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The map label for this gene is vanRB [H]

Identifier: 218904325

GI number: 218904325

Start: 3046003

End: 3046665

Strand: Reverse

Name: vanRB [H]

Synonym: BCAH820_3209

Alternate gene names: 218904325

Gene position: 3046665-3046003 (Counterclockwise)

Preceding gene: 218904327

Following gene: 218904324

Centisome position: 57.46

GC content: 44.04

Gene sequence:

>663_bases
ATGGATATACGAATACTGCTTGTCGAGGACGATGAGCATATTTGCAATGCAGTAAAAGTTTTTTTATCTGGAGCTGGATA
TAAGGTGGATGCTTGTTTTAACGGTGATGAAGCACATACCAAGTTTTATGATAACACTTATCAGCTTGTCATTCTTGATA
TCTTGCTACCGGGAATGAACGGTCATGAGCTTCTAAGGGAGTTCCGTAAGCTGAATAATACGCCGGTTCTGATGATGACC
GCTCTTTCCGATGATGAGAATCAAATCAGAGCGTTTGATGCGGAAGCGGACGATTATGTGACTAAGCCGTTCAAGATTCA
GCTATTGCTGAAACGTGTGGAGGCGCTGCTCCGTCGCAGCGGTGCAGTGGCAAAGGAACTGCACTATGGCAAGCTGACAA
TTTTGCCGGAAGATTTCAAGGTTTTTTATGACGACGAAGAATTACTTTTGACCCTTAAAGAGTTTGAAATCTTAATGCTA
CTGGTGCAAAACAATGGCAGAACACTATCTCATGAAGTTATTTTGTCCCGCGTGTGGGGCTACGATTTTGACGGTGATGG
CAGCACCGTGCATACTCACATTAAAAACCTACGGGCGAAGCTACCGGATAATATCATCAAAACAGTACGCGGAGTGGGCT
ACCGATTGGAGGAAACTTCATGA

Upstream 100 bases:

>100_bases
AGGATGCCGTAAAATCTGTTGATGGATGAACGAAATAAATCTTAAAACTACAGGGAAAATACAGATTGCTGTGTTATCTT
TTTTTTGGAGGTATACATTT

Downstream 100 bases:

>100_bases
AAAAGAATGGGATATTTATTAAGATTTTTGCCTATACGATAGTTGCTATGTTGTTGATTGTTTTCGTAACTACCGCATTG
TTTTCAGGTCAATTCTTAAC

Product: alkaline phosphatase synthesis transcriptional regulatory proteinphoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MDIRILLVEDDEHICNAVKVFLSGAGYKVDACFNGDEAHTKFYDNTYQLVILDILLPGMNGHELLREFRKLNNTPVLMMT
ALSDDENQIRAFDAEADDYVTKPFKIQLLLKRVEALLRRSGAVAKELHYGKLTILPEDFKVFYDDEELLLTLKEFEILML
LVQNNGRTLSHEVILSRVWGYDFDGDGSTVHTHIKNLRAKLPDNIIKTVRGVGYRLEETS

Sequences:

>Translated_220_residues
MDIRILLVEDDEHICNAVKVFLSGAGYKVDACFNGDEAHTKFYDNTYQLVILDILLPGMNGHELLREFRKLNNTPVLMMT
ALSDDENQIRAFDAEADDYVTKPFKIQLLLKRVEALLRRSGAVAKELHYGKLTILPEDFKVFYDDEELLLTLKEFEILML
LVQNNGRTLSHEVILSRVWGYDFDGDGSTVHTHIKNLRAKLPDNIIKTVRGVGYRLEETS
>Mature_220_residues
MDIRILLVEDDEHICNAVKVFLSGAGYKVDACFNGDEAHTKFYDNTYQLVILDILLPGMNGHELLREFRKLNNTPVLMMT
ALSDDENQIRAFDAEADDYVTKPFKIQLLLKRVEALLRRSGAVAKELHYGKLTILPEDFKVFYDDEELLLTLKEFEILML
LVQNNGRTLSHEVILSRVWGYDFDGDGSTVHTHIKNLRAKLPDNIIKTVRGVGYRLEETS

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=216, Percent_Identity=38.4259259259259, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=38.5321100917431, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=35.5855855855856, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.4444444444444, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=34.7222222222222, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=30.316742081448, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=32.1428571428571, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=33.9366515837104, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=28.8888888888889, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787229, Length=219, Percent_Identity=29.6803652968037, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790437, Length=104, Percent_Identity=35.5769230769231, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=114, Percent_Identity=32.4561403508772, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25203; Mature: 25203

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRILLVEDDEHICNAVKVFLSGAGYKVDACFNGDEAHTKFYDNTYQLVILDILLPGMN
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEECCCCCEEEEEEECCCCCC
GHELLREFRKLNNTPVLMMTALSDDENQIRAFDAEADDYVTKPFKIQLLLKRVEALLRRS
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
GAVAKELHYGKLTILPEDFKVFYDDEELLLTLKEFEILMLLVQNNGRTLSHEVILSRVWG
CCHHHHCCCCEEEEECCCCEEEECCHHHEEEHHHHEEEEEEEECCCCEEHHHHHHHHHCC
YDFDGDGSTVHTHIKNLRAKLPDNIIKTVRGVGYRLEETS
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCEEEECCC
>Mature Secondary Structure
MDIRILLVEDDEHICNAVKVFLSGAGYKVDACFNGDEAHTKFYDNTYQLVILDILLPGMN
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEECCCCCEEEEEEECCCCCC
GHELLREFRKLNNTPVLMMTALSDDENQIRAFDAEADDYVTKPFKIQLLLKRVEALLRRS
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
GAVAKELHYGKLTILPEDFKVFYDDEELLLTLKEFEILMLLVQNNGRTLSHEVILSRVWG
CCHHHHCCCCEEEEECCCCEEEECCHHHEEEHHHHEEEEEEEECCCCEEHHHHHHHHHCC
YDFDGDGSTVHTHIKNLRAKLPDNIIKTVRGVGYRLEETS
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]