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The map label for this gene is lysP [H]

Identifier: 218904201

GI number: 218904201

Start: 2920182

End: 2921648

Strand: Direct

Name: lysP [H]

Synonym: BCAH820_3085

Alternate gene names: 218904201

Gene position: 2920182-2921648 (Clockwise)

Preceding gene: 218904199

Following gene: 218904202

Centisome position: 55.07

GC content: 39.67

Gene sequence:

>1467_bases
ATGAATAGCGCAACGAATCAAACTACCTCTCAAACAGAAACTACAAAAGGAAAAGGTGAATTAAGACGCGGTCTAAAATC
AAGGCACCTTACGATGATTTCTCTCGGCGGTACAATTGGTACCGGACTATTTCTTGCCAGCGGTGGTGTCATTCATTCAG
CTGGACCTGGCGGCGCATTAATTGCATACGCCGCAATTGGAATTATGGTTTACTTTTTAATGACAAGCTTAGCCGAACTC
GCAGCTTACATGCCTGTTACTGGATCTTTTAGCACGTACGCAACAAAATTTGTTGATCCATCACTTGGCTTTGCACTTGG
ATGGAACTATTGGTATAACTGGGCAATTACTATCGCTGCTGAACTAGCGGCTGTAACATTAATTATGAAATTTTGGTTTC
CAGATACTCCTTCCCTCATTTGGAGCGGATTATGTTTAGCTATTATTTTCCTTTTAAACTACTTATCTGTTAAAGGATTT
GGTGAATCTGAATATTGGTTCGCACTTATTAAAGTAGCTACAATTATTATCTTTTTAATTGTCGGGTTTATGATGATTTT
CGGAATTATGGGCGGCGAAACTGTTGGATTTAAAAACTTCACTGTTGCAGATGCACCATTTAATGGCGGCATCATGGCAA
TTATCGGTGTATTTATGGCAGCTGGTTTCTCATTCCAAGGTACTGAATTATTAGGTGTAGCTGCTGGTGAAACATCTGAT
CCAGAGCGTAATATTCCAAAAGCAATTCGTTCGATCTTTTGGCGTATCCTTTTATTCTATATCCTTGCGATTCTCGTTAT
CGGTTTATTAATTCCTTATACAACTGAAAGTCTTGCCGCAAGTGATGTAACAGTAAGTCCATTTACACTTATTTTTGAAA
AAGCGGGCGTTGCCTTCGCTGCTTCTGTTATGAACGCTGTTATTTTAACGGCAGTACTATCTGCTGGTAACTCTGGTATG
TATGCATCAACTCGTATGCTTTGGGACTTAGCTCGCCAAGGGAAAGCACCAAAGTTTCTTGGTAAATTAGATAGCCGCGG
CGTACCTGTTAACGCATTAATCGTAACATCGATTGTCGGTAGTATCGCTTTCATTGCTTCTTTATTCGGTGACGGTGTTG
TATACATTTGGTTATTAAATGCATCCGGAATGTCTGGCTTTATCGCATGGGTTGGAATCGCAATTAGTCATTACCGTTTC
CGCAAAGCATATATCGCACAAGGAAAAGATTTAAATGACTTACCTTATAGAGCAAAATGGTTCCCATTCGGACCAATCTT
CGCTTTTGCACTTTGCGTCATCGTAATTTTAGGTCAAAACTACGGCGCATTTATGGGCGAATCAATCGATTGGAACGGCG
TACTCGTTTCTTACATCGGTTTACCACTCTTCTTAGTACTTTGGTTAGGATACAAATTTACGAAAAAAACAAAAGTCATT
CCACTTGATAAATGCGAACTAAAATAA

Upstream 100 bases:

>100_bases
GGGGTGGTTATTTGTGAAACGTTCCGCCAAATTCCTTTGGCGGTTTTTTGTATTTTTCTCCCCCGCTCCTTCCTATCTTA
CAAGAAAAGGAGTGTTGAAC

Downstream 100 bases:

>100_bases
AGTGAAACGAGCAAACAAATTTGTTTGCTCGTTTTTTATTGCAAACCTCTTTGCTTCCCTATTGCCCCTGTTTTTGCAAT
AATAAAGGAAATATAAATAA

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
AAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK

Sequences:

>Translated_488_residues
MNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
AAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK
>Mature_488_residues
MNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAEL
AAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGF
GESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGM
YASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRF
RKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
PLDKCELK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=481, Percent_Identity=62.993762993763, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=470, Percent_Identity=39.1489361702128, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1786789, Length=431, Percent_Identity=37.3549883990719, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=36.3829787234043, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=36.6589327146172, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87081915, Length=427, Percent_Identity=34.192037470726, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1790653, Length=349, Percent_Identity=37.8223495702006, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789017, Length=394, Percent_Identity=34.7715736040609, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=36.4102564102564, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87081869, Length=406, Percent_Identity=24.8768472906404, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082023, Length=411, Percent_Identity=25.7907542579075, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082250, Length=238, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=414, Percent_Identity=24.3961352657005, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=360, Percent_Identity=23.6111111111111, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=484, Percent_Identity=38.4297520661157, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=491, Percent_Identity=34.4195519348269, Blast_Score=318, Evalue=9e-88,
Organism=Saccharomyces cerevisiae, GI6322892, Length=498, Percent_Identity=37.3493975903614, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6324990, Length=494, Percent_Identity=33.4008097165992, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324059, Length=494, Percent_Identity=35.0202429149798, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324924, Length=493, Percent_Identity=34.0770791075051, Blast_Score=286, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6320717, Length=495, Percent_Identity=32.1212121212121, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=511, Percent_Identity=31.1154598825832, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=425, Percent_Identity=35.0588235294118, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319542, Length=505, Percent_Identity=30.8910891089109, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320251, Length=501, Percent_Identity=30.5389221556886, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6322967, Length=466, Percent_Identity=31.5450643776824, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319543, Length=495, Percent_Identity=31.1111111111111, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=509, Percent_Identity=28.8801571709234, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6321053, Length=468, Percent_Identity=32.0512820512821, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6324981, Length=487, Percent_Identity=30.5954825462012, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6319608, Length=474, Percent_Identity=27.6371308016878, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=553, Percent_Identity=27.3056057866184, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281366235, Length=390, Percent_Identity=23.5897435897436, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007820, Length=390, Percent_Identity=23.5897435897436, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007818, Length=391, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85725152, Length=391, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52751; Mature: 52751

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHH
IAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHH
ELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
HHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHH
ASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
SIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKW
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
PLDKCELK
CCCCCCCC
>Mature Secondary Structure
MNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHH
IAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHH
ELAAVTLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGFMMIFGIMGGETVGFKNFTVADAPFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSD
HHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHH
ASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
SIAFIASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKW
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FPFGPIFAFALCVIVILGQNYGAFMGESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVI
CCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
PLDKCELK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]