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The map label for this gene is yisK [H]

Identifier: 218904152

GI number: 218904152

Start: 2875853

End: 2876797

Strand: Reverse

Name: yisK [H]

Synonym: BCAH820_3036

Alternate gene names: 218904152

Gene position: 2876797-2875853 (Counterclockwise)

Preceding gene: 218904153

Following gene: 218904151

Centisome position: 54.25

GC content: 38.1

Gene sequence:

>945_bases
ATGAAACTTGTTACTTTTACACATAATGGAGAAACGCGAATTGCTGCTTTAGAAAATGGGGAATTGATTGATTTGCATGC
TGCTTATAAAGCAAAACTGACAAGTGAGGGAAACCTTAGGGCTACTCAAATTGCAGAGGCGTATATCCCAAAGGATATGA
ATGGGTTTTTACAAGGTGGATTAGAAAGTATGAATGTAGCAAAAGAGGCGATCAATTATGCACGTATGAAAAACCATAAA
GAAAAATTGGTATTTGAAGAAGGGGAAGTGAAAATTGAAGCTCCAGTACCTTCGCCAGGAAAAATTATATGTGTAGGTCA
CAATTATCGTGAACACATTTTGGAAATGAAACGAGAGTTACCTGCTTTTCCGGTTATCTTTGCAAAGTTTGCGAATACAG
TAGTCGGTCCACAAGATGATATTCCATTTTATCCGATTTCAGAACAATTAGATTACGAAGCTGAATTTGCTTTTGTAATT
GGAAATCGTGCTCGTAATGTTTCAGAAGAAGATGCCCTTCATTATGTAGCAGGTTACACAATTGTAAATGATATTACTTA
TCGTGATATTCAGCGCCGTACAATTCAATGGCTTCAAGGAAAGACCGTTGAAGGAAGCGCTCCAATGGGACCATGGTTAA
TTACTTCAGATGAATTAAAGAACCCATCTGGTTTGGAAATCGTATTAACGGTAAATGGAGAGAAACGGCAACAGTCTAAT
ACTGCTAATTTAGTATTCTCGGTACAATATCTCGTTTCGTTTTTATCCGGTCTAATGACACTAGAGCCAGGGGACGTCAT
TTTAACAGGTACGCCAGGTGGTGTAGGAGTTGCACGTAATCCGCAAACATTTCTTAAAGATGGAGATATCGTTCGAATTG
AAGTTGATGGAGTAGGTGTACTAGAAAATAAAGTGAGACAAAAGTTAGAGGTGCCAGTACTATGA

Upstream 100 bases:

>100_bases
TTTATAACAAAAAGTGGGGCGGGAAAGTTATACGCTATCATCGTTCTTGATTATTTGGGACGATAGAACTTTCAATTATT
TAGAGGAAAGGGAGATTACT

Downstream 100 bases:

>100_bases
CGAAAAACTTACAAGTCCATGCGACCGAGTCTATTTATGAATCAATCAATAAGATAAAAACGATTGTTAAGCCTTTACCA
GAGGAAATCATCTACTGGAA

Product: fumarylacetoacetate hydrolase domain-containing protein 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKLVTFTHNGETRIAALENGELIDLHAAYKAKLTSEGNLRATQIAEAYIPKDMNGFLQGGLESMNVAKEAINYARMKNHK
EKLVFEEGEVKIEAPVPSPGKIICVGHNYREHILEMKRELPAFPVIFAKFANTVVGPQDDIPFYPISEQLDYEAEFAFVI
GNRARNVSEEDALHYVAGYTIVNDITYRDIQRRTIQWLQGKTVEGSAPMGPWLITSDELKNPSGLEIVLTVNGEKRQQSN
TANLVFSVQYLVSFLSGLMTLEPGDVILTGTPGGVGVARNPQTFLKDGDIVRIEVDGVGVLENKVRQKLEVPVL

Sequences:

>Translated_314_residues
MKLVTFTHNGETRIAALENGELIDLHAAYKAKLTSEGNLRATQIAEAYIPKDMNGFLQGGLESMNVAKEAINYARMKNHK
EKLVFEEGEVKIEAPVPSPGKIICVGHNYREHILEMKRELPAFPVIFAKFANTVVGPQDDIPFYPISEQLDYEAEFAFVI
GNRARNVSEEDALHYVAGYTIVNDITYRDIQRRTIQWLQGKTVEGSAPMGPWLITSDELKNPSGLEIVLTVNGEKRQQSN
TANLVFSVQYLVSFLSGLMTLEPGDVILTGTPGGVGVARNPQTFLKDGDIVRIEVDGVGVLENKVRQKLEVPVL
>Mature_314_residues
MKLVTFTHNGETRIAALENGELIDLHAAYKAKLTSEGNLRATQIAEAYIPKDMNGFLQGGLESMNVAKEAINYARMKNHK
EKLVFEEGEVKIEAPVPSPGKIICVGHNYREHILEMKRELPAFPVIFAKFANTVVGPQDDIPFYPISEQLDYEAEFAFVI
GNRARNVSEEDALHYVAGYTIVNDITYRDIQRRTIQWLQGKTVEGSAPMGPWLITSDELKNPSGLEIVLTVNGEKRQQSN
TANLVFSVQYLVSFLSGLMTLEPGDVILTGTPGGVGVARNPQTFLKDGDIVRIEVDGVGVLENKVRQKLEVPVL

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=259, Percent_Identity=42.4710424710425, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI40786394, Length=259, Percent_Identity=42.4710424710425, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI66348062, Length=180, Percent_Identity=37.7777777777778, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI215422413, Length=180, Percent_Identity=37.7777777777778, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI13654274, Length=180, Percent_Identity=37.7777777777778, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1787428, Length=201, Percent_Identity=32.8358208955224, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557057, Length=215, Percent_Identity=33.953488372093, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324161, Length=230, Percent_Identity=26.9565217391304, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28572127, Length=219, Percent_Identity=41.0958904109589, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24663695, Length=223, Percent_Identity=36.7713004484305, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI28571789, Length=197, Percent_Identity=32.994923857868, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 34798; Mature: 34798

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVTFTHNGETRIAALENGELIDLHAAYKAKLTSEGNLRATQIAEAYIPKDMNGFLQGG
CEEEEEEECCCEEEEEECCCCEEEEEEHEEEEECCCCCEEHHHHHHHHCCCCCCHHHHCC
LESMNVAKEAINYARMKNHKEKLVFEEGEVKIEAPVPSPGKIICVGHNYREHILEMKREL
HHHHHHHHHHHHHHHHHCCCHHEEEECCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHC
PAFPVIFAKFANTVVGPQDDIPFYPISEQLDYEAEFAFVIGNRARNVSEEDALHYVAGYT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHEEEEECEE
IVNDITYRDIQRRTIQWLQGKTVEGSAPMGPWLITSDELKNPSGLEIVLTVNGEKRQQSN
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHCCCCCCCEEEEEECCCHHCCCC
TANLVFSVQYLVSFLSGLMTLEPGDVILTGTPGGVGVARNPQTFLKDGDIVRIEVDGVGV
CCEEEEEHHHHHHHHHHHEEECCCCEEEECCCCCCCCCCCCHHHHCCCCEEEEEECCCCH
LENKVRQKLEVPVL
HHHHHHHHHCCCCC
>Mature Secondary Structure
MKLVTFTHNGETRIAALENGELIDLHAAYKAKLTSEGNLRATQIAEAYIPKDMNGFLQGG
CEEEEEEECCCEEEEEECCCCEEEEEEHEEEEECCCCCEEHHHHHHHHCCCCCCHHHHCC
LESMNVAKEAINYARMKNHKEKLVFEEGEVKIEAPVPSPGKIICVGHNYREHILEMKREL
HHHHHHHHHHHHHHHHHCCCHHEEEECCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHC
PAFPVIFAKFANTVVGPQDDIPFYPISEQLDYEAEFAFVIGNRARNVSEEDALHYVAGYT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHEEEEECEE
IVNDITYRDIQRRTIQWLQGKTVEGSAPMGPWLITSDELKNPSGLEIVLTVNGEKRQQSN
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHCCCCCCCEEEEEECCCHHCCCC
TANLVFSVQYLVSFLSGLMTLEPGDVILTGTPGGVGVARNPQTFLKDGDIVRIEVDGVGV
CCEEEEEHHHHHHHHHHHEEECCCCEEEECCCCCCCCCCCCHHHHCCCCEEEEEECCCCH
LENKVRQKLEVPVL
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]