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The map label for this gene is lsrK [H]

Identifier: 218904093

GI number: 218904093

Start: 2814468

End: 2816030

Strand: Direct

Name: lsrK [H]

Synonym: BCAH820_2977

Alternate gene names: 218904093

Gene position: 2814468-2816030 (Clockwise)

Preceding gene: 218904092

Following gene: 218904094

Centisome position: 53.08

GC content: 40.31

Gene sequence:

>1563_bases
ATGTCCAATTTATTAGCTTTCGATGCTGGTACAGGAAGTATTCGAGCAGTTCTTTTTGATTTACATGGTAATCAAATTGC
AGTAAGTCAAAAAGAATGGATTCACAAATCTGACCCACGTTATCCAGGCTCTATGAACTTTGATGTAATAGAAAATTGGA
AACTAGTACAAGAATGCACGAAAGAGGTTCTTCAAAAAAGCAATACTCTTGCCTCTTCCATTCTTGCTATTAGTGCGACA
AGTATGCGGGAAGGGTTTGTTTTATATGATCAAGATGGGCAAGAAATATGGGCGTGTGCAAATGTTGATGGGCGCGCATC
TGCTGAGGTTAGTGAACTAAAAGAAATTCGGTCACACCTTGAAAAAGATTTATATACAAAGTCTGGTCAAACTTTTTCAT
TAGGTGCTTTACCCCGCCTACTTTGGATTAAAAAACATGAACCCGACGTCTATAATACTATTCACTCTTTTACAATGTTA
AACGATTGGATCTTATATAAATTAAGCGGAGTGCTACAAATCGATCCTTCAAACGGATGTACGTCAGGTATTTTTGACTT
ACAAAATAGAGTGTGGGATAACGATGTTGCTAAGGAGTGCGGTCTATCTTTACCATTTTCACCAACAGTAAATGAAGCTG
GTACAGTAATTGGCAACGTTACAAAAGAGTGTGCAGCATTAACTGGATTATGTGAAGGAATTCCTGTCGTAGCCGGGGGC
GGAGATGCTCAAATGGCATCGCTCGGAACTGGAGTCGTGAAACCGAATCAAACATTAATATGCGGAGGTAGTTTTTGGCA
ACAAGAAGTGAATGTTACTGAGCCAATACCAGATCCACAAGCTGCGATTCGTATAAATTGTCACGTCGTACGTAACCTAT
GGCAATACGAAACGATTGCCTTTTTCCCAGGCCTCGTTATGCGCTGGTTTCGAGACGCTTTTTGTCAAGAGGAAAAGAAA
CTTGCTGACAAACTCGGTGTAGATGCTTATGAATTACTAGAAGAACAAGCGAAAGACGTACCTGTCGGTTCACATGGCAT
TATCCCTACTTTTTCAAACGTTATGAACTACATTTCTTGGCGTCATGCCGCACCTTCTTTTTTAAATTTAAGTTTAGACG
CTGACAAATGCGGAAAAAAAGAACTGTTTCGTGCTATTGAAGAAAATGCCGCCTTCGTTACACTTGGAAACTTAAAATTA
ATAGAAAATCTAACTGGTATATTCCCTTCTGAAGTTATTTTTGCTGGTGGTGCCGCTAAAGGAAAACTATGGCCACAAAT
TCTATCAGACGTCCTTGGTATTCCTGTAAAAGTACCTGTTGTGAAAGAAGCAGCTGCTTTAGGAACTGCGATTGCTGCAG
GAGTTGGTGCTGGCATATATTCATCTATGGAAGAGACTGCCGAACAGTTTGTACAGTGGGAGCAAACATTCGAACCAGTT
ACTGAAAATCACGAACTATATAAAGAGTTCTATGAAACATGGAAAACTGTGTATAACAGTCAGCTCGCTTTAGCTGATAA
CGGGCTCACCTCACACATGTGGATTGCGCCTGGTGCACTGTAA

Upstream 100 bases:

>100_bases
TAGATGCAATTTATGGTGCCTTAAAAGGAAAGTTTATTCATACATTAATTACCGATGAGGAAACTGCCCTTTCCTTATTA
CGAAAGGATGGTGATTGTTA

Downstream 100 bases:

>100_bases
CACATTACATAAAGGAGTGGAATGTATGTTAAAAGCGAATGAAAATGACTTCTCCTATCGCTTCGGTGATAACGGGCCGA
AATATTTAATACAAGGTCCG

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAISAT
SMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTML
NDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
GDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEEKK
LADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLKL
IENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFEPV
TENHELYKEFYETWKTVYNSQLALADNGLTSHMWIAPGAL

Sequences:

>Translated_520_residues
MSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAISAT
SMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTML
NDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
GDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEEKK
LADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLKL
IENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFEPV
TENHELYKEFYETWKTVYNSQLALADNGLTSHMWIAPGAL
>Mature_519_residues
SNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAISATS
MREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLN
DWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGGG
DAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEEKKL
ADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLKLI
ENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFEPVT
ENHELYKEFYETWKTVYNSQLALADNGLTSHMWIAPGAL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=529, Percent_Identity=22.4952741020794, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787789, Length=516, Percent_Identity=54.4573643410853, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1789168, Length=498, Percent_Identity=23.4939759036145, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790361, Length=517, Percent_Identity=24.9516441005803, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789987, Length=506, Percent_Identity=24.5059288537549, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789138, Length=334, Percent_Identity=24.251497005988, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790005, Length=284, Percent_Identity=27.8169014084507, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=470, Percent_Identity=23.1914893617021, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 57131; Mature: 56999

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECT
CCCEEEEECCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHH
KEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHL
HHHHHHCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHH
EKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLNDWILYKLSGVLQIDPSNGC
HHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCCCC
TSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
CHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECC
GDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPIPDPQAAIRINCHVVRNLWQYETIA
CCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
FFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLKLIENLTGIFPSEVIFAGGAAK
HCCCCCEEEEECCHHHCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHEEECCCCC
GKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFEPV
CCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TENHELYKEFYETWKTVYNSQLALADNGLTSHMWIAPGAL
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCC
>Mature Secondary Structure 
SNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECT
CCEEEEECCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHH
KEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHL
HHHHHHCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHH
EKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLNDWILYKLSGVLQIDPSNGC
HHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCCCC
TSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
CHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECC
GDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPIPDPQAAIRINCHVVRNLWQYETIA
CCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
FFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLKLIENLTGIFPSEVIFAGGAAK
HCCCCCEEEEECCHHHCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHEEECCCCC
GKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFEPV
CCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TENHELYKEFYETWKTVYNSQLALADNGLTSHMWIAPGAL
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA