQIQIPVMYGRDTTEAHFYTENGTEYMEMASFLYVSESNVKSLDAGQLSKVTLQKNGHAKWFTIPQEAAGKTMNVE
LPSGSSFAVYDENGVCVNFSVVSNNNKVKLPENGTVVFAGAPNSEFTVALN
>Mature_691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKVDLDAPVARYIPDFKMKDKRYKRITPRMLLNHSSGLQGSTF
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGLYSPTYQGQLPSEMVNLIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTILQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDK
SFGKPVKAKVPQDVVKKAGFYGNSRSHFKIEITKKGELFLPTNPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
TYELSPGLGQTVLTQYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSMNYLGQLMPLNTQITIKDGYWDGKKITGP
NTATHQIQIPVMYGRDTTEAHFYTENGTEYMEMASFLYVSESNVKSLDAGQLSKVTLQKNGHAKWFTIPQEAAGKTMNVE
LPSGSSFAVYDENGVCVNFSVVSNNNKVKLPENGTVVFAGAPNSEFTVALN

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1786574, Length=315, Percent_Identity=24.7619047619048, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082101, Length=240, Percent_Identity=27.5, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=274, Percent_Identity=27.3722627737226, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533026, Length=280, Percent_Identity=26.7857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565630, Length=301, Percent_Identity=25.5813953488372, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 75856; Mature: 75856

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSGQTGKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCC
DLDAPVARYIPDFKMKDKRYKRITPRMLLNHSSGLQGSTFNNAFLFKDNDVYAHDILLQQ
CCCCCHHHHCCCCCCCCCHHHHCCHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCEECCCCCC
EDEKRAGLYSPTYQGQLPSEMVNLIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAM
CHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EQEEYKKGMWPGDSGNVFNYGLGWDSVKLYPFSEYGIKALTKGGDTILQHATLVVLPEQK
HHHHHHCCCCCCCCCCEEEECCCCCCEEEEECHHCCCCEECCCCHHHECCEEEEEECCHH
MAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDKSFGKPVKAKVPQDVVKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCC
YGNSRSHFKIEITKKGELFLPTNPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
CCCCCCEEEEEEEECCCEEECCCCCCCEEEECCCCEECCCCCCEEEEEEECCCEEEEEEC
TYELSPGLGQTVLTQYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSMNYLGQLMP
CEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHEEE
LNTQITIKDGYWDGKKITGPNTATHQIQIPVMYGRDTTEAHFYTENGTEYMEMASFLYVS
CCEEEEEECCCCCCCEECCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHEEEEE
ESNVKSLDAGQLSKVTLQKNGHAKWFTIPQEAAGKTMNVELPSGSSFAVYDENGVCVNFS
CCCCCCCCCCCCEEEEEECCCCEEEEECCHHHCCCEEEEECCCCCEEEEECCCCEEEEEE
VVSNNNKVKLPENGTVVFAGAPNSEFTVALN
EEECCCEEECCCCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSGQTGKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCC
DLDAPVARYIPDFKMKDKRYKRITPRMLLNHSSGLQGSTFNNAFLFKDNDVYAHDILLQQ
CCCCCHHHHCCCCCCCCCHHHHCCHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCEECCCCCC
EDEKRAGLYSPTYQGQLPSEMVNLIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKAM
CHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EQEEYKKGMWPGDSGNVFNYGLGWDSVKLYPFSEYGIKALTKGGDTILQHATLVVLPEQK
HHHHHHCCCCCCCCCCEEEECCCCCCEEEEECHHCCCCEECCCCHHHECCEEEEEECCHH
MAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDKSFGKPVKAKVPQDVVKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCC
YGNSRSHFKIEITKKGELFLPTNPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
CCCCCCEEEEEEEECCCEEECCCCCCCEEEECCCCEECCCCCCEEEEEEECCCEEEEEEC
TYELSPGLGQTVLTQYLAQKLENNVLPKKTAAAWAKREGGKFYLVNEKFNSMNYLGQLMP
CEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHEEE
LNTQITIKDGYWDGKKITGPNTATHQIQIPVMYGRDTTEAHFYTENGTEYMEMASFLYVS
CCEEEEEECCCCCCCEECCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHEEEEE
ESNVKSLDAGQLSKVTLQKNGHAKWFTIPQEAAGKTMNVELPSGSSFAVYDENGVCVNFS
CCCCCCCCCCCCEEEEEECCCCEEEEECCHHHCCCEEEEECCCCCEEEEECCCCEEEEEE
VVSNNNKVKLPENGTVVFAGAPNSEFTVALN
EEECCCEEECCCCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]